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We present a review of the latest framework achievements in geoarchaeological sciences applied to microstratigraphic and biomolecular studies of prehistoric archaeological contexts, highlighting the importance of musealized archaeological stratigraphies. We assess how today's scientific and technological accomplishments can be tailored for archaeological human ecology studies with analytical ensembles that provide unprecedented results. Sampling and processing workflows originating from resin consolidation and thin section micromorphology of undisturbed blocks of archaeological soils and sediments, guarantee subsampling accuracy at the micrometre scale granting access to individual components otherwise impossible to target: the achievable information yield makes even the smallest soil samples potential sources of pioneering discoveries. Yet, archaeological excavations are still the primary mode of retrieving new soil samples. We argue that, when dealing with archaeological sites that were excavated and partially musealised in the past, the exploration of related museum collections should be prioritized as perspective source of new study samples. Analysing old and potentially very informative samples, with an approach that we define as “Green Archaeology”, may represent a source of well-structured primary data as well as a means for planning new excavations, delivering novel discoveries while safeguarding site integrity and promoting Third Mission valorisation of sites and heritage dormant collections.

Abstract Tells are multi-layered, archaeological mounds representing anthropogenic landforms common in arid regions. In such contexts, the preservation of the archaeological record is mined by ongoing climate changes, shift in land use, and intense human overgrazing. Such natural and human-driven factors tune the response of archaeological soils and sediments to erosion. Geomorphology offers a plethora of tools for mapping natural and anthropogenic landforms and evaluating their response to unremitting weathering, erosional and depositional processes. Here, we present a geomorphological investigation on two anthropogenic mounds in the Kurdistan Region of Iraq, with a special focus on the ongoing erosional processes mining their slope stability and threatening the preservation of the local archaeological landscape. Applying the revised universal soil loss equation model for soil loess derived from UAV imagery and implemented with geoarchaeological investigation, we assess the erosion rate along anthropogenic mounds and estimate the risk of losing archaeological deposits. We argue that a large-scale application of our approach in arid and semi-arid regions may improve our ability to (i) estimate the rate of soil and/or archaeological sediments loss, (ii) propose mitigation strategies to prevent the dismantling of the archaeological record, and (iii) schedule archaeological operations in areas of moderate to extreme erosion risk.

ABSTRACTWe present the result of the geomorphological mapping of the central sector of the Kurdistan Region of Iraq. Therein, landscape evolution was mostly overseen by the regional geodynamic, related to the Arabia-Eurasia convergence, and in the Quaternary, regional climate fluctuations contributed to shaping landforms. The combination of such processes affected the distribution, types, and evolution of landforms (related to structural, hillslope, fluvial, and karst processes), with a noteworthy influence on the development of the local drainage network, which belongs to Tigris River catchment. The Great Zab and Little Zab Rivers – the main left tributaries of Tigris River – progressively cut anticline ridges growing in the area. Our analyses suggest that the structural deformation of the Zagros also controlled the evolution of the low-order channels of the hydrographic network. Since the Holocene, landforms dynamic was altered by intense human exploitation of the landscape and increased fluctuations between arid and humid conditions.

Abstract In the first millennia of the Holocene, human communities in the Fertile Crescent experienced drastic cultural and technological transformations that modified social and human-environments interactions, ultimately leading to the rise of complex societies. The potential influence of climate on this “Neolithic Revolution” has long been debated. Here we present a speleothem record from the Kurdistan Region of Iraq, covering from Early Neolithic to Early Chalcolithic periods (~ 11 to 7.3 ka, 9000–5300 BCE). The record reveals the influence of the Siberian High on regional precipitation, and shows large hydroclimatic variability at the multicentennial scale. In particular, it highlights wetter conditions between 9.7 and 9.0 ka, followed by an abrupt reduction of precipitation between 9.0 and 8.5 ka, and a wetter interval between 8.5 and 8.0 ka. A comparison with regional and local archaeological data demonstrates an influence of recorded hydroclimatic changes on settlement patterns (size, distribution, permanent vs. seasonal occupation) and on the exploitation of water resources by Neolithic to Chalcolithic populations. Our record does not show prominent hydroclimatic changes at 9.3 and 8.2 ka, thus not supporting direct influence of such rapid and widespread events on the process of Neolithization and its cultural dispersal.

