1,847 results on '"A., Horneffer"'
Search Results
2. Factors underlying the neurofunctional domains of the Addictions Neuroclinical Assessment assessed by a standardized neurocognitive battery
- Author
-
Gunawan, Tommy, Luk, Jeremy W., Schwandt, Melanie L., Kwako, Laura E., Vinson, Tonette, Horneffer, Yvonne, George, David T., Koob, George F., Ramchandani, Vijay A., Diazgranados, Nancy, and Goldman, David
- Published
- 2024
- Full Text
- View/download PDF
3. Improving departmental psychological safety through a medical school-wide initiative
- Author
-
Kirsten A. Porter-Stransky, Karen J. Horneffer-Ginter, Laura D. Bauler, Kristine M. Gibson, Christopher M. Haymaker, and Maggie Rothney
- Subjects
Psychological safety ,Academic medicine ,Leadership ,Healthcare teams ,Special aspects of education ,LC8-6691 ,Medicine - Abstract
Abstract Background Psychological safety is a team-based phenomenon whereby group members are empowered to ask questions, take appropriate risks, admit mistakes, propose novel ideas, and candidly voice concerns. Growing research supports the benefits of psychological safety in healthcare and education for patient safety, learning, and innovation. However, there is a paucity of research on how to create psychological safety, especially within academic medicine. To meet this need, the present study describes and evaluates a multi-year, medical school-wide psychological safety initiative. Methods We created, implemented, and assessed a multi-pronged psychological safety initiative including educational training sessions, departmental champions, videos, infographics, and targeted training for medical school leaders. Employees’ perceptions of psychological safety at both the departmental and institutional levels were assessed annually. The impact of educational training sessions was quantified by post-session surveys. Results Deidentified employee surveys revealed a statistically significant increase in departmental psychological safety between the first and second annual surveys. Perceived psychological safety remained lower at the institution-wide level than at the departmental level. No significant differences in psychological safety were observed based on gender, position, or employment length. Post-educational training session surveys showed that the sessions significantly increased knowledge of the topic as well as motivation to create a culture of psychological safety within the medical school. Conclusions This study establishes an evidence-based method for increasing psychological safety within medical school departments and serves as a template for other health professions schools seeking to promote psychological safety. Training leadership, faculty, and staff is an important first step towards creating a culture of psychological safety for everyone, including trainees.
- Published
- 2024
- Full Text
- View/download PDF
4. Factors underlying the neurofunctional domains of the Addictions Neuroclinical Assessment assessed by a standardized neurocognitive battery
- Author
-
Tommy Gunawan, Jeremy W. Luk, Melanie L. Schwandt, Laura E. Kwako, Tonette Vinson, Yvonne Horneffer, David T. George, George F. Koob, Vijay A. Ramchandani, Nancy Diazgranados, and David Goldman
- Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract The Addictions Neuroclinical Assessment (ANA) is a neurobiologically-informed framework designed to understand the etiology and heterogeneity of Alcohol Use Disorder (AUD). Previous studies validated the three neurofunctional domains of ANA: Incentive Salience (IS), Negative Emotionality (NE) and Executive Function (EF) using secondary data. The present cross-sectional observational study assessed these domains in an independent, prospective clinical sample. Adults across the drinking spectrum (N = 300) completed the ANA battery, a standardized collection of behavioral tasks and self-report assessments. Factor analyses were used to identify latent factors underlying each domain. Associations between identified domain factors were evaluated using structural equation models. Receiver operating characteristics analyses were used to determine factors with the strongest ability to classify individuals with problematic drinking and AUD. We found (1) two factors underlie the IS domain: alcohol motivation and alcohol insensitivity. (2) Three factors were identified for the NE domain: internalizing, externalizing, and psychological strength. (3) Five factors were found for the EF domain: inhibitory control, working memory, rumination, interoception, and impulsivity. (4) These ten factors showed varying degrees of cross-correlations, with alcohol motivation, internalizing, and impulsivity exhibiting the strongest correlations. (5) Alcohol motivation, alcohol insensitivity, and impulsivity showed the greatest ability in classifying individuals with problematic drinking and AUD. Thus, the present study identified unique factors underlying each ANA domain assessed using a standardized assessment battery. These results revealed additional dimensionality to the ANA domains, bringing together different constructs from the field into a single cohesive framework and advancing the field of addiction phenotyping. Future work will focus on identifying neurobiological correlates and identifying AUD subtypes based on these factors.
- Published
- 2024
- Full Text
- View/download PDF
5. Dynamics of Splenic Transient Elastography in Patients With Alcohol Use Disorder
- Author
-
Khalid, Mian B., Blaney, Hanna L., Vittal, Anusha, Yang, Alexander H., Asif, Bilal A., Kamal, Natasha, Wright, Elizabeth C., Koh, Chris, George, David, Goldman, David, Horneffer, Yvonne, Diazgranados, Nancy, and Heller, Theo
- Published
- 2024
- Full Text
- View/download PDF
6. LOPES 3D -- studies on the benefits of EAS-radio measurements with vertically aligned antennas
- Author
-
Huber, D., Apel, W. D., Arteaga-Velazquez, J. C., Bähren, L., Bekk, K., Bertaina, M., Biermann, P. L., Blümer, J., Bozdog, H., Brancus, I. M., Cantoni, E., Chiavassa, A., Daumiller, K., de Souza, V., Di Pierro, F., Doll, P., Engel, R., Falcke, H., Fuchs, B., Fuhrmann, D., Gemmeke, H., Grupen, C., Haungs, A., Heck, D., Hörandel, J. R., Horneffer, A., Huege, T., Isar, P. G., Kampert, K. -H., Kang, D., Krömer, O., Kuijpers, J., Link, K., Łuczak, P., Ludwig, M., Mathes, H. J., Melissas, M., Morello, C., Oehlschläger, J., Palmieri, N., Pierog, T., Rautenberg, J., Rebel, H., Roth, M., Rühle, C., Saftoiu, A., Schieler, H., Schmidt, A., Schoo, S., Schröder, F. G., Sima, O., Toma, G., Trinchero, G. C., Weindl, A., Wochele, J., Zabierowski, J., and Zensus, J. A.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
The LOPES experiment was a radio interferometer built at the existing air shower array KASCADE-Grande in Karlsruhe, Germany. The last configuration of LOPES was called LOPES 3D and consisted of ten tripole antennas. Each of these antennas consisted of three crossed dipoles east-west, north-south, and vertically aligned. With this, LOPES 3D had the unique possibility to study the benefits of measurements with vertically aligned antennas in the environment of the well understood and calibrated particle detector array KASCADE-Grande. The measurements with three spatially coincident antennas allows a redundant reconstruction of the electric field vector. Several methods to exploit the redundancy were developed and tested. Furthermore, for the first time in LOPES, the background noise could be studied polarization- and direction dependent. With LOPES 3D it could be demonstrated that radio detection reaches a higher efficiency for inclined showers when including measurements with vertically aligned antennas and that the vertical component gets more important for the measurement of inclined showers. In this contribution we discuss a weighting scheme for the best combination of three redundant reconstructed electric field vectors. Furthermore, we discuss the influence of these weighting schemes on the ability to reconstruct air showers using the radio method. We show an estimate of the radio efficiency for inclined showers with focus on the benefits of measurements with vertically aligned antennas and we present the direction dependent noise in the different polarizations., Comment: Submission to the proceedings of the ARENA2014 workshop, which unfortunately were never published; thus documented here for reference
- Published
- 2022
7. The Gross Anatomy Course: SARS-CoV-2 Pandemic-Related Effects on Students' Learning, Interest in Peer-Teaching, and Students' Perception of Its Importance
- Author
-
Messerer, David Alexander Christian, Behr, Jonathan Lukas, Kraft, Sophie Felice, Schön, Michael, Horneffer, Astrid, Kühl, Susanne Julia, Benedikt Seifert, Lukas, Huber-Lang, Markus, Böckers, Tobias Maria, and Böckers, Anja
- Abstract
The COVID-19 pandemic required adjustments and limitations in university teaching, thereby challenging teaching concepts in anatomy requiring in-person contact, including the gross anatomy course. Therefore, the present study investigates the impact of COVID-19-associated adjustments on students' perception of the gross anatomy course's importance and quality, students' preferred learning setting and outcome, and their motivation to involve themselves in academic activities, including becoming a future peer-teacher of the course. Using paper-based questionnaires in Ulm, Germany, 397 (response rate: 82.3%) students of the winter term of 2020/2021 were surveyed using quantitative and qualitative items, which were compared with cohorts prior to the pandemic. Students reported a higher global rating on course quality during COVID-19 (pre-COVID-19: 5.3 ± 0.9, during-COVID-19: 5.6 ± 0.7, p < 0.001; 1 = very bad, 6 = very good). Students' perceived importance of the gross anatomy course showed a small but significant increase (pre-COVID-19: 4.2 ± 0.6, during-COVID-19: 4.3 ± 0.6, p < 0.001; 1 = strongly disagree, 6 = strongly agree). Students' motivation to apply as a peer-teacher remained stable, nevertheless, they reported less interest in transferring their knowledge to junior students. Finally, students reported that they spent significantly more learning time alone and their examination grades remained unchanged during the pandemic. Astonishingly, despite radical changes of the teaching environment due to COVID-19, students appreciate the offered teaching and highly valued the gross anatomy course.
- Published
- 2023
- Full Text
- View/download PDF
8. Pathobionts in the tumour microbiota predict survival following resection for colorectal cancer
- Author
-
Alexander, James L., Posma, Joram M., Scott, Alasdair, Poynter, Liam, Mason, Sam E., Doria, M. Luisa, Herendi, Lili, Roberts, Lauren, McDonald, Julie A. K., Cameron, Simon, Hughes, David J., Liska, Vaclav, Susova, Simona, Soucek, Pavel, der Sluis, Verena Horneffer-van, Gomez-Romero, Maria, Lewis, Matthew R., Hoyles, Lesley, Woolston, Andrew, Cunningham, David, Darzi, Ara, Gerlinger, Marco, Goldin, Robert, Takats, Zoltan, Marchesi, Julian R., Teare, Julian, and Kinross, James
- Published
- 2023
- Full Text
- View/download PDF
9. Final results of the LOPES radio interferometer for cosmic-ray air showers
- Author
-
Apel, W. D., Arteaga-Velázquez, J. C., Bähren, L., Bekk, K., Bertaina, M., Biermann, P. L., Blümer, J., Bozdog, H., Cantoni, E., Chiavassa, A., Daumiller, K., de Souza, V., Di Pierro, F., Doll, P., Engel, R., Falcke, H., Fuchs, B., Gemmeke, H., Grupen, C., Haungs, A., Heck, D., Hörandel, J. R., Horneffer, A., Huber, D., Huege, T., Isar, P. G., Kampert, K. -H., Kang, D., Krömer, O., Kuijpers, J., Link, K., Luczak, P., Ludwig, M., Mathes, H. J., Melissas, M., Morello, C., Nehls, S., Oehlschläger, J., Palmieri, N., Pierog, T., Rautenberg, J., Rebel, H., Roth, M., Rühle, C., Saftoiu, A., Schieler, H., Schmidt, A., Schoo, S., Schröder, F. G., Sima, O., Toma, G., Trinchero, G. C., Weindl, A., Wochele, J., Zabierowski, J., Zensus, J. A., and Collaboration, LOPES
- Subjects
Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
LOPES, the LOFAR prototype station, was an antenna array for cosmic-ray air showers operating from 2003 - 2013 within the KASCADE-Grande experiment. Meanwhile, the analysis is finished and the data of air-shower events measured by LOPES are available with open access in the KASCADE Cosmic Ray Data Center (KCDC). This article intends to provide a summary of the achievements, results, and lessons learned from LOPES. By digital, interferometric beamforming the detection of air showers became possible in the radio-loud environment of the Karlsruhe Institute of Technology (KIT). As a prototype experiment, LOPES tested several antenna types, array configurations and calibration techniques, and pioneered analysis methods for the reconstruction of the most important shower parameters, i.e., the arrival direction, the energy, and mass-dependent observables such as the position of the shower maximum. In addition to a review and update of previously published results, we also present new results based on end-to-end simulations including all known instrumental properties. For this, we applied the detector response to radio signals simulated with the CoREAS extension of CORSIKA, and analyzed them in the same way as measured data. Thus, we were able to study the detector performance more accurately than before, including some previously inaccessible features such as the impact of noise on the interferometric cross-correlation beam. These results led to several improvements, which are documented in this paper and can provide useful input for the design of future cosmic-ray experiments based on the digital radio-detection technique., Comment: Accepted for publication by EPJ C
- Published
- 2021
- Full Text
- View/download PDF
10. Pathobionts in the tumour microbiota predict survival following resection for colorectal cancer
- Author
-
