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2. 20666. MIASTENIA-MIOSITIS ASOCIADA A INHIBIDORES DE PUNTOS DE CONTROL INMUNITARIO: ANÁLISIS RETROSPECTIVO MULTICÉNTRICO EN ESPAÑA

Author

R. Velasco Fargas, J. Cabrera Maqueda, C. Marco Cazcarra, E. Fonseca, J. Chico García, F. Gómez Fernández, L. del Pino Tejado, J. Cabello Murgui, R. Caldú, C. Fadrique, C. Sánchez Vizcaíno, H. Hernández Tost, M. Ros, J. Gállego Pérez- Larraya, C. Jauregui Larrañaga, M. García Yepes, A. Chavarría Miranda, C. González Mingot, G. Morís de la Tassa, M. Alañá García, L. Torné Hernández, A. Macías Gómez, J. Pouso Diz, S. Besora Tavera, P. Cabezudo García, C. Izquierdo Gracia, A. Boix Lago, A. Carvajal Hernández, J. Álvarez Troncoso, M. Barón Rubio, J. Riancho, M. Simó Parra, and E. Martínez Hernández

Subjects
Neurology. Diseases of the nervous system, RC346-429
Published
2024
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5. Cerebrovascular events and outcomes in hospitalized patients with COVID-19: The SVIN COVID-19 Multinational Registry.

Author

Siegler, James, Cardona, Pere, Arenillas, Juan, Talavera, Blanca, Guillen, Ana, Chavarría-Miranda, Alba, de Lera, Mercedes, Khandelwal, Priyank, Bach, Ivo, Patel, Pratit, Singla, Amit, Requena, Manuel, Ribo, Marc, Jillella, Dinesh, Rangaraju, Srikant, Nogueira, Raul, Haussen, Diogo, Vazquez, Alejandro, Urra, Xabier, Chamorro, Ángel, Román, Luis, Thon, Jesse, Then, Ryna, Sanborn, Emma, de la Ossa, Natalia, Millàn, Mònica, Ruiz, Isaac, Mansour, Ossama, Megahed, Mohammed, Tiu, Cristina, Terecoasa, Elena, Radu, Răzvan, Nguyen, Thanh, Curiale, Gioacchino, Kaliaev, Artem, Czap, Alexandra, Sebaugh, Jacob, Zha, Alicia, Liebeskind, David, Ortega-Gutierrez, Santiago, Farooqui, Mudassir, Hassan, Ameer, Preston, Laurie, Patterson, Mary, Bushnaq, Saif, Zaidat, Osama, and Jovin, Tudor

Subjects
All cerebrovascular diseases/stroke, COVID-19, cerebral venous thrombosis, intracranial hemorrhage, Adult, Age Factors, Aged, Aged, 80 and over, COVID-19, Cerebrovascular Disorders, Cohort Studies, Female, Hospital Mortality, Humans, Intracranial Hemorrhages, Ischemic Stroke, Lymphocyte Count, Male, Middle Aged, Prevalence, Registries, Retrospective Studies, Risk Factors, Sex Factors, Thrombosis, Tobacco Use, Young Adult
Abstract

BACKGROUND: Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has been associated with a significant risk of thrombotic events in critically ill patients. AIM: To summarize the findings of a multinational observational cohort of patients with SARS-CoV-2 and cerebrovascular disease. METHODS: Retrospective observational cohort of consecutive adults evaluated in the emergency department and/or admitted with coronavirus disease 2019 (COVID-19) across 31 hospitals in four countries (1 February 2020-16 June 2020). The primary outcome was the incidence rate of cerebrovascular events, inclusive of acute ischemic stroke, intracranial hemorrhages (ICH), and cortical vein and/or sinus thrombosis (CVST). RESULTS: Of the 14,483 patients with laboratory-confirmed SARS-CoV-2, 172 were diagnosed with an acute cerebrovascular event (1.13% of cohort; 1130/100,000 patients, 95%CI 970-1320/100,000), 68/171 (40.5%) were female and 96/172 (55.8%) were between the ages 60 and 79 years. Of these, 156 had acute ischemic stroke (1.08%; 1080/100,000 95%CI 920-1260/100,000), 28 ICH (0.19%; 190/100,000 95%CI 130-280/100,000), and 3 with CVST (0.02%; 20/100,000, 95%CI 4-60/100,000). The in-hospital mortality rate for SARS-CoV-2-associated stroke was 38.1% and for ICH 58.3%. After adjusting for clustering by site and age, baseline stroke severity, and all predictors of in-hospital mortality found in univariate regression (p