Here we present a compendium of 212 photographs of archaeological soils and sediments thin sections (micrographs) from the backfill of the Sennacherib Assyrian canal system of Northern Mesopotamia. The micrographs were produced using an optical petrographic microscope (Olympus BX41) mounting a digital camera (Olympus E420) for image acquisition. The dataset is composed of two folders containing (1) every micrograph in full resolution JPEG, and (2) a PDF file with scale bars and brief captions for each one. The dataset represents a photographic comparison collection for individuals working on similar geoarchaeological contexts and can be used for the composition of figures in novel publications, as well as being the first example of published large compendium for shared use in the field of archaeology.

Las secuelas producidas por un accidente cerebro vascular (ACV) impactan en el desempeño ocupacional y restringen la participación de la persona en sus roles ocupacionales. C. es una adulta joven de 31 años quien, luego de haber sufrido un ACV isquémico ingresa a un centro de rehabilitación de pacientes con lesión neurológica en modalidad de internación y recibe tratamiento de terapia ocupacional. Desde éste área se realiza un abordaje a partir de la planificación e implementación de intervenciones centradas en la persona, estableciendo los objetivos a corto y mediano plazo de manera colaborativa. La eficacia de estas intervenciones fueron medidas utilizando herramientas de evaluación específicas para documentar los cambios producidos entre el ingreso y el alta de internación. El reporte de este caso expone la implementación de estos abordajes en el proceso de rehabilitación de C. en el cual logró mejorar su desempeño ocupacional e incrementar su participación en ocupaciones significativas.

We present a geomorphological map of the Cilo Mountain range located in southeast Turkey that illustrates the recent evolution of the second-most glacierized area of Turkey. The map was produced by the manual delineating of landforms from highresolution satellite imagery (Pleiades and Google EarthTM images). Cilo Mountain glaciation played a crucial role in the evolution of the local physical landscape and even today glaciers are significant features. After the termination of Little Ice Age, deglaciation promoted the onset of multiple and intense surface processes; widespread slope instabilities, due to permafrost melting and frost weathering processes, are still the most active processes. Such processes are further promoted by the scarcity of vegetation. The occurrence of several proglacial lakes significantly contributes to the reduction of sediment output from glaciated watersheds, influencing the evolution of proglacial plains and resulting in a variety of landforms that we identified and described in this work.

Abstract The late Middle Pleistocene, starting at around 300 ka, witnessed large-scale biological and cultural dynamics in hominin evolution across Africa including the onset of the Middle Stone Age that is closely associated with the evolution of our species—Homo sapiens. However, archaeological and geochronological data of its earliest appearance are scarce. Here we report on the late Middle Pleistocene sequence of Wadi Lazalim, in the Sahara of Southern Tunisia, which has yielded evidence for human occupations bracketed between ca. 300–130 ka. Wadi Lazalim contributes valuable information on the spread of early MSA technocomplexes across North Africa, that likely were an expression of large-scale diffusion processes.

We present the geomorphological map of the northwestern part of the Kurdistan Region of Iraq, where the landscape expresses the tectonic activity associated with the Arabia-Eurasia convergence and Neogene climate change. These processes influenced the evolution of landforms and fluvial pathways, where major rivers Tigris, Khabur, and Great Zab incise the landscape of Northeastern Mesopotamia Anticlinal ridges and syncline trough compose the Zagros orogen. The development of water and wind gaps, slope, and karsts processes in the highlands and the tilting of fluvial terraces in the flat areas are the main evidence of the relationship between tectonics, climate variations and geomorphological processes. During the Quaternary, especially after the Last Glacial Maximum, fluctuating arid and wet periods also influenced local landforms and fluvial patterns of the area. Finally, the intensified Holocene human occupation and agricultural activities during the passage to more complex societies over time impacted the evolution of the landscape in this part of Mesopotamia.

We present the geomorphology of the Southern Atbai Plain (Eastern Sudan) and the western edge of the Eritrean Highlands (Western Eritrea), in the eastern Sahel. The mountainous area consists of Paleo-Proterozoic gneiss and Neo-Proterozoic igneous rocks and meta-volcanic assemblages shaped as inselbergs and whaleback landforms by weathering. Bare-rock hills emerge from a gentle glacis that oversees the Southern Atbai alluvial plain, located between the Atbara and Gash Rivers. The plain features the SSE-NNW-oriented endorheic terminal fan of the Gash River and is crossed by intricate Early to Late Pleistocene paleochannels, whose evolution was controlled by the interplay between Quaternary regional tectonics and arid to humid climatic and environmental oscillations. The map is intended to interpret the evolution of local landscape, thus representing a tool for reconstructing the spatial and temporal distribution of Late Quaternary archaeological features and their functional relationships with the fossil fluvial system and the western foothills.

