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3. Ictal Electroencephalographic Characteristics of Nodding Syndrome: A Comparative Case‐Series from South Sudan, Tanzania, and Uganda

Author

Mazumder, Rajarshi, Lagoro, David Kitara, Nariai, Hiroki, Danieli, Alberto, Eliashiv, Dawn, Engel, Jerome, Bernardina, Bernardo Dalla, Kegele, Josua, Lerche, Holger, Sejvar, James, Matuja, William, Schmutzhard, Erich, Bonanni, Paolo, De Polo, Gianni, Wagner, Thomas, and Winkler, Andrea Sylvia

Subjects
Neurosciences, Mental Health, Brain Disorders, Pediatric, Clinical Research, Good Health and Well Being, Electroencephalography, Humans, Nodding Syndrome, South Sudan, Tanzania, Uganda, Clinical Sciences, Neurology & Neurosurgery
Abstract

Nodding syndrome (NS) is a poorly understood form of childhood-onset epilepsy that is characterized by the pathognomonic ictal phenomenon of repetitive vertical head drops. To evaluate the underlying ictal neurophysiology, ictal EEG features were evaluated in nine participants with confirmed NS from South Sudan, Tanzania, and Uganda and ictal presence of high frequency gamma oscillations on scalp EEG were assessed. Ictal EEG during the head nodding episode predominantly showed generalized slow waves or sharp-and-slow wave complexes followed by electrodecrement. Augmentation of gamma activity (30-70 Hz) was seen during the head nodding episode in all the participants. We confirm that head nodding episodes in persons with NS from the three geographically distinct regions in sub-Saharan Africa share the common features of slow waves with electrodecrement and superimposed gamma activity. ANN NEUROL 2022;92:75-80.

Published
2022

4. QUALINET White Paper on Definitions of Immersive Media Experience (IMEx)

Author

Perkis, Andrew, Timmerer, Christian, Baraković, Sabina, Husić, Jasmina Baraković, Bech, Søren, Bosse, Sebastian, Botev, Jean, Brunnström, Kjell, Cruz, Luis, De Moor, Katrien, Saibanti, Andrea de Polo, Durnez, Wouter, Egger-Lampl, Sebastian, Engelke, Ulrich, Falk, Tiago H., Gutiérrez, Jesús, Hameed, Asim, Hines, Andrew, Kojic, Tanja, Kukolj, Dragan, Liotou, Eirini, Milovanovic, Dragorad, Möller, Sebastian, Murray, Niall, Naderi, Babak, Pereira, Manuela, Perry, Stuart, Pinheiro, Antonio, Pinilla, Andres, Raake, Alexander, Agrawal, Sarvesh Rajesh, Reiter, Ulrich, Rodrigues, Rafael, Schatz, Raimund, Schelkens, Peter, Schmidt, Steven, Sabet, Saeed Shafiee, Singla, Ashutosh, Skorin-Kapov, Lea, Suznjevic, Mirko, Uhrig, Stefan, Vlahović, Sara, Voigt-Antons, Jan-Niklas, and Zadtootaghaj, Saman

Subjects
Computer Science - Multimedia
Abstract

With the coming of age of virtual/augmented reality and interactive media, numerous definitions, frameworks, and models of immersion have emerged across different fields ranging from computer graphics to literary works. Immersion is oftentimes used interchangeably with presence as both concepts are closely related. However, there are noticeable interdisciplinary differences regarding definitions, scope, and constituents that are required to be addressed so that a coherent understanding of the concepts can be achieved. Such consensus is vital for paving the directionality of the future of immersive media experiences (IMEx) and all related matters. The aim of this white paper is to provide a survey of definitions of immersion and presence which leads to a definition of immersive media experience (IMEx). The Quality of Experience (QoE) for immersive media is described by establishing a relationship between the concepts of QoE and IMEx followed by application areas of immersive media experience. Influencing factors on immersive media experience are elaborated as well as the assessment of immersive media experience. Finally, standardization activities related to IMEx are highlighted and the white paper is concluded with an outlook related to future developments.

Published
2020

9. Cost‐effectiveness analysis of the new oncological drug durvalumab in Italian patients with stage III non‐small cell lung cancer

Author

Alessandra Buja, Giulia Pasello, Marco Schiavon, Giuseppe De Luca, Michele Rivera, Claudia Cozzolino, Anna De Polo, Manuela Scioni, Alberto Bortolami, Vincenzo Baldo, and PierFranco Conte

Subjects
cost‐effectiveness analysis, durvalumab, economic burden of cancer, new oncologic drugs, NSCLC, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background The monoclonal antibody durvalumab, an immune‐checkpoint inhibitor (ICI) antiprogrammed death ligand 1 (PD‐L1), is available for unresectable stage III NSCLC patients as consolidation therapy following induction chemoradiotherapy, with very promising overall survival (OS) and progression‐free survial (PFS) results in registration trials. The purpose of this study was to provide policymakers with an estimate of the cost‐effectiveness of durvalumab in the treatment of non‐small cell lung cancer (NSCLC). Methods The study developed a Markov model covering a 5‐year period to compare costs and outcomes of treating PD‐L1 positive patients with or without durvalumab. We conducted a series of sensitivity analyses (Tornado analysis and Monte Carlo simulation) by varying some parameters to assess the robustness of our model and identify the parameters with the greatest impact on cost‐effectiveness. Results Prior to the release of durvalumab, the management of NSCLC over a 5‐year period cost €33 317 per patient, with an average life expectancy of 2.01 years. After the introduction of the drug, this increased to €37 317 per patient, with an average life expectancy of 2.13 years. Treatment with durvalumab led to an incremental cost‐effectiveness ratio (ICER) of €35 526 per year. OS is the variable that contributes the most to the variability of the ICER. Conclusions The study observed that durvalumab is a cost‐effective treatment option for patients with unresectable stage III NSCLC.

Published
2022
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10. Nanodynamo quantifies subcellular RNA dynamics revealing extensive coupling between steps of the RNA life cycle

Author

Coscujuela Tarrero, L, Famà, V, D'Andrea, G, Maestri, S, de Polo, A, Biffo, S, Furlan, M, Pelizzola, M, Coscujuela Tarrero L., Famà V., D'Andrea G., Maestri S., de Polo A., Biffo S., Furlan M., Pelizzola M., Coscujuela Tarrero, L, Famà, V, D'Andrea, G, Maestri, S, de Polo, A, Biffo, S, Furlan, M, Pelizzola, M, Coscujuela Tarrero L., Famà V., D'Andrea G., Maestri S., de Polo A., Biffo S., Furlan M., and Pelizzola M.

Abstract

The coordinated action of transcriptional and post-transcriptional machineries shapes gene expression programs at steady state and determines their concerted response to perturbations. We have developed Nanodynamo, an experimental and computational workflow for quantifying the kinetic rates of nuclear and cytoplasmic steps of the RNA life cycle. Nanodynamo is based on mathematical modelling following sequencing of native RNA from cellular fractions and polysomes. We have applied this workflow to triple-negative breast cancer cells, revealing widespread post-transcriptional RNA processing that is mutually exclusive with its co-transcriptional counterpart. We used Nanodynamo to unravel the coupling between transcription, processing, export, decay and translation machineries. We have identified a number of coupling interactions within and between the nucleus and cytoplasm that largely contribute to coordinating how cells respond to perturbations that affect gene expression programs. Nanodynamo will be instrumental in unravelling the determinants and regulatory processes involved in the coordination of gene expression responses.

Published
2024

11. MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets

Author

Xintao Qiu, Nadia Boufaied, Tarek Hallal, Avery Feit, Anna de Polo, Adrienne M. Luoma, Walaa Alahmadi, Janie Larocque, Giorgia Zadra, Yingtian Xie, Shengqing Gu, Qin Tang, Yi Zhang, Sudeepa Syamala, Ji-Heui Seo, Connor Bell, Edward O’Connor, Yang Liu, Edward M. Schaeffer, R. Jeffrey Karnes, Sheila Weinmann, Elai Davicioni, Colm Morrissey, Paloma Cejas, Leigh Ellis, Massimo Loda, Kai W. Wucherpfennig, Mark M. Pomerantz, Daniel E. Spratt, Eva Corey, Matthew L. Freedman, X. Shirley Liu, Myles Brown, Henry W. Long, and David P. Labbé

Subjects
Science
Abstract

The role of MYC in transcriptional reprogramming in prostate cancer remains poorly characterized. Here, MYC overexpression antagonizes the canonical AR transcriptional program leading to prostate tumor initiation and progression by disrupting transcriptional pause release at AR-regulated genes.

