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The commencement of a new editorial tenure within the Journal of Personality and Social Psychology: Attitudes and Social Cognition (JPSP: ASC) provides an opportunity for reflection regarding the journal's core mission. The editors recognize that social psychology is at a crossroads due to competing demands that may have led to reduced submissions and posed challenges for previous editors in filling the journal's pages. Now, JPSP: ASC has been allotted more pages to allow for growth during this editorial term. Although this is desirable for the field, it adds to the pressure of identifying articles for publication given the difficulties filling the pages during previous editorial terms. As the premier outlet of social psychology since 1965, JPSP: ASC will retain its centrality if we increase submissions and publish more articles, while continuing to strive to communicate methodologically trustworthy, intellectually stimulating, and socially relevant research, in a responsible fashion. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Abstract: This research paper investigates and develops the persistence of piracy in some of Lord Byron’s literary works. The target works are basically narratives the poet had been told during his oriental voyages in Albany, Ottoman Empire, in Greece, etc… The Giaour, the Corsairs and the Bride of Abydos are all stories closely related to pirate activities all around the Mediterranean Sea. The objective of the study is therefore to account for some elements of piracy in selected works by Lord Byron. The sum total of all these are done within the theoretical context of socio-criticism. Since the study has used written documents as its primary instruments for the data collection, the qualitative methodology is therefore adopted in implementation of the study. The results of the study indicate that in the Corsairs, Conrad and his troops have assaulted upon Seyd’s harem. The pacha has contrived to defeat Conrad and his troops. Gulnare, the pacha’s favorite slave woman has successfully rescued Conrad and has taken him back to his homeland. In the Bride of Abydos, two young men have questioned their father’s authority, and subsequently have fled away to a grotto for refuge. Old Giaffir, their father, has sent troops to quell their sedition against social norms. In the Giaour, Giaour (the hero) has clashed with Hassan, the slave master, about one of his favorite slaves Leila. These three narratives echoed intense pirate activities relevant of the fifteenth century in the Mediterranean basin. Keywords: elopement, love, piracy, self-destruction, socio-criticism.

This study aims at investigating the chemical composition of root, stem and leaf essential oils from Ivorian Synedrella nodiflora, with the root oil being described for the first time. Sixty, fifty-one and forty-nine constituents were, respectively identified in the root, stem and leaf oils using a combination of GC(RI), GC-MS and 13C-NMR analyses. They accounted for 95.6–97.3%, 92.6–97.6% and 93.3–98.8% of the total composition, respectively. The main components of the root oil samples were γ-curcumene, (E)-β-caryophyllene, α-curcumene and curcuphenyl acetate. Three stem oil samples (S1, S2a, S3) were dominated by myrcene and limonene, while the most abundant components of sample S2b were thymol, germacrene D and β-elemene. (E)-β-caryophyllene and germacrene D were the major compounds of the leaf oil. Hierarchical cluster and principal component statistical analyses were performed and confirmed that the location does not influence the chemical composition. Group I consisted of the seven leaf oil samples, group II consisted of four stem oil samples and group III consisted of three root oil samples. The root oil composition differed considerably from the stem and leaf oil composition due to the presence of curcumene derivatives as major constituents. The leaf oil showed significant amounts of (E)-β-caryophyllene and germacrene D, while the stem oil stood out for its high myrcene, limonene and thymol contents.

The Hodgkin variant Richter syndrome (HvRS) is an infrequent complication occurring in 1% of lymphocytic lymphoma/chronic lymphocytic leukemia patients. We report a case of HvRS diagnosed in Sub-Saharan Africa. A 63-year-old patient was consulted for the investigation of an abdominal mass that had been evolving for 5 years prior to admission. His history revealed night sweats, 13% weight loss in 3 months and persistent pruritis. Examination revealed bilateral cervical axillary and inguinal macroadenopathies, painless abdominal distension, pruritic lesions and WHO 2 PS. The blood count showed anemia at 9.5 g/dL. Histology revealed a lymphomatous proliferation of diffuse architecture, nodular in places, with Hodgkin and Sternberg cells associated with small lymphocytes, histiocytes and eosinophilic polymorphs. Immunohistochemistry showed CD20, PAX5, BCL2, CD5, CD23 and MYC positivity; Ki67 at 10% and cyclin D1, BCL6 and CD10 negativity; CD30 positivity on Hodgkin and Sternberg cells that remained CD20 negative; difficulty interpreting CD15; EBV positivity (EBERs); and CD3 and CD5 positivity on reactive T cells. CD138 and kappa and lambda light chains were non-contributory. The extension work-up classified the patient as Ann Arbor stage III B with a Hasenclever score of 3/7. This case illustrates the difficulties in diagnosing HvRS in our countries, where the number of haematopathologists is insufficient and the technical facilities are limited.

