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Introduction: Due to its frequency and its complications, it constitutes a major public health problem in the world, particularly in Africa. According to the WHO, 350 million people suffer from chronic liver disease in the world, and Africa has 60 million with a quarter of deaths per year. The objective of our study was to describe the epidemiological aspects of cirrhosis at the Sominé DOLO Regional Hospital in Mopti, the first in the region. Methods and Patients: This is a descriptive cross-sectional study extending from January 1, 2021 to December 2021, carried out in the medical department of the Sominé Dolo hospital in Mopti. The diagnosis of cirrhosis was retained in the face of arguments: clinical: oedemato-ascites syndrome, portal hypertension syndrome, hepatocellular insufficiency syndrome; biologicals of hepatocellular insufficiency syndrome; ultrasound suggestive of cirrhosis (hepatic atrophy, hepatomegaly, irregular contours, heterogeneous echostructure, portal trunk greater than 15 mm in diameter, maximum portal blood flow velocity less than 15 cm/s , superior splenic vein 10 mm, splenomegaly and ascites); endoscopic (esophageal varices, cardio-tuberosity varices, antral vascular ectasia, portal hypertension gastropathy. Despite these clinical, biological and imaging arguments, the diagnosis of certainty remains the liver biopsy puncture. Result: The analysis concerned 46 patients out of the 865 hospitalized patients, ie a frequency of 5.31%. The average age was 47.5 with extremes of 21 and 70 years. The most represented age group was 46 – 65 years old. The patients were divided into 34 men (73.9%) and 12 women (26.1%) i.e. a sex ratio of 2.8. Farmers/herders and housewives accounted for 76.1% (35/46) of the patients and the majority were rural (89.1%). The clinical signs found on hospitalization were: abdominal pain (82.6%), impaired general condition syndrome (80.4%), ascites (76.1%), OMI (58.7%), Hepatomegaly (52.2%), CVC (43.8%), jaundice (32.6), ...

Blood cardiometabolic impairments are associated to high blood pressure which is a pivot cardiovascular risk factor. The objective of this study was to assess cardiometabolic risk factors rates in subjects with high blood pressure in the steady state. A total of 292subjects, 107 cases and 185 controls were enrolled in cross-sectional study. Clinical and biological data were assessed during visits and after overnight fasting. Data were analyzed on R. A p-value < 0.05 was considered for statistical significance.Univariate analysis showed thatage > 50 years, visceral obesity, metabolic syndrome and hs- CRP ≥ 3 mg/L were significant predictors of high blood pressure: OR = 2.1, 95% CI [1.3-3.5], p = 0.003; OR = 1.6, 95% CI [1.0-2.6], p = 0.05; OR = 3.3; 95% CI [2.0-5.4], p < 0.001; OR = 16.8; 95% CI [9.4-31.4], p < 0.001, respectively. Multivariate analysis showed a positive association between obesity, metabolic syndrome, hs-CRP and high blood pressure: aOR = 2.29; 95% CI [1.14-4.69], p = 0.02; aOR = 3.47; 95% CI [1.64-7.61], p = 0.001; aOR = 18.10; CI, 2.5% to 95% [9.40-36.99], p < 0.001, respectively. In contrast, female sex was negatively associated with high blood pressure aOR = 0.31; CI, 95% CI [0.13-0.72], p < 0.008. Prevention policiesshould take into account blood cardiometabolic level for subjects with high blood pressure even though in the steady sate.