Published
2022
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12. Lessons Learned from the COVID-19 Vaccination Campaigns in Veneto Region: Population Vaccination Centers as Support for the Traditional Outpatient Model

Author

Sandro Cinquetti, Anna De Polo, Vincenzo Marcotrigiano, Marica Battistin, Erica Bino, Giulia De Mattia, Jacopo Fagherazzi, Nahuel Fiorito, Mattia Manzi, Anna Voltolini, Martina Mognato, and Christian Napoli

Subjects
organizational model, healthcare workers, vaccination offer, mountain medicine, Medicine
Abstract

The extraordinary vaccination campaigns of the COVID-19 pandemic era put organizational and operational systems to the test in numerous territorial contexts. In the Veneto region, the activation of population vaccination centers (CVPs) guaranteed the provision of vaccines to mountain areas. These centers, drive-in and building-based, improved the efficiency of dose administration in relation to similar conditions where healthcare workers (HCWs) were routinely involved in clinics. Overall, a comparison of the two models investigated, with the same numbers of HCWs involved and the same opening hours for the vaccination sites, has shown that the CVPs are able to guarantee three times as many vaccines administered, compared with the traditional outpatient model. This study aims to provide a detailed analysis of the adopted organizational model, highlighting the best practices and improvements required to guarantee a timely and effective public health response, and evaluating the opportunities to deploy these innovative methods actively in a standard context.

Published
2023
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13. Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer

Author

Boufaied, Nadia, primary, Chetta, Paolo, additional, Hallal, Tarek, additional, Cacciatore, Stefano, additional, Lalli, Daniela, additional, Luthold, Carole, additional, Homsy, Kevin, additional, Imada, Eddie L., additional, Syamala, Sudeepa, additional, Photopoulos, Cornelia, additional, Di Matteo, Anna, additional, de Polo, Anna, additional, Storaci, Alessandra Maria, additional, Huang, Ying, additional, Giunchi, Francesca, additional, Sheridan, Patricia A., additional, Michelotti, Gregory, additional, Nguyen, Quang-De, additional, Zhao, Xin, additional, Liu, Yang, additional, Davicioni, Elai, additional, Spratt, Daniel E., additional, Sabbioneda, Simone, additional, Maga, Giovanni, additional, Mucci, Lorelei A., additional, Ghigna, Claudia, additional, Marchionni, Luigi, additional, Butler, Lisa M., additional, Ellis, Leigh, additional, Bordeleau, François, additional, Loda, Massimo, additional, Vaira, Valentina, additional, Labbé, David P., additional, and Zadra, Giorgia, additional

Published
2024
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14. Supplementary Figure S1 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer

Author

Boufaied, Nadia, primary, Chetta, Paolo, primary, Hallal, Tarek, primary, Cacciatore, Stefano, primary, Lalli, Daniela, primary, Luthold, Carole, primary, Homsy, Kevin, primary, Imada, Eddie L., primary, Syamala, Sudeepa, primary, Photopoulos, Cornelia, primary, Di Matteo, Anna, primary, de Polo, Anna, primary, Storaci, Alessandra Maria, primary, Huang, Ying, primary, Giunchi, Francesca, primary, Sheridan, Patricia A., primary, Michelotti, Gregory, primary, Nguyen, Quang-De, primary, Zhao, Xin, primary, Liu, Yang, primary, Davicioni, Elai, primary, Spratt, Daniel E., primary, Sabbioneda, Simone, primary, Maga, Giovanni, primary, Mucci, Lorelei A., primary, Ghigna, Claudia, primary, Marchionni, Luigi, primary, Butler, Lisa M., primary, Ellis, Leigh, primary, Bordeleau, François, primary, Loda, Massimo, primary, Vaira, Valentina, primary, Labbé, David P., primary, and Zadra, Giorgia, primary

Published
2024
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15. Data from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer

Author

Boufaied, Nadia, primary, Chetta, Paolo, primary, Hallal, Tarek, primary, Cacciatore, Stefano, primary, Lalli, Daniela, primary, Luthold, Carole, primary, Homsy, Kevin, primary, Imada, Eddie L., primary, Syamala, Sudeepa, primary, Photopoulos, Cornelia, primary, Di Matteo, Anna, primary, de Polo, Anna, primary, Storaci, Alessandra Maria, primary, Huang, Ying, primary, Giunchi, Francesca, primary, Sheridan, Patricia A., primary, Michelotti, Gregory, primary, Nguyen, Quang-De, primary, Zhao, Xin, primary, Liu, Yang, primary, Davicioni, Elai, primary, Spratt, Daniel E., primary, Sabbioneda, Simone, primary, Maga, Giovanni, primary, Mucci, Lorelei A., primary, Ghigna, Claudia, primary, Marchionni, Luigi, primary, Butler, Lisa M., primary, Ellis, Leigh, primary, Bordeleau, François, primary, Loda, Massimo, primary, Vaira, Valentina, primary, Labbé, David P., primary, and Zadra, Giorgia, primary

Published
2024
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16. Supplementary Tables S1-S19 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer

Author

Boufaied, Nadia, primary, Chetta, Paolo, primary, Hallal, Tarek, primary, Cacciatore, Stefano, primary, Lalli, Daniela, primary, Luthold, Carole, primary, Homsy, Kevin, primary, Imada, Eddie L., primary, Syamala, Sudeepa, primary, Photopoulos, Cornelia, primary, Di Matteo, Anna, primary, de Polo, Anna, primary, Storaci, Alessandra Maria, primary, Huang, Ying, primary, Giunchi, Francesca, primary, Sheridan, Patricia A., primary, Michelotti, Gregory, primary, Nguyen, Quang-De, primary, Zhao, Xin, primary, Liu, Yang, primary, Davicioni, Elai, primary, Spratt, Daniel E., primary, Sabbioneda, Simone, primary, Maga, Giovanni, primary, Mucci, Lorelei A., primary, Ghigna, Claudia, primary, Marchionni, Luigi, primary, Butler, Lisa M., primary, Ellis, Leigh, primary, Bordeleau, François, primary, Loda, Massimo, primary, Vaira, Valentina, primary, Labbé, David P., primary, and Zadra, Giorgia, primary

Published
2024
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17. Supplementary Information from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer

Author

Boufaied, Nadia, primary, Chetta, Paolo, primary, Hallal, Tarek, primary, Cacciatore, Stefano, primary, Lalli, Daniela, primary, Luthold, Carole, primary, Homsy, Kevin, primary, Imada, Eddie L., primary, Syamala, Sudeepa, primary, Photopoulos, Cornelia, primary, Di Matteo, Anna, primary, de Polo, Anna, primary, Storaci, Alessandra Maria, primary, Huang, Ying, primary, Giunchi, Francesca, primary, Sheridan, Patricia A., primary, Michelotti, Gregory, primary, Nguyen, Quang-De, primary, Zhao, Xin, primary, Liu, Yang, primary, Davicioni, Elai, primary, Spratt, Daniel E., primary, Sabbioneda, Simone, primary, Maga, Giovanni, primary, Mucci, Lorelei A., primary, Ghigna, Claudia, primary, Marchionni, Luigi, primary, Butler, Lisa M., primary, Ellis, Leigh, primary, Bordeleau, François, primary, Loda, Massimo, primary, Vaira, Valentina, primary, Labbé, David P., primary, and Zadra, Giorgia, primary

Published
2024
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18. Safety profile and impact on survival of tyrosine kinase inhibitors versus conventional therapy in relapse or refractory FLT3 positive acute myeloid leukemia patients