James L. Alexander, Joram M. Posma, Alasdair Scott, Liam Poynter, Sam E. Mason, M. Luisa Doria, Lili Herendi, Lauren Roberts, Julie A. K. McDonald, Simon Cameron, David J. Hughes, Vaclav Liska, Simona Susova, Pavel Soucek, Verena Horneffer-van der Sluis, Maria Gomez-Romero, Matthew R. Lewis, Lesley Hoyles, Andrew Woolston, David Cunningham, Ara Darzi, Marco Gerlinger, Robert Goldin, Zoltan Takats, Julian R. Marchesi, Julian Teare, and James Kinross
- Subjects
Colorectal cancer ,Gut microbiota ,Metabolome ,Metataxonomics ,Microbial ecology ,QR100-130 - Abstract
Abstract Background and aims The gut microbiota is implicated in the pathogenesis of colorectal cancer (CRC). We aimed to map the CRC mucosal microbiota and metabolome and define the influence of the tumoral microbiota on oncological outcomes. Methods A multicentre, prospective observational study was conducted of CRC patients undergoing primary surgical resection in the UK (n = 74) and Czech Republic (n = 61). Analysis was performed using metataxonomics, ultra-performance liquid chromatography-mass spectrometry (UPLC-MS), targeted bacterial qPCR and tumour exome sequencing. Hierarchical clustering accounting for clinical and oncological covariates was performed to identify clusters of bacteria and metabolites linked to CRC. Cox proportional hazards regression was used to ascertain clusters associated with disease-free survival over median follow-up of 50 months. Results Thirteen mucosal microbiota clusters were identified, of which five were significantly different between tumour and paired normal mucosa. Cluster 7, containing the pathobionts Fusobacterium nucleatum and Granulicatella adiacens, was strongly associated with CRC (P FDR = 0.0002). Additionally, tumoral dominance of cluster 7 independently predicted favourable disease-free survival (adjusted p = 0.031). Cluster 1, containing Faecalibacterium prausnitzii and Ruminococcus gnavus, was negatively associated with cancer (P FDR = 0.0009), and abundance was independently predictive of worse disease-free survival (adjusted p = 0.0009). UPLC-MS analysis revealed two major metabolic (Met) clusters. Met 1, composed of medium chain (MCFA), long-chain (LCFA) and very long-chain (VLCFA) fatty acid species, ceramides and lysophospholipids, was negatively associated with CRC (P FDR = 2.61 × 10−11); Met 2, composed of phosphatidylcholine species, nucleosides and amino acids, was strongly associated with CRC (P FDR = 1.30 × 10−12), but metabolite clusters were not associated with disease-free survival (p = 0.358). An association was identified between Met 1 and DNA mismatch-repair deficiency (p = 0.005). FBXW7 mutations were only found in cancers predominant in microbiota cluster 7. Conclusions Networks of pathobionts in the tumour mucosal niche are associated with tumour mutation and metabolic subtypes and predict favourable outcome following CRC resection. Video Abstract
- Published
- 2023
- Full Text
- View/download PDF
11. What Factors Motivate Male and Female Generation Z Students to Become Engaged as Peer Teachers? A Mixed-Method Study among Medical and Dental Students in the Gross Anatomy Course
- Author
-
Messerer, David A. C., Kraft, Sophie F., Horneffer, Astrid, Messerer, Laura A. S., Böckers, Tobias M., and Böckers, Anja
- Abstract
Peer-teaching is widely established in anatomy teaching and offers well-described advantages. Nevertheless, at Ulm University, Germany, a reduction in the number of peer teacher applicants for the dissection course was observed. This study examined factors related to the attractiveness of a position as a peer teacher for Generation Z students. Participants of the gross anatomy course were asked to evaluate factors influencing the attractiveness of a peer teacher position using a six-point Likert scale. Additionally, open-ended questions were analyzed qualitatively. Sex-specific subgroup analysis was performed comparing students of low and high motivation to apply for a tutorship. Of the 374 students who participated in this study (response rate 53%), 38% stated that they were intending to apply as peer teachers. Data indicated that students displayed intrinsic motivation to apply for a tutorship because of the opportunity to improve their anatomy knowledge and/or their pleasure in teaching. In contrast, extrinsic factors like remuneration of the tutorship and its relevance for their curriculum vitae were least important. Anatomy educators underestimated the demotivating factor of the workload associated with the tutorship and encouraged students less frequently to apply than peer teachers. Only minor sex-specific differences could be identified. Nevertheless, female students were encouraged less frequently to apply than their male peers. In summary, Generation Z students apply as peer teachers because they are enthusiastic about the task. To motivate students to commit to extracurricular activities like a tutorship, anatomy educators should actively encourage students--particularly females--more frequently to apply.
- Published
- 2022
- Full Text
- View/download PDF
12. On the usefulness of existing Solar-wind models for pulsar timing corrections
- Author
-
Tiburzi, C., Verbiest, J. P. W., Shaifullah, G. M., Janssen, G. H., Anderson, J. M., Horneffer, A., Kuensemoeller, J., Oslowski, S., Donner, J. Y., Kramer, M., Kumari, A., Porayko, N. K., Zucca, P., Ciardi, B., Dettmar, R. -J., Griessmeier, J. -M., Hoeft, M., and Serylak, M.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Dispersive delays due to the Solar wind introduce excess noise in high-precision pulsar timing experiments, and must be removed in order to achieve the accuracy needed to detect, e.g., low-frequency gravitational waves. In current pulsar timing experiments, this delay is usually removed by approximating the electron density distribution in the Solar wind either as spherically symmetric, or with a two-phase model that describes the contributions from both high- and low-speed phases of the Solar wind. However, no dataset has previously been available to test the performance and limitations of these models over extended timescales and with sufficient sensitivity. Here we present the results of such a test with an optimal dataset of observations of pulsar J0034-0534, taken with the German stations of LOFAR. We conclude that the spherical approximation performs systematically better than the two-phase model at almost all angular distances, with a residual root-mean-square (rms) given by the two-phase model being up to 28% larger than the result obtained with the spherical approximation. Nevertheless, the spherical approximation remains insufficiently accurate in modelling the Solar-wind delay (especially within 20 degrees of angular distance from the Sun), as it leaves timing residuals with rms values that reach the equivalent of 0.3 microseconds at 1400 MHz. This is because a spherical model ignores the large daily variations in electron density observed in the Solar wind. In the short term, broadband observations or simultaneous observations at low frequencies are the most promising way forward to correct for Solar-wind induced delay variations., Comment: Accepted for publication in MNRAS. 17 pages, 13 figures
- Published
- 2019
- Full Text
- View/download PDF
13. First detection of frequency-dependent, time-variable dispersion measures
- Author
-
Donner, J. Y., Verbiest, J. P. W., Tiburzi, C., Osłowski, S., Michilli, D., Serylak, M., Anderson, J. M., Horneffer, A., Kramer, M., Grießmeier, J. -M., Künsemöller, J., Hessels, J. W. T., Hoeft, M., and Miskolczi, A.
- Subjects
Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Context. High-precision pulsar-timing experiments are affected by temporal variations of the Dispersion Measure (DM), which are related to spatial variations in the interstellar electron content. Correcting for DM variations relies on the cold-plasma dispersion law which states that the dispersive delay varies with the squared inverse of the observing frequency. This may however give incorrect measurements if the probed electron content (and therefore the DM) varies with observing frequency, as is predicted theoretically. Aims. We study small-scale density variations in the ionised interstellar medium. These structures may lead to frequency-dependent DMs in pulsar signals and could inhibit the use of lower-frequency pulsar observations to correct time-variable interstellar dispersion in higher-frequency pulsar-timing data. Methods. We used high-cadence, low-frequency observations with three stations from the German LOng-Wavelength (GLOW) consortium, which are part of the LOw Frequency ARray (LOFAR). Specifically, 3.5 years of weekly observations of PSR J2219+4754 are presented. Results. We present the first detection of frequency-dependent DMs towards any interstellar object and a precise multi-year time-series of the time- and frequency-dependence of the measured DMs. The observed DM variability is significant and may be caused by extreme scattering events. Potential causes for frequency-dependent DMs are quantified and evaluated. Conclusions. We conclude that frequency-dependence of DMs has been reliably detected and is caused by small-scale (up to 10s of AUs) but steep density variations in the interstellar electron content. We find that long-term trends in DM variability equally affect DMs measured at both ends of our frequency band and hence the negative impact on long-term high-precision timing projects is expected to be limited., Comment: to be published in A&A (accepted 2019-02-06), 11 pages, 7 figures, update: A&A language editing, typos
- Published
- 2019
- Full Text
- View/download PDF
14. Testing the accuracy of the ionospheric Faraday rotation corrections through LOFAR observations of bright northern pulsars
- Author
-
Porayko, N. K., Noutsos, A., Tiburzi, C., Verbiest, J. P. W., Horneffer, A., Künsemöller, J., Osłowski, S., Kramer, M., Schnitzeler, D. H. F. M., Anderson, J. M., Brüggen, M., Grießmeier, J. -M., Hoeft, M., Schwarz, D. J., Serylak, M., and Wucknitz, O.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Faraday rotation of polarized emission from pulsars measured at radio frequencies provides a powerful tool to investigate the interstellar and interplanetary magnetic fields. However, besides being sensitive to the astrophysical media, pulsar observations in radio are affected by the highly time-variable ionosphere. In this article, the amount of ionospheric Faraday rotation has been computed by assuming a thin layer model. For this aim, ionospheric maps of the free electron density (based on Global Positioning System data) and semi-empirical geomagnetic models are needed. Through the data of five highly polarized pulsars observed with the individual German LOw-Frequency ARray stations, we investigate the performances of the ionospheric modelling. In addition, we estimate the parameters of the systematics and the correlated noise generated by the residual unmodelled ionospheric effects, and show the comparison of the different free-electron density maps. For the best ionospheric maps, we have found that the rotation measure corrections on one-year timescales after subtraction of diurnal periodicity are accurate to $\sim$ 0.06--0.07 rad m$^{-2}$., Comment: 18 pages, 13 figures, 4 tables
- Published
- 2018
- Full Text
- View/download PDF
15. Preliminary evidence for changes in frontoparietal network connectivity in the early abstinence period in alcohol use disorder: a longitudinal resting-state functional magnetic resonance imaging study
- Author
-
Jasper van Oort, Nancy Diazgranados, David T. George, Yvonne Horneffer, Melanie Schwandt, David Goldman, and Reza Momenan
- Subjects
fMRI ,addiction ,alcohol use disorder ,resting-state connectivity ,recovery ,Psychiatry ,RC435-571 - Abstract
The early abstinence period is a crucial phase in alcohol use disorder (AUD) in which patients have to find a new equilibrium and may start recovery, or conversely, relapse. However, the changes in brain functions during this key period are still largely unknown. We set out to study longitudinal changes in large-scale brain networks during the early abstinence period using resting-state scans. We scanned AUD patients twice in a well-controlled inpatient setting, with the first scan taking place shortly after admission and the second scan 4 weeks (±9 days) later near the end of the treatment period. We studied 37 AUD patients (22 males) and 27 healthy controls (16 males). We focused on three networks that are affected in AUD and underly core symptom dimensions in this disorder: the frontoparietal networks (left and right FPN) and default mode network (DMN). Both the whole brain and within network connectivity of these networks were studied using dual regression. Finally, we explored correlations between these brain networks and various neuropsychological and behavioral measures. In contrast to the controls (Z = −1.081, p = 0.280), the AUD patients showed a decrease in within left FPN connectivity (Z = −2.029, p = 0.042). However, these results did not survive a strict Bonferroni correction. The decrease in left FPN connectivity during the early abstinence period in AUD may reflect an initially upregulated FPN, which recovers to a lower resting-state connectivity level during subsequent weeks of abstinence. The AUD patients showed a trend for a positive association between the change in left FPN connectivity and trait anxiety (rs = 0.303, p = 0.068), and a trend for a negative association between the change in left FPN connectivity and delay discounting (rs = −0.283, p = 0.089) (uncorrected for multiple comparisons). This suggests that the FPN might be involved in top-down control of impulsivity and anxiety, which are important risk factors for relapse. Although there were no statistically significant results (after multiple comparison correction), our preliminary findings encourage further research into the dynamic neuroadaptations during the clinically crucial early abstinence period and could inform future study designs.
