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Objective. The purpose of the research is to develop an innovative automated program associated with a completely new irrigation regime based on a closed water supply system.Method. Methods of modeling, formalized description, optimal design and control of technological processes and production were used.Result. An automated control system in greenhouse farming based on Arduino controllers and ONI PLR Studio software for its operation are presented. The scientific novelty of the work lies in the creation of appropriate modes of the climate control system in greenhouses. The ONI PLR Studio program is written in FBD language. It solves important problems of controlling the cultivation of agricultural products, breeding new plant varieties, and controlling the technological process using certain signals. User input is limited to software adjustments and direct setting of controller parameters. The adjustment can be carried out remotely through a computer connected to the controller. The automatic operating mode is provided by sensors and a controller with electronic control circuits, which ensure that the actuators operate in the required mode.Conclusion. An automated control system (ACS) allows you to control air and soil temperature, soil and air humidity, soil nutrition, disinfection, air pressure, lighting, the presence of carbon dioxide in the greenhouse, and climate control.

The aim of the review is to provide an analysis and generalization of the main directions of research in the sphere of pharmaceutical services, and their characteristics associated with the determination of their main development trends.Materials and methods. For the analysis, the information store on the basis of scientific publications by Russian and foreign scientists, devoted to research in the field of pharmaceutical services (PSs), has been used. The search for publications was carried out in the open and accessible sources of the latest twenty years (the retrospective period of 2001-2021), located in scientific and technical libraries of institutions, as well as in electronic databases: Elibrary, Medline / PubMed, Cochrane Library, Scopus, Cyberleninka, Google-academy, J-stage. When forming the information array, the search for publications was carried out according to the following requests: pharmaceutical services (pharmaceutical care services), the provision of pharmaceutical services, the quality of pharmaceutical services. For the conceptualization of the study, 87 scientific publications obtained as a result of information retrieval, have been used.Results. In the course of the study, a logical and structural analysis of the main directions in which research in the field of providing PSs in our country is developing, has been carried out. The main trends in the study of the providing services’ activity in the sphere of drug circulation, are characterized. A comprehensive analysis of the category of "pharmaceutical service" has been carried out. The terminological content of this concept, the groups of features characterizing the economic and social essence of educational institutions have been generalized, and the most characteristic features that make up the structure and content of educational institutions, have been identified. The existing approaches to the development of the nomenclature and types of PSs have been analyzed and the systematization of pharmaceutical works and services using the process approach, have been proposed by the authors.Conclusion. The conducted study indicates the presence of several directions in the development of research in the field of providing PSs, aimed at improving the quality of services for the population in pharmaceutical organizations. However, the most important role in the research is assigned to the study and assessment of the quality of educational institutions, the development of approaches to its optimization. As evidenced by the results of the analysis and generalization, the most successful activity in the provision of services in the field of drug circulation requires the implementation of a process approach and the implementation of Quality Management Systems (QMSs).

The aim of the study is a theoretical justification and development of a mechanism for the implementation of quality management systems (QMS) in the activities of retail trade in pharmaceutical products.Materials and methods. The study is based on the analysis of scientific literature data and Analytical Normative Documents regulating various aspects of QMS functioning in pharmaceutical organizations. Methods of documentary content analysis of international and national ISO standards, Series 9000, were used as the basis for the development and implementation of QMS organizations despite the type of their activities.Results. In the course of the study, the organization of the production process has been studied and the main production (business-) operations of seven structural subdivisions of “Apteka-Alex” LLC in Angarsk have been analyzed. The basic principles of QMS functioning are set forth and the author’s methodology for its development for retail trade in pharmaceutical products has been presented, taking into account the specifics of the organizational structure and production activities of pharmacy organizations. The mechanisms and successive stages of the QMS implementation have been specified and given grounds for. In accordance with the requirements of GOST R ISO 9000:2015, the definitions and classification of the main production operations (business processes) of the studied pharmacies have been made up. In addition, the list of mandatory (core) and basic standard operating procedures (SOPs), detailing the main production (business-) processes, has been made up, and an algorithm for developing and testing SOPs has been outlined.Conclusion. The results of the study allowed us to justify and propose a step-by-step methods of QMS implementation into the work of pharmaceutical organizations in the retail sector. The first results of the approbation and use of the developed methodology show that it contributes to the rational construction and functioning of the QMS, in accordance with the requirements of the existing standards, as well as the optimization of administrative management of all production (business-) processes.