BackgroundAdults with ADHD exhibit a neuropsychological profile that may present deficits in many cognitive domains, particularly attention and executive functions (EFs). However, some authors do not consider executive disfunction as an important part of the clinical profile of the syndrome; this could be related to the use of inappropriate neuropsychological tests, probably not adapted and not sufficiently ecological. Moreover, new data are required on specific correlation of attentive-executive symptoms with socio-demographic factors. Therefore, the aim of this study is to analyze the neuropsychological performance of a group of adults with ADHD, also evaluating the influence of gender, age and education level.MethodsWe retrospectively collected health-related personal data of 40 adult ADHD patients, clinically diagnosed and evaluated via a battery of 4 neuropsychological tests and 1 self-administered questionnaire. Gender, age and years of education differences were assessed.ResultsAttention and EFs deficits have been highlighted mainly on the d2-R and 5-point neuropsychological tests, which therefore seem to be more sensitive in measuring the attention-executive dysfunction in an adult ADHD population, than TAP Go/No-go and ROCFT. ADHD patients also manifested subjective behavioral impulsivity disorders on BIS-11. There were no statistically significant gender differences in cognitive performance. On the contrary, younger patients performed worse on subscales TAP Go/No-go errors and 5-points number of drawings, while participants with a higher education level performed better on subscales d2-R speed of execution and d2-R errors. This supports a reduction in the number of errors and the execution time as a function of older age and a higher level of education. Finally, patients with higher education also self-reported greater impulsivity in planning.ConclusionOur preliminary findings suggest that adult ADHD is not a lifelong stable disorder, but it may change over time. Moreover, attention-executive deficits may be influenced and partially counterbalanced by experience (i.e., advancing age) and a higher level of education. This could underlie the development of specific psycho-behavioral and cognitive compensatory strategies. The use of self-administered questionnaires is therefore recommended to highlight attentional and executive difficulties that may not result in neuropsychological tests.

The focus of this systematic review was to collect and align studies which analyze the functionality of theory of mind (TOM) in patients with mild cognitive impairments (MCI). Specifically, we identified 20 papers published between 2012 and 2022 which met inclusion criteria. Papers search, selection, and extraction followed the PRISMA guidelines. In order to summarize data from the papers, we used a narrative synthesis approach. Results in 18 of these 20 papers show that theory of mind (TOM) is impaired in all types of MCI patients—regardless of different etiology and diagnostic criteria. Only 2 out of 20 reported no significant differences in TOM performance between MCI patients and healthy control subjects. The review additionally aimed to bundle the variety of the type of tasks used by the author to assess multiple domains of TOM. This heterogeneity does not allow us to make a comprehensive comparison between the results, so we suggest the need to align the results using the same type of tests and TOM assessment. In the end, our work highlights the 2 neuropsychological studies which confirm more of our results; due to the objective approach adopted to investigate this topic, we suggest exploring this point of view more in future research.

The purpose of this study was to investigate emotion recognition and processing in patients with mild cognitive impairment (MCI) in order to update the state of current literature on this important but undervalued topic. We identified 15 papers published between 2012 and 2022 that meet the inclusion criteria. Paper search, selection, and extraction followed the PRISMA guidelines. We used a narrative synthesis approach in order to report a summary of the main findings taken from all papers. The results collected are still ambiguous: some studies did not find any differences between MCI and healthy controls (HC) groups in emotion recognition and processing, and other results reported emotion-specific deficits in emotion recognition regarding MCI patients (both regarding negative and neutral emotions). It is essential to underline that these findings could not be generalized to the whole MCI population due to the heterogeneous use of measures and composition of the sample. This does not allow us to make a comprehensive comparison between the results. Our suggestion for future research is to align the results using the same type of tests and emotion recognition assessment.

Khartoum is one of the largest cities in Africa, located immediately south of the junction of the Blue and White Nile rivers in central Sudan. The growth of the Greater Khartoum-Omdurman conurbation arose – without a proper urban plan – from the agricultural wealth created through the completion of three dams, and mostly in the last three decades. Urban expansion was enabled by and helped to enhance the major agricultural expansion of the Gezira clay plains located to the south between the lower Blue and White Nile rivers. The region has been a focus of human settlement for at least 8,000 years, initially by semi-sedentary groups with a fishing-hunting-gathering lifestyle and later by Neolithic groups as shown by hundreds of archaeological sites. Today, Khartoum is a desert city, still very vulnerable to floods triggered by intense convectional storms. Such extreme events may become more common in future, representing a major geomorphological hazard. Moreover, uncontrolled urban and agricultural development is threatening most of the cultural heritage of the region.