Abstract Background The 13‐MD is a new generic instrument developed to measure general health‐related quality of life (GHRQoL). This instrument considers all aspects of health (i.e., physical, mental, and social) in a balanced way. A previous study led to minor changes in the original version of the 13‐MD. The objective of this study was to confirm the validity of the modified 13‐MD. Methods Validity was assessed with recent data from the general population of Quebec, Canada. The meta‐dimensions and items composing the 13‐MD were also subjected to a ranking procedure, which allowed to determine the most important aspects for respondents. Results A total of 1337 French‐speaking participants were recruited with 1099 completing the 13‐MD for validation purposes and 1084 completing the ranking procedure. The 13‐MD showed very satisfactory results and confirmed to be a valid instrument. The ranking of the meta‐dimensions revealed that “Well‐being” received the most points, followed by “Sleep and energy” and “Body functioning.” Conclusion These results will be very useful in the continuous improvement of the 13‐MD, ultimately leading to the valuation stage (i.e., development of a value set).

Background and Aim: Canine rabies is an endemic form of zoonosis and represents a major public health threat in Guinea, similar to other African countries. However, few investigations on the epidemiology of rabies in animals and humans have been conducted, and evidence-based data required to inform health policies remain inadequate. This study was conducted to update our knowledge of human dog-mediated rabies epidemiology and post-exposure prophylaxis (PEP) accessibility-related factors in Guinea. Materials and Methods: This retrospective study, conducted from January 2018 to December 2020, collected data on animal bite cases, veterinary observations, rabies diagnoses through fluorescent antibody test, and PEP delivery from three veterinary and medical entities. Statistical analysis utilized Chi-square test and Fisher’s exact test to evaluate relationships between variables. Results: An average of 775 bites was recorded annually, and dogs were responsible for 98% of bites. However, only 64% of the biting dogs were under veterinary observation as required for integrated bite case management. Regarding the geographical distribution of bite cases, the entire country was affected, with the highest number of bites recorded in the prefectures of Nzérékoré and the special zone of Conakry. In addition, the laboratory diagnosis of brain samples from biting dogs indicated that 72% of the samples were rabies-positive. However, regarding prevention, only 58% of the bitten individuals received full PEP. Conclusion: Improving disease surveillance and PEP provision for dog-transmitted rabies is crucial to preventing human cases and deaths. Increasing community awareness is essential for enhancing dog vaccination and PEP utilization. A national action plan integrating stakeholders for controlling canine rabies should be developed for effective One Health collaboration.

Objective The objective of this study is to analyze the influence of mental illness on the oral health status of psychiatric patients. Materials And Methods We performed a prospective, transverse and descriptive study based on the observation of the oral lesions in the patients received in psychiatric consultation. It took place in the department of Psychiatry of the Center Hospitalo Universitaire of Point G for one month (from June to July 2014). The target population was known psychiatric patients followed and / or hospitalized during the study period. The data were collected from the medical files and a questionnaire and entered and analyzed with the software Epi info fr 6.0. In 54.40% of patients, brushing of teeth was performed once daily and twice daily in 26.10% of cases. Results During the study period, 130 patients were selected according to our inclusion criteria, of which 70.0% were male with a sex ratio of 2.3. The age group 25-34 was the most represented, 31.50%. The majority of our patients had dental abrasion, or 90.80% of the cases. The CAD / D index of our population was 5.22. Halitosis and oral dryness were common in patients with chronic psychosis, respectively 63.5% and 56.90% of cases. Gingivorrhage was observed in 61.10% of patients with chronic psychosis. Conclusion This study shows the high frequency of oral infection in a psychiatric setting, hence the interest of a partnership between mental health professionals and those in the oral cavity. Keywords : Oral infections ; psychiatry ; buccal dryness, CAD index ; Point G Hospital

