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Background. Treatment results in patients with relapsed and refractory acute myeloid leukemia (AML) remain unsatis‑factory. Treatment options for these patients are limited.Aim. To retrospectively analyze the efficacy and safety of combined therapy with hypomethylating agents and venetoclax (VenHMA) in patients with relapsed AML and also to compare the results with the cohort of patients who received azacitidine as a monotherapy.Materials and methods. The study included patients with relapsed AML, over 50 years old, who received VenHMA therapy from 01.09.2019 to 01.06.2022 and azacytidine monotherapy from 01.03.2016 to 01.06.2022. In total we identified 38 patients who received VenHMA and 30 patients who received azacytidine alone.Results. The median age of patients in the VenHMA cohort was 66 years (range 51–84). The median number of previous therapy lines was 1.5 (range 1–3), and 12 (32 %) patients had AML evolving from prior myelodysplasia. The median follow-up was 6.2 months, with 20 patients monitored for more than 6 months. Complete response was obtained in 13 (34 %) patients, complete remission with incomplete recovery in 8 (21 %), leukemia-free state in 2 (5 %) patients. Thus, overall response was achieved in 23 (60 %) patients. The median time to achieve overall response was 2.6 months. At the time of the final analysis, 16 patients were still receiving treatment. The median of relapse-free survival in patients with response was not achieved; the median of overall survival was 15.6 months.The groups of patients receiving VenHMA or azacitidine alone were comparable in terms of the main characteristics, with the exception of initial thrombocytopenia 65 years, secondary AML, azacytidine monotherapy) only secondary AML was a significant factor for overall survival.Conclusion. The results of our retrospective study show the superiority of the combination regimen of venetoclax and azacitidine in the treatment of AML relapses, both in terms of the quality of remissions and their duration. Patients with relapse and primary refractory AML represent cases of poor cytogenetic prognosis, and have an aggravated somatic status. To date, the use of the VenGMA regimen allows finding the optimal balance between the intensity and toxicity of therapy.

Purpose: to improve the complex therapy of rotavirus infection in infants by including interferon and to evaluate its clinical and immunological effectiveness.Materials and methods. Infants without infectious pathology and with rotavirus infection, who were on standard therapy and treatment, including standard therapy and interferon (20 in each group), were examined using general clinical methods. The diagnosis of rotavirus infection was carried out by molecular-genetic method and immunochromatography. Indicators of cellular immunity were determined by flow cytometry. Statistical processing of the results was carried out using the STATISTICA 8.0 program for related and independent samples using the nonparametric Mann-Whitney test and χ2.Summary. In all infants with rotavirus infection, the disease occurred in a moderate form with symptoms of grade II exicosis. In the group of patients who received an additional interferon drug as part of complex therapy, the duration of intoxication symptoms was significantly less, and in the hemogram at discharge from the hospital, the relative content of neutrophils was higher and monocytes lower compared to infants who were only on standard treatment, which corresponded to the norm. In the acute period of rotavirus infection, the relative level of lymphocytes decreased, and NK cells and T-NK cells increased compared to healthy infants. The relative number of cells expressing TLR-3 at the beginning of the disease was lower than in the control group. The inclusion of interferon in the complex therapy contributes to normalization of the relative number of NK cells, while maintaining an increased content of T-NK cells in both relative and absolute terms compared to healthy infants, and a reduced content of cells expressing TLR-3.Conclusion. Currently, rotavirus infection in infants is typical, the most pronounced and long-lasting clinical symptom of the disease is watery diarrhea. The use of interferon in complex therapy helps to reduce the duration of intoxication and normalize the hemogram. Changes in the immune status in the acute period of rotavirus infection indicate increased antigenic stimulation of the cell link and inhibition of the synthesis of pro-inflammatory cytokines, including interferons, under the influence of rotavirus, which is the justification for the use of interferon therapy.