Author

Marconi, Giovanni, De Polo, Stefano, Martinelli, Giovanni, Nanni, Jacopo, Bertamini, Luca, Talami, Annalisa, Olivi, Matteo, Ragaini, Simone, Abbenante, Maria Chiara, Sartor, Chiara, Ottaviani, Emanuela, Bochicchio, Maria Teresa, Parisi, Sarah, Fontana, Maria Chiara, Cristiano, Gianluca, Raffini, Maddalena, Baldazzi, Carmen, Testoni, Nicoletta, Bonifazi, Francesca, Paolini, Stefania, Curti, Antonio, Cavo, Michele, and Papayannidis, Cristina

Published
2021
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20. Improving the Quality of Healthcare Provision Regarding HPV Immunization for Women with CIN2+ Lesions: The Experience of the Veneto Region in Italy

Author

Anna De Polo, Michele Tonon, Filippo Da Re, Sara Rosafio, Elena Narne, Davide Gentili, Silvia Cocchio, Vincenzo Baldo, Francesca Russo, and Alessandra Buja

Subjects
quality improvement, HPV vaccine, cervical screening, preventive healthcare, human papillomavirus, CIN2+, Medicine
Abstract

HPV is the most common cause of sexually-transmitted infections the world over. The aim of this study was to assess the impact of a healthcare quality improvement strategy designed to increase the rate of vaccination against HPV in women diagnosed with cervical lesions graded as CIN2 or higher (CIN2+) during routine screening. The Veneto Regional Health Service developed a 22-item questionnaire to measure the gap between ideal procedure and real practice regarding the offer of vaccination against HPV for women undergoing routine cervical screening. The questionnaire was administered to nine expert doctors, one at each of the region’s Local Health Units (LHUs). An additional specific assessment concerned the quality of the related web pages available on the LHU websites. Strategies to close the gap between ideal procedure and real practice were decided collegially, and a checklist to support good practices was developed and shared with operators at the LHUs. Changes in practice were measured using data relating to women diagnosed with CIN2+ lesions extracted from the regional oncological screening database before and after the publication of a Regional Procedure on the topic. The LHUs differed considerably in how they managed each step, in terms of training for healthcare personnel, organization and assessment of the pathway from cervical screening to HPV vaccination, and in dedicated website communication. After implementing the quality improvement strategy, the proportion of women given a first dose of HPV vaccine within 3 months of being diagnosed with CIN2+ lesions at 1st-level screening rose to 50% (compared with 30.85% beforehand), and the median time elapsing between a diagnosis of CIN2+ lesion and a first dose of HPV vaccine dropped from 158 to 90 days. These findings underscore the importance of providing training to promote vaccination for general practitioners and other clinicians. The study also confirms the need for more efforts in communication to ensure that any citizen has the opportunity to access preventive healthcare.

Published
2023
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21. Multidisciplinary Analysis and Modelling of a River Embankment Affected by Piping

Author

Bossi, Giulia, Bersan, Silvia, Cola, Simonetta, Schenato, Luca, De Polo, Fabio, Menegazzo, Celeste, Boaga, Jacopo, Cassiani, Giorgio, Donini, Fabiano, Simonini, Paolo, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Solari, Giovanni, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Bonelli, Stéphane, editor, Jommi, Cristina, editor, and Sterpi, Donatella, editor

Published
2019
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22. The importance of sex as a risk factor for hospital readmissions due to pulmonary diseases

Author

Alessandra Buja, Anna De Polo, Elisa De Battisti, Milena Sperotto, Tatjana Baldovin, Silvia Cocchio, Patrizia Furlan, Mario Saia, Maria Luisa Scapellato, Guido Viel, Vincenzo Baldo, Chiara Bertoncello, and Mark Ebell

Subjects
Pulmonary disease, Readmission risk, Sex differences, Elderly people, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Pulmonary diseases are a common and costly cause of 30-day readmissions. Few studies have focused on the difference in risk for rehospitalization between men and women in older patients. In this study we analyzed the association between sex and the risk of readmission in a cohort of patients admitted to the hospital for chronic obstructive pulmonary disease (COPD) exacerbation and other major pulmonary diseases. Methods This was a retrospective cohort study based on administrative data collected in the Veneto Region in 2016. We included 14,869 hospital admissions among residents aged ≥65 years for diagnosis related groups (DRGs) of the most common disorders of the respiratory system: bronchitis and asthma, pneumonia, pulmonary edema, respiratory failure, and COPD. Multilevel logistic regressions were performed to test the association between 30-day hospital readmission and sex, adjusting for confounding factors. Results For bronchitis and asthma, male patients had significantly higher odds of 30-day readmission than female patients (adjusted odds ratio (aOR), 2.07; 95% confidence interval (CI), 1.11–3.87). The odds of readmission for men were also significantly higher for pneumonia (aOR, 1.40; 95% CI, 1.13–1.72), for pulmonary edema and respiratory failure (aOR, 1.28; 95% CI, 1.05–1.55), and for COPD (aOR, 1.34; 95% CI, 1.00–1.81). Conclusions This study found that male sex is a major risk factors for readmission in patients aged more than 65 years with a primary pulmonary diagnosis. More studies are needed to understand the underlying determinants of this phenomena and to provide targets for future interventions.

Published
2020
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23. Lessons Learned from the COVID-19 Vaccination Campaigns in Veneto Region: Population Vaccination Centers as Support for the Traditional Outpatient Model

Author

Cinquetti, Sandro, primary, De Polo, Anna, additional, Marcotrigiano, Vincenzo, additional, Battistin, Marica, additional, Bino, Erica, additional, De Mattia, Giulia, additional, Fagherazzi, Jacopo, additional, Fiorito, Nahuel, additional, Manzi, Mattia, additional, Voltolini, Anna, additional, Mognato, Martina, additional, and Napoli, Christian, additional

Published
2023
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24. An integrated multidisciplinary approach to study the effects of copper and osmotic stress in fish

Author

De Polo, Anna, Scrimshaw, M., and Jobling, S.

Subjects
572, Copper, Carbonic anhydrase, Biotic ligand model, Oshotic stress, Sheepshead minnow
Abstract

Since many estuarine zones are impacted by copper contamination, there is an on-going effort to develop Biotic Ligand Models (BLMs) predicting copper toxicity in transitional environments. In the first stage of this project, a critical analysis of the BLM framework identified some aspects of the model that required further investigation. In particular, a BLM for estuaries needed (a) a better characterization of the dissolved organic matter (DOC) and its effect on copper availability, and (b) the inclusion in the model’s equation of a salinity-correction factor modulating the relationship between copper accumulation on the biotic ligand and toxicity. The first issue was addressed by modelling the data produced using a Chelex resin method to determine the labile fraction of copper in samples of mixed riverine and estuarine waters. A refined and simplified BLM equation was then presented, accounting for both the DOC characteristics and the relevance of the osmotic gradient in modulating the relationship between copper accumulation and toxicity. A critical analysis of the literature on copper toxicity and salinity led to the hypothesis that copper-exposed fish are more sensitive to osmotic stresses, as copper interferes with their osmoregulatory pathways. In particular, the cytosolic isoform-2 of the enzyme carbonic anhydrase (CA2) was identified as an osmotic effector protein targeted by copper and involved in osmotic stress response pathways, hence representing a mechanistic link between the combined effects of copper exposure and osmotic stress. To test this hypothesis, two in vivo studies were performed, using the euryhaline fish sheepshead minnow (Cyprinodon variegatus) and applying different rates of salinity changes as a way of dosing osmotic stress. The results showed a disturbance in plasma ion homeostasis after the salinity transitions, but notably the magnitude of the disturbance was greater in the copper-exposed individuals, suggesting a sensitizing effect of copper on the responses of fish to osmotic stress. Gene expression data demonstrated that CA2 is targeted by copper and confirmed the role of the enzyme in osmoregulatory pathways, as further supported by a promoter analysis of the gene coding for zebrafish CA2, which revealed the presence of osmotic-stress related elements. Overall, these results suggest that CA2 is an osmotic effector protein whose response can be activated by a medium level of osmotic stress through a combination of transcriptional and post-translational control circuits.

