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1. Characterization and prognostic impact of ACTBL2-positive tumor-infiltrating leukocytes in epithelial ovarian cancer

Author

N. E. Topalov, D. Mayr, C. Kuhn, A. Leutbecher, C. Scherer, F. B. T. Kraus, C. V. Tauber, S. Beyer, S. Meister, A. Hester, T. Kolben, A. Burges, S. Mahner, F. Trillsch, M. Kessler, U. Jeschke, and B. Czogalla

Subjects
Medicine, Science
Abstract

Abstract Actin beta-like 2 (ACTBL2) was recently identified as a new mediator of migration in ovarian cancer cells. Yet, its impact on tumor-infiltrating and thus migrating leukocytes (TILs) remains to date unknown. This study characterizes the subset of ACTBL2-expressing TILs in epithelial ovarian cancer (EOC) and elucidates their prognostic influence on the overall survival of EOC patients with special regard to different histological subtypes. Comprehensive immunohistochemical analyses of Tissue-Microarrays of 156 ovarian cancer patients revealed, that a tumor infiltration by ACTBL2-positive leukocytes was significantly associated with an improved overall survival (OS) (61.2 vs. 34.4 months; p = 0.006) and was identified as an independent prognostic factor (HR = 0.556; p = 0.038). This significant survival benefit was particularly evident in patients with low-grade serous carcinoma (OS: median not reached vs. 15.6 months, p

Published
2023
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2. Genome-wide association analyses of ovarian cancer patients undergoing primary debulking surgery identify candidate genes for residual disease

Author

Ramachandran, Dhanya, Tyrer, Jonathan P, Kommoss, Stefan, DeFazio, Anna, Riggan, Marjorie J, Webb, Penelope M, Fasching, Peter A, Lambrechts, Diether, García, María J, Rodríguez-Antona, Cristina, Goodman, Marc T, Modugno, Francesmary, Moysich, Kirsten B, Karlan, Beth Y, Lester, Jenny, Kjaer, Susanne K, Jensen, Allan, Høgdall, Estrid, Goode, Ellen L, Cliby, William A, Kumar, Amanika, Wang, Chen, Cunningham, Julie M, Winham, Stacey J, Monteiro, Alvaro N, Schildkraut, Joellen M, Cramer, Daniel W, Terry, Kathryn L, Titus, Linda, Bjorge, Line, Thomsen, Liv Cecilie Vestrheim, Pejovic, Tanja, Høgdall, Claus K, McNeish, Iain A, May, Taymaa, Huntsman, David G, Pfisterer, Jacobus, Canzler, Ulrich, Park-Simon, Tjoung-Won, Schröder, Willibald, Belau, Antje, Hanker, Lars, Harter, Philipp, Sehouli, Jalid, Kimmig, Rainer, de Gregorio, Nikolaus, Schmalfeldt, Barbara, Baumann, Klaus, Hilpert, Felix, Burges, Alexander, Winterhoff, Boris, Schürmann, Peter, Speith, Lisa-Marie, Hillemanns, Peter, Berchuck, Andrew, Johnatty, Sharon E, Ramus, Susan J, Chenevix-Trench, Georgia, Pharoah, Paul DP, Dörk, Thilo, and Heitz, Florian

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Genetics, Cancer, Clinical Research, Prevention, Orphan Drug, Women's Health, Ovarian Cancer, Rare Diseases, Human Genome, 2.1 Biological and endogenous factors, AOCS Group, OPAL Study Group, Medical biotechnology
Abstract

Survival from ovarian cancer depends on the resection status after primary surgery. We performed genome-wide association analyses for resection status of 7705 ovarian cancer patients, including 4954 with high-grade serous carcinoma (HGSOC), to identify variants associated with residual disease. The most significant association with resection status was observed for rs72845444, upstream of MGMT, in HGSOC (p = 3.9 × 10-8). In gene-based analyses, PPP2R5C was the most strongly associated gene in HGSOC after stage adjustment. In an independent set of 378 ovarian tumours from the AGO-OVAR 11 study, variants near MGMT and PPP2R5C correlated with methylation and transcript levels, and PPP2R5C mRNA levels predicted progression-free survival in patients with residual disease. MGMT encodes a DNA repair enzyme, and PPP2R5C encodes the B56γ subunit of the PP2A tumour suppressor. Our results link heritable variation at these two loci with resection status in HGSOC.