The article studies in linguo-philosophical and linguo-communicative angles the problem of speech ecology in the conditions of the present-day society along with the violations, caused by it, of linguistic and communicative norms of cooperative speech intercourse. Proceeding from the language-as-a-doer conception and also from the fact of limited linguistic censorship in the sphere of present-day mass communication, the author justifies possibility of all kinds of irregularities in public discourse and analyses how their appearance can affect the eventual communicative efficiency of the discourse as a whole. The article gives a chronological observation of the practice of discourse analysis acquiring the four basic criteria of evaluating linguistic utterances – grammaticality, acceptability, truth, and reference – which were gradually introduced in linguistics as the result of influence from adjacent areas of knowledge. On the basis of selected examples the author tries to find out whether appliance of these speech evaluation methods is justified inasmuch as they help to evaluate linguistic conventions implementation and ability of speech utterances to transmit communicator's intentions implicated in them. Having studied different kinds of speech deviations violating, to this or that extant, the norms of grammar, syntax, conceptualization processes, and communication canons, the author comes to the conclusion that violations of norms do not always cause ultimate communicative failures. According to the author, verbal communication can only be estimated as unsuccessful when it fails to receive adequate perception on the part of the addressee. Based on that, the conclusion is made that while evaluating discourse linguistic correctness and pragmatic consistency, one should, first of all, consider peculiarities of the extra-linguistic context and the category of the receptive audience rather than whether the discourse does or does not conform to the norms of usage and standard speech ethics.

Human usage of coastal water bodies continues to increase and many invertebrates face a broad suite of anthropogenic stressors (e.g., warming, pollution, acidification, fishing pressure). Underwater sound is a stressor that continues to increase in coastal areas, but the potential impact on invertebrates is not well understood. In addition to masking natural sound cues which may be important for behavioral interactions, there is a small but increasing body of scientific literature indicating sublethal physiological stress may occur in invertebrates exposed to high levels of underwater sound, particularly low frequency sounds such as vessel traffic, construction noise, and some types of sonar. Juvenile and sub-adult blue crabs (Callinectes sapidus) and American lobsters (Homarus americanus) were exposed to simulated low-frequency vessel noise (a signal was low-pass filtered below 1 kHz to ensure low-frequency content only) and mid-frequency sonar (a 1-s 1.67 kHz continuous wave pulse followed by a 2.5 to 4.0 kHz 1-s linear frequency modulated chirp) and behavioral response (the animal’s activity level) was quantified during and after exposure using EthoVision XT™ from overhead video recordings. Source noise was quantified by particle acceleration and pressure. Physiological response to the insults (stress and recovery) were also quantified by measuring changes in hemolymph heat shock protein (HSP27) and glucose over 7 days post-exposure. In general, physiological indicators returned to baseline levels within approximately 48 h, and no observable difference in mortality between treatment and control animals was detected. However, there was a consistent amplified hemolymph glucose signal present 7 days after exposure for those animals exposed to mid-frequency sound and there were changes to C. sapidus competitive behavior within 24 h of exposure to sound. These results stress the importance of considering the impacts of underwater sound among the suite of stressors facing marine and estuarine invertebrates, and in the discussion of management actions such as protected areas, impact assessments, and marine spatial planning efforts.

In this paper, structural features of the NiO-SiO2 nanocrystalline catalyst synthesized by the sol-gel method were studied by X-ray diffraction (XRD), high-resolution transmission electron microscopy (TEM), and differential dissolution (DD). The XRD pattern of NiO-SiO2 significantly differs from the “ideal” NiO pattern: the peaks of the NiO-like phase are asymmetric, especially the 111 diffraction peak. The NiO-SiO2 nanocrystalline catalyst was investigated by means of XRD simulations based on two approaches: conventional Rietveld analysis and statistical models of 1D disordered crystals. Through a direct simulation of XRD profiles, structural information is extracted from both the Bragg and diffuse scattering. XRD simulations showed that the asymmetry of all the diffraction peaks is due to the presence of two NiO-like oxides with different lattice constants and different average sizes: ~90 wt% of mixed Ni-Si oxide (Ni:Si = 0.14:0.86) with average crystallite sizes (D ~ 27.5 Å) and ~10 wt% of pure NiO (D ~ 50 Å). The high asymmetry of the 111 diffraction peak is due to the appearance of diffuse scattering caused by the inclusion of tetrahedral SiO2 layers between octahedral NiO layers. Such methods as TEM and DD were applied as independent criteria to prove the structural model, and the results obtained confirm the formation of mixed Ni-Si oxide.