Published
2014

27. Use of an Artificial Neural Network to Identify Patient Clusters in a Large Cohort of Patients with Melanoma by Simultaneous Analysis of Costs and Clinical Characteristics

Author

Giovanni Damiani, Alessandra Buja, Enzo Grossi, Michele Rivera, Anna De Polo, Giuseppe De Luca, Manuel Zorzi, Antonella Vecchiato, Paolo Del Fiore, Mario Saia, Vincenzo Baldo, Massimo Rugge, Carlo Riccardo Rossi, and Gianfranco Damiani

Subjects
artificial neural networks, cutaneous melanoma, costs, semantic connectivity map, non-linear associations, machine learning, Dermatology, RL1-803
Published
2020
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28. Inotuzumab ozogamicin is effective in relapsed/refractory extramedullary B acute lymphoblastic leukemia

Author

Luca Bertamini, Jacopo Nanni, Giovanni Marconi, Mariachiara Abbenante, Valentina Robustelli, Francesco Bacci, Antonella Matti, Stefania Paolini, Chiara Sartor, Silvia Lo Monaco, Maria Chiara Fontana, Stefano De Polo, Michele Cavo, Antonio Curti, Giovanni Martinelli, and Cristina Papayannidis

Subjects
Inotuzumab ozogamicin, Extramedullary, Acute lymphoblastic leukemia, PET-CT scan, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Extramedullary involvement of B-cell Acute Lymphoblastic Leukemia (EM-ALL) is a rare occurrence, characterized by dismal outcome and the absence of a defined and shared therapeutic approach. In the landscape of innovative compounds, inotuzumab ozogamicin (IO) is a promising drug, whose mechanism of action relies on the killing of CD22 positive leukemic cells, through the delivery, after cell binding, of a molecule of calicheamicin. Case presentation We report two cases of CD22 positive relapsed EM-ALL treated with IO, obtained as compassionate use. Case 1, a 66 years old woman, affected by Philadelphia (Ph) negative B-ALL, relapsed with extramedullary involvement after 6 standard chemotherapy courses, who reached a complete metabolic response with IO treatment. Case 2, a 67 years old man with Ph positive B-ALL, initially treated with ponatinib, a third generation tyrosine-kinase inhibitor (TKI), obtaining a prolonged deep molecular remission. Nevertheless, for skin relapse during TKI treatment, the patient received local radiotherapy and, shortly after, standard chemotherapy, as multiple abdominal sites of relapse were detected too, with no response. The patient then received IO, obtained as compassionate use, with a good metabolic response. Conclusions These two cases suggest a possible key role of IO in the setting of advanced CD22 positive ALL, and underline its potential activity also in patients with EM involvement, relapsed after or refractory to conventional chemotherapy. Despite the well known hepatotoxic effect of the compound (Sinusoid Occlusive Syndrome), neither of them had such adverse event, moreover the second patient safely underwent allogeneic bone marrow transplantation.

Published
2018
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30. QUALINET White Paper on Definitions of Immersive Media Experience (IMEx).

Author

Andrew Perkis, Christian Timmerer, Sabina Barakovic, Jasmina Barakovic Husic, Søren Bech, Sebastian Bosse, Jean Botev, Kjell Brunnström, Luís Alberto da Silva Cruz, Katrien De Moor, Andrea de Polo Saibanti, Wouter Durnez, Sebastian Egger-Lampl, Ulrich Engelke, Tiago H. Falk, Asim Hameed, Andrew Hines, Tanja Kojic, Dragan Kukolj, Eirini Liotou, Dragorad Milovanovic, Sebastian Möller 0001, Niall Murray, Babak Naderi, Manuela Pereira, Stuart W. Perry, António M. G. Pinheiro, Andres Pinilla Palacios, Alexander Raake, Sarvesh Rajesh Agrawal, Ulrich Reiter, Rafael Rodrigues, Raimund Schatz, Peter Schelkens, Steven Schmidt 0001, Saeed Shafiee Sabet, Ashutosh Singla, Lea Skorin-Kapov, Mirko Suznjevic, Stefan Uhrig, Sara Vlahovic, Jan-Niklas Voigt-Antons, and Saman Zadtootaghaj

Published
2020

31. Using Failure Mode, Effect and Criticality Analysis to Improve Safety in the COVID Mass Vaccination Campaign

Author

Alessandra Buja, Mariagiovanna Manfredi, Giuseppe De Luca, Chiara Zampieri, Sofia Zanovello, Davor Perkovic, Francesca Scotton, Anil Minnicelli, Anna De Polo, Vittorio Cristofori, Laura Biasi, Tatjana Baldovin, Chiara Bertoncello, Silvia Cocchio, and Vincenzo Baldo

Subjects
patient safety, proactive management, vaccination campaign, SARS-COV-2, Medicine
Abstract

Vaccination against SARS-CoV-2 will likely be the most promising way to combat the pandemic. Even if mass vaccination is urgent, it should still always be supported by appropriate patient safety management. The aim of this study, based on failure mode, effects and criticality analysis (FMECA), was to identify possible failures and highlight measures that can be adopted to prevent their occurrence. A team of resident doctors in public health from the University of Padua and specialists in risk analysis in public health examined the mass vaccination process. A diagram was drafted to illustrate the various phases of mass vaccination, analyze the process, and identify all failure modes. Criticalities were ascertained by rating the severity, frequency and likelihood of failure detection on a scale of 1 to 10. We identified a total of 71 possible faults distributed over the various phases of the process, and 34 of them were classified as carrying a high risk. For the potentially high-risk failure modes, we identified 63 recommended actions to contain the cause of their occurrence or improve their detection. For the purpose of detecting potential failures, FMECA can be successfully applied to mass vaccination, which should be considered a high-risk process.

Published
2021
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34. Convenio entre el Ministerio de Hacienda y Función Pública, el Consejo Superior de Deportes, el Ayuntamiento de Barcelona, la Fundación Real Club de Polo de Barcelona y el Real Club de Polo de Barcelona

Author

Ajuntament de Barcelona, Ministerio de Hacienda y Función Pública, Consejo Superior de Deportes (Espanya), Fundació Real Club de Polo de Barcelona, Real Club de Polo de Barcelona, Ajuntament de Barcelona, Ministerio de Hacienda y Función Pública, Consejo Superior de Deportes (Espanya), Fundació Real Club de Polo de Barcelona, and Real Club de Polo de Barcelona

Published
2022

35. Ictal Electroencephalographic Characteristics of Nodding Syndrome: A Comparative Case‐Series from South Sudan, Tanzania, and Uganda

Author

Rajarshi Mazumder, David Kitara Lagoro, Hiroki Nariai, Alberto Danieli, Dawn Eliashiv, Jerome Engel, Bernardo Dalla Bernardina, Josua Kegele, Holger Lerche, James Sejvar, William Matuja, Erich Schmutzhard, Paolo Bonanni, Gianni De Polo, Thomas Wagner, and Andrea Sylvia Winkler

Subjects
Pediatric, Neurology & Neurosurgery, Clinical Sciences, Neurosciences, Electroencephalography, Tanzania, Nodding Syndrome, Brain Disorders, Mental Health, Neurology, Clinical Research, Humans, Uganda, Neurology (clinical), South Sudan
Abstract

Nodding syndrome (NS) is a poorly understood form of childhood-onset epilepsy that is characterized by the pathognomonic ictal phenomenon of repetitive vertical head drops. To evaluate the underlying ictal neurophysiology, ictal EEG features were evaluated in nine participants with confirmed NS from South Sudan, Tanzania, and Uganda and ictal presence of high frequency gamma oscillations on scalp EEG were assessed. Ictal EEG during the head nodding episode predominantly showed generalized slow waves or sharp-and-slow wave complexes followed by electrodecrement. Augmentation of gamma activity (30-70 Hz) was seen during the head nodding episode in all the participants. We confirm that head nodding episodes in persons with NS from the three geographically distinct regions in sub-Saharan Africa share the common features of slow waves with electrodecrement and superimposed gamma activity. ANN NEUROL 2022;92:75-80.