Published
2021

6. Anosmia is associated with lower in-hospital mortality in COVID-19

Author

Talavera, Blanca, García-Azorín, David, Martínez-Pías, Enrique, Trigo, Javier, Hernández-Pérez, Isabel, Valle-Peñacoba, Gonzalo, Simón-Campo, Paula, de Lera, Mercedes, Chavarría-Miranda, Alba, López-Sanz, Cristina, Gutiérrez-Sánchez, María, Martínez-Velasco, Elena, Pedraza, María, Sierra, Álvaro, Gómez-Vicente, Beatriz, Guerrero, Ángel, and Arenillas, Juan Francisco

Published
2020
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7. Zika; A Threat to Making Important Decisions on Maternal and Perinatal Health

Author

Reynoso Vázquez Josefina, Ruvalcaba Ledezma Jesús Carlos, Chavarría Miranda Alejandra, Jiménez Sánchez Reyna Cristina, Guzmán Meneses Karla Patricia, and Alamilla Pérez Karina

Subjects
zika, association, microcephaly, asymptomatic., Microbiology, QR1-502
Abstract

The Zika virus disease represents a great challenge for the medical-scientific community not only because of the association that exists with microcephaly and other congenital anomalies, but also because of the presence of confirmed cases of congenital syndrome associated with Zika in asymptomatic pregnant women, It is very important to carry out a timely detection and diagnosis to evaluate the probability of having an anomaly, the quality of life that the baby will have or the probability of the legal interruption of pregnancy.

Published
2019
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9. Neurological symptoms in Covid‐19 patients in the emergency department

Author

David García‐Azorín, Javier Trigo, Enrique Martínez‐Pías, Isabel Hernández‐Pérez, Gonzalo Valle‐Peñacoba, Blanca Talavera, Paula Simón‐Campo, Mercedes deLera, Alba Chavarría‐Miranda, Cristina López‐Sanz, María Gutiérrez‐Sánchez, Elena Martínez‐Velasco, María Pedraza, Álvaro Sierra, Beatriz Gómez‐Vicente, Ángel Guerrero, and Juan Francisco Arenillas

Subjects
COVID‐19, mortality, nervous system diseases, olfaction disorders, prognosis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Abstract Background Coronavirus disease 2019 (Covid‐19) might present neurological symptoms. We aimed to evaluate the frequency of them at the moment of emergency department (ED) visit and their impact in the prognosis. Methods Retrospective cohort study including all consecutive hospitalized cases between March 8th and April 11th, 2020. Covid‐19 diagnosis was confirmed by polymerase chain reaction test and/or serology. We compared, in patients with and without neurological symptoms on admission, demographic, clinical presentation, and frequency and type of abnormal laboratory values. We analyzed the variables that were associated with in‐hospital all‐cause mortality by Cox‐regression log‐rank test. Results We included 576 hospitalized patients, 250 (43.3%) female, aged 67.2 years. At the moment of ED visit, 320 (55.6%) described neurological symptoms, including anosmia (146, 25.3%), myalgia (139, 24.1%), headache (137, 23.8%), and altered mental status (98, 17.0%). Neurological symptoms started the first symptomatic day in 198 (54.2%) cases. Patients with neurological symptoms presented later to the ED (7.9 versus. 6.6 days, p = .019). Only four (0.6%) cases had no typical Covid‐19 general symptoms, and only six (1.9%) had a normal laboratory results, for a sensitivity of 98.7% (95% confidence interval (CI): 96.6%–99.6%) and 98.1% (95% CI: 95.7%–99.2%), respectively. In the multivariate Cox‐regression of mortality predictors, anosmia (HR: 0.358, 95%CI: 0.140–0.916) and altered mental status (HR: 1.867, 95%CI: 1.162–3.001) were significant. Conclusion Neurological symptoms were the most frequent extrapulmonary symptoms. They were present in half of the Covid‐19 patients at the time of the ED visit. Anosmia on admission was an independent predictor of lower in‐hospital mortality and altered mental status on admission predicted in‐hospital mortality.

Published
2021
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15. Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study

Author

Trigo, Javier, García-Azorín, David, Planchuelo-Gómez, Álvaro, Martínez-Pías, Enrique, Talavera, Blanca, Hernández-Pérez, Isabel, Valle-Peñacoba, Gonzalo, Simón-Campo, Paula, de Lera, Mercedes, Chavarría-Miranda, Alba, López-Sanz, Cristina, Gutiérrez-Sánchez, María, Martínez-Velasco, Elena, Pedraza, María, Sierra, Álvaro, Gómez-Vicente, Beatriz, Arenillas, Juan Francisco, and Guerrero, Ángel L.

Published
2020
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16. Bioeconomy ecosystem in Argentina: Rosario city experience

Author

Patricia Melina Acetta, Sol Gonzalez De Cap, Celestina Brenes Porras, and Hugo Chavarría Miranda

Subjects
Innovación, Cooperación técnica, General Engineering, Rosario, Capacidades, Bioeconomy, Innovation, Bioeconomía, Capabilities, Ecosistema, Ecosystem
Abstract

La formación de capacidades técnicas sobre bioeconomía por medio de alianzas estratégicas es una de las formas en la que se puede apoyar en el desarrollo de profesionales capacitados para enfrentar los retos del siglo XXI, a su vez, la virtualidad facilita el intercambio de conocimiento con personas internacionales expertas. En ese sentido, este documento describe los resultados del trabajo conjunto entre el Ministerio de Educación argentino y el Instituto Interamericano de Cooperación para la agricultura (IICA) en la creación de una metodología mixta para el posgrado internacional “Bioeconomía para la Agroindustria y los Territorios Rurales: buenas prácticas y lecciones aprendidas”, haciendo especial énfasis en la gira de campo a la ciudad de Rosario, uno de los polos que ha desarrollo diferentes iniciativas en innovación bioeconómica. Dar a conocer estos proyectos permite que se (re)conozca el trabajo que ha realizado el Estado argentino en la materia y además que se visibilice la valía de continuar construyendo profesionales en bioconomía por medio de la cooperación técnica. Además, facilita que se puedan replicar estas oportunidades de aprendizaje en otras latitudes. Finalmente, gracias a la metodología implementada se visibiliza el potencial con el que cuenta Argentina para adoptar una estrategia basada en bioeconomía. The development of technical capabilities in the bioeconomy through strategic alliances is one of the ways in which support can be provided for the development of professionals trained to face the challenges of the 21st century, while virtuality facilitates exchanges of knowledge with international experts. This document describes the results of the joint work between the Argentine Ministry of Education and the Inter-American Institute for Cooperation on Agriculture (IICA) in the creation of a mixed methodology for the international postgraduate course "Bioeconomy for Agroindustry and Rural Territories: good practices and lessons learned," with special emphasis on the field trip to the city of Rosario, one of the centers that has developed various initiatives in bioeconomic innovation. Publicizing these projects allows the work done by the Argentine State in this area to be (re)known and makes visible the value of continuing to build professionals in bioeconomics through technical cooperation. It also facilitates the replication of these learning opportunities in other latitudes. Finally, thanks to the methodology implemented, Argentina's potential to adopt a bioeconomy-based strategy is made visible.

Published
2022
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