Introduction: Hepatitis B virus (HBV) infects more than 2 billion people worldwide, with more than 257 million chronic carriers and 88,700 deaths per year. In Mali, the prevalence of HBsAg in the general population is estimated at 14.7% [2] and 15.5% in pregnant women. The objective of this work was to describe the characteristics of the biological markers of pregnant women carrying the hepatitis B virus in the hepato-gastroenterology unit of the district hospital of commune IV of Bamako (Mali). Patients and Methods: This was a descriptive cross-sectional study that took place at the district hospital of commune IV of Bamako between March 1, 2020 and February 1, 2021. The study population was consisting of pregnant women referred to our unit for positive HBSAg detected during prenatal biological examinations. Were included in this study, the pregnant women referred for Ag HBS positive and who made the biological markers of follow-up. Were not included, those who did not make the biological markers. Results: During the study period, we received 177 pregnant carriers of the hepatitis B virus out of 1008 consultations, ie a frequency of 13.09%. Among the 177 pregnant women referred to our unit, 132 were able to carry out the biological markers, i.e. a completion rate of 74.58%. The age of the patients varied between 16 and 44 years with an average age of 28.5 years ± 6.6. HBsAg was discovered in 81.1% of women during the current pregnancy and it was prior to pregnancy in 18.9%. Positive viral markers in pregnant women were: HBeAg (6.8%), anti- HBe Ac (84.8%), anti - HBc Ac IgG (100%). Viral DNA was undetectable in 17.4% of pregnant women, it was between 1-2 million IU/ml in 77.3% and greater than 2 million IU/ml in 5.3%. Conclusion: This study showed a high frequency of hepatitis B virus infection during pregnancy. A better knowledge of serological markers, particularly in pregnant women, seems to be the most effective means of combating this scourge.

Introduction: Peptic ulcer disease is a benign condition, but its severity is linked to the risk of complications, hemorrhage, perforation, stenosis and gastric cancer. The objective of this work was to describe the epidemiological aspects of peptic ulcer disease in Mopti (Mali). Methods and patients: From 1st January 2019 to December 2021, we carried out a descriptive cross-sectional study on cases of peptic ulcer disease in patients seen in upper digestive endoscopy in the medical department of the Sominé Dolo hospital in Mopti and the BRICO II medical center in Sévaré. Were included in this study, all patients with a peptic ulcer objectified by upper digestive endoscopy with biopsy for histological examination. Were not included, cases of gastric ulceration related to cancer, lymphoma, granuloma. Result: During the study period, 1894 upper digestive endoscopies were performed and 107 gastroduodenal ulcers were diagnosed, representing a frequency of 5.64%. The patients were divided into 65 men (60.75%) and 42 women (39.25%), i.e. a sex ratio of 1.54. Housewives and farmers were respectively represented (36.4%) and (19.6%). The lesions were located on: the antrum (70.10%), the bulb (25.20%), the antrum and bulb (4.70%). The other gastroduodenal affections found were: erosive duodenitis (2.8%), gastropathy erythematous antral (7.8%), gastropathy corporeal - antral erythematous (15.8%), mosaic PH gastropathy (5.6%). Helicobacter _ pylori was found in 96% of patients and all patients had chronic, active gastritis more or less atrophic according to the Sydney classification. Conclusion: Our study revealed a high frequency of Helicobacter pylori. The proliferation of digestive endoscopy centers makes it possible to better improve diagnosis and management at the regional level.