Clinical practice and content analysis of scientifi c literature indicate that for treatment of the immune-infl amatory disease called juvenile rheumatoid arthritis (JRA), the use of only basic medicines (BM) is not suffi cient.The aim of the study is the organization of pharmacotherapy of JRA patients by genetically engineered biological preparations (GEBP), affecting the immune processes of the body directly.Materials and methods: the theory of marketing, content analysis, the ABC-analysis, sociological survey, pharmacoeconomic methods.Results and discussion. Depending on the individual characteristics of patients, the clinical picture of the disease can manifest itself in different ways, which requires justifi cation of the necessary schemes of GEBP pharmacotherapy at each stage of the carried out treatment. In the course of studying the organization of pharmaceutical assistance at the inpatient stage, we carried out a content analysis of 175 medical records of the patients (aged 2–17 years old) of the cardiologic department of Irkutsk State Children’s Clinical Hospital, in the dynamics of a few years (2015–2017), and the expert assessment of the degree of GEBP demand was carried out by the doctors. The analysis of the pharmacotherapy has shown that GEBP is used as monotherapy in patients with intolerance to basic medicines or to combinations with basic medicines. It is irrational to start the GIBP treatment immediately because of possible side effects and their high cost. According to the content analysis of the reports of the regional Ministry of Health on preferential drug provision of handicapped children, both in hospital and at outpatient treatment stage, the pharmacotherapy schemes including Adalimumab, Abatacept, Infl iximab, Tocilizumab, Etanercept are most in demand.Conclusion. The study of the organization of GEBP pharmacotherapy, the expert assessment carried out by the doctors, the results of the marketing analysis of the regional pharmaceutical market made it possible to substantiate and propose a rational assortment portfolio of this group of medicines for treatment of various JRA options, taking into account the price component in the Irkutsk region. The obtained results can be used for the formation of the medicinal budget of medical organizations in the region.

A growing potential of Russian pharmaceutical market and constant medicinal drugs range widening requires a necessity to search for more effective ways of pharmaceutical product promotion. The purpose of this study is to estimate current marketing spiral of MD promotion from producer to consumer, and revelation of obstacles encountered by means of comparing method.The conducted study about current marketing spiral of MD promotion from producer to the consumer gives evidence about obstacles of ethic and legal, professional and legal, ethics and professional, ethics and marketing, professional and marketing, and professional work-related character. We have pointed the characteristics and substantiated the schemes of "ideal", legally formed, and functioning marketing spiral of MD promotion. Understanding of the factors considered and revelation of obstacles for successful MD promotion from producer to the consumer is important, since it is the ground for practical recommendations on this field optimization.

The article proposes a method for inactivating the anti-nutritional factors of vegetable soy proteins by biological modification. It was carried out by germinating soy seeds in a mineralized medium, resulting in a decrease in trypsin-inhibiting activity and saturation of soy seeds with minerals. The change in the chemical composition of soy seeds is presented. Sprouted soybean seeds were later used for food production. Studies are presented on the basis of which a technology for obtaining structured food systems from soy has been developed, including operations for joint disintegration and extraction, pre-soaked soybean seeds and crushed fresh beet or pumpkin in a ratio of 1:1, separation of the resulting mixture, coagulation with 5% ascorbic acid solution, separation from whey, granulation and drying. The remaining whey was used to make drinks and sauces. Based on the analysis of mathematical models, the optimal parameters of coagulation of the protein-suspension system were determined. The mass fraction of ascorbic acid solution is 13.4-14.05%, the concentration of ascorbic acid solution – 4.7-5.4%, the duration of coagulation – 5.3-5.5 min, the optimal temperature of coagulation – 66.1-66.7 ° C and granulate drying: the initial moisture content of granules – 36.7-40.0%; drying temperature – 71.5-72.9 ° C; drying duration – 58-63 min., the strength of the obtained granules – 94.5-96.9%. Analysis of the chemical composition of the developed soy-vegetable food systems showed that the proposed technology allowed increasing the protein content to 26.4%, fat to 7%, dietary fiber to 8.6%, which exceeds similar indicators for dried vegetable concentrates existing on the market.