- Published
- 2023
- Full Text
- View/download PDF
16. Discovery of synchronous X-ray and radio moding of PSR B0823+26
- Author
-
Hermsen, W., Kuiper, L., Basu, R., Hessels, J. W. T., Mitra, D., Rankin, J. M., Stappers, B. W., Wright, G. A. E., Griessmeier, J. M., Serylak, M., Horneffer, A., Tiburzi, C., and Ho, W. C. G.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena - Abstract
Simultaneous observations of PSR B0823+26 with ESA's XMM-Newton, the Giant Metrewave Radio Telescope and international stations of the Low Frequency Array revealed synchronous X-ray/radio switching between a radio-bright (B) mode and a radio-quiet (Q) mode. During the B mode we detected PSR B0823+26 in 0.2$-$2 keV X-rays and discovered pulsed emission with a broad sinusoidal pulse, lagging the radio main pulse by 0.208 $\pm$ 0.012 in phase, with high pulsed fraction of 70$-$80%. During the Q mode PSR B0823+26 was not detected in X-rays (2 $\sigma$ upper limit a factor ~9 below the B-mode flux). The total X-ray spectrum, pulse profile and pulsed fraction can globally be reproduced with a magnetized partially ionized hydrogen atmosphere model with three emission components: a primary small hot spot ($T$$\sim$3.6$\times10^6$ K, $R$$\sim$17 m), a larger cooler concentric ring ($T$$\sim$1.1$\times10^6$ K, $R$$\sim$280 m) and an antipodal hot spot ($T$$\sim$1.1$\times10^6 $ K, $R$$\sim$100 m), for the angle between the rotation axis and line of sight direction $\sim66^\circ$. The latter is in conflict with the radio derived value of $(84\pm0.7)^\circ$. The average X-ray flux within hours-long B-mode intervals varied by a factor $\pm$20%, possibly correlated with variations in the frequency and lengths of short radio nulls or short durations of weak emission. The correlated X-ray/radio moding of PSR B0823+26 is compared with the anti-correlated moding of PSR B0943+10, and the lack of X-ray moding of PSR B1822-09. We speculate that the X-ray/radio switches of PSR B0823+26 are due to variations in the rate of accretion of material from the interstellar medium through which it is passing., Comment: 16 pages, 11 figures
- Published
- 2018
- Full Text
- View/download PDF
17. Reliable detection and characterization of low-frequency polarized sources in the LOFAR M51 field
- Author
-
Neld, A., Horellou, C., Mulcahy, D. D., Beck, R., Bourke, S., Carozzi, T. D., Chyży, K. T., Conway, J. E., Farnes, J. S., Fletcher, A., Haverkorn, M., Heald, G., Horneffer, A., Nikiel-Wroczyński, B., Paladino, R., Sridhar, S. S., and Van Eck, C. L.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
The new generation of broad-band radio continuum surveys will provide large data sets with polarization information. New algorithms need to be developed to extract reliable catalogs of linearly polarized sources that can be used to characterize those sources and produce a dense rotation measure (RM) grid to probe magneto-ionized structures along the line of sight via Faraday rotation. The aim of the paper is to develop a computationally efficient and rigorously defined source-finding algorithm for linearly polarized sources. We used a calibrated data set from the LOw Frequency ARray (LOFAR) at 150 MHz centered on the nearby galaxy M51 to search for polarized background sources. With a new imaging software, we re-imaged the field at a resolution of 18''x15'' and cataloged a total of about 3000 continuum sources within 2.5 degrees of the center of M51. We made small Stokes Q and U images centered on each source brighter than 100 mJy in total intensity (201 sources) and used RM synthesis to create corresponding Faraday cubes that were analyzed individually. For each source, the noise distribution function was determined from a subset of measurements at high Faraday depths where no polarization is expected; the peaks in polarized intensity in the Faraday spectrum were identified and the p-value of each source was calculated. Finally, the false discovery rate method was applied to the list of p-values to produce a list of polarized sources and quantify the reliability of the detections. We also analyzed sources fainter than 100 mJy but that were reported as polarized in the literature at at least another radio frequency. Of the 201 sources that were searched for polarization, 6 polarized sources were detected confidently (with a false discovery rate of 5 percent). This corresponds to a number density of 1 polarized source per 3.3 square degrees, or 0.3 source/square degree. [Abridged], Comment: 17 pages, 11 figures, accepted for publication in A&A
- Published
- 2018
- Full Text
- View/download PDF
18. Investigation of the cosmic ray population and magnetic field strength in the halo of NGC 891
- Author
-
Mulcahy, D. D., Horneffer, A., Beck, R., Krause, M., Schmidt, P., Basu, A., Chyzy, K. T., Dettmar, R. -J., Haverkorn, M., Heald, G., Heesen, V., Horellou, C., Iacobelli, M., Nikiel-Wroczynski, B., Paladino, R., Scaife, A. M. M., Sridhar, Sarrvesh S., Strom, R. G., Tabatabaei, F. S., Cantwel, T., Carey, S. H., Grainge, K., Hickish, J., Perrot, Y., Razavi-Ghods, N., Scott, P., and Titterington, D.
- Subjects
Astrophysics - Astrophysics of Galaxies ,J.2 - Abstract
Low-frequency radio continuum observations of edge-on galaxies are ideal to study cosmic-ray electrons (CREs) in halos via radio synchrotron emission and to measure magnetic field strengths. We obtained new observations of the edge-on spiral galaxy NGC 891 at 129-163 MHz with the LOw Frequency ARray (LOFAR) and at 13-18 GHz with the Arcminute Microkelvin Imager (AMI) and combine them with recent high-resolution Very Large Array (VLA) observations at 1-2 GHz, enabling us to study the radio continuum emission over two orders of magnitude in frequency. The spectrum of the integrated nonthermal flux density can be fitted by a power law with a spectral steepening towards higher frequencies or by a curved polynomial. Spectral flattening at low frequencies due to free-free absorption is detected in star-forming regions of the disk. The mean magnetic field strength in the halo is 7 +- 2 $\mu$G. The scale heights of the nonthermal halo emission at 146 MHz are larger than those at 1.5 GHz everywhere, with a mean ratio of 1.7 +- 0.3, indicating that spectral ageing of CREs is important and that diffusive propagation dominates. The halo scale heights at 146 MHz decrease with increasing magnetic field strengths which is a signature of dominating synchrotron losses of CREs. On the other hand, the spectral index between 146 MHz and 1.5 GHz linearly steepens from the disk to the halo, indicating that advection rather than diffusion is the dominating CRE transport process. This issue calls for refined modelling of CRE propagation., Comment: Accepted for publication in Astronomy & Astrophysics
- Published
- 2018
- Full Text
- View/download PDF
19. Multifrequency behaviour of the anomalous events of PSR J0922+0638
- Author
-
Shaifullah, G., Tiburzi, C., Osłowski, S., Verbiest, J. P. W., Szary, A., Künsemöller, J., Horneffer, A., Anderson, J., Kramer, M., Schwarz, D. J., Mann, G., Steinmetz, M., and Vocks, C.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena - Abstract
PSR J0922+0638 (B0919+06) shows unexplained anomalous variations in the on-pulse phase, where the pulse appears to episodically move to an earlier longitude for a few tens of rotations before reverting to the usual phase for approximately several hundred to more than a thousand rotations. These events, where the pulse moves in phase by up to 5$^{\circ}$, have been previously detected in observations from $\sim$300 to 2000 MHz. We present simultaneous observations from the Effelsberg 100-m radio telescope at 1350 MHz and the Bornim (Potsdam) station of the LOw Frequency ARray at 150 MHz. Our observations present the first evidence for an absence of the anomalous phase-shifting behaviour at 150 MHz. Instead, the observed intensity at the usual pulse-phase typically decreases, often showing a pseudo-nulling feature corresponding to the times when phase shifts are observed at 1350 MHz. The presence of weak emission at the usual pulse-phase supports the theory that these shifts may result from processes similar to the 'profile-absorption' expected to operate for PSR J0814+7429 (B0809+74). A possible mechanism for this could be intrinsic variations of the emission within the pulsar's beam combined with absorption by expanding shells of electrons in the line of sight., Comment: 5 pages, 3 figures, accepted for publication in MNRAS Letters
- Published
- 2018
- Full Text
- View/download PDF
20. Exploring the making of a galactic wind in the star-bursting dwarf irregular galaxy IC 10 with LOFAR
- Author
-
Heesen, V., Rafferty, D. A., Horneffer, A., Beck, R., Basu, A., Westcott, J., Hindson, L., Brinks, E., Chyży, K. T., Scaife, A. M. M., Brüggen, M., Heald, G., Fletcher, A., Horellou, C., Tabatabaei, F. S., Paladino, R., Nikiel-Wroczyński, B., Hoeft, M., and Dettmar, R. -J.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
Low-mass galaxies are subject to strong galactic outflows, in which cosmic rays may play an important role, they can be best traced with low-frequency radio continuum observations, which are less affected by spectral ageing. We present a study of the nearby star burst dwarf irregular galaxy IC 10 using observations at 140 MHz with the LOw-Frequency ARray (LOFAR), at 1580 MHz with the Very Large Array (VLA) and at 6200 MHz with the VLA and the 100-m Effelsberg telescope. We find that IC 10 has a low-frequency radio halo, which manifests itself as a second component (thick disc) in the minor axis profiles of the non-thermal radio continuum emission at 140 and 1580 MHz. These profiles are then fitted with 1D cosmic-ray transport models for pure diffusion and advection. We find that a diffusion model fits best, with a diffusion coefficient of $D=(0.4$-$0.8) \times 10^{26}(E/{\rm GeV})^{0.5}~{\rm cm^2\,s^{-1}}$, which is at least an order of magnitude smaller than estimates both from anisotropic diffusion and the diffusion length. In contrast, advection models, which cannot be ruled out due to the mild inclination, while providing poorer fits, result in advection speeds close to the escape velocity of $\approx$$50~\rm km\,s^{-1}$, as expected for a cosmic-ray driven wind. Our favoured model with an accelerating wind provides a self-consistent solution, where the magnetic field is in energy equipartition with both the warm neutral and warm ionized medium with an important contribution from cosmic rays. Consequently, cosmic rays can play a vital role for the launching of galactic winds in the disc--halo interface., Comment: 10 pages, 5 colour figures, 1 table. Accepted by MNRAS
- Published
- 2018
- Full Text
- View/download PDF
21. Improved quantitation of short-chain carboxylic acids in human biofluids using 3-nitrophenylhydrazine derivatization and liquid chromatography with tandem mass spectrometry (LC-MS/MS)
- Author
-
Valdivia-Garcia, Maria A., Chappell, Katie E., Camuzeaux, Stephane, Olmo-García, Lucía, van der Sluis, Verena Horneffer, Radhakrishnan, Shiva T., Stephens, Hannah, Bouri, Sonia, de Campos Braz, Lucia M., Williams, Horace T., Lewis, Matthew R., Frost, Gary, and Li, Jia V.
- Published
- 2022
- Full Text
- View/download PDF
22. Immature human engineered heart tissues engraft in a guinea pig chronic injury model
- Author
-
Constantin von Bibra, Aya Shibamiya, Andrea Bähr, Birgit Geertz, Maria Köhne, Tim Stuedemann, Jutta Starbatty, Verena Horneffer-van der Sluis, Ulrich C. Klostermeier, Nadja Hornaschewitz, Xinghai Li, Eckhard Wolf, Nikolai Klymiuk, Markus Krane, Christian Kupatt, Bernhard Hiebl, Thomas Eschenhagen, and Florian Weinberger
- Subjects
cardiac repair ,cell transplantation ,chronic injury model ,engineered heart tissue ,heart failure ,tissue engineering ,Medicine ,Pathology ,RB1-214 - Published
- 2023
- Full Text
- View/download PDF
23. Video Didactic Preparation Augments Problem-Based Learning for First Year Medical Students
- Author
-
Kelly L Hamilton, Yu-Chun Kuo, Peter Horneffer, T Peter Stein, and Gary S Goldberg
- Subjects
Special aspects of education ,LC8-6691 ,Medicine (General) ,R5-920 - Abstract
Problem-based learning (PBL) utilizes a self-directed strategy. This process relies on group participation to succeed. Students without a background in biology or medicine can feel overwhelmed by the complexity of the subject matter and unable to participate in the group learning process. We incorporated curated educational videos in the PBL curriculum to help address this situation. First year medical students participated in this study in the form of a typical PBL session. They were then assessed on basic and clinical science knowledge and their learning experience. Student basic science and clinical knowledge were similar between the student groups. However, the students given a list of suggested videos scored higher in their learning experience, perception of feeling prepared, and participating in the group PBL experience than students who were not given the video list. Results from this study indicate that videos can be utilized to enhance the PBL process.
