Search

Your search keyword '"A Priou"' showing total 1,659 results
Start Over Author "A Priou"

Refine your results

more »

more »

more »

more »

more »
1,659 results on '"A Priou"'

2. Neoadjuvant and adjuvant pembrolizumab in advanced high-grade serous carcinoma: the randomized phase II NeoPembrOV clinical trial

Author

Ray-Coquard, Isabelle L., Savoye, Aude-Marie, Schiffler, Camille, Mouret-Reynier, Marie-Ange, Derbel, Olfa, Kalbacher, Elsa, LeHeurteur, Marianne, Martinez, Alejandra, Cornila, Corina, Martinez, Mathilde, Bengrine Lefevre, Leila, Priou, Frank, Cloarec, Nicolas, Venat, Laurence, Selle, Frédéric, Berton, Dominique, Collard, Olivier, Coquan, Elodie, Le Saux, Olivia, Treilleux, Isabelle, Gouerant, Sophie, Angelergues, Antoine, Joly, Florence, and Tredan, Olivier

Published
2024
Full Text
View/download PDF

6. Neoadjuvant and adjuvant pembrolizumab in advanced high-grade serous carcinoma: the randomized phase II NeoPembrOV clinical trial

Author

Isabelle L. Ray-Coquard, Aude-Marie Savoye, Camille Schiffler, Marie-Ange Mouret-Reynier, Olfa Derbel, Elsa Kalbacher, Marianne LeHeurteur, Alejandra Martinez, Corina Cornila, Mathilde Martinez, Leila Bengrine Lefevre, Frank Priou, Nicolas Cloarec, Laurence Venat, Frédéric Selle, Dominique Berton, Olivier Collard, Elodie Coquan, Olivia Le Saux, Isabelle Treilleux, Sophie Gouerant, Antoine Angelergues, Florence Joly, and Olivier Tredan

Subjects
Science
Abstract

Abstract This open-label, non-comparative, 2:1 randomized, phase II trial (NCT03275506) in women with stage IIIC/IV high-grade serous carcinoma (HGSC) for whom upfront complete resection was unachievable assessed whether adding pembrolizumab (200 mg every 3 weeks) to standard-of-care carboplatin plus paclitaxel yielded a complete resection rate (CRR) of at least 50%. Postoperatively patients continued assigned treatment for a maximum of 2 years. Postoperative bevacizumab was optional. The primary endpoint was independently assessed CRR at interval debulking surgery. Secondary endpoints were Completeness of Cytoreduction Index (CCI) and peritoneal cancer index (PCI) scores, objective and best response rates, progression-free survival, overall survival, safety, postoperative morbidity, and pathological complete response. The CRR in 61 pembrolizumab-treated patients was 74% (one-sided 95% CI = 63%), exceeding the prespecified ≥50% threshold and meeting the primary objective. The CRR without pembrolizumab was 70% (one-sided 95% CI = 54%). In the remaining patients CCI scores were ≥3 in 27% of the standard-of-care group and 18% of the investigational group and CC1 in 3% of the investigational group. PCI score decreased by a mean of 9.6 in the standard-of-care group and 10.2 in the investigational group. Objective response rates were 60% and 72%, respectively, and best overall response rates were 83% and 90%, respectively. Progression-free survival was similar with the two regimens (median 20.8 versus 19.4 months in the standard-of-care versus investigational arms, respectively) but overall survival favored pembrolizumab-containing therapy (median 35.3 versus 49.8 months, respectively). The most common grade ≥3 adverse events with pembrolizumab-containing therapy were anemia during neoadjuvant therapy and infection/fever postoperatively. Pembrolizumab was discontinued prematurely because of adverse events in 23% of pembrolizumab-treated patients. Combining pembrolizumab with neoadjuvant chemotherapy is feasible for HGSC considered not completely resectable; observed activity in some subgroups justifies further evaluation to improve understanding of the role of immunotherapy in HGSC.