Bevezetés: A halláscsökkenés olyan érzékszervi károsodás, mely a beszédértést, a kommunikációt, így az életminőséget is rontja. Előfordul, hogy a beteg által megélt funkcióvesztés túlzó, a mérések során a szubjektív és az objektív vizsgálati eredmények ellentmondásosak, a szubjektíven jelzett halláscsökkenés mértéke jelentősebb; ezen esetekben felmerül a funkcionális halláscsökkenés véleményezése. Célkitűzés: Célul tűztük ki funkcionális halláscsökkenés diagnózisú eseteink összegyűjtését és retrospektív elemzését, melyek alapján következtetéseket vonhatunk le a funkcionális halláscsökkenés jellemzőiről, a figyelemfelhívó jelekről, állapotokról és a megfelelő rehabilitáció mérlegeléséről. Módszerek: A szubjektív vizsgálatok a tisztahang-hallásküszöb, a beszédértés és a kommunikáció vizsgálatával történtek, majd ezeket összevetettük az objektív impedanciaméréssel, a stapediusreflex-vizsgálattal, az otoakusztikus emisszió mérésével, az agytörzsi kiváltott válaszok regisztrálásával nyert eredményekkel. Képalkotó vizsgálatok, pszichológus, pszichiáter, szurdopedagógus, neurológus, illetve további társszakmák bevonása történt szükség szerint. Kizártuk a szándékosan anyagi vagy egyéb előnyszerzésre irányuló megtévesztés eseteit. Eredmények: 2007 és 2022 között 19 beteg esetében diagnosztizáltunk funkcionális halláscsökkenést. A betegségben többségében (17 eset) nők érintettek, jellemzőek a fiatal életkorban (10–41 év) jelentkező panaszok; az átlagéletkor a vizsgált beteganyagban 19,6 év, az érintett páciensek nagyobb része (13 eset) 10–17 év közötti gyermek volt. Organikus okot 11 esetben nem találtunk, a többi esetben kimutatható organikus eltérés sem magyarázza a beteg által megélt halláscsökkenés mértékét. A funkcionális hallásveszteség mértéke különböző (35–120 dB) volt, átlagosan 60,2 dB. Következtetés: A funkcionális halláscsökkenés felismerése és diagnosztikája nagyon nehéz, komplex vizsgálati sort, szakmai együttműködést igényel. Felismerés nélkül a beteg indokolatlan, akár számára káros, anyagilag is megterhelő ellátásban részesülhet, mely állapotának romlását is okozhatja. Orv Hetil. 2023; 164(8): 283–292.

Emergency gastrointestinal endoscopy for patients who have ingested a caustic substance may overestimate burn injury and lead to unnecessary gastric resection. Caustic gastric lesions of stage III, without immediate life threat, do not systematically require an emergency total gastrectomy. This work was to evaluate the results of a conservative attitude of gastric stage III in two patients, by only proposing surgery in the presence of clinical, biological and radiological signs of severity. Reconstructive surgery and/or endoscopic dilation may be considered depending on the occurrence of strictures. We report two cases of caustic burn of the upper digestive tract in adults at the Sominé Dolo hospital in Mopti. Both patients were referred for surgery for partial gastrectomy with gastro - entero -anastomosis. The postoperative follow-up was simple and an endoscopic control carried out on D 15 and D 30 postoperatively did not find any obstacle at the level of the anastomoses. Cardial stenosis benefited from dilation sessions at a rate of 21 days until satisfaction.

Morpheas are characterized by cutaneous induration (sclerosis), evidence of fibrosis of the dermis and sometimes of the underlying tissues without recognized etiology. We report a case of linear Morpheus in saber cut with aesthetic repercussions. A 17-year-old Malian boy consulted for a hypochromic strip of the face and scalp that had been evolving for 8 months. The lesion began with a non-pruritic and slightly painful erythematous spot. On inspection, it was a slightly atrophic hypochromic band, 2 cm wide and 12 cm long extending from the head of the left eyebrow to the vertex. Palpation found cutaneous sclerosis along the entire length of the band. There was no Raynaud's phenomenon or sclerodactyly. The rest of the clinical examination was normal. A biopsy of the lesion with anatomopathological examination was performed and the diagnosis of morphea was retained. The biological assessment carried out did not show any inflammatory syndrome or antinuclear factors. The skull x-ray did not find any bone abnormality. Treatment with systemic corticosteroids (prednisone) at a rate of 1 mg/kg/day associated with methotrexate 20 mg/week was introduced. After 3 months of well-monitored treatment, the evolution was favourable, with stabilization of the skin band. Morpheas cause aesthetic or functional damage that is sometimes significant. Their management must take into account the quality of life of affected subjects whose life expectancy is considered normal with an assessment of the risk- benefit of potentially aggressive therapies.