- Published
- 2023
- Full Text
- View/download PDF
24. X-rays from the mode-switching PSR B0943+10
- Author
-
Mereghetti, S., Kuiper, L., Tiengo, A., Hessels, J., Hermsen, W., Stovall, K., Possenti, A., Rankin, J., Esposito, P., Turolla, R., Mitra, D., Wright, G., Stappers, B., Horneffer, A., Oslowski, S., Serylak, M., Griessmeier, J. -M., and Rigoselli, M.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena - Abstract
New simultaneous X-ray and radio observations of the archetypal mode-switching pulsar PSR B0943+10 have been carried out with XMM-Newton and the LOFAR, LWA and Arecibo radio telescopes in November 2014. They allowed us to better constrain the X-ray spectral and variability properties of this pulsar and to detect, for the first time, the X-ray pulsations also during the X-ray-fainter mode. The combined timing and spectral analysis indicates that unpulsed non-thermal emission, likely of magnetospheric origin, and pulsed thermal emission from a small polar cap are present during both radio modes and vary in a correlated way., Comment: 4 pages, 1 figure, 1 table - To appear in the proceedings of "IAUS 337: Pulsar Astrophysics - The Next 50 Years" eds: P. Weltevrede, B.B.P. Perera, L. Levin Preston & S. Sanidas
- Published
- 2017
- Full Text
- View/download PDF
25. Source Finding in Linear Polarization for LOFAR, and SKA Predecessor Surveys, using Faraday Moments
- Author
-
Farnes, J. S., Heald, G., Junklewitz, H., Mulcahy, D. D., Haverkorn, M., Van Eck, C. L., Riseley, C. J., Brentjens, M., Horellou, C., Vacca, V., Jones, D. I., Horneffer, A., and Paladino, R.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The optimal source-finding strategy for linear polarization data is an unsolved problem, with many inhibitive factors imposed by the technically-challenging nature of polarization observations. Such an algorithm is essential for Square Kilometre Array (SKA) pathfinder surveys, such as the Multifrequency Snapshot Sky Survey (MSSS) with the LOw Frequency ARray (LOFAR), as data volumes are significant enough to prohibit manual inspection. We present a new strategy of `Faraday Moments' for source-finding in linear polarization with LOFAR, using the moments of the frequency-dependent full-Stokes data (i.e. the mean, standard deviation, skewness, and excess kurtosis). Through simulations of the sky, we find that moments can identify polarized sources with a high completeness: 98.5% at a signal-to-noise of 5. While the method has low reliability, Rotation Measure (RM) Synthesis can be applied per candidate source to filter out instrumental and spurious detections. This combined strategy will result in a complete and reliable catalogue of polarized sources that includes the full sensitivity of the observational bandwidth. We find that the technique can reduce the number of pixels on which RM Synthesis needs to be performed by a factor of $\approx1\times10^{5}$ for source distributions anticipated with modern radio telescopes. Through tests on LOFAR data, we find that the technique works effectively in the presence of diffuse emission. Extensions of this method are directly applicable to other upcoming radio surveys such as the POlarization Sky Survey of the Universe's Magnetism (POSSUM) with the Australia Square Kilometre Array Pathfinder (ASKAP), and the SKA itself., Comment: Accepted for publication in MNRAS
- Published
- 2017
- Full Text
- View/download PDF
26. LOFAR MSSS: Discovery of a 2.56 Mpc giant radio galaxy associated with a disturbed galaxy group
- Author
-
Clarke, A. O., Heald, G., Jarrett, T., Bray, J. D., Hardcastle, M. J., Cantwell, T. M., Scaife, A. M. M., Brienza, M., Bonafede, A., Breton, R. P., Broderick, J. W., Carbone, D., Croston, J. H., Farnes, J. S., Harwood, J. J., Heesen, V., Horneffer, A., van der Horst, A. J., Iacobelli, M., Jurusik, W., Kokotanekov, G., McKean, J. P., Morabito, L. K., Mulcahy, D. D., Nikiel-Wroczynski, B. S., Orru, E., Paladino, R., Pandey-Pommier, M., Pietka, M., Pizzo, R., Pratley, L., Riseley, C. J., Rottgering, H. J. A., Rowlinson, A., Sabater, J., Sendlinger, K., Shulevski, A., Sridhar, S. S., Stewart, A. J., Tasse, C., van Velzen, S., van Weeren, R. J., and Wise, M. W.
- Subjects
Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We report on the discovery in the LOFAR Multifrequency Snapshot Sky Survey (MSSS) of a giant radio galaxy (GRG) with a projected size of $2.56 \pm 0.07$ Mpc projected on the sky. It is associated with the galaxy triplet UGC 9555, within which one is identified as a broad-line galaxy in the Sloan Digital Sky Survey (SDSS) at a redshift of $0.05453 \pm 1 \times 10^{-5} $, and with a velocity dispersion of $215.86 \pm 6.34$ km/s. From archival radio observations we see that this galaxy hosts a compact flat-spectrum radio source, and we conclude that it is the active galactic nucleus (AGN) responsible for generating the radio lobes. The radio luminosity distribution of the jets, and the broad-line classification of the host AGN, indicate this GRG is orientated well out of the plane of the sky, making its physical size one of the largest known for any GRG. Analysis of the infrared data suggests that the host is a lenticular type galaxy with a large stellar mass ($\log~\mathrm{M}/\mathrm{M}_\odot = 11.56 \pm 0.12$), and a moderate star formation rate ($1.2 \pm 0.3~\mathrm{M}_\odot/\mathrm{year}$). Spatially smoothing the SDSS images shows the system around UGC 9555 to be significantly disturbed, with a prominent extension to the south-east. Overall, the evidence suggests this host galaxy has undergone one or more recent moderate merger events and is also experiencing tidal interactions with surrounding galaxies, which have caused the star formation and provided the supply of gas to trigger and fuel the Mpc-scale radio lobes., Comment: Compressed for arXiv, see journal for full resolution images
- Published
- 2017
- Full Text
- View/download PDF
27. Faraday tomography of the local interstellar medium with LOFAR: Galactic foregrounds towards IC342
- Author
-
Van Eck, C. L., Haverkorn, M., Alves, M. I. R., Beck, R., de Bruyn, A. G., Enßlin, T., Farnes, J. S., Ferrière, K., Heald, G., Horellou, C., Horneffer, A., Iacobelli, M., Jelić, V., Martí-Vidal, I., Mulcahy, D. D., Reich, W., Röttgering, H. J. A., Scaife, A. M. M, Schnitzeler, D. H. F. M., Sobey, C., and Sridhar, S. S.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
The new generation of low-frequency radio telescopes, such as the Low Frequency Array (LOFAR: a Square Kilometre Array-low pathfinder), provides advancements in our capability of probing Galactic magnetism through low-frequency polarimetry. Maps of diffuse polarized radio emission and Faraday rotation can be used to infer properties of, and trace structure in, the magnetic fields in the ISM. However, to date very little of the sky has been probed at high angular and Faraday depth resolution. We observed a 5x5 degree region centred on the nearby galaxy IC342 using LOFAR in the frequency range 115-178 MHz at 4 arcmin resolution and performed Faraday tomography to detect foreground Galactic polarized synchrotron emission separated by Faraday depth (different amounts of Faraday rotation). Our Faraday depth cube shows rich polarized structure, with up to 30 K of polarized emission at 150 MHz. We detect two overlapping diffuse polarized features that are clearly separated in Faraday depth. Faraday-thick structures at such low frequencies would be too strongly depolarized to explain the observations and are therefore rejected. Only Faraday thin structures will not be strongly depolarized; producing such structures requires localized variations in the ratio of synchrotron emissivity to Faraday depth per unit distance, which can arise from several physical phenomena, such as a transition between regions of ionized and neutral gas. We conclude that the observed polarized emission is Faraday thin, and propose that the emission originates from two neutral clouds in the local ISM. We have modeled the Faraday rotation for this line of sight and estimated that the line of sight component of magnetic field of the local ISM for this direction varies between -0.86 and +0.12 uG. We propose that this may be a useful method for mapping magnetic fields within the local ISM., Comment: 17 pages, 12 figures, accepted for publication in A&A
- Published
- 2016
- Full Text
- View/download PDF
28. The gut microbiota and metabolome are associated with diminished COVID-19 vaccine-induced antibody responses in immunosuppressed inflammatory bowel disease patientsResearch in context
- Author
-
James L. Alexander, Benjamin H. Mullish, Nathan P. Danckert, Zhigang Liu, Marton L. Olbei, Aamir Saifuddin, Melissa Torkizadeh, Hajir Ibraheim, Jesús Miguéns Blanco, Lauren A. Roberts, Claire M. Bewshea, Rachel Nice, Simeng Lin, Hemanth Prabhudev, Caroline Sands, Verena Horneffer-van der Sluis, Matthew Lewis, Shaji Sebastian, Charlie W. Lees, Julian P. Teare, Ailsa Hart, James R. Goodhand, Nicholas A. Kennedy, Tamas Korcsmaros, Julian R. Marchesi, Tariq Ahmad, and Nick Powell
- Subjects
Gut microbiota ,Metabolome ,SARS-CoV-2 ,Inflammatory bowel disease ,Anti-TNF therapy ,Infliximab ,Medicine ,Medicine (General) ,R5-920 - Abstract
Summary: Background: Patients with inflammatory bowel disease (IBD) treated with anti-TNF therapy exhibit attenuated humoral immune responses to vaccination against SARS-CoV-2. The gut microbiota and its functional metabolic output, which are perturbed in IBD, play an important role in shaping host immune responses. We explored whether the gut microbiota and metabolome could explain variation in anti-SARS-CoV-2 vaccination responses in immunosuppressed IBD patients. Methods: Faecal and serum samples were prospectively collected from infliximab-treated patients with IBD in the CLARITY-IBD study undergoing vaccination against SARS-CoV-2. Antibody responses were measured following two doses of either ChAdOx1 nCoV-19 or BNT162b2 vaccine. Patients were classified as having responses above or below the geometric mean of the wider CLARITY-IBD cohort. 16S rRNA gene amplicon sequencing, nuclear magnetic resonance (NMR) spectroscopy and bile acid profiling with ultra-high-performance liquid chromatography mass spectrometry (UHPLC-MS) were performed on faecal samples. Univariate, multivariable and correlation analyses were performed to determine gut microbial and metabolomic predictors of response to vaccination. Findings: Forty-three infliximab-treated patients with IBD were recruited (30 Crohn's disease, 12 ulcerative colitis, 1 IBD-unclassified; 26 with concomitant thiopurine therapy). Eight patients had evidence of prior SARS-CoV-2 infection. Seventeen patients (39.5%) had a serological response below the geometric mean. Gut microbiota diversity was lower in below average responders (p = 0.037). Bilophila abundance was associated with better serological response, while Streptococcus was associated with poorer response. The faecal metabolome was distinct between above and below average responders (OPLS-DA R2X 0.25, R2Y 0.26, Q2 0.15; CV-ANOVA p = 0.038). Trimethylamine, isobutyrate and omega-muricholic acid were associated with better response, while succinate, phenylalanine, taurolithocholate and taurodeoxycholate were associated with poorer response. Interpretation: Our data suggest that there is an association between the gut microbiota and variable serological response to vaccination against SARS-CoV-2 in immunocompromised patients. Microbial metabolites including trimethylamine may be important in mitigating anti-TNF-induced attenuation of the immune response. Funding: JLA is the recipient of an NIHR Academic Clinical Lectureship (CL-2019-21-502), funded by Imperial College London and The Joyce and Norman Freed Charitable Trust. BHM is the recipient of an NIHR Academic Clinical Lectureship (CL-2019-21-002). The Division of Digestive Diseases at Imperial College London receives financial and infrastructure support from the NIHR Imperial Biomedical Research Centre (BRC) based at Imperial College Healthcare NHS Trust and Imperial College London. Metabolomics studies were performed at the MRC-NIHR National Phenome Centre at Imperial College London; this work was supported by the Medical Research Council (MRC), the National Institute of Health Research (NIHR) (grant number MC_PC_12025) and infrastructure support was provided by the NIHR Imperial Biomedical Research Centre (BRC). The NIHR Exeter Clinical Research Facility is a partnership between the University of Exeter Medical School College of Medicine and Health, and Royal Devon and Exeter NHS Foundation Trust. This project is supported by the National Institute for Health Research (NIHR) Exeter Clinical Research Facility. The views expressed are those of the authors and not necessarily those of the NIHR or the UK Department of Health and Social Care.