A solvent-free method was proposed for the synthesis of hexaimidazolecobalt(II) nitrate and perchlorate complexes—[Co(C3H4N2)6](NO3)2 and [Co(C3H4N2)6](ClO4)2—by adding cobalt salts to melted imidazole. The composition, charge state of the metal, and the structure of the resulting complexes were confirmed by elemental analysis, XPS, IR spectroscopy, and XRD. The study of the thermochemical properties of the synthesized complexes showed that [Co(C3H4N2)6](NO3)2 and [Co(C3H4N2)6](ClO4)2 are thermally stable up to 150 and 170 °C, respectively. When the critical temperature of thermal decomposition is reached, oxidative two-stage gasification is observed. In this case, the organic component of the [Co(C3H4N2)6](NO3)2 complex undergoes almost complete gasification to form Co3O4 with a slight admixture of CoO, which makes it attractive as a component of gas-generation compositions, like airbags. [ABSTRACT FROM AUTHOR]

The development of solvent-free techniques for nanoparticles synthesis is one of the challenges of Green chemistry. In this work, the principled opportunity to obtain copper-containing nanosized particles without use of any solvents was shown. The copper complexes were prepared as precursors by the melting-assisted solvent-free synthesis. The formation of tetra(imidazole)copper(II) nitrate complex was confirmed by XRD, elemental analysis, FTIR spectroscopy, and thermal analysis. It was noted that their thermal decomposition occurs in two stages: (I) the low-temperature step may be related to redox interaction between organic ligands and nitrate-anions; (II) the high-temperature step may be related to the oxidation of the products of incomplete imidazole decomposition. TEM and XRD studies of solid products of complex combustion have shown that they are oxides with particle size less than 40 nm. Thus, the combustion of [Cu(Im)4](NO3)2 complex under air can be considered as a new approach to prepare nanosized particles of copper oxides without the use of solvents.

In this work two approaches to the synthesis of energetic complex compound Ni(Im)6(NO3)2 from imidazole and nicklel (II) nitrate were applied: a traditional synthesis from solution and a solvent-free melting-assisted method. According to infrared spectroscopy, X-ray diffraction, elemental and thermal analysis data, it was shown that the solvent-free melt synthesis is a faster, simpler and environmentally friendly method of Ni(Im)6(NO3)2 preparation. The results show that this compound is a promising precursor for the production of nanocrystalline Ni-NiO materials by air-assisted combustion method. The combustion of this complex together with inorganic supports makes it possible to synthesize supported nickel catalysts for different catalytic processes.

The eruption of permanent teeth in children is a complex physiological process that is important for the development of the dentoalveolar system. The timing of eruption is a key indicator of biological age and prenosological diagnosis of children's health. The need to update research on this topic is due both to changes in society and the importance of modern data for pediatric dentistry and public health. The aim of the study was to determine the regional characteristics of the terms of eruption of permanent teeth in early mixed dentition among children of Odesa. Material and methods. Dental examination was performed on children aged 4 to 8 years of both sexes. The examination was performed according to the generally accepted methodology, using standard dental instruments included in the examination kit. The children were divided into groups according to age and sex. Patients were examined on the basis of age and period of teeth eruption. Results. The results of the study of the eruption of the permanent teeth of the upper and lower jaws in children aged 4.5-8.5 years in Odesa indicate an earlier eruption of the permanent teeth in girls. Thus, in girls the eruption of the first permanent molars began at the age of 4.5 years and ended at the age of 6 years. In boys, the age of onset of first molar eruption was 5 years and the age of completion was 6.5 years. It was found that the timing of the beginning and the end of the eruption of the central permanent incisors of the upper jaw was the same in boys and girls (6 years), but the average duration of eruption was different. The timing of the beginning and end of eruption of the upper lateral incisors was identical in boys and girls. However, differences in the average terms of eruption of permanent upper lateral incisors were obtained. The analysis of the results of the terms of eruption of the central permanent incisors of the lower jaw in boys and girls shows the same terms of beginning of eruption and average terms of eruption of these teeth. However, there were differences in the time of the end of eruption. The beginning of the eruption of the permanent central incisors of the upper jaw was noted earlier (at the age of 6 years) than the data given in the modern dental manuals of Ukraine and was completed at the age of 8 years. The age of the beginning and the end of eruption was one year earlier than the generally accepted data. The data on the time of eruption of the first permanent molars and incisors obtained as a result of the study are necessary for planning programs for prevention of dental caries in children in the period of early replacement dentition. The data obtained as a result of the study indicate the need for further epidemiological studies in other regions of Ukraine in order to establish the current national norms for the eruption of permanent teeth in children. Conclusion. The discrepancy between the dates of eruption of permanent incisors and molars in Odesa children and the standard dates of eruption of teeth was revealed, which indicates the need to clarify them in each region. Gender differences were found - earlier eruption of permanent teeth in girls. The data of the conducted research substantiate the necessity to revise the terms of caries prophylaxis in Odessa children and the necessity to conduct in-depth examination of children with violation of the terms of teeth eruption. [ABSTRACT FROM AUTHOR]