Résumé Le service de pédiatrie fait partie des grands utilisateurs de produits sanguins mais ses besoins transfusionnels ne sont pas définis. Notre étude avait pour objectif d’évaluer la part des causes infectieuses dans les anémies de l enfant nécessitant une transfusion dans le département de pédiatrie du Centre Hospitalier et Universitaire Gabriel Touré. Méthodologie : il s’agissait d’une étude prospective et descriptive sur une période de douze mois, allant du 01 mai 2012 au 30 avril 2013. Elle a concerné les enfants de 0 à 15 ans transfusés au cours de leur hospitalisation dans le département de pédiatrie du Centre Hospitalier et Universitaire Gabriel Touré. Nos critères d’anémies étaient: pâleur associée à des signes de décompensations (tachycardie, souffle cardiaque, détresse respiratoire, choc hypovolémique, désaturation). Nos méthodes diagnostiques étaient la numération formule sanguine, les hémocultures, la goutte épaisse pour la recherche du Plasmodium, l’électrophorèse de l’hémoglobine et le dosage des facteurs VIII et IX. L’assentiment des parents était obtenu avant l’inclusion de leur enfant. Les données ont été recueillies sur des fiches individuelles. La saisie et l’analyse des données ont été faites par les logiciels SPSS Version 17. Résultats : Sur 10842 enfants hospitalisés nous avons recensé 854 enfants transfusés soit une fréquence de 7,9 % avec un sexe ratio de 1,5. Les besoins transfusionnels du département de pédiatrie étaient estimés à 3497 unités de produits sanguins par an. Concernant l’indication transfusionnelle, 64,2 % d’anémie était d’origine palustre, suivie respectivement des infections bactériennes invasives, de la malnutrition et de la drépanocytose dans 15,1% ; 7,9% et 2,7%. Plus de la majorité soit 58,1% des enfants avaient un taux d’hémoglobine pré transfusionnel compris entre 2 et 5 g/dl avec un taux moyen de 4,86 g/dl. Le gain moyen d’hémoglobine post transfusionnel était de 4,96 g/dl. Conclusion : les besoins transfusionnels restent élevés dans notre contexte, la prévention du paludisme reste le meilleur moyen de réduction des transfusions en pédiatrie.

Résumé Les infections sont responsables d'une part importante de la morbidité et de la mortalité chez l'enfant drépanocytaire. Notre objectif était d’étudier le profil clinique et bactériologique des infections bactériennes de l’enfant drépanocytaire dans le service de pédiatrie du CHU Gabriel Touré. Matériel et méthodes: Nous avons réalisé une étude rétrospective sur 25 dossiers d’hospitalisation d’enfants drépanocytaires fébriles ayant bénéficié d’une hémoculture sur une période de 5 ans (2005-2010). Nous avons analysé les caractéristiques cliniques et bactériologiques des enfants ayant une hémoculture positive. Résultats: Dix des 25 hémocultures réalisées étaient positives. La tranche d’âge de 0-5 ans était la plus touchée (60%). Le suivi était irrégulier pour 7 enfants et 6/10 n'avaient pas reçu le vaccin anti pneumococcique. Sur le plan clinique, 5 cas de sepsis, une infection pulmonaire et 4 cas infections ostéo articulaires ont été diagnostiquées. La goutte épaisse était positive pour 4 patients. Les germes retrouvés ont été : Salmonella enterica sérotype Typhi (4 fois), Streptococcus pneumoniae (4 fois), Staphylococcus aureus (1fois), Enterobacter cloacae (1fois) ont été isolés. Salmonella enterica sérotypeTyphia été isolé dans 3 cas d'infections ostéo-articulaires et un cas de sepsis, Streptococcus pneumoniae était en cause dans l'infection pulmonaire et dans un cas de sepsis. L'antibiothérapie probabiliste dans la majorité des cas était basée sur les céphalosporines de troisième génération. L’évolution a été favorable dans 80% des cas. Conclusion : Les complications infectieuses de la drépanocytose peuvent être graves. La disponibilité de l'hémoculture doit nous permettre de caractériser le profil bactériologique dans notre contexte.

