1. Going for a stroll on lurasidone: Considerations on an atypical case of acute compartment syndrome of both legs
- Author
-
L. Bosco, T. Russo, Y.M. Falzone, C. Butera, A. Del Prete, R. Mellone, U. Del Carro, M. Filippi, and S.C. Previtali
- Subjects
Foot-drop ,Walking ,Rhabdomyolysis ,Atypical antipsychotics ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Non-traumatic acute bilateral compartment syndrome is a rare condition that may lead to limb ischemia. We describe a case of this syndrome occurring after a five-kilometer walk in a young woman receiving chronic treatment with lurasidone, leading to a bilateral foot-drop and rhabdomyolysis of the anterolateral compartment of both legs. Due to her late presentation in the emergency department, we opted for a conservative approach, closely monitoring her renal function. We noticed a subsequent clinical and biochemical improvement over the following days, with the patient returning to her daily routine in a matter of weeks, despite a persisting bilateral foot drop. Since atypical antipsychotics are known to be associated with rhabdomyolysis, while possibly exerting a toxic effect on mitochondria, we hypothesize that a mild aerobic physical exertion might have triggered the event, in the context of an iatrogenic muscle susceptibility to oxidative distress.
- Published
- 2023
- Full Text
- View/download PDF