- Published
- 2023
- Full Text
- View/download PDF
29. Hepatology consultation is associated with decreased early return to alcohol use after discharge from an inpatient alcohol use disorder treatment program
- Author
-
Blaney, Hanna L., primary, Khalid, Mian B., additional, Yang, Alexander H., additional, Asif, Bilal A., additional, Vittal, Anusha, additional, Kamal, Natasha, additional, Wright, Elizabeth C., additional, Abijo, Tomilowo, additional, Koh, Chris, additional, George, David, additional, Goldman, David, additional, Horneffer, Yvonne, additional, Diazgranados, Nancy, additional, and Heller, Theo, additional
- Published
- 2024
- Full Text
- View/download PDF
30. The LOFAR Two-metre Sky Survey - I. Survey Description and Preliminary Data Release
- Author
-
Shimwell, T. W., Röttgering, H. J. A., Best, P. N., Williams, W. L., Dijkema, T. J., de Gasperin, F., Hardcastle, M. J., Heald, G. H., Hoang, D. N., Horneffer, A., Intema, H., Mahony, E. K., Mandal, S., Mechev, A. P., Morabito, L., Oonk, J. B. R., Rafferty, D., Retana-Montenegro, E., Sabater, J., Tasse, C., van Weeren, R. J., Brüggen, M., Brunetti, G., Chyży, K. T., Conway, J. E., Haverkorn, M., Jackson, N., Jarvis, M. J., McKean, J. P., Miley, G. K., Morganti, R., White, G. J., Wise, M. W., van Bemmel, I. M., Beck, R., Brienza, M., Bonafede, A., Rivera, G. Calistro, Cassano, R., Clarke, A. O., Cseh, D., Deller, A., Drabent, A., van Driel, W., Engels, D., Falcke, H., Ferrari, C., Fröhlich, S., Garrett, M. A., Harwood, J. J., Heesen, V., Hoeft, M., Horellou, C., Israel, F. P., Kapińska, A. D., Kunert-Bajraszewska, M., McKay, D. J., Mohan, N. R., Orrú, E., Pizzo, R. F., Prandoni, I., Schwarz, D. J., Shulevski, A., Sipior, M., Smith, D. J. B., Sridhar, S. S., Steinmetz, M., Stroe, A., Varenius, E., van der Werf, P. P., Zensus, J. A., and Zwart, J. T. L.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The LOFAR Two-metre Sky Survey (LoTSS) is a deep 120-168 MHz imaging survey that will eventually cover the entire Northern sky. Each of the 3170 pointings will be observed for 8 hrs, which, at most declinations, is sufficient to produce ~5arcsec resolution images with a sensitivity of ~0.1mJy/beam and accomplish the main scientific aims of the survey which are to explore the formation and evolution of massive black holes, galaxies, clusters of galaxies and large-scale structure. Due to the compact core and long baselines of LOFAR, the images provide excellent sensitivity to both highly extended and compact emission. For legacy value, the data are archived at high spectral and time resolution to facilitate subarcsecond imaging and spectral line studies. In this paper we provide an overview of the LoTSS. We outline the survey strategy, the observational status, the current calibration techniques, a preliminary data release, and the anticipated scientific impact. The preliminary images that we have released were created using a fully-automated but direction-independent calibration strategy and are significantly more sensitive than those produced by any existing large-area low-frequency survey. In excess of 44,000 sources are detected in the images that have a resolution of 25arcsec, typical noise levels of less than 0.5 mJy/beam, and cover an area of over 350 square degrees in the region of the HETDEX Spring Field (right ascension 10h45m00s to 15h30m00s and declination 45d00m00s to 57d00m00s)., Comment: 23 pages, 15 figures, 3 tables, accepted for publication in A&A
- Published
- 2016
- Full Text
- View/download PDF
31. A comparison of the cosmic-ray energy scales of Tunka-133 and KASCADE-Grande via their radio extensions Tunka-Rex and LOPES
- Author
-
Apel, W. D., Arteaga-Velázquez, J. C., Bähren, L., Bezyazeekov, P. A., Bekk, K., Bertaina, M., Biermann, P. L., Blümer, J., Bozdog, H., Brancus, I. M., Budnev, N. M., Cantoni, E., Chiavassa, A., Daumiller, K., de Souza, V., Di Pierro, F., Doll, P., Engel, R., Falcke, H., Fedorov, O., Fuchs, B., Gemmeke, H., Gress, O. A., Grupen, C., Haungs, A., Heck, D., Hiller, R., Hörandel, J. R., Horneffer, A., Huber, D., Huege, T., Isar, P. G., Kampert, K. -H., Kang, D., Kazarina, Y., Kleifges, M., Korosteleva, E. E., Kostunin, D., Krömer, O., Kuijpers, J., Kuzmichev, L. A., Link, K., Lubsandorzhiev, N., Luczak, P., Ludwig, M., Mathes, H. J., Melissas, M., Mirgazov, R. R., Monkhoev, R., Morello, C., Oehlschläger, J., Osipova, E. A., Pakhorukov, A., Palmieri, N., Pankov, L., Pierog, T., Prosin, V. V., Rautenberg, J., Rebel, H., Roth, M., Rubtsov, G. I., Rühle, C., Saftoiu, A., Schieler, H., Schmidt, A., Schoo, S., Schröder, F. G., Sima, O., Toma, G., Trinchero, G. C., Weind, A., Wischnewski, R., Wochele, J., Zabierowski, J., Zagorodnikov, A., and Zensus, J. A.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
The radio technique is a promising method for detection of cosmic-ray air showers of energies around $100\,$PeV and higher with an array of radio antennas. Since the amplitude of the radio signal can be measured absolutely and increases with the shower energy, radio measurements can be used to determine the air-shower energy on an absolute scale. We show that calibrated measurements of radio detectors operated in coincidence with host experiments measuring air showers based on other techniques can be used for comparing the energy scales of these host experiments. Using two approaches, first via direct amplitude measurements, and second via comparison of measurements with air shower simulations, we compare the energy scales of the air-shower experiments Tunka-133 and KASCADE-Grande, using their radio extensions, Tunka-Rex and LOPES, respectively. Due to the consistent amplitude calibration for Tunka-Rex and LOPES achieved by using the same reference source, this comparison reaches an accuracy of approximately $10\,\%$ - limited by some shortcomings of LOPES, which was a prototype experiment for the digital radio technique for air showers. In particular we show that the energy scales of cosmic-ray measurements by the independently calibrated experiments KASCADE-Grande and Tunka-133 are consistent with each other on this level.
- Published
- 2016
- Full Text
- View/download PDF
32. LBCS: the LOFAR Long-Baseline Calibrator Survey
- Author
-
Jackson, N., Tagore, A., Deller, A., Moldón, J., Varenius, E., Morabito, L., Wucknitz, O., Carozzi, T., Conway, J., Drabent, A., Kapinska, A., Orrù, E., Brentjens, M., Blaauw, R., Kuper, G., Sluman, J., Schaap, J., Vermaas, N., Iacobelli, M., Cerrigone, L., Shulevski, A., ter Veen, S., Fallows, R., Pizzo, R., Sipior, M., Anderson, J., Avruch, M., Bell, M., van Bemmel, I., Bentum, M., Best, P., Bonafede, A., Breitling, F., Broderick, J., Brouw, W., Brüggen, M., Ciardi, B., Corstanje, A., de Gasperin, F., de Geus, E., Eislöffel, J., Engels, D., Falcke, H., Garrett, M., Griessmeier, J., Gunst, A., van Haarlem, M., Heald, G., Hoeft, M., Hörandel, J., Horneffer, A., Intema, H., Juette, E., Kuniyoshi, M., van Leeuwen, J., Loose, G., Maat, P., McFadden, R., McKay-Bukowski, D., McKean, J., Mulcahy, D., Munk, H., Pandey-Pommier, M., Polatidis, A., Reich, W., Röttgering, H., Rowlinson, A., Scaife, A., Schwarz, D., Steinmetz, M., Swinbank, J., Thoudam, S., Toribio, M., Vermeulen, R., Vocks, C., van Weeren, R., Wise, M., Yatawatta, S., and Zarka, P.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
(abridged). We outline LBCS (the LOFAR Long-Baseline Calibrator Survey), whose aim is to identify sources suitable for calibrating the highest-resolution observations made with the International LOFAR Telescope, which include baselines >1000 km. Suitable sources must contain significant correlated flux density (50-100mJy) at frequencies around 110--190~MHz on scales of a few hundred mas. At least for the 200--300-km international baselines, we find around 1 suitable calibrator source per square degree over a large part of the northern sky, in agreement with previous work. This should allow a randomly selected target to be successfully phase calibrated on the international baselines in over 50% of cases. Products of the survey include calibrator source lists and fringe-rate and delay maps of wide areas -- typically a few degrees -- around each source. The density of sources with significant correlated flux declines noticeably with baseline length over the range 200--600~km, with good calibrators on the longest baselines appearing only at the rate of 0.5 per square degree. Coherence times decrease from 1--3 minutes on 200-km baselines to about 1 minute on 600-km baselines, suggesting that ionospheric phase variations contain components with scales of a few hundred kilometres. The longest median coherence time, at just over 3 minutes, is seen on the DE609 baseline, which at 227km is close to being the shortest. We see median coherence times of between 80 and 110 seconds on the four longest baselines (580--600~km), and about 2 minutes for the other baselines. The success of phase transfer from calibrator to target is shown to be influenced by distance, in a manner that suggests a coherence patch at 150-MHz of the order of 1 degree., Comment: Accepted by Astronomy & Astrophysics. Error in figure 6 corrected
- Published
- 2016
- Full Text
- View/download PDF
33. A deep campaign to characterize the synchronous radio/X-ray mode switching of PSR B0943+10
- Author
-
Mereghetti, S., Kuiper, L., Tiengo, A., Hessels, J., Hermsen, W., Stovall, K., Possenti, A., Rankin, J., Esposito, P., Turolla, R., Mitra, D., Wright, G., Stappers, B., Horneffer, A., Oslowski, S., Serylak, M., and Griessmeier, J. -M.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena - Abstract
We report on simultaneous X-ray and radio observations of the mode-switching pulsar PSR B0943+10 obtained with the XMM-Newton satellite and the LOFAR, LWA and Arecibo radio telescopes in November 2014. We confirm the synchronous X-ray/radio switching between a radio-bright (B) and a radio-quiet (Q) mode, in which the X-ray flux is a factor ~2.4 higher than in the B-mode. We discovered X-ray pulsations, with pulsed fraction of 38+/-5% (0.5-2 keV), during the B-mode, and confirm their presence in Q-mode, where the pulsed fraction increases with energy from ~20% up to ~65% at 2 keV. We found marginal evidence for an increase in the X-ray pulsed fraction during B-mode on a timescale of hours. The Q-mode X-ray spectrum requires a fit with a two-component model (either a power-law plus blackbody or the sum of two blackbodies), while the B-mode spectrum is well fit by a single blackbody (a single power-law is rejected). With a maximum likelihood analysis, we found that in Q-mode the pulsed emission has a thermal blackbody spectrum with temperature ~3.4x10^6 K and the unpulsed emission is a power-law with photon index ~2.5, while during B-mode both the pulsed and unpulsed emission can be fit by either a blackbody or a power law with similar values of temperature and photon index. A Chandra image shows no evidence for diffuse X-ray emission. These results support a scenario in which both unpulsed non-thermal emission, likely of magnetospheric origin, and pulsed thermal emission from a small polar cap (~1500 m^2) with a strong non-dipolar magnetic field (~10^{14} G), are present during both radio modes and vary in intensity in a correlated way. This is broadly consistent with the predictions of the partially screened gap model and does not necessarily imply global magnetospheric rearrangements to explain the mode switching., Comment: To be published on The Astrophysical Journal
- Published
- 2016
- Full Text
- View/download PDF
34. A large light-mass component of cosmic rays at 10^{17} - 10^{17.5} eV from radio observations
- Author
-
Buitink, S., Corstanje, A., Falcke, H., Hörandel, J. R., Huege, T., Nelles, A., Rachen, J. P., Rossetto, L., Schellart, P ., Scholten, O., ter Veen, S., Thoudam, S., Trinh, T. N. G., Anderson, J., Asgekar, A., Avruch, I. M., Bell, M. E., Bentum, M. J., Bernardi, G., Best, P., Bonafede, A., Breitling, F., Broderick, J. W., Brouw, W. N., Brüggen, M., Butcher, H. R., Carbone, D., Ciardi, B., Conway, J. E., de Gasperin, F., de Geus, E., Deller, A., Dettmar, R. -J., van Diepen, G., Duscha, S., Eislöffel, J., Engels, D., Enriquez, J. E., Fallows, R. A., Fender, R., Ferrari, C., Frieswijk, W., Garrett, M. A., Griessmeier, J. M., Gunst, A. W., van Haarlem, M. P., Hassall, T. E., Heald, G., Hessels, J. W. T., Hoeft, M., Horneffer, A., Iacobelli, M., Intema, H., Juette, E., Karastergiou, A., Kondratiev, V. I., Kramer, M., Kuniyoshi, M., Kuper, G., van Leeuwen, J., Loose, G. M., Maat, P., Mann, G., Markoff, S., McFadden, R., McKay-Bukowski, D., McKean, J. P., Mevius, M., Mulcahy, D. D., Munk, H., Norden, M. J., Orru, E., Paas, H., Pandey-Pommier, M., Pandey, V. N., Pietka, M., Pizzo, R., Polatidis, A. G., Reich, W., Röttgering, H. J. A., Scaife, A. M. M., Schwarz, D. J., Serylak, M., Sluman, J., Smirnov, O., Stappers, B. W., Steinmetz, M., Stewart, A., Swinbank, J., Tagger, M., Tang, Y., Tasse, C., Toribio, M. C., Vermeulen, R., Vocks, C., Vogt, C., van Weeren, R. J., Wijers, R. A. M. J., Wijnholds, S. J., Wise, M. W., Wucknitz, O., Yatawatta, S., Zarka, P., and Zensus, J. A.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena ,High Energy Physics - Experiment - Abstract
Cosmic rays are the highest energy particles found in nature. Measurements of the mass composition of cosmic rays between 10^{17} eV and 10^{18} eV are essential to understand whether this energy range is dominated by Galactic or extragalactic sources. It has also been proposed that the astrophysical neutrino signal comes from accelerators capable of producing cosmic rays of these energies. Cosmic rays initiate cascades of secondary particles (air showers) in the atmosphere and their masses are inferred from measurements of the atmospheric depth of the shower maximum, Xmax, or the composition of shower particles reaching the ground. Current measurements suffer from either low precision, or a low duty cycle and a high energy threshold. Radio detection of cosmic rays is a rapidly developing technique, suitable for determination of Xmax with a duty cycle of in principle nearly 100%. The radiation is generated by the separation of relativistic charged particles in the geomagnetic field and a negative charge excess in the shower front. Here we report radio measurements of Xmax with a mean precision of 16 g/cm^2 between 10^{17}-10^{17.5} eV. Because of the high resolution in $Xmax we can determine the mass spectrum and find a mixed composition, containing a light mass fraction of ~80%. Unless the extragalactic component becomes significant already below 10^{17.5} eV, our measurements indicate an additional Galactic component dominating at this energy range., Comment: 35 pages, 11 figures, updated version: Pierre Auger Observatory data ICRC 2015 added to Fig 2
- Published
- 2016
- Full Text
- View/download PDF
35. Common Factors Underlying Diverse Responses in Alcohol Use Disorder
- Author
-
Esha Chebolu, Melanie L. Schwandt, Vijay A. Ramchandani, Bethany L. Stangl, David T. George, Yvonne Horneffer, Tonette Vinson, Emily L. Vogt, Brandon A. Manor, Nancy Diazgranados, and David Goldman
- Subjects
Psychiatry ,RC435-571 - Abstract
Objective Interindividual variation in responses to alcohol is substantial, posing challenges for medical management and for understanding the biological underpinnings of alcohol use disorders (AUD). It is important to understand whether diverse alcohol responses such as sedation, which is predictive of risk and partly heritable, occur concurrently or independently from responses such as blackouts and withdrawal. We hypothesized that latent factors accounting for sources of variance in diverse alcohol response phenotypes could be identified in a large, deeply phenotyped sample of patients with AUD. Methods We factor analyzed 17 alcohol response related items from the Alcohol Dependence Scale (ADS) in 938 individuals diagnosed with AUD via structured clinical interviews. Demographic, genetic, and clinical characteristics were tested as predictors of the latent factors by multiple indicators, multiple causes analysis. Results The final factor solution included three alcohol response factors: Physical Symptoms, Perceptual Disturbances, and Neurobiological Effects. Both gender and genetic ancestry were identified as variables influencing alcohol response. Major depressive disorder positively predicted physical symptoms and aggression negatively predicted physical symptoms. Barratt's Impulsivity Scale total score predicted the Physical and Perceptual domains. Family history, average drinks per drinking day, and negative urgency (an impulsivity measure) predicted all three domains. Conclusions Diverse items from the ADS concurrently load onto three correlated alcohol response factors rather than loading independently. Genetic ancestry and clinical characteristics predicted the severity of items that define the alcohol response factors even after accounting for degree of alcohol consumption. Co‐occurring phenotypes point towards an underlying shared physiology of diverse alcohol responses.