Published
2024
Full Text
View/download PDF

7. Automated Uncertainty-Based Clustering and Tracking of Modal Parameters Under Strong Variations

Author

Priou, Johann, Greś, Szymon, Mendler, Alexander, Perrault, Matthieu, Guerineau, Laurent, Döhler, Michael, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Cui, Zhen-Dong, Series Editor, Rainieri, Carlo, editor, Gentile, Carmelo, editor, and Aenlle López, Manuel, editor

Published
2024
Full Text
View/download PDF

8. Normalization of Environmental Effects in Modal Parameter Tracking

Author

Priou, Johann, Mendler, Alexander, Perrault, Matthieu, Guerineau, Laurent, Döhler, Michael, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Cui, Zhen-Dong, Series Editor, Rainieri, Carlo, editor, Gentile, Carmelo, editor, and Aenlle López, Manuel, editor

Published
2024
Full Text
View/download PDF

9. Reactivation of Epstein–Barr virus among intensive care patients: a prospective observational study

Author

Guiouillier, François, Derely, Jean, Salvadori, Alexandre, Pochard, Jonas, Le Goff, Jérôme, Martinez, Thibault, Raffin, Florent, Laitselart, Philippe, Beaucreux, Charlotte, Priou, Sonia, Conan, Pierre-Louis, Foissaud, Vincent, Servonnet, Aurélie, Vest, Philippe, Boutonnet, Mathieu, de Rudnicki, Stéphane, Bigaillon, Christine, and Libert, Nicolas

Published
2024
Full Text
View/download PDF

10. Evaluation of a new score associated with acute kidney injury in patients treated with cisplatin based EXTREME regimen

Author

François Avry, Charles Roseau, Zoé Leguay, Sixtine Brabant, Alexandre Ganea, Elise Champeaux-Orange, and Véronique Priou

Subjects
Cisplatin, Cetuximab, EXTREME, Acute kidney injury, Head and neck cancer, Diuresis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background This study evaluates the association of diuresis and hydration through a new monitoring indicator called $${U}_{sen}$$ U sen and the risk of acute kidney injury in patients treated with cisplatin based-EXTREME regimen. Methods We retrospectively reviewed all the cycles of patients with recurrent and/or metastatic head and neck cancer who received cisplatin based-EXTREME regimen from June 2008 to July 2022. Hydration regimen, urine output and concomitant treatments data were collected on the day of cisplatin infusion and the following day of each course received. Results Of the 110 courses received by 46 patients, 38 (34.5%) results in AKI. No patient characteristics showed a significant difference between AKI (70%) and non-AKI (30%) group. In univariate analysis, dose reduction of cisplatin (odds ratio = 0.166 [0.04; 0.75], p = 0.01)) and $${U}_{sen}$$ U sen >8 (odds ratio = 0.316 [0.133; 0.755], p = 0.015) and cardiac treatments (odds ratio = 3.24 [1.26; 8.52], p = 0.02) were significantly associated with AKI risk. In multivariate analysis, cisplatin dose reduction (odds ratio = 0.129 [0.0241; 0.687], p = 0.016) and $${U}_{sen}$$ U sen >8 (odds ratio = 0.184 [0.0648; 0.523], p = 0.0015) were associated with a risk reduction of cisplatin-related AKI. Concomitant administration of cardiac treatments (odds ratio = 3.18 [1.1; 9.22], p = 0.033) showed an increased risk of cisplatin-related AKI. Conclusion The combination of diuresis and i.v. hydration through the $${U}_{sen}$$ U sen composite score was shown to be associated with cisplatin-induced AKI risk in patients treated with cisplatin based EXTREME regimen. It could be used as a practical indicator to trigger specific clinical management to limit the risk of cisplatin induced AKI.

Published
2024
Full Text
View/download PDF

12. The expanded French compassionate programme for elexacaftor–tezacaftor–ivacaftor use in people with cystic fibrosis without a F508del CFTR variant: a real-world study

