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Post-course instructor ratings are a common practice at universities in Europe, Australia, and North America. Rather than solely describing teaching practice, however, such ratings may be associated with a range of non-pedagogical factors. We explored engineering students' instructor ratings at a large United States institution, investigating relationships between overall instructor rating and some of those non-pedagogical factors, including subject area, class size, and students' course grades. Instructor ratings were more favourable in humanities courses than in science or math courses, and students gave higher ratings to instructors who taught smaller class sizes. The strongest relationship existed between overall rating and students' course grades: students who received A's rated instructors an average 0.84 points higher on a 6-point scale than students who received F's. Students who withdrew from a course provided the lowest instructor ratings. When instructor ratings are used as metrics of teaching ability in discussions related to promotion, tenure, or salary adjustments, there is an inherent inequity in the system that must be acknowledged beyond already well-documented biases, as non-pedagogical factors often outside of the instructor's control may be significantly associated with those ratings.

We discuss various critiques of the research literature on flourishing. We fully agree with calls for greater attention to qualitative work, to cultural differences, and to questions of power and justice concerning flourishing. We argue, however, that in spite of notable differences in understandings of flourishing across cultures, there is also a great deal that is held in common, including on topics considered by some as more controversial, such as character and virtue. We also argue that while qualitative research and understanding is important, it is likewise important not to be dismissive of rigorous quantitative research even if certain groups find its results to be unappealing. We further propose that the best way to navigate diverse understandings of flourishing in pluralistic contexts is to identify those aspects of flourishing which are in fact held in common, and to promote these together, but then to acknowledge that certain understandings of flourishing will vary by culture or religious tradition, and to allow and enable each community to exposit, study, and promote flourishing, as it understands it, in critical dialogue with others.

Comparing outcomes for individuals remaining married to those for single or divorced individuals might overstate the positive effects of the decision to marry, since marriage carries an inherent risk of divorce and its associated negative outcomes. While a growing literature has examined marital transitions, confounding by past marital history remains a concern and only a limited set of outcomes have been examined. To address these issues, this study examined incident first-time marriage and incident divorce/separation in relation to multiple subsequent physical health, health behavior, psychological distress, and psychosocial well-being outcomes in a large sample of female nurses in the U.S.. Data from the Nurses' Health Study II were studied (1993 to 2015/2017 questionnaire wave, Nmarriage analyses = 11,830, Ndivorce/separation analyses = 73,018, interquartile range of baseline age = 35 to 42 years). A set of regression models were used to regress each outcome on marital transition status, adjusting for a wide range of initial health and wellbeing status in addition to other covariates. Bonferroni correction was performed to account for multiple testing. Among the initially never married, those who became married had lower mortality (RR = 0.65, 95%CI = 0.50, 0.84), lower risks of cardiovascular diseases (e.g., RRstroke = 0.64, 95%CI = 0.50, 0.82), greater psychological wellbeing and less psychological distress (e.g., ßdepressive symptoms = −0.10, 95%CI = -0.15, −0.06). Among the initially married, those who became divorced/separated had lower social integration (β = −0.15, 95%CI = -0.19, −0.11), greater psychosocial distress (e.g., RRdepression = 1.23, 95%CI = 1.10, 1.37), and possibly greater risks of mortality, cardiovascular diseases, and smoking. Future research could study similar questions using data from more recent cohorts, examine potential mechanisms and heterogeneity, and also examine alternative social relationship types.

Female cancer patients who have undergone chemotherapy have an elevated risk of developing ovarian dysfunction and failure. Experimental approaches to treat iatrogenic infertility are evolving rapidly; however, challenges and risks remain that hinder clinical translation. Biomaterials have improved in vitro follicle maturation and in vivo transplantation in mice, but there has only been marginal success for early-stage human follicles. Here, we developed methods to obtain an ovarian-specific extracellular matrix hydrogel to facilitate follicle delivery and establish an in situ ovary (ISO), which offers a permissive environment to enhance follicle survival. We demonstrate sustainable follicle engraftment, natural pregnancy, and the birth of healthy pups after intraovarian microinjection of isolated exogenous follicles into chemotherapy-treated (CTx) mice. Our results confirm that hydrogel-based follicle microinjection could offer a minimally invasive delivery platform to enhance follicle integration for patients post-chemotherapy.

The trace magnetic power spectrum in the solar wind is known to be characterized by a double power law at scales much larger than the proton gyro-radius, with flatter spectral exponents close to −1 found at the lower frequencies below an inertial range with indices closer to [−1.5, −1.67]. The origin of the 1/ f range is still under debate. In this study, we selected 109 magnetically incompressible solar wind intervals ( δ ∣ B ∣/∣ B ∣ ≪ 1) from Parker Solar Probe encounters 1–13 that display such double power laws, with the aim of understanding the statistics and radial evolution of the low-frequency power spectral exponents from Alfvén point up to 0.3 au. New observations from closer to the Sun show that in the low-frequency range solar wind, turbulence can display spectra much shallower than 1/ f , evolving asymptotically to 1/ f as advection time increases, indicating a dynamic origin for the 1/ f range formation. We discuss the implications of this result on the Matteini et al. conjecture for the 1/ f origin as well as example spectra displaying a triple power law consistent with the model proposed by Chandran et al., supporting the dynamic role of parametric decay in the young solar wind. Our results provide new constraints on the origin of the 1/ f spectrum and further show the possibility of the coexistence of multiple formation mechanisms.

Introduction: Fitted filtration performance of an N95 respirator may benefit from differing levels of instructions. Methods: Using a modified Occupational Safety and Health Administration fit test protocol, we measured fitted filtration efficiency for an N95 respirator in 21 screened, healthy participants given 4 levels of escalating instruction: (1) uninstructed (baseline), (2) written/pictorial manufacturer instructions, (3) step-by-step video demonstration, and (4) staff instruction (visual inspection of respirator fit and verbal suggestions to adjust when applicable). Results: Baseline fitted filtration efficiency was not significantly different between participants with or without previous experience of N95 use. Clear improvements in fitted filtration efficiency were observed progressing from baseline (average=86.1%) to manufacturer paper instructions (93.3%), video instructions (97.5%), and post staff intervention (98.3%). Baseline fitted filtration efficiency values were significantly lower than those after video instruction (p

Background: Over one-third of the U.S. population is exposed to unsafe levels of ozone (O3). Dietary supplementation with fish oil (FO) or olive oil (OO) has shown protection against other air pollutants. This study evaluates potential cardiopulmonary benefits of FO or OO supplementation against acute O3 exposure in young healthy adults. Methods: Forty-three participants (26 ± 4 years old; 47% female) were randomized to receive 3 g/day of FO, 3 g/day OO, or no supplementation (CTL) for 4 weeks prior to undergoing 2-hour exposures to filtered air and 300 ppb O3 with intermittent exercise on two consecutive days. Outcome measurements included spirometry, sputum neutrophil percentage, blood markers of inflammation, tissue injury and coagulation, vascular function, and heart rate variability. The effects of dietary supplementation and O3 on these outcomes were evaluated with linear mixed-effect models. Results: Compared with filtered air, O3 exposure decreased FVC, FEV1, and FEV1/FVC immediately post exposure regardless of supplementation status. Relative to that in the CTL group, the lung function response to O3 exposure in the FO group was blunted, as evidenced by O3-induced decreases in FEV1 (Normalized CTL −0.40 ± 0.34 L, Normalized FO −0.21 ± 0.27 L) and FEV1/FVC (Normalized CTL −4.67 ± 5.0 %, Normalized FO −1.4 ± 3.18 %) values that were on average 48% and 70% smaller, respectively. Inflammatory responses measured in the sputum immediately post O3 exposure were not different among the three supplementation groups. Systolic blood pressure elevations 20-h post O3 exposure were blunted by OO supplementation. Conclusion: FO supplementation appears to offer protective effects against lung function decrements caused by acute O3 exposure in healthy adults.

The Global Vegetation Project (http://gveg.wyobiodiversity.org) is a new initiative to host an online database of open-access, georeferenced vegetation photos. The mission of the Global Vegetation Project is ‘to inspire and empower people of all ages to learn about the diversity of vegetation on our planet and to provide educators with a resource for teaching ecology online’. The beta release includes two R-Shiny web applications that allow users to 1) submit photos of plant communities through a user-friendly online portal and 2) explore submissions made by others through an interactive global map. The spatial coordinates of each photo are used to extract information about the location including long-term and recent climate data to create Walter and Leith climate diagrams for each photo. User submitted photos can be filtered by biome, temperature, precipitation, and elevation on the map. The Global Vegetation Project will evolve to match the needs of vegetation scientists and ecology educators. We intend to enhance the educational value of the mapping application by incorporating additional search features, global data layers, and the publication of curricula geared towards primary, secondary, and post-secondary education. We encourage the global community of vegetation scientists to use this resource in their classrooms and to contribute photos of vegetation to grow this valuable resource for the world.

Abstract Background Fine particulate matter (PM2.5) related mild inflammation, altered autonomic control of cardiovascular function, and changes to cell function have been observed in controlled human exposure studies. Methods To measure the systemic and cardiopulmonary impacts of low-level PM exposure, we exposed 20 healthy, young volunteers to PM2.5, in the form of concentrated ambient particles (mean: 37.8 μg/m3, SD 6.5), and filtered air (mean: 2.1 μg/m3, SD 2.6). In this double-blind, crossover study the exposure order was randomized. During the 4 h exposure, volunteers (7 females and 13 males) underwent light intensity exercise to regulate ventilation rate. We measured pulmonary, cardiac, and hematologic end points before exposure, 1 h after exposure, and again 20 h after exposure. Results Low-level PM2.5 resulted in both pulmonary and extra-pulmonary changes characterized by alterations in systematic inflammation markers, cardiac repolarization, and decreased pulmonary function. A mean increase in PM2.5 concentration (37.8 μg/m3) significantly increased serum amyloid A (SAA), C-reactive protein (CRP), soluble intercellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1), 1 h after exposure by 8.7, 9.1, 10.7, and 6.6%, respectively, relative to the filtered air control. SAA remained significantly elevated (34.6%) 20 h after PM2.5 exposure which was accompanied by a 5.7% decrease in percent neutrophils. Decreased pulmonary function was observed 1 h after exposure through a 0.8 and 1.2% decrease in forced expiratory volume in 1 s (FEV1) and FEV1/ forced vital capacity (FEV1/FVC) respectively. Additionally, sex specific changes were observed in repolarization outcomes following PM2.5 exposure. In males, P-wave and QRS complex were increased by 15.4 and 5.4% 1 h after exposure. Conclusions This study is the first controlled human exposure study to demonstrate biological effects in response to exposure to concentrated ambient air PM2.5 particles at levels near the PM2.5 US NAAQS standard. Clinical trial registration information clinicaltrials.gov ; Identifier: NCT03232086 . The study was registered retrospectively on July 25, 2017, prior to final data collection on October 25, 2017 and data analysis.

Solar Probe Cup (SPC) is a Faraday cup instrument on board NASA’s Parker Solar Probe ( PSP ) spacecraft designed to make rapid measurements of thermal coronal and solar wind plasma. The spacecraft is in a heliocentric orbit that takes it closer to the Sun than any previous spacecraft, allowing measurements to be made where the coronal and solar wind plasma is being heated and accelerated. The SPC instrument was designed to be pointed directly at the Sun at all times, allowing the solar wind (which is flowing primarily radially away from the Sun) to be measured throughout the orbit. The instrument is capable of measuring solar wind ions with an energy between 100 and 6000 V (protons with speeds from 139 to 1072 km s ^−1 ). It also measures electrons with an energy/charge between 100 and 1500 V. SPC has been designed to have a wide dynamic range that is capable of measuring protons and alpha particles at the closest perihelion (9.86 solar radii from the center of the Sun) and out to 0.25 au. Initial observations from the first orbit of PSP indicate that the instrument is functioning well.