Abstract The onset of the Acheulean, marked by the emergence of large cutting tools (LCTs), is considered a major technological advance in the Early Stone Age and a key turning point in human evolution. The Acheulean originated in East Africa at ~ 1.8–1.6 Ma and is reported in South Africa between ~ 1.6 and > 1.0 Ma. The timing of its appearance and development in North Africa have been poorly known due to the near-absence of well-dated sites in reliable contexts. The ~ 1 Ma stone artefacts of Tighennif (Algeria) and Thomas Quarry I-Unit L (ThI-L) at Casablanca (Morocco) are thus far regarded as documenting the oldest Acheulean in North Africa but whatever the precision of their stratigraphical position, both deserve a better chronology. Here we provide a chronology for ThI-L, based on new magnetostratigraphic and geochemical data. Added to the existing lithostratigraphy of the Casablanca sequence, these results provide the first robust chronostratigraphic framework for the early North African Acheulean and firmly establish its emergence in this part of the continent back at least to ~ 1.3 Ma.

The aim of this systematic review was to collect and align the research on social cognition impairments in adults with Attention-deficit/hyperactivity disorder (ADHD). In particular, we selected and analyzed papers on emotion recognition and processing, Theory of Mind (TOM), empathy, and other facets of social cognition as decision making. We identified 16 papers published between 2012 and 2022 which meet inclusion criteria. Papers search, selection, and extraction followed the PRISMA guidelines. In order to summarize data from papers, we used a narrative synthesis approach. Results show different evidence of impairment in social cognition domains in adults with ADHD. Our systematic review suggests the importance of promoting more research on this topic because it is essential to keep in mind that social cognition plays a central role in socialization and social relationships.

Since the end of the Little Ice Age (LIA, ~1830), the accelerated glaciers’ shrinkage along mid-latitude high mountain areas promoted a quick readjustment of geomorphological processes with the onset of the paraglacial dynamic, making proglacial areas among the most sensitive Earth’s landscapes to ongoing climate change. A potentially useful remote-sensing method for investigating such dynamic areas is the DEM (Digital Elevation Model) of Difference (DoD) technique, which quantifies volumetric changes in a territory between successive topographic surveys. After a detailed geomorphological analysis and comparison with historical maps of the Martello Valley (central Italian Alps), we applied the DoD for reconstructing post-LIA deglaciation dynamics and reported on the surface effects of freshly-onset paraglacial processes. The head of the valley is still glacierized, with three main ice bodies resulting from the huge reduction of a single glacier present at the apogee of the LIA. Aftermath: the glaciers lose 60% of their initial surface area, largely modifying local landforms and expanding the surface of the proglacial areas. The DoD analysis of the 2006–2015 timeframe (based on registered DEM derived from LiDAR—Light Detection and Ranging—data) highlights deep surface elevation changes ranging from +38 ± 4.01 m along the foot of rock walls, where gravitative processes increased their intensity, to −47 ± 4.01 m where the melting of buried ice caused collapses of the proglacial surface. This approach permits estimating the volume of sediments mobilized and reworked by paraglacial processes. Here, in less than 10 years, −23,675 ± 1165 m3 of sediment were removed along the proglacial area and transported down valley, highlighting the dynamicity of proglacial areas.