The Mn-Ce oxide catalysts active in the oxidation of CO were studied by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), temperature-programmed reduction (TPR), transition electron microscopy (TEM), energy dispersive X-Ray (EDX), and a differential dissolution technique. The Mn-Ce catalysts were prepared by thermal decomposition of oxalates by varying the Mn:Ce ratio. The nanocrystalline oxides with a fluorite structure and particle sizes of 4–6 nm were formed. The introduction of manganese led to a reduction of the oxide particle size, a decrease in the surface area, and the formation of a MnyCe1−yO2−δ solid solution. An increase in the manganese content resulted in the formation of manganese oxides such as Mn2O3, Mn3O4, and Mn5O8. The catalytic activity as a function of the manganese content had a volcano-like shape. The best catalytic performance was exhibited by the catalyst containing ca. 50 at.% Mn due to the high specific surface area, the formation of the solid solution, and the maximum content of the solid solution.

Nickel catalysts were synthesized for solid-state NaBH4 composites by reducing nickel chloride with sodium borohydride. The effect of heat treatment on their magnetic properties and the hydrogen generation rate was studied. It has been established that calcination of nickel catalysts to 350 °C has a negligible effect on the rate of gas generation but provides fast separation of more than 70% of the catalyst from the spent reaction medium using a magnet. According to XRD data (in situ) and the found Curie point value (358 °C), the enhancement of magnetic properties results from the accumulation of the ferromagnetic phase of the reduced Ni0 metal. A further increase in the heat treatment temperature (≥400 °C) decreases the activity of nickel catalysts, accompanied by a decrease in the specific surface area of the samples, by the complete conversion of cobalt boride Ni3B into the metallic form Ni0 and by the formation of the boron oxide shell around the nickel particles. To increase the activity of the nickel catalyst calcined at 350 °C, cobalt was deposited using incipient wetness impregnation, followed by reduction with sodium borohydride. The proposed technique allowed us to uniformly anchor cobalt on the surface of nickel particles, which ensured an increase in the gas generation rate. Thus, an effective ferromagnetic cobalt–nickel catalyst has been proposed for solid-state hydrogen-generating materials based on sodium borohydride. Note that the removal extent of this catalyst from the spent solution was about 85%. [ABSTRACT FROM AUTHOR]

The article deals with the consequences of influence caused by socially conditioned extra linguistic phenomena on the language policy in present-day national communities, and with the issue of keeping language norms and conventions in speech communication. Comparing the language system with its original openness and variability, on the one hand, and the language norm characterized by its conservatism and rigid regulations, on the other, the author detects a basic contradiction between these two, which reflects upon ways of organizing communication in today's societies. It is proved in the article that when speech behavior of most communicators is conditioned by ethnocultural, moral-ethic, and pragmatic-commercial specificities, appearance of various linguistic irregularities in public discourse becomes unavoidable. The author classifies language norm violations into two categories: unconscious and conscious, individually viewing the cases of positive and negative communicative effects caused by language anomalies. Based on the analysis of the examples of conscious deviations detected in advertising as a typical variation of present-day public discourse, the article reveals a variety of forms of language anomalies in the pragmatically oriented text, as well as their high degree of communicative effectiveness. The author also makes a suggestion that the scale of deviative phenomena in speech practices of world communities will extend in the near future.

Background. In the spite of the intensive search of effective ways to treat EM, there is no common concept in systemic therapy for EM, and the published data are fragmentary in nature The purpose. Evaluation of epithelization of erosion and ulcers of the oral mucosa in patients with multiforme exudative erythema after the pathogenetically substantiated therapy have been done. Results and conclusion. The following investigations show that the use of the pr4eparation "Solcoseryl" in combination with interferon or prednisolone allow to improve the metabolism of the epithelium of a mucous membrane of the oral cavity and to improve the processes of repair and regeneration of damaged tissues in patients with toxic-allergic and infectious-allergic forms of an exudative erythema multiforme.