Malgré les efforts consentis par les services de santé pour la prévention et l’éradication de la poliomyélite antérieure aiguë, la surveillance de la Paralysie Flasque Aiguë (PFA) reste un instrument sensible pour suivre les progrès de l'Initiative Mondiale pour l'éradication de la poliomyélite. Cette étude rétrospective et descriptive avait comme objectif principal d’évaluer l’effet de la vaccination sur la morbi-mortalité liée à la poliomyélite au Mali pendant la période de 2001 à 2012. La couverture vaccinale en Vaccin Polio Oral1 était inférieure à 100% de 2001 à 2003, mais supérieure à 100% de 2004 à 2012. Celle en VPO3 était inférieure à 100% dans l’ensemble. La couverture vaccinale en VPO3 en 2001 était faible, moins de 60% dans la plupart des districts. La quasi totalité des districts sanitaires du Nord du Mali avait des couvertures vaccinales en VPO inférieures à 60% en 2012. De 2001 à 2012, le Mali a enregistré 1956 cas suspects de PFA. La plus forte prévalence a été enregistrée en 2012 avec 266 cas soit proportion de 13,6%. La tranche d’âge de 1- 4 ans a été la plus représentée avec 1098 cas soit 56,1%. Entre 2001 et 2012, le Mali a notifié des épidémies de poliovirus sauvage: 19 cas de PVS1 en 2004, 3 cas de PVS1 en 2005, 1 cas de PVS1 en 2008, 2 cas de PVS1 en 2009, 3 cas de PVS1 et 1 cas de PVS3 en 2010 et 7 cas de PVS3 en 2011. Les causes de ces insuffisances pourront être liées à l’inaccessibilité géographique à ces districts, l’instabilité du personnel qualifié, la destruction des infrastructures sanitaires et surtout l’insécurité qui s’sévissait dans le Nord du pays en 2012. L’étude a montré également que la baisse de la couverture vaccinale entraine une augmentation du nombre de cas de maladie, ce qui favorise l’élévation de la susceptibilité pour la survenue d’épidémies.

Evidence should be the foundation for a well-designed family planning (FP) program, but existing evidence is rarely aligned with and/or synthesized to speak directly to FP programmatic needs. Based on our experience cocreating FP research and learning agendas (FP RLAs) in Côte dIvoire, Malawi, Mozambique, Nepal, Niger, and Uganda, we argue that FP RLAs can drive the production of coordinated research that aligns with national priorities.To cocreate FP RLAs, stakeholders across 6 countries conducted desk reviews of 349 documents and 106 key informant interviews, organized consultation meetings in each country to prioritize evidence gaps and generate research and learning questions, and, ultimately, formed 6 FP RLAs comprising 190 unique questions. We outline the process for consensus-driven development of FP RLAs and communicate the results of an analysis of the questions in each FP RLA across 4 technical areas: self-care, equity, high impact practices, and youth. Each question was categorized as a learning versus research question, the former indicating an opportunity to synthesize existing evidence and the latter to conduct new research to answer the question. Themes emerging from the data shed light on shared evidence gaps across the 6 countries. We argue that similarities and differences in the questions in each FP RLA reflect the unique implementation experience and context, as well as each countrys placement on the FP S-curve. Early uses of the FP RLAs include informing the development of FP costed implementation plans and FP2030 commitments. FP RLAs have also been discussed in multiple thematic working groups. For FP stakeholders, these FP RLAs represent a consensus-based agenda that can guide the generation and synthesis of evidence to answer each countrys most pressing questions, ultimately driving progress toward increasingly evidence-based programming and policy.