Published
2022
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36. Association of Early Rib Plating on Clinical and Financial Outcomes: A National Analysis

Author

Tran, Zachary, Cho, Nam Yong, De Polo, Nicole, Mukherjee, Kaushik, Benharash, Peyman, and Burruss, Sigrid

Abstract

Background With reported improvements in patient outcomes, surgical stabilization of rib fractures (SSRF) has been increasingly adopted. While institutional series have sought to define the role of early SSRF, large scale analysis remains lacking. The present study evaluated clinical and financial outcomes of SSRF in a nationally representative cohort.Methods Patients (≥16 years) admitted with multiple rib fractures were identified using the 2016-2020 National Inpatient Sample. Those who underwent rib plating >14 days following admission were omitted. Using restricted cubic spline analysis, patients who underwent SSRF within 2 days of hospitalization were classified as Expeditedwhile fixation >2 days were deemed Routine.Multivariable regressions were used to evaluate the association of operative timing on outcomes of interest.Results Of 8150 patients meeting final inclusion criteria, 4090 (50.2%) were Expedited. Compared to Routine, Expeditedtended to be older but were of comparable race, primary payer, and income quartile. Traumatic mechanism was also similar but rates of concomitant sternal fracture as well as intra-abdominal and cardiac injuries were higher in Routine. After adjustment, Expeditedwas associated with lower odds of respiratory complications, which included need for mechanical ventilation, prolonged mechanical ventilation, and pneumonia, compared to Routine. Expeditedwas associated with similar hospitalization duration but had lower incremental costs (β: -$19.1 K, 95% CI: -24.1 to -14.2).Discussion Early SSRF was associated with lower likelihood of a number of respiratory complications and in-hospital costs. While patient selection criteria may limit our findings, expeditious fixation may limit morbidity while enhancing value of care.

Published
2024
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38. Assessment of small intestinal bacterial overgrowth and methane production in patients on chronic proton-pump inhibitor treatment: prevalence and role of rifaximin in its management in primary care

Author

DE Bastiani, Rudi, Lopetuso, Loris Riccardo, DE Bastiani, Marco, Bacchin, Paolo, Benedetto, Edoardo, Boscariolo, Laura, Caneve, Rosanna, Chesani, Fabio, Chiumeo, Francesco, Civic, Zinaida, Dainese, Antonio, DE Polo, Manuela, Disclafani, Giuseppe, Grattagliano, Ignazio, Mana, Ornella, Mancuso, Maurizio Stefano, Mastronuzzi, Tecla, Pati, Antonino, Pirrotta, Enzo, Salandini, Maurizio, Sanna, Guido, Scoglio, Riccardo, Severino, Pietro, Tosetti, Cesare, Turnava, Leyla, Zamparella, Maria, Elisei, Walter, Gasbarrini, Antonio, Tursi, Antonio, Lopetuso, Loris R, Mancuso, Maurizio, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), DE Bastiani, Rudi, Lopetuso, Loris Riccardo, DE Bastiani, Marco, Bacchin, Paolo, Benedetto, Edoardo, Boscariolo, Laura, Caneve, Rosanna, Chesani, Fabio, Chiumeo, Francesco, Civic, Zinaida, Dainese, Antonio, DE Polo, Manuela, Disclafani, Giuseppe, Grattagliano, Ignazio, Mana, Ornella, Mancuso, Maurizio Stefano, Mastronuzzi, Tecla, Pati, Antonino, Pirrotta, Enzo, Salandini, Maurizio, Sanna, Guido, Scoglio, Riccardo, Severino, Pietro, Tosetti, Cesare, Turnava, Leyla, Zamparella, Maria, Elisei, Walter, Gasbarrini, Antonio, Tursi, Antonio, Lopetuso, Loris R, Mancuso, Maurizio, and Gasbarrini, Antonio (ORCID:0000-0002-7278-4823)

Abstract

Background: Although proton pump inhibitor (PPI) drugs have considered able to induce small intestinal bacterial overgrowth (SIBO), no data are so far available from primary care (PC). We assessed the prevalence of SIBO and methane (CH4) production consequent to chronic PPI therapy using Lactulose Breath Test (LBT). Secondary aim was to explore the possible role of rifaximin in treating PPI-induced SIBO patients. Methods: One hundred twenty-five gastroesophageal reflux disease patients, constantly treated with PPI for at least 6 months and undergoing to LBT, were retrospectively assessed. An age-matched control population (control) of 100 patients, which had not used PPI in the last 6 months, was also enrolled. In the PPI group, SIBO positive patients and CH4 producers were treated with rifaximin 1200 mg/daily for 14 days and re-checked with LBT one month after the end of treatment. The area under the curve (AUC) before and after treatment was also calculated for both SIBO positive patients and CH4 producers. Results: In the PPI group, SIBO prevalence was significantly higher vs. controls (38/125 [30.4%] vs. 27/100 [27%], P<0.05). 77/125 (61.6%) PPI patients were found to be CH4 producers vs. 21/100 (21%) controls (P<0.05). Among SIBO patients in the PPI group, 34 (89.4%) were also CH4 producers vs. 17/27 (63%) controls (P<0.05). After treatment, LBT resulted negative in 15/22 SIBO patients (68.1%) (P<0.05) and in 18/34 CH4 producers (52.9%) (P<0.05). At the AUC analysis, an overall reduction of 54.2% for H2 in SIBO patients and of 47.7% for CH4 was assessed after rifaximin treatment (P<0.05). Conclusions: Our data showed that chronic use of PPI could be able to increase the prevalence of SIBO and to shift the intestinal microbial composition towards a CH4-producing flora. rifaximin could represent a useful therapeutical option for PPI-induced SIBO and for modulating CH4-producing flora.

Published
2023

40. Assessment of small intestinal bacterial overgrowth and methane production in patients on chronic proton-pump inhibitor treatment: prevalence and role of rifaximin in its management in primary care

Author

DE BASTIANI, Rudi, primary, LOPETUSO, Loris R., additional, DE BASTIANI, Marco, additional, BACCHIN, Paolo, additional, BENEDETTO, Edoardo, additional, BOSCARIOLO, Laura, additional, CANEVE, Rosanna, additional, CHESANI, Fabio, additional, CHIUMEO, Francesco, additional, CIVIC, Zinaida, additional, DAINESE, Antonio, additional, DE POLO, Manuela, additional, DISCLAFANI, Giuseppe, additional, GRATTAGLIANO, Ignazio, additional, MANA, Ornella, additional, MANCUSO, Maurizio, additional, MASTRONUZZI, Tecla, additional, PATI, Antonino, additional, PIRROTTA, Enzo, additional, SALANDINI, Maurizio, additional, SANNA, Guido, additional, SCOGLIO, Riccardo, additional, SEVERINO, Pietro, additional, TOSETTI, Cesare, additional, TURNAVA, Leyla, additional, ZAMPARELLA, Maria, additional, ELISEI, Walter, additional, GASBARRINI, Antonio, additional, and TURSI, Antonio, additional

Published
2023
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41. Prevalence of celiac disease in family medicine setting: lower than expected and often with uncorrected diagnosis

Author

DE BASTIANI, Rudi, primary, BARBETTI, Emiliano, additional, BERTOLUSSO, Luciano, additional, CASELLA, Giovani, additional, CAUCHI, Salvatore, additional, DE BASTIANI, Marco, additional, DE POLO, Manuela, additional, FABBRICA, Davide, additional, FASULO, Serenella, additional, LAZZAROTTO, Lorenzo, additional, MARIANI, Giovanni, additional, NAPOLI, Luigi, additional, ROSSI, Francesca, additional, SANNA, Guido, additional, TOSETTI, Cesare, additional, TURNAVA, Leyla, additional, UBALDI, Enzo, additional, VANNI, Emanuela, additional, ZAMPARELLA, Maria, additional, ELISEI, Walter, additional, and TURSI, Antonio, additional

Published
2023
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43. Prevalence of celiac disease in family medicine setting: lower than expected and often with uncorrected diagnosis

Author

Rudi DE BASTIANI, Emiliano BARBETTI, Luciano BERTOLUSSO, Giovani CASELLA, Salvatore CAUCHI, Marco DE BASTIANI, Manuela DE POLO, Davide FABBRICA, Serenella FASULO, Lorenzo LAZZAROTTO, Giovanni MARIANI, Luigi NAPOLI, Francesca ROSSI, Guido SANNA, Cesare TOSETTI, Leyla TURNAVA, Enzo UBALDI, Emanuela VANNI, Maria ZAMPARELLA, Walter ELISEI, and Antonio TURSI

Subjects
General Medicine
Published
2023
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44. Are all people with diabetes and cardiovascular risk factors or microvascular complications at very high risk? Findings from the Risk and Prevention Study

Author

Marzona, Irene, Avanzini, Fausto, Lucisano, Giuseppe, Tettamanti, Mauro, Baviera, Marta, Nicolucci, Antonio, Roncaglioni, Maria Carla, Tombesi, M., Tognoni, G., Massa, E., Marrocco, W., Micalella, M., Caimi, V., Longoni, P., Avanzini, F., Franzosi, M. G., Roncaglioni, M. C., Marzona, I., Baviera, M., Monesi, L., Pangrazzi, I., Barlera, S., Milani, V., Nicolis, E., Casola, C., Clerici, F., Palumbo, A., Sgaroni, G., Marchioli, R., Silletta, M. G., Pioggiarella, R., Scarano, M., Marfisi, R. M., Flamminio, A., Macino, L., Ferri, B., Pera, C., Polidoro, A., Abbatino, D., Acquati, M., Addorisio, G., Adinolfi, D., Adreani, L., Agistri, M. R., Agneta, A., Agnolio, M. L., Agostini, N., Agostino, G., Airò, A., Alaimo, N., Albano, M., Albano, N., Alecci, G., Alemanno, S., Alexanian, A., Alfarano, M., Alfè, L., Alonzo, N., Alvino, S., Ancora, A., Andiloro, S., Andreatta, E., Angeli, S., Angiari, F., Angilletti, V., Annicchiarico, C., Anzivino, M., Aprea, R., Aprile, A., Aprile, E., Aprile, I., Aprile, L., Armellani, V., Arnetoli, M., Aronica, A., Autiero, V., Bacca, G., Baccalaro, A. M., Bacci, M., Baglio, G., Bagnani, M., Baiano, A., Baldari, A., Ballarini, L., Banchi, G., Bandera, R., Bandini, F., Baratella, M., Barbieri, A., Barbieri Vita, A., Bardi, M., Barlocchi, M., Baron, P., Bartoli, M., Basile, A., Basile, F., Basile, S., Battaggia, A., Battaglia, A., Baù, A., Beconcini, G., Beggio, R., Belfiore, P. A., Belicchi, M., Bellamoli, S., Bellini, C., Bellomo, M., Benetollo, C., Benetti, R., Beretta, E., Bertalero, P., Bertaso, F. G., Bertolani, U., Bettelli, G., Biagiotti, G., Bianchi, S., Bianco, G., Biccari, F., Bigioli, F., Bindi, M., Bisanti, G., Bitetti, E. M., Blasetti, M. P., Blesi, F., Boato, V., Boga, S., Boidi, E., Boldrin, G., Bollati, A., Bolzan, L., Bolzonella, S., Bonardi, P., Bonato, G. B., Bonci, M., Bonfitto, G., Bonincontro, E., Boninsegna, F., Bonissone, D., Bono, L., Bonollo, E., Borghi, M., Borioli, N., Borsatto, M., Bosco, T., Bosisio Pioltelli, M., Botarelli, C., Botassis, S., Bottini, F., Bottos, C., Bova, G., Bova, V., Bozzani, A., Bozzetto, R. M., Braga, V. T., Braglia, M., Bramati, E., Brazzoli, C., Breglia, G., Brescia, A., Briganti, D., Brigato, G., Brocchi, A., Brosio, F. A., Bruni, E., Buscaglia, E., Bussini, M. D., Bussotti, A., Buzzaccarini, F., Buzzatti, A., Caccamo, G., Cacciavillani, C., Caggiano, G., Caimi, V., Calciano, F. P., Calderisi, M., Calienno, S., Caltagirone, P., Calzolari, I., Cammisa, M., Campanaro, M., Campanella, G. B., Campese, F., Canali, G., Candiani, D. E. L., Canepa, R., Canini, D., Canino, A., Cantoro, E. A., Capilupi, V., Capotosto, P., Cappelli, B., Capraro, G., Carafa, F. A., Carano, Q., Carcaterra, V., Carriero, D., Carrozzo, G., Cartanese, M., Casalena, M., Casarola, M., Caso, C., Casotto, M., Castaldi, F., Castegnaro, R., Castellani, G., Castri, S., Catalano, E., Catinello, N., Caturano, G., Cavallaro, R., Cavallo, A. M., Cavallo, G., Cavion, M. T., Cavirani, G., Cazzaniga, F., Cazzetta, D., Cecconi, V., Cefalo, A., Celebrano, M., Celora, A., Centonze, P., Cerati, D., Cesaretti, D., Checchia, G., Checchin, A., Cherubini, M., Chianese, L., Chiappa, A., Chiappa, M. V., Chiariello, G., Chiavini, G., Chicco, M., Chiumeo, F., Ciacciarelli, A., Ciaci, D., Ciancaglini, R., Cicale, C., Cicale, S., Cipolla, A., Ciruolo, A., Citeri, A. L., Citterio, G., Clerici, M., Coazzoli, E., Collecchia, G., Colletta, F., Colombo, I., Colorio, P., Coluccia, S., Comerio, M., Comoretto, P., Compagni, M., Conte, O., Contri, S., Contrisciani, A., Coppetti, T., Corasaniti, F., Corradi, M. T., Corsano, A., Corsini, A., Corti, N., Costantini, G., Costantino, A., Cotroneo, S., Cozzi, D., Cravello, M. G., Cristiano, E., Cucchi, R., Cusmai, L., D’Errico, G. B., D’Agostino, P., Dal Bianco, L., Dal Mutto, U., Dal Pozzo, G., Dallapiccola, P., Dallatorre, G., Dalle Molle, G., Dalloni, E., D’Aloiso, A., D’Amicis, G., Danese, R., Danieli, D., Danisi, G., D’Anna, M. A., Danti, G., D’Ascanio, S., Davidde, G., De Angeli, D., De Bastiani, R., De Battisti, A., De Bellis, A., De Berardinis, G., De Carlo, F., De Giorgi, D., De Gobbi, R., De Lorenzis, E., De Luca, P., De Martini, G., De Marzi, M., De Matteis, D., De Padova, S., De Polo, P., De Sabato, N., De Stefano, T., De Vita, M. T., De Vito, U., De Zolt, V., Debernardi, F., Del Carlo, A., Del Re, G., Del Zotti, F., D’Elia, R., Della Giovanna, P., Dell’Acqua, L., Dell’Orco, R. L., Demaria, G., Di Benedetto, M. G., Di Chiara, G., Di Corcia, V., Di Domizio, O., Di Donato, P., Di Donato, S., Di Fermo, G., Di Franco, M., Di Giovannantonio, G., Di Lascio, G., Di Lecce, G., Di Lorenzo, N., Di Maro, T., Di Mattia, Q., Di Michele, E., Di Modica, R. S., Di Murro, D., Di Noi, M. C., Di Paoli, V., Di Santi, M., Di Sanzo, A., Di Turi, C., Diazzi, A., Dileo, I., D’Ingianna, A. P., Dolci, A., Donà, G., Donato, C., Donato, P., Donini, A., Donna, M. E., Donvito, T. V., Esposito, L., Esposito, N., Evangelista, M., Faita, G., Falco, M., Falcone, D. A., Falorni, F., Fanciullacci, A., Fanton, L., Fasolo, L., Fassina, R., Fassone, A., Fatarella, P., Fedele, F., Fera, I., Fera, L., Ferioli, S., Ferlini, M. G., Ferlino, R., Ferrante, G., Ferrara, F. N., Ferrarese, M. F., Ferrari, G., Ferrari, O., Ferreri, A., Ferroni, M., Fezzi, G., Figaroli, C., Fina, M. G., Fioretta, A., Fiorucci, C., Firrincieli, R., Fischetti, M., Fischietti, G., Fiume, D. C., Flecchia, G., Forastiere, G., Fossati, B., Franceschi, P. L., Franchi, L., Franzoso, F., Frapporti, G., Frasca, G., Frisotti, A., Fumagalli, G., Fusco, D., Gabriele, P., Gabrieli, A., Gagliano, D., Galimberti, G., Galli, A., Gallicchio, N., Gallio, F., Gallipoli, T., Gallo, P., Galopin, T., Gambarelli, L., Garbin, A., Garozzo, G. M., Gasparri, R., Gastaldo, M., Gatti, E., Gazzaniga, P., Gennachi, N., Gentile, R. V., Germani, P., Gesualdi, F., Gherardi, E., Ghezzi, C., Ghidini, M. G., Ghionda, F., Giacci, L., Gialdini, D., Giampaolo, C., Giancane, R., Giannanti, A., Giannese, S., Giannini, L., Giaretta, M., Giaretta, R., Giavardi, L., Giordano, P., Giordano, E., Giordano, B., Gioria, G. M., Giugliano, R., Grassi, E. A., Greco, A., Greco, L., Grilletti, N., Grimaldi, N., Grisetti, G., Groppelli, G., Gualtieri, L., Guarducci, M., Guastella, G., Guerra, M., Guerrini, F., Guglielmini, A., Guido, A., Gulotta, P., Iacono, E., Iadarola, G., Ianiro, G., Iarussi, V., Ieluzzi, M. L., Ierardi, C., Ingaldi, F., Interlandi, S., Iocca, M., Iorno, A., Ioverno, E., Iurato, R., La Pace, L., La Piscopia, C., La