Published
2024

19. Comparison of healthy blood donor Greyhounds and non‐Greyhounds using a novel point‐of‐care viscoelastic coagulometer

Author

Chang, Johnson, Jandrey, Karl E, Burges, Julie W, and Kent, Michael S

Subjects
Veterinary Sciences, Agricultural, Veterinary and Food Sciences, Hematology, Clinical Research, Bioengineering, Animals, Blood Coagulation, Blood Coagulation Tests, Blood Donors, Cohort Studies, Dogs, Humans, Point-of-Care Systems, blood donor program, canine, clot formation, coagulopathy, hemostasis, Veterinary sciences
Abstract

ObjectiveTo measure and compare viscoelastic coagulation in 2 canine blood donor populations using a novel, point-of-care device (VCM Vet Analyzer, VCM).DesignCohort study.SettingAcademic and commercial veterinary blood banks.AnimalsNon-Greyhounds from community-based blood donor program and Greyhounds from a blood bank colony.InterventionBlood was collected from all dogs via direct venipuncture for a complete hemogram, biochemistry, and point-of-care viscoelastic coagulation.Measurement and main resultsAll biochemical measurements for all dogs in Group NG (n = 38, non-Greyhounds) and Group G (n = 53, Greyhounds) were within local reference intervals. Hematology data showed significant statistical differences between groups in hemoglobin, RBC, platelet, and WBC concentrations. Group G demonstrated lower maximum clot firmness (MCF) with 17 VCM units (26 VCM units in Group NG), increased lysis with 30 VCM units at 30 minutes (LI30) and 27 VCM units at 45 minutes (LI45) (86 VCM units LI30 and 85 VCM units LI45 in Group NG), and decreased amplitude of 13 VCM units 10 minutes (A10) after clot time (CT) and 6 VCM units 20 minutes after CT (A20) (18 VCM units [A10] and 22 VCM units [A20] in Group NG).ConclusionThis study found differences between healthy Greyhound and non-Greyhound blood donors in measures of clot strength and fibrinolysis as measured by the VCM. Whereas Greyhound have unique hematologic and hemostatic profiles, these measured viscoelastic differences are important to note prior to and following surgical intervention to aid in clinical decision-making if bleeding complications develop.

Published
2021

20. Fibroblast Growth Factor Receptors and Ligands in Context of Bevacizumab Response in Ovarian Carcinoma: An Exploratory Analysis of AGO-OVAR11/ICON-7

Author

Heublein, Sabine, Pfisterer, Jacobus, du Bois, Andreas, Anglesio, Michael, Aminossadati, Behnaz, Bhatti, Irfan, Sehouli, Jalid, Wimberger, Pauline, Schochter, Fabienne, Hilpert, Felix, Hillemanns, Peter, Kalder, Matthias, Schroeder, Willibald, Mahner, Sven, Burges, Alexander, Canzler, Ulrich, Gropp-Meier, Martina, Jackisch, Christian, Harter, Philipp, Kommoss, Stefan, and Marmé, Frederik

Published
2024
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26. Efficacy of subsequent therapies in patients with advanced ovarian cancer who relapse after first-line olaparib maintenance: results of the PAOLA-1/ENGOT-ov25 trial

