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BACKGROUND p53 is a transcription factor that regulates the cell cycle, DNA repair, and apoptosis. A variant at codon 72, rs1042522, results in altered activities for p53 and is, notably, differentially distributed among different ethnic populations. However, associations of this variant with cancer in men of African descent have not been explored. Herein, we tested the hypothesis that rs1042522 was associated with prostate cancer (PCa) risk. MATERIALS AND METHODS Genotypes were determined by PCR-RFLP methods in a study population of African descent consisting of 266 PCa patients and 196 male controls. RESULTS Our results indicate that the p53 polymorphism may be associated with increased risk of PCa. Genotypes were significantly and marginally associated with PCa risk using the dominant and log-additive genetic models (OR = 1.53, 95% CI: 1.02–2.29, P = 0.04; OR = 1.33, 95% CI: 0.99–1.78, P = 0.06, respectively). After adjusting for age, the associations with PCa remained, but results were not statistically significant (OR = 1.48, 95% CI: 0.95–2.31, P = 0.08; OR = 1.30, 95% CI: 0.95–1.80, P = 0.10, respectively). CONCLUSIONS The present study demonstrates that population-dependent differences in allele frequencies associated with health disparities provide a valuable framework for the interrogation of complex diseases in all populations. Prostate 70: 1739–1745, 2010. © 2010 Wiley-Liss, Inc.

p53 is a transcription factor that regulates the cell cycle, DNA repair, and apoptosis. A variant at codon 72, rs1042522, results in altered activities for p53 and is, notably, differentially distributed among different ethnic populations. However, associations of this variant with cancer in men of African descent have not been explored. Herein, we tested the hypothesis that rs1042522 was associated with prostate cancer (PCa) risk.Genotypes were determined by PCR-RFLP methods in a study population of African descent consisting of 266 PCa patients and 196 male controls.Our results indicate that the p53 polymorphism may be associated with increased risk of PCa. Genotypes were significantly and marginally associated with PCa risk using the dominant and log-additive genetic models (OR=1.53, 95% CI: 1.02-2.29, P=0.04; OR=1.33, 95% CI: 0.99-1.78, P=0.06, respectively). After adjusting for age, the associations with PCa remained, but results were not statistically significant (OR=1.48, 95% CI: 0.95-2.31, P=0.08; OR=1.30, 95% CI: 0.95-1.80, P=0.10, respectively).The present study demonstrates that population-dependent differences in allele frequencies associated with health disparities provide a valuable framework for the interrogation of complex diseases in all populations.

1-(2-Methoxycarbonylphenyl)pyrrole product: 1-(2-methoxycarbonylphenyl)pyrrole product: 1-(2-carboxyphenyl)pyrrole product: 9-keto-9H-pyrrole-(1,2-a)indole Keywords: annulation, heterocyclic-[5]; cyclization, miscellaneous

Electron‐spin‐density distributions in a variety of π systems have been obtained from proton‐contact interaction shifts in paramagnetic nickel II chelates of N,N′‐disubstituted aminotroponeimines. The results have furnished a great deal of new information regarding the detailed manner in which π electrons are distributed via conjugative effects. Spin‐density distributions in these systems calculated by the valence‐bond scheme are shown to be in quite good general agreement with experimental determinations. Effects attributable to hyperconjugation have been observed and the conjugating abilities of linking groups C=C, N=N, NH, O, S, and SO2 have been assessed. It is shown also that metal‐ligand π‐bond formation results in transfer of 0.1 of an unpaired electron from nickel to the π system of each of the ligands of these bischelates.

``Chemical shifts'' for protons in the paramagnetic Ni II aminotroponeimineates are up to 250 times greater than for shifts of analogous protons in the diamagnetic chelates or ligands. These increased shifts are attributed to isotropic hyperfine contact interactions between protons and pπ spin densities transferred from Ni II to aminotroponeimine ligand as the result of pπ—dπ bonding. Widths of the nuclear resonances for these chelates in solution are sufficiently narrow that in many cases spin—spin (I·I) couplings can be resolved. The large separations between the different resonances lead to simple first‐order spectra from which the spin—spin coupling constants can be obtained directly. Proton coupling constants for a number of simple conjugated groups obtained in this way are reported and compared with values for analogous diamagnetic compounds. Close agreement is found. Proton coupling constants have also been obtained for the first time for a number of more complex groups which give rise to prohibiti...