Selva, R., Lafratta, M., Lamparelli, M., Lanaro, G., Lancerotto, R., Larcher, M., Lassandro, M., Lattuada, G., Laurino, P., Lefons, C., Legrottaglie, F., Lemma, A., Leone, D., Leone, F., Leso, A., Leuzzi, G., Levato, G., Libardi, L., Libralesso, N., Licini, P. I., Licursi, G., Lidonnici, F., Lillo, C., Liveri, L., Livio, A., Loiero, R. A., Loison, M., Lombardo, G., Lombardo, T., Lomunno, V., Lomuscio, S., Lonedo, A., Longo, E., Longoni, P., Lora, L., Lotterio, A., Lucatello, L., Luongo, A., Lupoli, M., Macchia, C., Macri, G., Mafessanti, M., Maggialetti, V., Maggioni, A., Magnani, M., Maiellaro, G., Mancuso, A., Maniglio, A. R., Mannari, G. L., Manni, A., Manocchio, B., Mao, M., Maranò, A., Maraone, E., Marascio, D., Marcheselli, P., Marchetto, B., Marchetto, S., Marchi, A., Marchi, G. L., Mariano, C., Marinacci, S., Marinelli, S., Marini, G., Marra, V. C., Marrali, F., Marseglia, C., Martello, G., Martino, C., Martino, G., Martino, M., Marulli, C. F., Maruzzi, G., Marzotti, A., Mascheroni, G., Mascolo, P., Masoch, G., Masone, R., Massa, E., Massa, L., Massafra, M., Massi, M., Massignani, D. M., Matarese, A. M., Matini, G., Mauro, R., Mazzi, M., Mazzillo, A., Mazzocato, E., Mazzoleni, N. S., Mazzone, A., Melacci, A., Mele, E., Meliota, P., Menaspà, S., Meneghello, F., Merola, G., Merone, L., Metrucci, A., Mezzina, V., Micchi, A., Michielon, A., Migliore, N., Minero, G., Minotta, F., Mirandola, C., Mistrorigo, S., Modafferi, L., Moitre, R., Mola, E., Monachese, C., Mongiardini, C., Montagna, F., Montani, M., Montemurno, I., Montolli, R., Montorsi, S., Montresor, M., Monzani, M. G., Morabito, F., Mori, G., Moro, A., Mosca, M. F., Motti, F., Muddolon, L., Mugnai, M., Muscas, F., Naimoli, F., Nanci, G., Nargi, E., Nasorri, R., Nastrini, G., Negossi, M., Negrini, A., Negroni, A., Neola, V., Niccolini, F., Niro, C. M., Nosengo, C., Novella, G., Nuti, C., Obici, F., Olita, C., Oliverio, S. S., Olivieri, I., Oriente, S., Orlando, G., Paci, C., Pagano, G., Pagliara, C., Paita, G., Paladini, G., Paladino, G., Palano, T., Palatella, A., Palermo, P., Palmisano, M., Pando, P., Panessa, P., Panigo, F., Panozzo, G., Panvini, F., Panzieri, F., Panzino, A., Panzitta, F., Paoli, N., Papagna, R., Papaleo, M. G., Papalia, G., Parisi, R., Parotti, N., Parravicini, D., Passarella, P., Pastore, G. A., Patafio, M., Pavone, P., Pedroli, W., Pedroni, M., Pelligra, G., Pellizzari, M., Penati, A., Perlot, M., Perrone, A., Perrone, G., Peruzzi, P., Peselli, C., Petracchini, L., Petrera, L., Petrone, S., Peverelli, C., Pianorsi, F., Piazza, G. P., Piazzolla, G., Picci, A., Pienabarca, G., Pietronigro, T. P., Pignocchino, P., Pilone, R., Pinto, D., Pirovano, E., Pirrotta, D., Pisante, V., Pitotto, P., Pittari, L., Piva, A., Pizzoglio, A., Plantera, O. R., Plebani, W., Plessi, S., Podrecca, D., Poerio, V., Poggiani, F., Pogliani, W., Poli, L., Poloni, F. G., Porcelli, R., Porto, S., Pranzo, L., Prevedello, C., Profeta, C., Profico, D., Punzi, A., Quaglia, G. M., Racano, M., Raccone, A., Radice, F., Raho, C. A., Raimondi, R., Rainò, M., Ramponi, R., Ramunni, A., Ramunni, A. L., Ravasio, F., Ravera, M., Re Sartò, G., Rebustello, G., Regazzoli, S., Restelli, C., Rezzonico, M., Ricchiuto, F., Rigo, S., Rigon, G., Rigon, R., Rinaldi, O. V., Rinaldi, M., Risplendente, P. G., Rispoli, M., Riundi, R., Riva, M. G., Rizzi, A. L., Rizzi, D., Rizzo, L. D., Rocchi, L., Rondinone, B., Rosa, B., Rosati, F., Roselli, F., Rossetti, A., Rossetti, C., Rossi, R., Rossi, P. R., Rossi, A., Rossi, C. L., Rossitto, A., Ruffini, R., Ruffo, A., Ruggio, S., Ruo, M., Russo, B., Russo, L., Russo, R., Russo, S., Russo, U., Russo, V., Ruta, G., Sacchi, F., Sacco Botto, F., Saia, A., Salladini, G., Salmoiraghi, S., Saluzzo, F., Salvatore, C., Salvatori, E., Salvio, G., Sandri, P., Sandrini, T., Sangermano, V., Santoni, N., Saracino, A. D., Saracino, A., Sarasin, P., Sardo Infirri, C., Sarrì, B., Sartori, G., Sartori, N., Sauro, C., Scaglioni, M., Scalfi, C., Scamardella, A. M., Scandale, G., Scandone, L., Scannavini, G., Scarati, R., Scardi, A., Scarpa, F. M., Scazzi, P., Schifone, A., Schiroso, G., Scigliano, G., Scilla, A., Sciortino, M., Scolaro, G., Scollo, E., Scorretti, G., Sellitti, R., Selmo, A., Selvaggio, G., Sempio, A., Seren, F., Serio, L., Serra, C., Serra, L., Siciliano, D., Sideri, A., Sighele, M., Signore, R., Siliberto, F., Silvestro, M., Simioni, G., Simmini, G., Simonato, L., Sinchetto, F., Sizzano, E., Smajato, G., Smaldone, M., Sola, G., Sordillo, L., Sovran, C. S., Spagnul, P., Spanò, F., Sproviero, S., Squintani, A., Stella, L., Stilo, V., Stocchiero, B., Stornello, M. C., Stracka, G., Strada, S., Stranieri, G., Stucci, N., Stufano, N., Suppa, A., Susca, V. G., Sutti, M., Taddei, M., Tagliabue, E., Tagliente, G., Talato, F., Talerico, P., Talia, R., Taranto, R., Tartaglia, M., Tauro, N., Tedesco, A., Tieri, P., Tirelli, M., Tocci, L., Todesco, P., Tognolo, M., Tomba, A., Tonello, P., Tonon, R., Toscano, L., Tosi, A., Tosi, G., Toso, S., Travaglio, P., Tremul, L., Tresso, C., Triacchini, P., Triggiano, L., Trigilio, A., Trimeloni, J., Tripicchio, G., Tritto, G. S., Trono, F., Trotta, E., Trotta, G., Tubertini, A., Turri, C., Turri, L., Tuttolani, M. P., Urago, M., Ursini, G., Valcanover, F., Valente, L., Valenti, M., Valentini, F., Vallone, G., Valz, P., Valzano, L., Vanin, V., Vatteroni, M., Vegetti, L., Vendrame, D., Veramonti, I., Veronelli, G., Vesco, A., Vicariotto, G., Vignale, G., Villa, P. L., Vinciguerra, R., Visco, A., Visentin, G., Visonà, E., Vitali, E., Vitali, S., Vitti, F., Volpone, D. A., Zambon, N., Zammarrelli, A., Zanaboni, A., Zane, D., Zanetti, B., Zanibellato, R., Zappetti, M., Zappone, P., Zerilli, G., Zirino, V., Zoccali, R., Zuin, F., Altomonte, M., Anelli, N., Angiò, F., Annale, P., Antonacci, S., Anzilotta, R., Bano, F., Basadonna, O., Beduschi, L., Becagli, P., Bellotti, G., Blotta, C., Bruno, G., Cappuccini, A., Caramatti, S., Cariolato, M. P., Castellana, M., Castellani, L., Catania, R., Chielli, A., Chinellato, A., Ciaccia, A., Clerici, E., Cocci, A., Costanzo, G., D’Ercole, F., De Stefano, G., Decè, F., Di Cicco, N., Di Marco, A., Donati Sarti, C., Draghi, E., Dusi, G., Esposito, V., Ferraro, L., Ferretti, A., Ferri, E., Foggetti, L., Foglia, A., Fonzi, E., Frau, G., Fuoco, M. R., Furci, G., Gallo, L., Garra, V., Giannini, A., Gris, A., Iacovino, R., Interrigi, R., Joppi, R., Laner, B., La Fortezza, G., La Padula, A., Lista, M. R., Lupi, G., Maffei, D., Maggioni, G., Magnani, L., Marrazzo, E., Marcon, L., Marinò, V., Maroni, A., Martinelli, C., Mastandrea, E., Mastropierro, F., Meo, A. T., Mero, P., Minesso, E., Moschetta, V., Mosele, E., Nanni, C., Negretti, A., Nisticò, C., Orsini, A., Osti, M., Pacilli, M. C., Pennestre, C., Picerno, G., Piol, K., Pivano, L., Pizzuti, E., Poggi, L., Poidomani, I., Pozzetto, M., Presti, M. L., Ravani, R., Recalenda, V., Romagnuolo, F., Rossignoli, S., Rossin, E., Sabatella, C., Sacco, F., Sanità, F., Sansone, E., Servadei, F., Sisto, M. T., Sorio, A., Sorrentino, A., Spinelli, E., Spolaor, A., Squillacioti, A., Stella, P., Talerico, A., Todisco, C., Vadino, M., Zuliani, C., and Risk & Prevention Collaborative Group