Author

Bogner, Gerhard, Marth, Christian, Petru, Edgar, Reinthaller, Alexander, Schauer, Christian, Sevelda, Paul, D’Hondt, Lionel, Vergote, Ignace, Vuylsteke, Peter, Hietanen, Sakari, Lindahl, Gabriel, Mäenpää, Johanna, Nøttrup, Trine Jakobi, Puistola, Ulla, Abadie-Lacourtoisie, Sophie, Alexandre, Jérôme, Berton-Rigaud, Dominique, Boissier, Emilie, Bourgeois, Hugues, Chevalier-Place, Annick, Combe, Pierre, Costan, Cristina, Dauba, Jérôme, De Cock, Laure, Desauw, Christophe, Despax, Raymond, Dohollou, Nadine, Dubot, Coraline, Fabbro, Michel, Favier, Laure, Floquet, Anne, Follana, Philippe, Tixidre, Claire Garnier, Garnier, Georges, Gladieff, Laurence, Grenier, Julien, Guillemet, Cécile, Hardy-Bessard, Anne-Claire, Joly, Florence, Kalbacher, Elsa, Kaminsky, Marie-Christine, Kurtz, Jean-Emmanuel, Largillier, Rémy, Lefeuvre-Plesse, Claudia, Lesoin, Anne, Levache, Charles Briac, L’Haridon, Tifenn, Lortholary, Alain, Lotz, Jean-Pierre, Medioni, Jacques, Meunier, Jérôme, Mousseau, Mirerille, Mouret-Reynier, Marie-Ange, Pautier, Patricia, Petit, Thierry, Provansal, Magali, Pujade-Lauraine, Eric, Raban, Nadia, Ray-Coquard, Isabelle, Rodrigues, Manuel, Selle, Frédéric, Sverdlin, Robert, Tazi, Youssef, You, Benoît, Aktas, Bahriye, Olaf Bauerschlag, Dirk, Beck, Thomas, Belau, Antje, Bronger, Holger, Buchholz, Stefan, Buderath, Paul, Burges, Alexander, Canzler, Ulrich, de Gregorio, Nikolaus, Denschlag, Dominik, Dieterich, Max, Eichbaum, Michael, El-Balat, Ahmed, Emons, Günter, Fasching, Peter, Feisel-Schwickardi, Gabriele, Frank, Matthias, Friedrich, Michael, Grischke, Eva-Maria, Gropp-Meier, Martina, Hanker, Lars, Hannig, Carla, Harter, Philipp, Hasenburg, Annette, Hellriegel, Martin, Herwig, Uwe, Heubner, Martin, Hulde, Joachim, Jackisch, Christian, Kögel, Matthias, Krieger, Peter, Kühn, Thorsten, Liebrich, Clemens, Lück, HansJoachim, Mallmann, Peter, Marmé, Frederik, Meier, Werner, Möbus, Voker, Mohamed, Omar Farag, Nestle-Krämling, Carolin, Neunhöffer, Tanja, Oskay-Özcelik, Gülten, Park-Simon, Tjoung-Won, Rautenberg, Beate, Rein, Daniel, Ruhwedel, Wencke, Runnebaum, Ingo, Sagasser, Jacqueline, Schmalfeldt, Barbara, Schneeweiss, Andreas, Schnelzer, Andreas, Scholz, Heinz, Sehouli, Jalid, Sperfeld, Antje, Steckkönig, Annette, Strauß, Hans-Georg, Tomé, Oliver, Treustedt, Jörn, Voß, Hermann, Wischnik, Arthur, Witteler, Ralf, Wöckel, Achim, Woeltjen, Hans-Heinrich, Zorr, Andreas, Bologna, Alessandra, Colombo, Nicoletta, Tognon, Germana, Cinieri, Saverio, Lorusso, Domenica, Mosconi, Anna Maria, Pignata, Sandro, Savarese, Antonella, Scambia, Giovanni, Sorio, Roberto, Zamagni, Claudio, Fujiwara, Keiichi, Fujiwara, Hiroyuki, Kobayashi, Hiroaki, Matsumoto, Takashi, Nagao, Shoji, Satoh, Toyomi, Yonemori, Kan, Yoshida, Hiroyuki, Bratos, Raquel, Caballero, Cristina, Garica, Yolanda, González-Martín, Antonio, Guerra-Alía, Eva Maria, Hernando, Susana, Herrero, Ana, Lainez, Nuria, Manso, Luis, Martin, Cristina, Murata, Eleonor, Ortega, Eugenia, Palacio, Isabel, Poveda, Andres, Romero, Ignacio, Rubio-Pérez, María Jesús, Harter, P., Marth, C., Mouret-Reynier, M.-A., Cropet, C., Lorusso, D., Guerra-Alía, E.M., Matsumoto, T., Vergote, I., Colombo, N., Mäenpää, J., Lebreton, C., de Gregorio, N., Mosconi, A.M., Rubio-Pérez, M.J., Bourgeois, H., Fasching, P.A., Cecere, S.C., Hardy-Bessard, A.-C., Denschlag, D., de Percin, S., Hanker, L., Favier, L., Bauerschlag, D., Desauw, C., Hillemanns, P., Largillier, R., Sehouli, J., Grenier, J., Pujade-Lauraine, E., and Ray-Coquard, I.