Author

Kanaan, Reem, Carlier, Nicolas, Honoré, Isabelle, Chedevergne, Frédérique, Dreano, Elise, Hatton, Aurélie, Hinzpeter, Alexandre, Pranke, Iwona, Le Clainche-Viala, Laurence, Mayer, Sophie, Corvol, Harriet, Thouvenin, Guillaume, de Miranda, Sandra, Remus, Natascha, Douvry, Benoit, Duthoit, Louise, Perez, Thierry, Le Rouzic, Olivier, Wizla, Nathalie, Bon, Claire, Bui, Stéphanie, Poey, Nora, Stremler, Nathalie, Coltey, Bérengère, Dufeu, Nadine, Lebihan, Jean, Gabsi, Asma, Pouradier, Delphine, Andrejak, Claire, Rames, Cinthia, Dupuy-Grasset, Magali, Languepin, Jeanne, Marguet, Christophe, Pramil, Stéphanie, Arnouat, Baptiste, Fanton, Annlyse, Abely, Michel, Ravoninjatovo, Bruno, Blondé, Aurore, Guillaumot, Anne, Kieffer, Sebastien, Tatopoulos, Aurélie, Nove-Josserand, Raphaële, Ohlmann, Camille, Perrin, Thomas, Reynaud, Quitterie, Llerena, Catherine, Quétant, Sébastien, Valois, Sophie, Dalphin, Marie-Laure, Richaud-Thiriez, Bénédicte, Deneuville, Eric, Chiron, Raphael, Socchi, Floriane, Bihouée, Tiphaine, Mankikian, Julie, Flament, Thomas, Coolen-Allou, Nathalie, Gachelin, Elsa, Périsson, Caroline, Vuillard, Constance, Dupuis, Marion, Alkoussa, Wael, Marchal, Sarah, Leroy, Sylvie, Scalbert, Manuela, Campbell, Karine, Laurans, Muriel, Labbé, Guillaume, Montcouquiol, Sylvie, Priou, Pascaline, de Carli, Paola, Lemonnier, Lydie, Dehillotte, Clémence, Nouvel, Thierry, Burgel, Pierre-Régis, Sermet-Gaudelus, Isabelle, Girodon, Emmanuelle, Durieu, Isabelle, Houdouin, Véronique, Audousset, Camille, Macey, Julie, Grenet, Dominique, Porzio, Michele, Murris-Espin, Marlène, Reix, Philippe, Baravalle, Mélisande, Belleguic, Chantal, Mely, Laurent, Verhille, Juliette, Weiss, Laurence, Reynaud-Gaubert, Martine, Mittaine, Marie, Hamidfar, Rebecca, Ramel, Sophie, Cosson, Laure, Danner-Boucher, Isabelle, Foucaud, Pierre, Roy, Charlotte, Burnet, Espérie, Raynal, Caroline, Audrezet, Marie-Pierre, Da Silva, Jennifer, and Martin, Clémence

Published
2024
Full Text
View/download PDF

15. Impact of the Sars-Cov-2 outbreak on the initial clinical presentation of new solid cancer diagnoses: a systematic review and meta-analysis

Author

Simon Marty, Guillaume Lamé, Etienne Guével, Sonia Priou, Gilles Chatellier, Christophe Tournigand, Emmanuelle Kempf, and a CRAB* initiative

Subjects
COVID-19, Delivery of health care, Early detection of cancer, Health services research, Neoplasm staging, Neoplasm metastasis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background The COVID-19 pandemic might have delayed cancer diagnosis and management. The aim of this systematic review was to compare the initial tumor stage of new cancer diagnoses before and after the pandemic. Methods We systematically reviewed articles that compared the tumor stage of new solid cancer diagnoses before and after the initial pandemic waves. We conducted a random-effects meta-analysis to compare the rate of metastatic tumors and the distribution of stages at diagnosis. Subgroup analyses were performed by primary tumor site and by country. Results From 2,013 studies published between January 2020 and April 2022, we included 58 studies with 109,996 patients. The rate of metastatic tumors was higher after the COVID-19 outbreak than before (pooled OR: 1.29 (95% CI, 1.06-1.57), I 2 : 89% (95% CI, 86-91)). For specific cancers, common ORs reached statistical significance for breast (OR: 1.51 (95% CI 1.07-2.12)) and gynecologic (OR: 1.51 (95% CI 1.04-2.18)) cancers, but not for other cancer types. According to countries, common OR (95% CI) reached statistical significance only for Italy: 1.55 (1.01-2.39) and Spain:1.14 (1.02-1.29). Rates were comparable for stage I-II versus III-IV in studies for which that information was available, and for stages I-II versus stage III in studies that did not include metastatic patients. Conclusions Despite inter-study heterogeneity, our meta-analysis showed a higher rate of metastatic tumors at diagnosis after the pandemic. The burden of social distancing policies might explain those results, as patients may have delayed seeking care.