Currently, a lot of standardized elliptic curve cryptographic algorithms are widely used. Due to the constantly increasing execution speed demands, implementation optimization problem become actual. Using elliptic curve arithmetic on a different information security devices require to form an mathematical programming problem of elliptic curves calculation. Solution of this problem allows to find optimal way of calculation in the current condition. This approach increases the speed of cryptographic algorithms on information security devices. The paper present one of the possible ways to optimize computations in elliptic curve arithmetic by using mathematical programming. An optimization problem is formed that describes the calculation of scalar multiplication. Operations composition and multiplication methods composition are introduced to form the corresponding optimization problem. Adduction of elliptic curve calculations to the mathematical programming problem allow to research applicability of known optimization methods to computations in elliptic curves.

The given article provides an analysis of collective discursive personalities of members of Internet fan communities which are devoted to performers working in two different music styles – pop and metal. Such kind of communicative interaction forms a unique discourse – the discourse of music fan Internet community which combines features of both subcultural group discourse (as the reason which led to the formation of the very fan community) and Internet discourse itself (as the environment for the given discourse). Through the use of content analysis method the authors find out both typical and specific psychological and cognitive features which fan community members implement during communication in the given discourse. These features include different ways of perception (visual vs. audial), major mindsets, emotionality level, etc. The main way of perception which is represented in the texts of conversations between pop music fan community members turns to be a visual one, while metal music fans are likely to have the audial way of perception as a major one. In the given discourse these features are represented by word groups of different perception semantics which are used by community members and belong to different parts of speech. The analysis of conversations in both fan groups demonstrates that concrete thinking could be characterized as a main way of thinking for fans of two aforementioned music styles. It is represented within the vocabulary and grammatical features used. Conversations between music fans of both types could be also characterized by a heightened emotionality level which directly depends on the specific character of music fanaticism. This specific character is based on over-positive attitude to favourite artists. The special attention is given to the system of language means which help to form general emotional background during communication process.

The study evaluated the efficacy of reamberin in complex treatment of patients with acute small bowel obstruction. Methods. The research is based on the results of complex examination of 202 patients with acute small bowel obstruction (ASBO). The patients were hospitalized in Ivano-Frankovsk central municipal clinical hospital at the period from 2009 to 2015. The patients were divided into two groups according to the method of treatment. The complex treatment using common method was applied for the first group of 100 patients with ASBO. The complex treatment using common method and reamberin intravenously (800 ml/day) during 7 days was applied for the second group of 102 patients. Results. The application of reamberin reduced a lot of indices such as leukocytic intoxication, intoxication index, level of middle mass molecule, formation of malonic dialdehyde. The drug stimulated antioxidant system and normalized organ-specific liver enzymes. Conclusions. The application of reamberin is pathogenetically validated in cases of ASBO.

Background: Analysis and discussion of the studies of authors from different countries and their experimental data on the level and dynamics of development, gender differences, and trainability of different coordination abilities (CAs) in students aged from 18 to 24 years. Methods: The study involved freestyle wrestlers aged 10-13, 14-16, and 17-20 years (n = 127); male (n = 20) and female (n = 10) kickboxers, and male (n = 15) and female (n = 13) taekwondo fighters aged 18 to 27 years; Taekwondo students (n = 24); female (n = 95) and male (n = 65) first-year students of the Faculty of Medicine of the University of Krakow aged 20.1 to 23.5 years. Results: It was found that compared to the somatic indicators and the level of development of abilities related to strength and conditioning (strength, speed, endurance), in which men aged 18-24 years showed significantly higher performance than women (by 10-20% or more), gender differences in the development of CAs are not manifested so obviously and unambiguously. Actually, the development of CAs at the age over 18-19 years without special targeted training and regular training sessions using coordination exercises stops in different sports; when using approximately the same targeted coordination training, approximately the same training potential of male and female students for the improvement of different CAs is observed. Conclusions: The level and rates of improvement of all CAs with age largely depend on the individual characteristics of the students, including their response to the same training load. With age, with an increase in the length of time spent in sports and an increase in performance, a decrease in sex differences in the level of most CAs is observed, which, most likely, can be explained by the similarity of neurophysiological and psychophysiological substrates and mechanisms underlying the optimal control and regulation of complex motor activities. [ABSTRACT FROM AUTHOR]