Published
2024
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27. An in vitro study of canine cryopoor plasma to correct vitamin K–dependent coagulopathy in dogs

Author

Cheung, Hilvy, Jandrey, Karl E, Burges, Julie, Brooks, Marjory, and Kent, Michael S

Subjects
Veterinary Sciences, Agricultural, Veterinary and Food Sciences, Hematology, Animals, Blood Coagulation, Blood Coagulation Disorders, Blood Coagulation Factors, Dogs, Factor VIII, Fibrinogen, Partial Thromboplastin Time, Plasma, Prothrombin Time, Vitamin K, canine, coagulation, fresh frozen plasma, rodenticide, Veterinary sciences
Abstract

ObjectiveTo compare the efficacy of fresh frozen plasma (FFP) with cryopoor plasma (CPP) to treat vitamin K-dependent factor deficiency in a canine in vitro setting.DesignIn vitro laboratory study.SettingUniversity veterinary medical teaching hospital.AnimalsSeven units of FFP and 6 units of CPP from unique canine donors from the university veterinary blood bank.InterventionsCanine FFP was adsorbed by oral barium sulfate suspension to mimic vitamin K-dependent coagulopathy. A sequential mixing study was completed by adding FPP or CPP to the adsorbed plasma. Measurements of prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, and factor activities of factors II, VII, and IX (FII, FVII, and FIX) were compared between the 2 treatment groups.Measurements and main resultsWhen comparing the sequential addition of CPP or FPP to adsorbed plasma, the following had no statistical significance: PT (P = 0.94), aPTT (P = 0.66), FII (P = 0.05), and FIX (P = 0.90). There was a dose-dependent decrease with PT and aPTT and a dose-dependent increase with FII and FIX. In contrast, after the addition of either CPP or FFP, there was a significant difference between the treatment groups for the concentration of fibrinogen (P = 0.005) and activity of FVII (P = 0.044), with FFP resulting in a greater concentration of fibrinogen and CPP resulting in a greater concentration of FVII. Measurements of factor X (FX) were initially included in the study but were later excluded because FX appeared to be continually adsorbed even after the addition of CPP or FFP.ConclusionsCPP partially corrected the coagulation times and concentration of vitamin K-dependent coagulation factors to the same degree as FFP. CPP, generally less expensive than FFP, may provide an alternative treatment option for vitamin K-dependent coagulopathies, although in vivo testing is needed.

Published
2021

37. Olaparib plus bevacizumab first-line maintenance in ovarian cancer: final overall survival results from the PAOLA-1/ENGOT-ov25 trial

Author

Ray-Coquard, I., Leary, A., Pignata, S., Cropet, C., González-Martín, A., Marth, C., Nagao, S., Vergote, I., Colombo, N., Mäenpää, J., Selle, F., Sehouli, J., Lorusso, D., Guerra Alia, E.M., Bogner, G., Yoshida, H., Lefeuvre-Plesse, C., Buderath, P., Mosconi, A.M., Lortholary, A., Burges, A., Medioni, J., El-Balat, A., Rodrigues, M., Park-Simon, T.-W., Dubot, C., Denschlag, D., You, B., Pujade-Lauraine, E., and Harter, P.

Published
2023
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38. Model Adaptation via Model Interpolation and Boosting for Web Search Ranking

Author

Gao, Jianfeng, Wu, Qiang, Burges, Chris, Svore, Krysta, Su, Yi, Khan, Nazan, Shah, Shalin, and Zhou, Hongyan

Subjects
Computer Science - Machine Learning, Statistics - Machine Learning
Abstract

This paper explores two classes of model adaptation methods for Web search ranking: Model Interpolation and error-driven learning approaches based on a boosting algorithm. The results show that model interpolation, though simple, achieves the best results on all the open test sets where the test data is very different from the training data. The tree-based boosting algorithm achieves the best performance on most of the closed test sets where the test data and the training data are similar, but its performance drops significantly on the open test sets due to the instability of trees. Several methods are explored to improve the robustness of the algorithm, with limited success.