Comparison of interpretation of acute lymphoblastic leukemia (ALL) flow cytometric diagnostics data was the aim of the study. Immunophenotyping data obtained from 10 patients with ALL were analysed separately in 26 laboratories from Russian Federation and Kazahstan. Results comparison showed four main type of discordance: B-lineage ALL diagnostics during heavy bone marrow regeneration, great variability of T-ALL interpretation, complexity of ambiguous lineage acute leukemia and, finally, very different report types, unique for each laboratory. All these problems are the serious obstacles for standardization of flow cytometric ALL diagnostics in multicenter setting. Continuation of similar QC rounds following by consecutive discussions with further development of consensus diagnostic algorithm could be the first step for standardization of ALL immunophenotyping in Russian Federation and CIS countries.

Pochtar V. N., Nаsibullin B. А. Структурно-функциональные изменения в организме крыс при развитии экспериментальной гиперчувствительности организма и возможность коррекции их введением солкосерила = Structural and functional changes in the organism of rats with hypersensitivity development of experimental organisms and the possibility of correcting their introduction solkoseril. Journal of Education, Health and Sport. 2016;6(9):276-284. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.61761 http://ojs.ukw.edu.pl/index.php/johs/article/view/3843 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2016; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.08.2016. Revised 25.08.2016. Accepted: 06.09.2016. СТРУКТУРНО-ФУНКЦИОНАЛЬНЫЕ ИЗМЕНЕНИЯ В ОРГАНИЗМЕ КРЫС ПРИ РАЗВИТИИ ЭКСПЕРИМЕНТАЛЬНОЙ ГИПЕРЧУВСТВИТЕЛЬНОСТИ ОРГАНИЗМА И ВОЗМОЖНОСТЬ КОРРЕКЦИИ ИХ ВВЕДЕНИЕМ СОЛКОСЕРИЛА 1В. Н. Почтарь, 2Б. А. Насибуллин 1Украинский НИИ стоматологии НАМН Украины, Одесса 2ГУ "Украинский НИИ медицинской реабилитации и курортологии", Одесса Резюме Авторы, по результатам исследований 65 белых крыс линии Вистар аутбредного разведения, у которых моделировали гиперчувствительность иммунной системы замедленного типа и травму слизистой щеки, выявили системное нарушение дизрегуляционного характера в виде ослабления дифференциации эпителиоцитов, снижении активности NO˗S и накоплении липидов в кишечнике и аорте. Эти изменения формировались на фоне дистрофических изменений лимфоидных фолликул стенки кишечника. Курс солкосерила восстанавливал структуру фолликул и нормализовал остальные исследуемые показатели. Авторы полагают, что изменение лимфоидных фолликул способствует развитию дизрегуляционных и аутоиммунных процес сов в организме, что делает возможным формирование МЭЭ. Солкосерил, в силу своих свойств (стимулятор репарации), оказывал положительное влияние не только на эпителий, но и на структурно-функциональную организацию лимфоузлов, что способствовало снижению аутоиммунных реакций. Ключевые слова: гиперчувствительность иммунной системы; солкосерил; фолликулы, NO˗синтаза; экссудативная эритема. STRUCTURAL AND FUNCTIONAL CHANGES IN THE ORGANISM OF RATS WITH HYPERSENSITIVITY development of experimental organisms and the possibility of correcting their introduction solkoseril 1V. N. Pochtar, 2B. А. Nаsibullin 1Ukrainian Research Institute of Dental Academy of Medical Sciences Ukraine 2The Ukrainian scientific and research institute of medical rehabilitation and balneology of the Ministry of health of Ukraine, Odessa, Ukraine Abstract The authors, based on the results of research of 65 white outbred Wistar rats breeding in which simulated hypersensitivity of the immune system and delayed-type injury buccal mucosa revealed a systemic disorder dizregulyatsionnogo nature in the form of weakening the differentiation of epithelial cells, reducing NO˗S activity and the accumulation of lipids in the intestine and aorta. These changes are formed on the background of degenerative changes in the lymphoid follicles of the intestinal wall. Course solcoseryl restoring the follicle structure and normalized the remaining studied parameters. The authors suggest that a change in the lymphoid follicles contributes to the development of autoimmune processes dizregulyatsionnyh and owls in the body, which makes possible the formation of the magnetoelectric effect. Solkoseril, by virtue of its properties (repair stimulant), had a positive impact not only on the epithelium, but also on the structural and functional organization of the lymph nodes, which contributed to the reduction of autoimmune reactions. Keywords: hypersensitivity of the immune system; solkoseril; follicles NO˗sintaza; erythema.