- Published
- 2021
- Full Text
- View/download PDF
36. A methodology for identifying high-need, high-cost patient personas for international comparisons
- Author
-
Figueroa, Jose F., Horneffer, Kathryn E., Riley, Kristen, Abiona, Olukorede, Arvin, Mina, Atsma, Femke, Bernal-Delgado, Enrique, Blankart, Carl Rudolf, Bowden, Nicholas, Deeny, Sarah, Estupinan-Romero, Francisco, Gauld, Robin, Hansen, Tonya Moen, Haywood, Philip, Janlov, Nils, Knight, Hannah, Lorenzoni, Luca, Marino, Alberto, Or, Zeynep, Pellet, Leila, Orlander, Duncan, Penneau, Anne, Schoenfeld, Andrew J., Shatrov, Kosta, Skudal, Kjersti Eeg, Stafford, Mai, Galien, Onno van de, Gool, Kees van, Wodchis, Walter P., Tanke, Marit, Jha, Ashish K., and Papanicolas, Irene
- Subjects
Business ,Health care industry - Abstract
Objective: To establish a methodological approach to compare two high-need, highcost (HNHC) patient personas internationally. Data sources: Linked individual-level administrative data from the inpatient and outpatient sectors compiled by the International Collaborative on Costs, Outcomes, and Needs in Care (ICCONIC) across 11 countries: Australia, Canada, England, France, Germany, the Netherlands, New Zealand, Spain, Sweden, Switzerland, and the United States. Study design: We outline a methodological approach to identify HNHC patient types for international comparisons that reflect complex, priority populations defined by the National Academy of Medicine. We define two patient profiles using accessible patient-level datasets linked across different domains of care-hospital care, primary care, outpatient specialty care, post-acute rehabilitative care, long-term care, homehealth care, and outpatient drugs. The personas include a frail older adult with a hip fracture with subsequent hip replacement and an older person with complex multimorbidity, including heart failure and diabetes. We demonstrate their comparability by examining the characteristics and clinical diagnoses captured across countries. Data collection/extraction methods: Data collected by ICCONIC partners. Principal findings: Across 11 countries, the identification of HNHC patient personas was feasible to examine variations in healthcare utilization, spending, and patient outcomes. The ability of countries to examine linked, individual-level data varied, with the Netherlands, Canada, and Germany able to comprehensively examine care across all seven domains, whereas other countries such as England, Switzerland, and New Zealand were more limited. All countries were able to identify a hip fracture persona and a heart failure persona. Patient characteristics were reassuringly similar across countries. Conclusion: Although there are cross-country differences in the availability and structure of data sources, countries had the ability to effectively identify comparable HNHC personas for international study. This work serves as the methodological paper for six accompanying papers examining differences in spending, utilization, and outcomes for these personas across countries. KEYWORDS international comparison, vignettes, What is known on this topic * International comparisons of health systems mostly rely on comparisons of the inpatient setting. * Little comparative work examines patterns of spending and utilization [...]
- Published
- 2021
- Full Text
- View/download PDF
37. LOFAR MSSS: Detection of a low-frequency radio transient in 400 hrs of monitoring of the North Celestial Pole
- Author
-
Stewart, A. J., Fender, R. P., Broderick, J. W., Hassall, T. E., Muñoz-Darias, T., Rowlinson, A., Swinbank, J. D., Staley, T. D., Molenaar, G. J., Scheers, B., Grobler, T. L., Pietka, M., Heald, G., McKean, J. P., Bell, M. E., Bonafede, A., Breton, R. P., Carbone, D., Cendes, Y., Clarke, A. O., Corbel, S., de Gasperin, F., Eislöffel, J., Falcke, H., Ferrari, C., Grießmeier, J. -M., Hardcastle, M. J., Heesen, V., Hessels, J. W. T., Horneffer, A., Iacobelli, M., Jonker, P., Karastergiou, A., Kokotanekov, G., Kondratiev, V. I., Kuniyoshi, M., Law, C. J., van Leeuwen, J., Markoff, S., Miller-Jones, J. C. A., Mulcahy, D., Orru, E., Pandey-Pommier, M., Pratley, L., Rol, E., Röttgering, H. J. A., Scaife, A. M. M., Shulevski, A., Sobey, C. A., Stappers, B. W., Tasse, C., van der Horst, A. J., van Velzen, S., van Weeren, R. J., Wijers, R. A. M. J., Wijnands, R., Wise, M., Zarka, P., Alexov, A., Anderson, J., Asgekar, A., Avruch, I. M., Bentum, M. J., Bernardi, G., Best, P., Breitling, F., Brüggen, M., Butcher, H. R., Ciardi, B., Conway, J. E., Corstanje, A., de Geus, E., Deller, A., Duscha, S., Frieswijk, W., Garrett, M. A., Gunst, A. W., van Haarlem, M. P., Hoeft, M., Hörandel, J., Juette, E., Kuper, G., Loose, M., Maat, P., McFadden, R., McKay-Bukowski, D., Moldon, J., Munk, H., Norden, M. J., Paas, H., Polatidis, A. G., Schwarz, D., Sluman, J., Smirnov, O., Steinmetz, M., Thoudam, S., Toribio, M. C., Vermeulen, R., Vocks, C., Wijnholds, S. J., Wucknitz, O., and Yatawatta, S.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present the results of a four-month campaign searching for low-frequency radio transients near the North Celestial Pole with the Low-Frequency Array (LOFAR), as part of the Multifrequency Snapshot Sky Survey (MSSS). The data were recorded between 2011 December and 2012 April and comprised 2149 11-minute snapshots, each covering 175 deg^2. We have found one convincing candidate astrophysical transient, with a duration of a few minutes and a flux density at 60 MHz of 15-25 Jy. The transient does not repeat and has no obvious optical or high-energy counterpart, as a result of which its nature is unclear. The detection of this event implies a transient rate at 60 MHz of 3.9 (+14.7, -3.7) x 10^-4 day^-1 deg^-2, and a transient surface density of 1.5 x 10^-5 deg^-2, at a 7.9-Jy limiting flux density and ~10-minute time-scale. The campaign data were also searched for transients at a range of other time-scales, from 0.5 to 297 min, which allowed us to place a range of limits on transient rates at 60 MHz as a function of observation duration., Comment: 23 pages, 16 figures, 5 tables, accepted for publication in MNRAS
- Published
- 2015
- Full Text
- View/download PDF
38. Wide-Band, Low-Frequency Pulse Profiles of 100 Radio Pulsars with LOFAR
- Author
-
Pilia, M., Hessels, J. W. T., Stappers, B. W., Kondratiev, V. I., Kramer, M., van Leeuwen, J., Weltevrede, P., Lyne, A. G., Zagkouris, K., Hassall, T. E., Bilous, A. V., Breton, R. P., Falcke, H., Grießmeier, J. -M., Keane, E., Karastergiou, A., Kuniyoshi, M., Noutsos, A., Osłowski, S., Serylak, M., Sobey, C., ter Veen, S., Alexov, A., Anderson, J., Asgekar, A., Avruch, I. M., Bell, M. E., Bentum, M. J., Bernardi, G., Bîrzan, L., Bonafede, A., Breitling, F., Broderick, J. W., Brüggen, M., Ciardi, B., Corbel, S., de Geus, E., de Jong, A., Deller, A., Duscha, S., Eislöffel, J., Fallows, R. A., Fender, R., Ferrari, C., Frieswijk, W., Garrett, M. A., Gunst, A. W., Hamaker, J. P., Heald, G., Horneffer, A., Jonker, P., Juette, E., Kuper, G., Maat, P., Mann, G., Markoff, S., McFadden, R., McKay-Bukowski, D., Miller-Jones, J. C. A., Nelles, A., Paas, H., Pandey-Pommier, M., Pietka, M., Pizzo, R., Polatidis, A. G., Reich, W., Röttgering, H., Rowlinson, A., Schwarz, D., Smirnov, O., Steinmetz, M., Stewart, A., Swinbank, J. D., Tagger, M., Tang, Y., Tasse, C., Thoudam, S., Toribio, M. C., van der Horst, A. J., Vermeulen, R., Vocks, C., van Weeren, R. J., Wijers, R. A. M. J., Wijnands, R., Wijnholds, S. J., Wucknitz, O., and Zarka, P.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
LOFAR offers the unique capability of observing pulsars across the 10-240 MHz frequency range with a fractional bandwidth of roughly 50%. This spectral range is well-suited for studying the frequency evolution of pulse profile morphology caused by both intrinsic and extrinsic effects: such as changing emission altitude in the pulsar magnetosphere or scatter broadening by the interstellar medium, respectively. The magnitude of most of these effects increases rapidly towards low frequencies. LOFAR can thus address a number of open questions about the nature of radio pulsar emission and its propagation through the interstellar medium. We present the average pulse profiles of 100 pulsars observed in the two LOFAR frequency bands: High Band (120-167 MHz, 100 profiles) and Low Band (15-62 MHz, 26 profiles). We compare them with Westerbork Synthesis Radio Telescope (WSRT) and Lovell Telescope observations at higher frequencies (350 and1400 MHz) in order to study the profile evolution. The profiles are aligned in absolute phase by folding with a new set of timing solutions from the Lovell Telescope, which we present along with precise dispersion measures obtained with LOFAR. We find that the profile evolution with decreasing radio frequency does not follow a specific trend but, depending on the geometry of the pulsar, new components can enter into, or be hidden from, view. Nonetheless, in general our observations confirm the widening of pulsar profiles at low frequencies, as expected from radius-to-frequency mapping or birefringence theories. We offer this catalog of low-frequency pulsar profiles in a user friendly way via the EPN Database of Pulsar Profiles (http://www.epta.eu.org/epndb/)., Comment: 38 pages, 11 figures, 5 tables, A&A in press, updated with editorial corrections
- Published
- 2015
- Full Text
- View/download PDF
39. The LOFAR Multifrequency Snapshot Sky Survey (MSSS) I. Survey description and first results
- Author
-
Heald, G. H., Pizzo, R. F., Orrú, E., Breton, R. P., Carbone, D., Ferrari, C., Hardcastle, M. J., Jurusik, W., Macario, G., Mulcahy, D., Rafferty, D., Asgekar, A., Brentjens, M., Fallows, R. A., Frieswijk, W., Toribio, M. C., Adebahr, B., Arts, M., Bell, M. R., Bonafede, A., Bray, J., Broderick, J., Cantwell, T., Carroll, P., Cendes, Y., Clarke, A. O., Croston, J., Daiboo, S., de Gasperin, F., Gregson, J., Harwood, J., Hassall, T., Heesen, V., Horneffer, A., van der Horst, A. J., Iacobelli, M., Jelić, V., Jones, D., Kant, D., Kokotanekov, G., Martin, P., McKean, J. P., Morabito, L. K., Nikiel-Wroczyński, B., Offringa, A., Pandey, V. N., Pandey-Pommier, M., Pietka, M., Pratley, L., Riseley, C., Rowlinson, A., Sabater, J., Scaife, A. M. M., Scheers, L. H. A., Sendlinger, K., Shulevski, A., Sipior, M., Sobey, C., Stewart, A. J., Stroe, A., Swinbank, J., Tasse, C., Trüstedt, J., Varenius, E., van Velzen, S., Vilchez, N., van Weeren, R. J., Wijnholds, S., Williams, W. L., de Bruyn, A. G., Nijboer, R., Wise, M., Alexov, A., Anderson, J., Avruch, I. M., Beck, R., Bell, M. E., van Bemmel, I., Bentum, M. J., Bernardi, G., Best, P., Breitling, F., Brouw, W. N., Brüggen, M., Butcher, H. R., Ciardi, B., Conway, J. E., de Geus, E., de Jong, A., de Vos, M., Deller, A., Dettmar, R. J., Duscha, S., Eislöffel, J., Engels, D., Falcke, H., Fender, R., Garrett, M. A., Grießmeier, J., Gunst, A. W., Hamaker, J. P., Hessels, J. W. T., Hoeft, M., Hörandel, J., Holties, H. A., Intema, H., Jackson, N. J., Jütte, E., Karastergiou, A., Klijn, W. F. A., Kondratiev, V. I., Koopmans, L. V. E., Kuniyoshi, M., Kuper, G., Law, C., van Leeuwen, J., Loose, M., Maat, P., Markoff, S., McFadden, R., McKay-Bukowski, D., Mevius, M., Miller-Jones, J. C. A., Morganti, R., Munk, H., Nelles, A., Noordam, J. E., Norden, M. J., Paas, H., Polatidis, A. G., Reich, W., Renting, A., Röttgering, H., Schoenmakers, A., Schwarz, D., Sluman, J., Smirnov, O., Stappers, B. W., Steinmetz, M., Tagger, M., Tang, Y., ter Veen, S., Thoudam, S., Vermeulen, R., Vocks, C., Vogt, C., Wijers, R. A. M. J., Wucknitz, O., Yatawatta, S., and Zarka, P.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present the Multifrequency Snapshot Sky Survey (MSSS), the first northern-sky LOFAR imaging survey. In this introductory paper, we first describe in detail the motivation and design of the survey. Compared to previous radio surveys, MSSS is exceptional due to its intrinsic multifrequency nature providing information about the spectral properties of the detected sources over more than two octaves (from 30 to 160 MHz). The broadband frequency coverage, together with the fast survey speed generated by LOFAR's multibeaming capabilities, make MSSS the first survey of the sort anticipated to be carried out with the forthcoming Square Kilometre Array (SKA). Two of the sixteen frequency bands included in the survey were chosen to exactly overlap the frequency coverage of large-area Very Large Array (VLA) and Giant Metrewave Radio Telescope (GMRT) surveys at 74 MHz and 151 MHz respectively. The survey performance is illustrated within the "MSSS Verification Field" (MVF), a region of 100 square degrees centered at J2000 (RA,Dec)=(15h,69deg). The MSSS results from the MVF are compared with previous radio survey catalogs. We assess the flux and astrometric uncertainties in the catalog, as well as the completeness and reliability considering our source finding strategy. We determine the 90% completeness levels within the MVF to be 100 mJy at 135 MHz with 108" resolution, and 550 mJy at 50 MHz with 166" resolution. Images and catalogs for the full survey, expected to contain 150,000-200,000 sources, will be released to a public web server. We outline the plans for the ongoing production of the final survey products, and the ultimate public release of images and source catalogs., Comment: 23 pages, 19 figures. Accepted for publication in Astronomy & Astrophysics. MSSS Verification Field images and catalog data may be downloaded from http://vo.astron.nl