Published
2024
Full Text
View/download PDF

19. Adrenal Metastases Are Associated with Poor Outcomes in Patients with Metastatic Clear Cell Renal Cell Carcinoma Treated with Nivolumab in the GETUG-AFU-26 NIVOREN Phase 2 Trial

Author

Billon, Emilien, Dalban, Cécile, Oudard, Stephane, Chevreau, Christine, Laguerre, Brigitte, Barthélémy, Philippe, Borchiellini, Delphine, Geoffrois, Lionnel, Negrier, Sylvie, Joly, Florence, Thiery-Vuillemin, Antoine, Gross-Goupil, Marine, Rolland, Frederic, Priou, Frank, Mahammedi, Hakim, Tantot, Florence, Escudier, Bernard, Chabaud, Sylvie, Albiges, Laurence, and Gravis, Gwenaelle

Published
2024
Full Text
View/download PDF

21. Impact of the COVID‐19 pandemic on clinical presentation, treatments, and outcomes of new breast cancer patients: A retrospective multicenter cohort study

Author

Etienne Guével, Sonia Priou, Guillaume Lamé, Johanna Wassermann, Romain Bey, Catherine Uzan, Gilles Chatellier, Yazid Belkacemi, Xavier Tannier, Sophie Guillerm, Rémi Flicoteaux, Joseph Gligorov, Ariel Cohen, Marc‐Antoine Benderra, Luis Teixeira, Christel Daniel, Barbara Hersant, Christophe Tournigand, Emmanuelle Kempf, and the Assistance Publique–Hôpitaux de Paris (AP‐HP) Cancer Group, a Cancer Research Application on Big Data (CRAB) initiative

Subjects
COVID‐19, breast neoplasms, early detection of cancer, health services research, quality of health care, routinely collected health data, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background The SARS CoV‐2 pandemic disrupted healthcare systems. We compared the cancer stage for new breast cancers (BCs) before and during the pandemic. Methods We performed a retrospective multicenter cohort study on the data warehouse of Greater Paris University Hospitals (AP‐HP). We identified all female patients newly referred with a BC in 2019 and 2020. We assessed the timeline of their care trajectories, initial tumor stage, and treatment received: BC resection, exclusive systemic therapy, exclusive radiation therapy, or exclusive best supportive care (BSC). We calculated patients' 1‐year overall survival (OS) and compared indicators in 2019 and 2020. Results In 2019 and 2020, 2055 and 1988, new BC patients underwent cancer treatment, and during the two lockdowns, the BC diagnoses varied by −18% and by +23% compared to 2019. De novo metastatic tumors (15% and 15%, p = 0.95), pTNM and ypTNM distributions of 1332 cases with upfront resection and of 296 cases with neoadjuvant therapy did not differ (p = 0.37, p = 0.3). The median times from first multidisciplinary meeting and from diagnosis to treatment of 19 days (interquartile 11–39 days) and 35 days (interquartile 22–65 days) did not differ. Access to plastic surgery (15% and 17%, p = 0.08) and to treatment categories did not vary: tumor resection (73% and 72%), exclusive systemic therapy (13% and 14%), exclusive radiation therapy (9% and 9%), exclusive BSC (5% and 5%) (p = 0.8). Among resected patients, the neoadjuvant therapy rate was lower in 2019 (16%) versus 2020 (20%) (p = 0.02). One‐year OS rates were 99.3% versus 98.9% (HR = 0.96; 95% CI, 0.77–1.2), 72.6% versus 76.6% (HR = 1.28; 95% CI, 0.95–1.72), 96.6% versus 97.8% (HR = 1.09; 95% CI, 0.61–1.94), and 15.5% versus 15.1% (HR = 0.99; 95% CI, 0.72–1.37), in the treatment groups. Conclusions Despite a decrease in the number of new BCs, there was no tumor stage shift, and OS did not vary.

Published
2023
Full Text
View/download PDF

22. Consensus français sur les syndrome d’apnées et hypopnées centrales du sommeil (SAHCS) de l’adulte. Préambule : contexte et méthodologie utilisée

Author

Launois Rollinat, Sandrine, Barateau, Lucie, Bironneau, Vanessa, Barone-Rochette, Gilles, D’Ortho, Marie Pia, Jullian-Desayes, Ingrid, Gentina, Thibaut, Lequeux, Benoit, Lombard, Rémy, Mallet, Jean Pierre, Martin, Francis, Meslier, Nicole, Monaca, Christelle, Nowak, Stefan, Petiau, Christophe, Perrin, Christophe, Philippe, Carole, Portel, Laurent, Priou, Pascaline, Puel, Vincent, Redolfi, Stefania, Roche, Frédéric, Roubille, François, Tamisier, Renaud, Thoin, Fabrice, Trzepizur, Wojciech, Meurice, Jean Claude, Gagnadoux, Frédéric, and Jaffuel, Dany

Published
2024
Full Text
View/download PDF

23. CT Imaging Assessment of Response to Treatment in Allergic Bronchopulmonary Aspergillosis in Adults With Bronchial Asthma

Author

Mal, Hervé, Le Guen, Pierre, Dupin, Clairelyne, Meurice, Jean Claude, Verdaguer, Marion, de Keizer, Joe, Delétage-Métreau, Céline, Le Mao, Raphael, Tromer, Cécile, Fajole, Gaëlle, Rayez, Mélanie, Raymond, Christel Saint, Gheerbrant, Hubert, Badatcheff, Anne, Person, Christine, Macey, Julie, Dermant, Xavier, Boitiaux, Jean-François, Gosset-Woimant, Marine, Metz-Favre, Carine, Degot, Tristan, Poulet, Claire, Popin, Elisabeth, Gamez, Anne Sophie, Boissin, Clément, Prevotat, Anne, Mangiapan, Gilles, Brouquières, Danielle, Le Floch, Hervé, Morisse-Pradier, Hélène, Sattler, Caroline, Muti, Daniela, Germaud, Patrick, Dirou, Stéphanie, Paris, Audrey, Melloni, Boris, Ballouhey, Julia, Bondeelle, Louise, Laurent, Lucie, Belleguic, Chantal, Kerjouan, Mallorie, Deslée, Gaëtan, Dury, Sandra, Bergot, Emmanuel, Magnier, Romain, Morel, Hugues, Lemaire, Bertrand, Tumino, Cécile, Sénéchal, Agathe, Choinier, Pascaline, Parrot, Antoine, Godet, Cendrine, Brun, Anne-Laure, Couturaud, Francis, Laurent, François, Frat, Jean-Pierre, Marchand-Adam, Sylvain, Gagnadoux, Frédéric, Blanchard, Elodie, Taillé, Camille, Philippe, Bruno, Hirschi, Sandrine, Andréjak, Claire, Bourdin, Arnaud, Chenivesse, Cécile, Dominique, Stéphane, Murris-Espin, Marlène, Rivière, Frédéric, Garcia, Gilles, Blanc, François-Xavier, Goupil, François, Bergeron, Anne, Flament, Thomas, Priou, Pascaline, Ragot, Stéphanie, and Cadranel, Jacques

Published
2024
Full Text
View/download PDF

27. A Randomized, Open-label, Cross-over Phase 2 Trial of Darolutamide and Enzalutamide in Men with Asymptomatic or Mildly Symptomatic Metastatic Castrate-resistant Prostate Cancer: Patient Preference and Cognitive Function in ODENZA

Author

Colomba, Emeline, Jonas, Sarah Flora, Eymard, Jean-Christophe, Delva, Rémi, Brachet, Pierre Emmanuel, Neuzillet, Yann, Penel, Nicolas, Roubaud, Guilhem, Bompas, Emmanuelle, Mahammedi, Hakim, Longo, Raffaelle, Helissey, Carole, Barthélemy, Philippe, Borchiellini, Delphine, Hasbini, Ali, Priou, Franck, Saldana, Carolina, Voog, Eric, Narcisso, Bérangère, Ladoire, Sylvain, Berdah, Jean-François, Aisenfarb, Jean-Baptiste, Foulon, Stéphanie, and Fizazi, Karim

Published
2024
Full Text
View/download PDF

28. FACE study: 2-year follow-up of adaptive servo-ventilation for sleep-disordered breathing in a chronic heart failure cohort

Author

Attali, Valérie, Maria-Anna, Balice, Laurent, Barthel, Rosa, Buendia, Bertien, Buyse, Laurent, Boyer, Marie-Pierre, Cadars, Pascal, Cornec, Thibaud, Damy, Jean-Marc, Davy, Geoffroy, De Faverges, Toufik, Didi, Marie-Pia, d'ortho, Frédéric, Gagnadoux, Thibaud, Gentina, François, Goupil, Frédéric, Goutorbe, Jean-Maurice, Guillemot, Carmen, Iamandi, Richard, Isnard, François, Jounieaux, Christian, Koltes, Alain, Le Coz, Benoit, Lequeux, René, Lerest, Lionel, Lerousseau, Jean-Pierre, Mallet, Francis, Martin, Jean-Claude, Meurice, Ala, Noroc, Frédéric, Ortuno, Alain, Palot, Philippe, Papola, Audrey, Paris, