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334 results on '"A. Alonso-Lomillo"'

27. Electrochemical devices for cholesterol detection

Author

Olga Domínguez-Renedo, A. Marta Navarro-Cuñado, and M. Asunción Alonso-Lomillo

Subjects
Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Química analítica, Chemistry, Analytic, Spectroscopy, Analytical Chemistry
Abstract

Cholesterol can be considered as a biomarker of illnesses such as heart and coronary artery diseases or arteriosclerosis. Therefore, the fast determination of its concentration in blood is interesting as a means of achieving an early diagnosis of these unhealthy conditions. Electrochemical sensors and biosensors have become a potential tool for selective and sensitive detection of this biomolecule, combining the analytical advantages of electrochemical techniques with the selective recognition features of modified electrodes. This review covers the different approaches carried out in the development of electrochemical sensors for cholesterol, differentiating between enzymatic biosensors and non-enzymatic systems, highlighting lab-on-a-chip devices. A description of the different modification procedures of the working electrode has been included and the role of the different functional materials used has been discussed.

Published
2022

28. Acetylcholinesterase Inhibition-Based Biosensor for Aluminum(III) Chronoamperometric Determination in Aqueous Media

Author

Miriam Barquero-Quirós, Olga Domínguez-Renedo, Maria Asunción Alonso-Lomillo, and María Julia Arcos-Martínez

Subjects
acetylcholinesterase, biosensor, aluminum, acetylthiocholine iodide, screen-printed electrodes, gold nanoparticles, Chemical technology, TP1-1185
Abstract

A novel amperometric biosensor for the determination of Al(III) based on the inhibition of the enzyme acetylcholinesterase has been developed. The immobilization of the enzyme was performed on screen-printed carbon electrodes modified with gold nanoparticles. The oxidation signal of acetylthiocholine iodide enzyme substrate was affected by the presence of Al(III) ions leading to a decrease in the amperometric current. The developed system has a detection limit of 2.1 ± 0.1 μM for Al(III). The reproducibility of the method is 8.1% (n = 4). Main interferences include Mo(VI), W(VI) and Hg(II) ions. The developed method was successfully applied to the determination of Al(III) in spiked tap water . The analysis of a certified standard reference material was also carried out. Both results agree with the certified values considering the respective associated uncertainties.

Published
2014
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