- Published
- 2015
- Full Text
- View/download PDF
40. Revised absolute amplitude calibration of the LOPES experiment
- Author
-
Link, K., Huege, T., Apel, W. D., Arteaga-Velázquez, J. C., Bähren, L., Bekk, K., Bertaina, M., Biermann, P. L., Blümer, J., Bozdog, H., Brancus, I. M., Cantoni, E., Chiavassa, A., Daumiller, K., de Souza, V., Di Pierro, F., Doll, P., Engel, R., Falcke, H., Fuchs, B., Gemmeke, H., Grupen, C., Haungs, A., Heck, D., Hiller, R., Hörandel, J. R., Horneffer, A., Huber, D., Isar, P. G., Kampert, K-H., Kang, D., Krömer, O., Kuijpers, J., Łuczak, P., Ludwig, M., Mathes, H. J., Melissas, M., Morello, C., Oehlschläger, J., Palmieri, N., Pierog, T., Rautenberg, J., Rebel, H., Roth, M., Rühle, C., Saftoiu, A., Schieler, H., Schmidt, A., Schoo, S., Schröder, F. G., Sima, O., Toma, G., Trinchero, G. C., Weindl, A., Wochele, J., Zabierowski, J., and Zensus, J. A.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,High Energy Physics - Experiment ,Physics - Instrumentation and Detectors - Abstract
One of the main aims of the LOPES experiment was the evaluation of the absolute amplitude of the radio signal of air showers. This is of special interest since the radio technique offers the possibility for an independent and highly precise determination of the energy scale of cosmic rays on the basis of signal predictions from Monte Carlo simulations. For the calibration of the amplitude measured by LOPES we used an external source. Previous comparisons of LOPES measurements and simulations of the radio signal amplitude predicted by CoREAS revealed a discrepancy of the order of a factor of two. A re-measurement of the reference calibration source, now performed for the free field, was recently performed by the manufacturer. The updated calibration values lead to a lowering of the reconstructed electric field measured by LOPES by a factor of $2.6 \pm 0.2$ and therefore to a significantly better agreement with CoREAS simulations. We discuss the updated calibration and its impact on the LOPES analysis results., Comment: Proceedings of the 34th ICRC, The Hague, The Netherlands, PoS(ICRC2015)311
- Published
- 2015
41. Calibrating the absolute amplitude scale for air showers measured at LOFAR
- Author
-
Nelles, A., Hörandel, J. R., Karskens, T., Krause, M., Buitink, S., Corstanje, A., Enriquez, J. E., Erdmann, M., Falcke, H., Haungs, A., Hiller, R., Huege, T., Krause, R., Link, K., Norden, M. J., Rachen, J. P., Rossetto, L., Schellart, P., Scholten, O., Schröder, F. G., ter Veen, S., Thoudam, S., Trinh, T. N. G., Weidenhaupt, K., Wijnholds, S. J., Anderson, J., Bähren, L., Bell, M. E., Bentum, M. J., Best, P., Bonafede, A., Bregman, J., Brouw, W. N., Bruüggen, M., Butcher, H. R., Carbone, D., Ciardi, B., de Gasperin, F., Duscha, S., Eislöffel, J., Fallows, R. A., Frieswijk, W., Garrett, M. A., van Haarlem, M. P., Heald, G., Hoeft, M., Horneffer, A., Iacobelli, M., Juette, E., Karastergiou, A., Kohler, J., Kondratiev, V. I., Kuniyoshi, M., Kuper, G., van Leeuwen, J., Maat, P., McFadden, R., McKay-Bukowski, D., Orru, E., Paas, H., Pandey-Pommier, M., Pandey, V. N., Pizzo, R., Polatidis, A. G., Reich, W., Röttgering, H., Schwarz, D., Serylak, M., Sluman, J., Smirnov, O., Tasse, C., Toribio, M. C., Vermeulen, R., van Weeren, R. J., Wijers, R. A. M. J., Wucknitz, O., and Zarka, P.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Air showers induced by cosmic rays create nanosecond pulses detectable at radio frequencies. These pulses have been measured successfully in the past few years at the LOw Frequency ARray (LOFAR) and are used to study the properties of cosmic rays. For a complete understanding of this phenomenon and the underlying physical processes, an absolute calibration of the detecting antenna system is needed. We present three approaches that were used to check and improve the antenna model of LOFAR and to provide an absolute calibration of the whole system for air shower measurements. Two methods are based on calibrated reference sources and one on a calibration approach using the diffuse radio emission of the Galaxy, optimized for short data-sets. An accuracy of 19% in amplitude is reached. The absolute calibration is also compared to predictions from air shower simulations. These results are used to set an absolute energy scale for air shower measurements and can be used as a basis for an absolute scale for the measurement of astronomical transients with LOFAR., Comment: 34 pages, 10 figures
- Published
- 2015
- Full Text
- View/download PDF
42. Investigation of the radio wavefront of air showers with LOPES measurements and CoREAS simulations (ARENA 2014)
- Author
-
Schröder, F. G., Apel, W. D., Arteaga-Velazquez, J. C., Bähren, L., Bekk, K., Bertaina, M., Biermann, P. L., Blümer, J., Bozdog, H., Brancus, I. M., Cantoni, E., Chiavassa, A., Daumiller, K., de Souza, V., Di Pierro, F., Doll, P., Engel, R., Falcke, H., Fuchs, B., Fuhrmann, D., Gemmeke, H., Grupen, C., Haungs, A., Heck, D., Hörandel, J. R., Horneffer, A., Huber, D., Huege, T., Isar, P. G., Kampert, K. -H., Kang, D., Krömer, O., Kuijpers, J., Link, K., Luczak, P., Ludwig, M., Mathes, H. J., Melissas, M., Morello, C., Oehlschläger, J., Palmieri, N., Pierog, T., Rautenberg, J., Rebel, H., Roth, M., Rühle, C., Saftoiu, A., Schieler, H., Schmidt, A., Schoo, S., Sima, O., Toma, G., Trinchero, G. C., Weindl, A., Wochele, J., Zabierowski, J., and Zensus, J. A.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
We investigated the radio wavefront of cosmic-ray air showers with LOPES measurements and CoREAS simulations: the wavefront is of approximately hyperbolic shape and its steepness is sensitive to the shower maximum. For this study we used 316 events with an energy above 0.1 EeV and zenith angles below $45^\circ$ measured by the LOPES experiment. LOPES was a digital radio interferometer consisting of up to 30 antennas on an area of approximately 200 m x 200 m at an altitude of 110 m above sea level. Triggered by KASCADE-Grande, LOPES measured the radio emission between 43 and 74 MHz, and our analysis might strictly hold only for such conditions. Moreover, we used CoREAS simulations made for each event, which show much clearer results than the measurements suffering from high background. A detailed description of our result is available in our recent paper published in JCAP09(2014)025. The present proceeding contains a summary and focuses on some additional aspects, e.g., the asymmetry of the wavefront: According to the CoREAS simulations the wavefront is slightly asymmetric, but on a much weaker level than the lateral distribution of the radio amplitude., Comment: Proceedings of ARENA 2014, Anapolis, USA
- Published
- 2015
43. Improved absolute calibration of LOPES measurements and its impact on the comparison with REAS 3.11 and CoREAS simulations
- Author
-
Apel, W. D., Arteaga-Velazquez, J. C., Bähren, L., Bekk, K., Bertaina, M., Biermann, P. L., Blümer, J., Bozdog, H., Brancus, I. M., Cantoni, E., Chiavassa, A., Daumiller, K., de Souza, V., Di Pierro, F., Doll, P., Engel, R., Falcke, H., Fuchs, B., Gemmeke, H., Grupen, C., Haungs, A., Heck, D., Hiller, R., Hörandel, J. R., Horneffer, A., Huber, D., Huege, T., Isar, P. G., Kampert, K. -H., Kang, D., Krömer, O., Kuijpers, J., Link, K., Luczak, P., Ludwig, M., Mathes, H. J., Melissas, M., Morello, C., Nehls, S., Oehlschläger, J., Palmieri, N., Pierog, T., Rautenberg, J., Rebel, H., Roth, M., Rühle, C., Saftoiu, A., Schieler, H., Schmidt, A., Schoo, S., Schröder, F. G., Sima, O., Toma, G., Trinchero, G. C., Weindl, A., Wochele, J., Zabierowski, J., and Zensus, J. A.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
LOPES was a digital antenna array detecting the radio emission of cosmic-ray air showers. The calibration of the absolute amplitude scale of the measurements was done using an external, commercial reference source, which emits a frequency comb with defined amplitudes. Recently, we obtained improved reference values by the manufacturer of the reference source, which significantly changed the absolute calibration of LOPES. We reanalyzed previously published LOPES measurements, studying the impact of the changed calibration. The main effect is an overall decrease of the LOPES amplitude scale by a factor of $2.6 \pm 0.2$, affecting all previously published values for measurements of the electric-field strength. This results in a major change in the conclusion of the paper 'Comparing LOPES measurements of air-shower radio emission with REAS 3.11 and CoREAS simulations' published in Astroparticle Physics 50-52 (2013) 76-91: With the revised calibration, LOPES measurements now are compatible with CoREAS simulations, but in tension with REAS 3.11 simulations. Since CoREAS is the latest version of the simulation code incorporating the current state of knowledge on the radio emission of air showers, this new result indicates that the absolute amplitude prediction of current simulations now is in agreement with experimental data., Comment: Partly changes results and conclusion of publication Astroparticle Physics 50-52 (2013) 76-91 (arXiv:1309.5920)
- Published
- 2015
- Full Text
- View/download PDF
44. The peculiar radio galaxy 4C 35.06: a case for recurrent AGN activity?
- Author
-
Shulevski, A., Morganti, R., Barthel, P. D., Murgia, M., van Weeren, R. J., White, G. J., Brüggen, M., Kunert-Bajraszewska, M., Jamrozy, M., Best, P. N., Röttgering, H. J. A., Chyzy, K. T., de Gasperin, F., Bîrzan, L., Brunetti, G., Brienza, M., Rafferty, D. A., Anderson, J., Beck, R., Deller, A., Zarka, P., Schwarz, D., Mahony, E., Orrú, E., Bell, M. E., Bentum, M. J., Bernardi, G., Bonafede, A., Breitling, F., Broderick, J. W., Butcher, H. R., Carbone, D., Ciardi, B., de Geus, E., Duscha, S., Eislöffel, J., Engels, D., Falcke, H., Fallows, R. A., Fender, R., Ferrari, C., Frieswijk, W., Garrett, M. A., Grießmeier, J., Gunst, A. W., Heald, G., Hoeft, M., Hörandel, J., Horneffer, A., van der Horst, A. J., Intema, H., Juette, E., Karastergiou, A., Kondratiev, V. I., Kramer, M., Kuniyoshi, M., Kuper, G., Maat, P., Mann, G., McFadden, R., McKay-Bukowski, D., McKean, J. P., Meulman, H., Mulcahy, D. D., Munk, H., Norden, M. J., Paas, H., Pandey-Pommier, M., Pizzo, R., Polatidis, A. G., Reich, W., Rowlinson, A., Scaife, A. M. M., Serylak, M., Sluman, J., Smirnov, O., Steinmetz, M., Swinbank, J., Tagger, M., Tang, Y., Tasse, C., Thoudam, S., Toribio, M. C., Vermeulen, R., Vocks, C., Wijers, R. A. M. J., Wise, M. W., and Wucknitz, O.