Abstract Background The term sepsis is used to designate a systemic condition of infection and inflammation associated with hemodynamic changes that result in organic dysfunction. Gestational sepsis can impair the development of the central nervous system and may promote permanent behavior alterations in the offspring. The aim of our work was to evaluate the effects of maternal sepsis on inflammatory cytokine levels and synaptic proteins in the hippocampus, neocortex, frontal cortex, and cerebellum of neonatal, young, and adult mice. Additionally, we analyzed the motor development, behavioral features, and cognitive impairments in neonatal, young and adult offspring. Methods Pregnant mice at the 14th embryonic day (E14) were intratracheally instilled with saline 0.9% solution (control group) or Klebsiella spp. (3 × 108 CFU) (sepsis group) and started on meropenem after 5 h. The offspring was sacrificed at postnatal day (P) 2, P8, P30, and P60 and samples of liver, lung, and brain were collected for TNF-α, IL-1β, and IL-6 measurements by ELISA. Synaptophysin, PSD95, and β-tubulin levels were analyzed by Western blot. Motor tests were performed at all analyzed ages and behavioral assessments were performed in offspring at P30 and P60. Results Gestational sepsis induces a systemic pro-inflammatory response in neonates at P2 and P8 characterized by an increase in cytokine levels. Maternal sepsis induced systemic downregulation of pro-inflammatory cytokines, while in the hippocampus, neocortex, frontal cortex, and cerebellum an inflammatory response was detected. These changes in the brain immunity were accompanied by a reduction of synaptophysin and PSD95 levels in the hippocampus, neocortex, frontal cortex, and cerebellum, in all ages. Behavioral tests demonstrated motor impairment in neonates, and depressive-like behavior, fear-conditioned memory, and learning impairments in animals at P30 and P60, while spatial memory abilities were affected only at P60, indicating that gestational sepsis not only induces an inflammatory response in neonatal mouse brains, but also affects neurodevelopment, and leads to a plethora of behavioral alterations and cognitive impairments in the offspring. Conclusion These data suggest that maternal sepsis may be causatively related to the development of depression, learning, and memory impairments in the litter.

(1) Background: Patients with mild cognitive impairment (MCI) often present impairment in executive functions (EFs). This study aimed to investigate the effect of high-frequency repetitive transcranial magnetic stimulation (rTMS) on EFs in patients with MCI. (2) Methods: A prospective trial was conducted on 11 patients with MCI. Participants underwent 25 min of 20 Hz rTMS for ten days on the right temporo-parietal junction (RTPJ) and medial prefrontal cortex (MPFC). Before (T0) and after rTMS treatment (T1), global cognitive profile and EFs were investigated using the Montreal cognitive assessment (MoCA), trial making test (TMT) A and B, and frontal assessment battery (FAB). Depression symptoms were assessed using the geriatric depression scale (GDS). Statistical analysis included Wilcoxon signed-rank test. (3) Results: After treatment, patients showed a significant improvement in the MoCA EFs subtask (T0 vs. T1, p = 0.015) and TMT-B (T0 vs. T1, p = 0.028). Five MCI patients with EF impairment showed full recovery of these deficits. No significant changes in the GDS were observed. (4) Conclusions: rTMS stimulation over the TPJ and MPFC induced significant short-term improvements in EFs in MCI patients. These findings suggest that the TPJ and MPFC may be involved in the attention-executive skills to redirect attention toward behaviorally relevant stimuli.

We present the results of the geomorphological mapping of a region of the Dhofar (Sultanate of Oman) including two contrasting physiographic units sharing a common drainage system into the Arabian Sea: the Jebel Qara limestone massif and the coastal plain of Salalah. Neogene to Quaternary tectonic activity controlled the formation of an extensive system of faults and caused the uplift of the Jebel Qara, forming structural escarpments. The massif underwent karstification and subsequent linear erosion. Today the Jebel is cut by a dendritic net of dry valleys, occasionally dammed by calcareous tufa dams. The transition between the southern escarpment of the Jebel and the plain below displays flat alluvial fans, bordered by a strip of beachrock, coastal dunes, and coastal lagoons, located in correspondence to estuaries. Dramatic soil erosion is evident, linked to intense human-triggered zoogeomorphological processes started in the Mid-Late Holocene after the introduction of pastoral land-use.

A propósito de una observación clínica que realiza una revisión sobre el síndrome de Plummer-Vinson, se estudian sus componentes c'líñícos, hematológicos, radiológicos y endoscópicos. El análisis de los conceptos patogénicos muestra la variedad de opiniones en el mecanismo de produ;::ción de esta curiosa afección, destacándose el valor de las perturbaciones hematológicas como elementos prínceps. La anemia hipocrómica microcítica, probablemente debida a perturbaciones en el metabolismo férrico y a la avitaminosis parecen ser los principales responsables de la situación. El diagnóstico se funda en el conocimiento del síndrome y en la pesquisa de sus componentes. El tratamiento exige la reposición de los elementos en déficit y una vigilancia permanente del paciente, dado el curso crónico de la enfermedad y su tendencia a rem1s10nes y exacerbaciones. Debe considerarse la posibilidad de la transformación neoplásica, lo que exige un control periódico de los pacientes portadores de este original síndrome.