Pochtar V. N. Особенности течения процессов регенерации травмы слизистой ротовой полости крыс, развивающейся на фоне гиперчувствительности замедленного типа = Features during the process of regeneration of oral mucosa injury rats, develops on the background of delayed type hypersensitivity. Journal of Education, Health and Sport. 2016;6(6):579-586. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.56699 http://ojs.ukw.edu.pl/index.php/johs/article/view/3645 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2016; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 25.05.2016. Revised 25.06.2016. Accepted: 28.06.2016. Особенности течения процессов регенерации травмы слизистой ротовой полости крыс, развивающейся на фоне гиперчувствительности замедленного типа В. Н. Почтарь Украинский НИИ стоматологии НАМН Украины Резюме Автор провела экспериментальное исследование особенностей репарационных процессов слизистой щеки у 60 крыс с гиперчувствительностью замедленного типа. Результаты исследований показали, что репарационные процессы меняются по отношению к контролю: пролиферативная активность выше, а дифференциация замедленна. Одновременно снижается активность NO-синтазы в стенке сосудов и слизистой. Автор полагает, что увеличение содержания сенсибилизованных Т-лимфоцитов влияет на процессы пролиферации — дифференциации эпителиоцитов, а изменение содержания NO — нарушает деятельность сосудов, что усугубляет тяжесть патологического процесса. Ключевые слова: гиперчувствительность замедленного типа, репарация, слизистая, NO-синтаза. FEATURES during the process of regeneration of oral mucosa INJURY RATS, develops on the background of delayed type hypersensitivity V. N. Pochtar Ukrainian Research Institute of Dental Academy of Medical Sciences Ukraine The author conducted a pilot study of the peculiarities of reparative processes buccal mucosa in 60 rats with delayed-type hypersensitivity. The results showed that the repair processes are changing in relation to the control: higher proliferative activity and differentiation of slowing down. Simultaneously decreased NO-synthase activity in the vascular wall and mucosa. The author believes that the increase of sensitized T-lymphocytes affect the processes of proliferation - differentiation of epithelial cells and the change in NO content - violates the activities of the vessels, which contributes to the severity of the pathological process. Keywords: delayed type hypersensitivity, repair, mucous, NO-synthase.

In the preparation of materials with desired functional properties, the determination of the spatial and local heterogeneity of their composition and structure is of paramount importance. In fact, solid-phase samples [...], A two-step method of stoichiographic calculations used in the determination of the formulas of phases encapsulated in the bulk of matrices of another composition is proposed. At the first stage of calculations, the stoichiometric composition of the encapsulated phase is determined and, at the second step, the concentrations of this phase and the matrix are found. The use of this method in the analysis of oxide La-Cu catalysts by the method of differential dissolution ensures the detection of the phase [La.sub.1][Cu.sub.1] ([La.sub.2][Cu.sub.2][O.SUB.5]), incorporated within the matrix [La.sub.1]Cu[O.sub.5] ([La.sub.2]Cu[O.sub.4]) phase. Keywords: phase analysis, stoichiography, method of differential dissolution DOI: 10.1134/S1061934817070097

The associations among preschool teachers' attributions about child responsibility, intentionality, knowledge, and the seriousness of hypothetical displays of children's aggressive behavior are examined in United States ("N"?=?82) and Vietnamese ("N"?=?91) preschool teachers. The results suggest cross-cultural differences as well as similarities in the relations among preschool teachers' cognitions, affect, and disapproval of physical aggression. Teachers' perceptions of the seriousness of and their negative affective responses to aggression, but not their beliefs about intent, predict teacher disapproval for both Vietnamese and US samples. Cross-cultural comparisons indicate in general US teachers express more negative attributions about, and Vietnamese teachers endorse more disapproval of, child aggression. Although the overall cognitive model is consistent across cultures, cross-cultural differences are found on teacher perception and responses to child aggression. It is important to consider such group differences in light of considerations to employ Western educational models or psychological interventions with individuals in non-Western countries.