Published
2019
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39. Establishment of a reference interval for a novel viscoelastic coagulometer and comparison with thromboelastography in healthy cats

Author

Rosati, Tommaso, Jandrey, Karl E, Burges, Julie W, and Kent, Michael S

Subjects
Veterinary Sciences, Agricultural, Veterinary and Food Sciences, Animals, Blood Coagulation, Blood Coagulation Tests, Cat Diseases, Cats, Reference Values, Thrombelastography, Thrombosis, coagulation, feline, point&#8208, of&#8208, care, VCM Vet, point-of-care, Zoology, Veterinary sciences
Abstract

BackgroundViscoelastic analysis provides information on the dynamics and strength of clot formation as well as clot stability. A novel point-of-care viscoelastic test (Viscoelastic Coagulation Monitor Vet, VCM Vet) could be more cost-effective, simpler to use, and more portable than thromboelastography (TEG).ObjectivesThe primary aim of this study was to establish a feline reference interval (RI) for the VCM Vet. A secondary aim was to compare VCM Vet analysis with TEG in healthy cats.MethodsFifty-six healthy cats were enrolled in this study. Linear regression was completed to determine whether age and CBC parameters were associated with the VCM Vet parameters and if TEG parameters were correlated with VCM Vet data. Statistical significance was set at P

Published
2020

40. Reducing Antibiotic Prescribing in Primary Care for Respiratory Illness.

Author

Kronman, Matthew P, Gerber, Jeffrey S, Grundmeier, Robert W, Zhou, Chuan, Robinson, Jeffrey D, Heritage, John, Stout, James, Burges, Dennis, Hedrick, Benjamin, Warren, Louise, Shalowitz, Madeleine, Shone, Laura P, Steffes, Jennifer, Wright, Margaret, Fiks, Alexander G, and Mangione-Smith, Rita

Subjects
Humans, Streptococcal Infections, Respiratory Tract Infections, Pharyngitis, Bronchitis, Sinusitis, Otitis Media, Acute Disease, Anti-Bacterial Agents, Confidence Intervals, Logistic Models, Odds Ratio, Communication, Pediatric Nursing, Education, Distance, Child, Child, Preschool, Infant, Outpatients, Program Development, Primary Health Care, Chicago, Female, Male, Intention to Treat Analysis, Inappropriate Prescribing, Quality Improvement, Pediatricians, Pediatrics, Medical and Health Sciences, Psychology and Cognitive Sciences
Abstract

BackgroundOne-third of outpatient antibiotic prescriptions for pediatric acute respiratory tract infections (ARTIs) are inappropriate. We evaluated a distance learning program's effectiveness for reducing outpatient antibiotic prescribing for ARTI visits.MethodsIn this stepped-wedge clinical trial run from November 2015 to June 2018, we randomly assigned 19 pediatric practices belonging to the Pediatric Research in Office Settings Network or the NorthShore University HealthSystem to 4 wedges. Visits for acute otitis media, bronchitis, pharyngitis, sinusitis, and upper respiratory infection for children 6 months to

Published
2020

49. Equine platelet concentrate preparation and validation

Author

Bozorgmanesh, Rana, Magdesian, K Gary, Sutton‐Burges, Julie W, Owens, Sean D, and Tablin, Fern

Subjects
Veterinary Sciences, Agricultural, Veterinary and Food Sciences, Hematology, Clinical Research, Animals, Blood Platelets, Blood Preservation, Centrifugation, Horses, Male, Platelet Count, Platelet-Rich Plasma, Prospective Studies, horse, thrombocyte, thrombocytopenia, transfusion, Veterinary sciences
Abstract

BackgroundDevelopment of equine platelet concentrate (PC) would aid management of cases requiring transfused platelets (PLTs), where adminstration of whole-blood or platelet-rich plasma (PRP) might be contraindicated.ObjectivesTo test and validate a method for production of an equine PRP-PC product.AnimalsSix healthy Thoroughbred geldings from a research herd.MethodsIn this prospective experimental study, whole blood was collected and processed through multiple centrifugation steps to yield 120 mL of PC. The PC was stored at 22°C and gently and continuously agitated. Measurements of PLT count, pH, and concentrations of glucose, lactate, electrolytes, lactate dehydrogenase (LDH), and aspartate aminotransferase (AST), as well as partial pressures of oxygen and carbon dioxide were performed on days 0, 1, 2, 3, 5, and 7. Platelet aggregometry and bacterial culture were also performed.ResultsThe PC always had a PLT count of ≥550 × 103 cells/μL. Aggregometry graph amplitude (P

Published
2019

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