- Subjects
Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Using observations obtained with the LOw Fequency ARray (LOFAR), the Westerbork Synthesis Radio Telescope (WSRT) and archival Very Large Array (VLA) data, we have traced the radio emission to large scales in the complex source 4C 35.06 located in the core of the galaxy cluster Abell 407. At higher spatial resolution (~4"), the source was known to have two inner radio lobes spanning 31 kpc and a diffuse, low-brightness extension running parallel to them, offset by about 11 kpc (in projection). At 62 MHz, we detect the radio emission of this structure extending out to 210 kpc. At 1.4 GHz and intermediate spatial resolution (~30"), the structure appears to have a helical morphology. We have derived the characteristics of the radio spectral index across the source. We show that the source morphology is most likely the result of at least two episodes of AGN activity separated by a dormant period of around 35 Myr. The AGN is hosted by one of the galaxies located in the cluster core of Abell 407. We propose that it is intermittently active as it moves in the dense environment in the cluster core. Using LOFAR, we can trace the relic plasma from that episode of activity out to greater distances from the core than ever before. Using the the WSRT, we detect HI in absorption against the center of the radio source. The absorption profile is relatively broad (FWHM of 288 km/s), similar to what is found in other clusters. Understanding the duty cycle of the radio emission as well as the triggering mechanism for starting (or restarting) the radio-loud activity can provide important constraints to quantify the impact of AGN feedback on galaxy evolution. The study of these mechanisms at low frequencies using morphological and spectral information promises to bring new important insights in this field., Comment: 10 pages, 6 figures. Accepted to A&A
- Published
- 2015
- Full Text
- View/download PDF
45. Mass spectrometry imaging highlights dynamic patterns of lipid co‐expression with Aβ plaques in mouse and human brains.
- Author
-
Huang, Helen Xuexia, Inglese, Paolo, Tang, Jiabin, Yagoubi, Riad, Correia, Gonçalo D. S., Horneffer‐van der Sluis, Verena M., Camuzeaux, Stephane, Wu, Vincen, Kopanitsa, Maksym V., Willumsen, Nanet, Jackson, Johanna S., Barron, Anna M., Saito, Takashi, Saido, Takaomi C., Gentlemen, Steve, Takats, Zoltan, and Matthews, Paul M.
- Subjects
MASS spectrometry ,ALZHEIMER'S disease ,CEREBROSPINAL fluid examination ,CERAMIDES ,MICE ,LIPIDS - Abstract
Lipids play crucial roles in the susceptibility and brain cellular responses to Alzheimer's disease (AD) and are increasingly considered potential soluble biomarkers in cerebrospinal fluid (CSF) and plasma. To delineate the pathological correlations of distinct lipid species, we conducted a comprehensive characterization of both spatially localized and global differences in brain lipid composition in AppNL‐G‐F mice with spatial and bulk mass spectrometry lipidomic profiling, using human amyloid‐expressing (h‐Aβ) and WT mouse brains controls. We observed age‐dependent increases in lysophospholipids, bis(monoacylglycerol) phosphates, and phosphatidylglycerols around Aβ plaques in AppNL‐G‐F mice. Immunohistology‐based co‐localization identified associations between focal pro‐inflammatory lipids, glial activation, and autophagic flux disruption. Likewise, in human donors with varying Braak stages, similar studies of cortical sections revealed co‐expression of lysophospholipids and ceramides around Aβ plaques in AD (Braak stage V/VI) but not in earlier Braak stage controls. Our findings in mice provide evidence of temporally and spatially heterogeneous differences in lipid composition as local and global Aβ‐related pathologies evolve. Observing similar lipidomic changes associated with pathological Aβ plaques in human AD tissue provides a foundation for understanding differences in CSF lipids with reported clinical stage or disease severity. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
46. Failure Resilient Traffic Engineering Using Segment Routing.
- Author
-
Timmy Schüller, Nils Aschenbruck, Markus Chimani, and Martin Horneffer
- Published
- 2019
- Full Text
- View/download PDF
47. Final results of the LOPES radio interferometer for cosmic-ray air showers
- Author
-
W. D. Apel, J. C. Arteaga-Velázquez, L. Bähren, K. Bekk, M. Bertaina, P. L. Biermann, J. Blümer, H. Bozdog, E. Cantoni, A. Chiavassa, K. Daumiller, V. de Souza, F. Di Pierro, P. Doll, R. Engel, H. Falcke, B. Fuchs, H. Gemmeke, C. Grupen, A. Haungs, D. Heck, J. R. Hörandel, A. Horneffer, D. Huber, T. Huege, P. G. Isar, K.-H. Kampert, D. Kang, O. Krömer, J. Kuijpers, K. Link, P. Łuczak, M. Ludwig, H. J. Mathes, M. Melissas, C. Morello, S. Nehls, J. Oehlschläger, N. Palmieri, T. Pierog, J. Rautenberg, H. Rebel, M. Roth, C. Rühle, A. Saftoiu, H. Schieler, A. Schmidt, S. Schoo, F.G. Schröder, O. Sima, G. Toma, G. C. Trinchero, A. Weindl, J. Wochele, J. Zabierowski, J. A. Zensus, and LOPES Collaboration
- Subjects
Astrophysics ,QB460-466 ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract LOPES, the LOFAR prototype station, was an antenna array for cosmic-ray air showers operating from 2003 to 2013 within the KASCADE-Grande experiment. Meanwhile, the analysis is finished and the data of air-shower events measured by LOPES are available with open access in the KASCADE Cosmic Ray Data Center (KCDC). This article intends to provide a summary of the achievements, results, and lessons learned from LOPES. By digital, interferometric beamforming the detection of air showers became possible in the radio-loud environment of the Karlsruhe Institute of Technology (KIT). As a prototype experiment, LOPES tested several antenna types, array configurations and calibration techniques, and pioneered analysis methods for the reconstruction of the most important shower parameters, i.e., the arrival direction, the energy, and mass-dependent observables such as the position of the shower maximum. In addition to a review and update of previously published results, we also present new results based on end-to-end simulations including all known instrumental properties. For this, we applied the detector response to radio signals simulated with the CoREAS extension of CORSIKA, and analyzed them in the same way as measured data. Thus, we were able to study the detector performance more accurately than before, including some previously inaccessible features such as the impact of noise on the interferometric cross-correlation beam. These results led to several improvements, which are documented in this paper and can provide useful input for the design of future cosmic-ray experiments based on the digital radio-detection technique.
- Published
- 2021
- Full Text
- View/download PDF
48. The Words We Use, the Actions We Take, and the Perceptions We Hold: First-step assessments to inform wellness curricula and burnout prevention programming
- Author
-
Karen Horneffer-Ginter, Jeffrey Greene, Lisa Graves, Kristine Gibson, Roger Apple, Julia Tullio, and Adrienne Kaufman
- Subjects
wellness curricula ,burnout ,medical school ,Medicine ,Psychology ,BF1-990 - Abstract
Introduction: In response to concerns about burnout, many medical schools have been initiating wellness curricula and programming. A key to the success of these efforts is having engagement from targeted audiences. Gathering input from these groups regarding preferred lexicon, wellness actions, and perceptions of judgement or guilt around such actions can help in developing and promoting such curricular and programmatic offerings. Engagement is especially important when it comes to the predictors of burnout (e.g., self-care, self-compassion, and emotional self-disclosure). Methods: Utilizing a focus-group methodology as a preliminary step, medical school faculty and students discussed terms regarding burnout predictors. Thematic analysis using grounded theory was used to analyze transcriptions with the generated preferred terms being incorporated into a follow-up survey. Surveys were completed by 23 faculty, 65 students, 23 residents, and 124 staff (n = 235). The survey asked for ranked preferences of lexicon terms, ratings of engagement and importance around wellness actions, perceptions of judgement and guilt around engaging in self-care, and disengagement and exhaustion via the Oldenburg Burnout Inventory. Results: Overall, results revealed a preference for alternative language (i.e., “personal well-being” (p < 0.001), “being kind to yourself” (p < 0.001), “sharing your feelings” (p < 0.001)) compared to phrases commonly used in the wellness literature (i.e., self-care, self-compassion, and emotional self-disclosure). Engagement in self-care (p < 0.001), and self-compassion actions (p = 0.001) were inversely correlated with burnout, while perceptions of being judged (p < 0.001) and feeling guilty for self-care (p < 0.001) were positively correlated with burnout. Conclusion: Incorporating preferred lexicon terms and mitigation factors (correlating with the reduction of burnout) into wellness curricular development is encouraged as a valuable initial step for medical schools and organizations as they reach out to their intended audiences.
- Published
- 2021
- Full Text
- View/download PDF
49. Randomised controlled monocentric trial to compare the impact of using professional actors or peers for communication training in a competency-based inverted biochemistry classroom in preclinical medical education
- Author
-
Achim Schneider, Christoph Nikendei, David Alexander Christian Messerer, Astrid Horneffer, Michael Kuhl, Veronika Kühn, Till Johannes Bugaj, and Susanne Julia Kühl
- Subjects
Medicine - Abstract
Objective In medical education, biochemistry topics are usually knowledge based, and students often are unaware of their clinical relevance. To improve students’ awareness of the relevance, we integrated communication skills training into biochemistry education. No studies before have examined the difference between peer and standardised patient (SP) role plays where students explain the biochemical background of a disease in patient-centred language. Therefore, we evaluated whether students’ self-perceived competency in Canadian Medical Education Directives for Specialists (CanMEDS) roles and their opinion of the quality of role play differ if the layperson is played by peers or SPs.Methods We randomly assigned medical students in a preclinical semester to one of the two groups. The groups used predefined scripts to role play a physician–parent consultation with either a peer (peer group) or an SP (SP group) in the parent role. Students then assessed the activity’s effects on their competency in CanMEDS roles and motivation and the relevance of the role play. To determine whether students achieved biochemistry learning goals, we evaluated results of a biochemistry exam.Results Students’ self-perceived competency improved in both groups. The SP group rated their competency in the roles ‘Scholar’ and ‘Professional’ significantly higher than the peer group did. The peer group rated their competency in the role of ‘Medical Expert’ significantly higher if they played the role of the parent rather than physician or observer. The SP group agreed more that they were motivated by the role play and wanted to receive more role play-based teaching. The SP group perceived the role play as being realistic and rated the feedback discussion as more beneficial. The examination results were the same in both groups.Conclusion We showed that role plays in a biochemistry seminar improve students’ self-perceived competency. The use of SPs has some advantages, such as being more realistic.
- Published
- 2022
- Full Text
- View/download PDF
50. Measuring a Cherenkov ring in the radio emission from air showers at 110-190 MHz with LOFAR
- Author
-
Nelles, A., Schellart, P., Buitink, S., Corstanje, A., de Vries, K. D., Enriquez, J. E., Falcke, H., Frieswijk, W., Hörandel, J. R., Scholten, O., ter Veen, S., Thoudam, S., Akker, M. van den, Anderson, J., Asgekar, A., Bell, M. E., Bentum, M. J., Bernardi, G., Best, P., Bregman, J., Breitling, F., Broderick, J., Brouw, W. N., Brüggen, M., Butcher, H. R., Ciardi, B., Deller, A., Duscha, S., Eislöffel, J., Fallows, R. A., Garrett, M. A., Gunst, A. W., Hassall, T. E., Heald, G., Horneffer, A., Iacobelli, M., Juette, E., Karastergiou, A., Kondratiev, V. I., Kramer, M., Kuniyoshi, M., Kuper, G., Maat, P., Mann, G., Mevius, M., Norden, M. J., Paas, H., Pandey-Pommier, M., Pietka, G., Pizzo, R., Polatidis, A. G., Reich, W., Röttgering, H., Scaife, A. M. M., Schwarz, D., Smirnov, O., Stapper, B. W., Steinmetz, M., Stewart, A., Tagger, M., Tang, Y., Tasse, C., Vermeulen, R., Vocks, C., van Weeren, R. J., Wijnholds, S. J., Wucknitz, O., Yatawatta, S., and Zarka, P.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Measuring radio emission from air showers offers a novel way to determine properties of the primary cosmic rays such as their mass and energy. Theory predicts that relativistic time compression effects lead to a ring of amplified emission which starts to dominate the emission pattern for frequencies above ~100 MHz. In this article we present the first detailed measurements of this structure. Ring structures in the radio emission of air showers are measured with the LOFAR radio telescope in the frequency range of 110 - 190 MHz. These data are well described by CoREAS simulations. They clearly confirm the importance of including the index of refraction of air as a function of height. Furthermore, the presence of the Cherenkov ring offers the possibility for a geometrical measurement of the depth of shower maximum, which in turn depends on the mass of the primary particle., Comment: 20 pages, 10 figures, accpeted for publication in Astroparticle Physics
- Published
- 2014
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.