Published
2017
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45. Business Models and Exploitation

Author

Habibi Minelli, Sam, de Polo, Andrea, Tropea, Giuseppe, Gkonis, Panagiotis, Hang, Alina, Tanase, Mihai, Sequeira, Daniel, Lemaitre, Francis, Chiariglione, Riccardo, Almeida, Fernando, editor, Andrade, Maria Teresa, editor, Blefari Melazzi, Nicola, editor, Walker, Richard, editor, Hussmann, Heinrich, editor, and Venieris, Iakovos S., editor

Published
2014
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46. Vínculos parentales tempranos y dependencia emocional en las relaciones de pareja de jóvenes universitarios panameños

Author

Orquídea Robles De Polo and Jenifer Pinzón Agrazal

Abstract

Introducción: El vínculo parental nos habla de la percepción que se tiene sobre la conducta y actitud de uno o ambos padres en relación con aspectos de la infancia o adolescencia del sujeto. Este concepto está basado en la teoría del apego desarrollada por el psicoanalista inglés John Bowlby, el cual describe los efectos que producen las experiencias tempranas y la relación con la primera figura vincular en el desarrollo del niño. Objetivo: El objetivo de esta investigación fue determinar la relación que existe entre los vínculos parentales tempranos y la dependencia emocional en las relaciones de pareja de jóvenes universitarios panameños. Materiales y método: Se realizó un estudio de diseño no experimental de tipo transeccional y relacional, fue aplicado a una muestra de 383 estudiantes universitarios de la República de Panamá. Para la recolección de datos se utilizó el Instrumento de Vínculo Parental (Parental Bonding Instrument, PBI) de Parker, Tupling and Brown (1979) y el Inventario de Dependencia Emocional (IDE) creado por el psicólogo Jesús Joel Aiquipa Tello (2012). Los datos se analizaron de manera descriptiva y con el estadístico chi-cuadrado. Resultados: Aproximadamente la mitad de los participantes mostraron un nivel de dependencia emocional que reflejaba una vinculación afectiva patológica y no adaptativa en sus relaciones de pareja. Un porcentaje significativo de estos participantes también reflejó un apego inseguro hacia la figura paterna. Discusión: Los resultados encontrados coinciden con lo planteado por la literatura, que indica que las características, positivas o negativas del estilo de apego con nuestros padres o cuidadores en la infancia, van a determinar la calidad de nuestras relaciones afectivas en la vida adulta. Conclusiones: Existe una relación estadísticamente significativa entre el nivel de dependencia emocional y el tipo de apego hacia los padres o cuidadores.

Published
2022
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49. PATHS - Exploring Digital Cultural Heritage Spaces.

Author

Mark M. Hall, Eneko Agirre, Nikolaos Aletras, Runar Bergheim, Konstantinos Chandrinos, Paul D. Clough, Samuel Fernando, Kate Fernie, Paula Goodale, Jillian Griffiths, Oier Lopez de Lacalle, Andrea de Polo, Aitor Soroa, and Mark Stevenson

Published
2012
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50. Untersuchung des Zusammenhangs zwischen (dunklen) Persönlichkeitsmerkmalen und objektiver Messung der Nutzung sozialer Medien und soziosexuellen Resultate

Author

Freyth de Polo Leon, Lennart Victor Wilhelm

Subjects
sex differences, dating apps, dunkle Tetrade, dark tetrad, Tinder, life history theory, behavioral data, facets, Verhaltensdaten, Soziosexualität, Dark triad, Geschlechtsunterschiede, Instagram, Dunkle Triade, Facetten, sociosexuality, Social Media
Abstract

In a series of studies, I investigated the associations between different personality taxonomies (i.e., the Dark Triad traits, the Big Five traits) and objective social media use (i.e., dating apps, Instagram, Facebook). I expanded initial results on the links between dating apps with the Dark Triad traits and the Big Five traits by using facets of the Dark Tetrad traits and the HEXACO traits (the Big Five traits and honesty-humility) to study their link to Instagram and Facebook use. The use of both visual social media, dating apps and Instagram–– but not Facebook––, is associated with dark personality traits indicating a tendency for short-term reproductive benefits. Subsequently, we investigated the relationships of the Dark Triad traits, their latent dark core, and disagreeableness towards sociosexuality. Here, the “dark” traits, but not the “bright” traits were associated with visual social media use and provided incremental validity on top of the dark core. In summary, dark personality traits show connections to several behaviors providing agentic advantages for the individual in the specific environments. All findings are discussed in the light of life-history theory. eingereicht von Lennart Freyth de Polo Abweichender Titel laut Übersetzung der Verfasserin/des Verfassers Dissertation Universität Linz 2023

Published
2023

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