Abstract Background The WHO 2016 antenatal care (ANC) policy recommends at least eight antenatal contacts during pregnancy. This study assessed ANC8 uptake following policy implementation and explored the relationship between ANC attendance and intermittent preventive treatment in pregnancy (IPTp) coverage in sub-Saharan Africa following the rollout of the World Health Organization (WHO) 2016 ANC policy, specifically, to assess differences in IPTp uptake between women attending eight versus four ANC contacts. Methods A secondary analysis of data from 20 sub-Saharan African countries with available Demographic Health and Malaria Indicator surveys from 2018 to 2023 was performed. The key variables were the number of ANC contacts and IPTp doses received during a participant's last completed pregnancy in the past two years. Pooled crude and multivariable logistic regression models were used to explore factors associated with attendance of at least four or eight ANC contacts as well as receipt of at least three doses of IPTp during pregnancy. Results Overall, only a small proportion of women (median = 3.9%) completed eight or more ANC contacts (ANC8 +). Factors significantly associated with increased odds of ANC8 + included early ANC attendance (AOR: 4.61: 95% CI 4.30—4.95), literacy (AOR: 1.20; 95% CI 1.11—1.29), and higher wealth quintile (AOR: 3.03; 95% CI 2.67—3.44). The pooled estimate across all countries showed a very slight increase in the odds of IPTp3 + among women with eight (AOR: 1.06; 95% CI 1.00—1.12) compared to those with four contacts. In all but two countries, having eight instead of four ANC contacts did not confer significantly greater odds of receiving three or more doses of IPTp (IPTp3 +), except in Ghana (AOR: 1.67; 95% CI 1.38—2.04) and Liberia (AOR: 1.43; 95% CI 1.18—1.72). Conclusion Eight years after the WHO ANC policy recommendation, all countries still had sub-optimal ANC8 + coverage rates. This paper is a call to action to actualize the vision of the WHO and the global malaria community of a malaria free world. Policies to improve ANC and IPTp coverage should be operationalized with clear actionable guidance and local ownership. Study findings can be used to inform multi-level policy, programmatic, and research recommendations to optimize ANC attendance and malaria in pregnancy prevention, thus improving maternal and child health outcomes, including the reduction of malaria in pregnancy.

Abstract Natural spices play an essential role in human nutrition and well-being. However, their processing on different scales can expose them to potential sources of contamination. This study aimed to describe the bacterial community genomic footprint in spices sold in Senegal. Spice samples were collected in August 2022 in Saint-Louis, Senegal. The genomic region coding bacterial 16S rRNA was then amplified and sequenced using Oxford Nanopore Technology (ONT). Sequencing was carried out on two batches of samples, one containing part of the “Local Spices or Herbs” (n = 10), and the other, a mixture of 7 spices, Curcuma, Thyme and the other part of the “Local Spices or Herbs” (n = 39). Results showed high bacterial diversity and the predominance of Escherichia coli and Salmonella enterica in samples, with total reads of 65,744 and 165,325 for the two batches, respectively. The sample category “Homemade mixture of food condiments “, which includes all “Local Spices or Herbs” samples, showed remarkable bacterial diversity. These were followed by Curcuma, a blend of 7 spices and thyme. Also, the different categories of spices studied show similarities in their bacterial composition. These results highlight the microbial community’s highly diverse genomic profile, including pathogenic bacteria, in spice samples.

The management of the aesthetic parameter represents an important factor in the integration of removable prostheses. The current major social interest in beauty has made patients more and more demanding with regard to their appearance. [1] The main objective of this study was to assess the aesthetic expectations of patients with removable prostheses at the CHU-CNOS in Bamako. Our prospective and descriptive study having collected 78 patients was carried out over a period from March 2, 2019 to March 9, 2020 at the removable prosthesis department of the CHU-CNOS in Bamako. The female sex represented 55.1% with a sex ratio of 0.65. Removable prosthetic rehabilitation mainly concerned young adults aged 21-41 (41%) Aesthetics was the main reason for rehabilitation most represented with 60.3% of cases. The white tooth was the most requested dental shade with 70.5% of cases Bonded teeth were the most represented in our patients with 71.79% of cases. Pink gum was the shade most requested by our patients with 43.6% of cases. Obtaining a personalized prosthesis in harmony with the facial framework, giving the illusion of naturalness and restoring the smile to patients is the objective to be achieved

Abstract Background Perennial malaria chemoprevention (PMC) aims to protect children at risk from severe malaria by the administration of anti-malarial drugs to children of defined ages throughout the year. Sulfadoxine-pyrimethamine (SP) has been widely used for chemoprevention in Africa and a child-friendly dispersible tablet formulation has recently become available. Methods This qualitative non-interventional observational study was conducted in Benin, Côte d’Ivoire, and Mozambique between February and June 2022. Prototype blister packs, dispensing boxes and job aids designed to support dispersible SP deployment for PMC were evaluated using focus group discussions (FGD) and semi-structured in-depth individual interviews (IDI) with health authorities, health personnel, community health workers (CHWs) and caregivers. The aim was to evaluate knowledge and perceptions of malaria and chemoprevention, test understanding of the tools and identify gaps in understanding, satisfaction, user-friendliness and acceptability, and assess the potential role of CHWs in PMC implementation. Interviews were transcribed and imported to ATLAS.ti for encoding and categorization. Thematic content analysis used deductive and inductive coding with cross-referencing of findings between countries and participants to enrich data interpretation. Continuous comparison across the IDI and FGD permitted iterative, collaborative development of materials. Results Overall, 106 participants completed IDIs and 70 contributed to FGDs. Malaria was widely recognised as the most common disease affecting children, and PMC was viewed as a positive intervention to support child health. The role of CHWs was perceived differently by the target groups, with caregivers appreciating their trusted status in the community, whereas health authorities preferred clinic-based deployment of PMC by health professionals. Empirical testing of the prototype blister packs, dispensing boxes and job aids highlighted the context-specific expectations of respondents, such as familiar situations and equipment, and identified areas of confusion or low acceptance. A key finding was the need for a clear product identity reflecting malaria. Conclusion Simple modifications profoundly affected the perception of PMC and influenced acceptability. Iterative quantitative investigation resulted in PMC-specific materials suited to the local context and socio-cultural norms of the target population with the aim of increasing access to chemoprevention in children most at risk of severe malaria.

To tackle the current pressing atmospheric science issues, as well as those in the future, a robust scientific community is necessary in all regions across the globe. Unfortunately, this does not yet exist. There are many geographical areas that are still underrepresented in the atmospheric science community, many of which are in the Global South. There are also larger gaps in the understanding of atmospheric composition, processes, and impacts in these regions. In this opinion, we focus on two geographical areas in the Global South to discuss some common challenges and constraints, with a focus on our strengths in atmospheric science research. It is these strengths, we believe, that highlight the critical role of Global South researchers in the future of atmospheric science research.

Background and objectivesProgressive myoclonic epilepsy (PME) is a group of neurological disorders characterized by recurrent myoclonic seizures with progressive neurological deterioration. We investigated the genetics of three unrelated patients with PME from Mali, a country in sub-Saharan Africa highly underrepresented in genetic and genomic research.MethodsParticipants were carefully examined and phenotyped. DNA was obtained for genetic analysis including whole exome sequencing (WES). In silico prediction tools and ACMG criteria were used to assess the deleteriousness of putative candidate variants.ResultsPedigree analysis suggests autosomal recessive inheritance patterns for one family and sporadic forms of PME for the two other cases. WES identified novel homozygous missense variants in all the three patients, one each for NHLRC1, EPM2A, and NEU1. The sequence variants segregated with PME in each family and in silico studies including protein 3D structures, CADD scores and ACMG criteria suggested that they were damaging.DiscussionPME is a group of clinically heterogeneous neurological disorders. Most reported cases in the literature are from European background with only a few cases described in North Africa. We report here novel pathogenic variants in three different genes causing PME phenotypes in three unrelated Malian patients, suggesting that genetic studies of underrepresented populations may expand the genetic epidemiology of PME. These findings also emphasize the need for inclusive genetic research to ensure a more targeted diagnostic and therapeutic approaches for diverse patient populations.

Cet article met l’accent dans une première partie sur les quatre principaux jeux qui rassemblèrent les Grecs d’Europe et d’Asie. Ces quatre concours majeurs étaient les jeux olympiques, les jeux isthmiques, les jeux pythiques et les jeux néméens. En outre, il souligne la conclusion des trêves qui étaient considérées comme une condition incontournable pour l’organisation de ces jeux. Dans une seconde partie, l’étude montre que des Grecs venaient de toutes les cités pour participer aux jeux. Elle mentionne également l’honneur autant un athlète qu’une cité tirait d’une victoire pendant ces jeux. Enfin, l’étude aborde le fait que les jeux furent des occasions pour renforcer les liens de parenté culturelle entre les cités grecques et des occasions pour des négociations diplomatiques.

Objectives: This study aimed to investigate the prevalence of orthoebolavirus antibodies in Madina Oula, a non-epidemic rural area in Guinea, in 2022. Methods: A cross-sectional study was conducted from March 14 to April 3, 2022 involving recording household and socio-demographic characteristics, lifestyle data, and collecting dried blood spots from 878 individuals in 235 households. Dried blood spots were tested using multiplex serology to detect antibodies to different orthoebolaviruses: Ebola virus, Bundibugyo virus, Sudan virus, Reston virus, and Bombali virus. Seroprevalence was estimated with a 95% confidence interval and a Z-test was performed to compare the seropositivity between children aged under 15 years and those over 15 years. Household and participant characteristics were analyzed using descriptive statistic, and socio-historical conditions were discussed. Results: The serological analysis conducted in 2022 on 878 participants revealed varying reactivity to orthoebolavirus antigens, notably, with glycoprotein antigens, particularly, glycoprotein Sudan virus (16%). A total of 21 samples exhibited reactivity with at least two antigens, with a median age of 27 years (interquartile range 10.00-35.00), ranging from 2 to 80 years. There is no significant difference between seropositivity in children aged under 15 (2.86%) years and those over 15 (2.14%) years. The antibody presence varied per village, with the highest prevalence observed in Ouassou and Dar-es-Salam. Conclusions: Serological data in a region unaffected by recent Ebola outbreaks indicate possible orthoebolavirus endemicity, emphasizing the need for preparedness against known or novel orthoebolaviruses with potential cross-reactivity.

Les cellulites nécrosantes descendantes d'origine dentaire sont graves et de prise en charge difficile. Leur diffusion se fait classiquement vers le médiastin, les cavités pleurales, voir le cerveau. La diffusion spécifique à la glande mammaire est atypique, rare et peu décrite. Nous rapportons 2 cas colligés en 15 ans de pratique de chirurgie thoracique. Il s'agissait de deux patientes, l'une âgée de 32 ans et l'autre de 25 ans toutes vivaient en milieu rural. Leurs itinéraires diagnostiques et thérapeutiques, les facteurs de risque, les moyens thérapeutiques utilisés et leurs pronostics ont été discutés. Le but de ce travail était de mettre l'accent sur la gravité de cette pathologie et inciter à la mise en œuvre d'une politique de prévention à l'échelle nationale. Mots clés : cellulite, glande mammaire, dentaire.

Les infections sont responsables d'une part importante de la morbidité et de la mortalité chez l'enfant drépanocytaire. Notre objectif était d'étudier le profil clinique et bactériologique des infections bactériennes de l'enfant drépanocytaire dans le service de pédiatrie du CHU Gabriel Touré. Matériel et méthodes: Nous avons réalisé une étude rétrospective sur 25 dossiers d'hospitalisation d'enfants drépanocytaires fébriles ayant bénéficié d'une hémoculture sur une période de 5 ans (2005-2010). Nous avons analysé les caractéristiques cliniques et bactériologiques des enfants ayant une hémoculture positive. Résultats: Dix des 25 hémocultures réalisées étaient positives. La tranche d'âge de 0-5 ans était la plus touchée (60%). Le suivi était irrégulier pour 7 enfants et 6/10 n'avaient pas reçu le vaccin anti pneumococcique. Sur le plan clinique, 5 cas de sepsis, une infection pulmonaire et 4 cas infections ostéo articulaires ont été diagnostiquées. La goutte épaisse était positive pour 4 patients. Les germes retrouvés ont été : Salmonella enterica sérotype Typhi (4 fois), Streptococcus pneumoniae (4 fois), Staphylococcus aureus (1fois), Enterobacter cloacae (1fois) ont été isolés. Salmonella enterica sérotypeTyphia été isolé dans 3 cas d'infections ostéo-articulaires et un cas de sepsis, Streptococcus pneumoniae était en cause dans l'infection pulmonaire et dans un cas de sepsis. L'antibiothérapie probabiliste dans la majorité des cas était basée sur les céphalosporines de troisième génération. L'évolution a été favorable dans 80% des cas. Conclusion : Les complications infectieuses de la drépanocytose peuvent être graves. La disponibilité de l'hémoculture doit nous permettre de caractériser le profil bactériologique dans notre contexte.

Le service de pédiatrie fait partie des grands utilisateurs de produits sanguins mais ses besoins transfusionnels ne sont pas définis. Notre étude avait pour objectif d'évaluer la partdes causes infectieuses dans les anémies de l enfant nécessitant une transfusion dans le département de pédiatrie du Centre Hospitalier et Universitaire Gabriel Touré. Méthodologie : il s'agissait d'une étude prospective et descriptive sur une période de douze mois, allant du 01 mai 2012 au 30 avril 2013. Elle a concerné les enfants de 0 à 15 ans transfusés au cours de leur hospitalisation dans le département de pédiatrie du Centre Hospitalier et Universitaire Gabriel Touré. Nos critères d'anémies étaient: pâleur associée à des signes de décompensations (tachycardie, souffle cardiaque, détresse respiratoire, choc hypovolémique, désaturation). Nos méthodes diagnostiques étaient la numération formule sanguine, les hémocultures, la goutte épaisse pour la recherche du Plasmodium, l'électrophorèse de l'hémoglobine et le dosage des facteurs VIII et IX. L'assentiment des parents était obtenu avant l'inclusion de leur enfant. Les données ont été recueillies sur des fiches individuelles. La saisie et l'analyse des données ont été faites par les logiciels SPSS Version 17. Résultats : Sur 10842 enfants hospitalisés nous avons recensé 854 enfants transfusés soit une fréquence de 7,9 % avec un sexe ratio de 1,5. Les besoins transfusionnels du département de pédiatrie étaient estimés à 3497 unités de produits sanguins par an. Concernant l'indication transfusionnelle, 64,2 % d'anémie était d'origine palustre, suivie respectivement des infections bactériennes invasives, de la malnutrition et de la drépanocytose dans 15,1% ; 7,9% et 2,7%. Plus de la majorité soit 58,1% des enfants avaient un taux d'hémoglobine pré transfusionnel compris entre 2 et 5 g/dl avec un taux moyen de 4,86 g/dl. Le gain moyen d'hémoglobine post transfusionnel était de 4,96 g/dl. Conclusion : les besoins transfusionnels restent élevés dans notre contexte, la prévention du paludisme reste le meilleur moyen de réduction des transfusions en pédiatrie.

Abstract Background Following WHO guidelines, microscopy is the gold standard for malaria diagnosis in endemic countries. The Parasitology-Mycology laboratory (LPM) is the National Reference Laboratory and is currently undergoing ISO 15189 accreditation. In this context, we assessed the performance of the laboratory by confirming the reliability and the accuracy of results obtained in accordance with the requirements of the ISO 15189 standards. This study aimed to verify the method of microscopic diagnosis of malaria at the LPM, in the Aristide Le Dantec hospital (HALD) in Dakar, Senegal. Methods This is a validation/verification study conducted from June to August 2020. Twenty (20) microscopic slides of thick/thin blood smear with known parasite densities (PD) selected from the Cheick Anta Diop University malaria slide bank in Dakar were used for this assessment. Six (6) were used to assess microscopists’ ability to determine PD and fourteen (14) slides were used for detection (positive vs negative) and identification of parasites. Four (4) LPM-HALD microscopists read and recorded their results on prepared sheets. Data analysis was done with Microsoft Excel 2010 software. Results A minimum threshold of 50% concordance was used for comparison. Of the twenty (20) slides read, 100% concordance was obtained on eight (8) detection (positive vs negative) slides. Four (4) out of the six (6) parasite density evaluation slides obtained a concordance of less than 50%. Thirteen (13) out of the fourteen (14) identification slides obtained a concordance greater than 50%. Only one (1) identification slide obtained zero agreement from the microscopists. For species identification a concordance greater than 80% was noted and the microscopists obtained scores between 0.20 and 0.4 on a scale of 0 to 1 for parasite density reading. The microscopists obtained 100% precision, sensitivity, specificity and both negative and positive predictive values. Conclusion This work demonstrated that the microscopic method of malaria diagnosis used in the LPM/HALD is in accordance with the requirements of WHO and ISO 15189. Further training of microscopists may be needed to maintain competency.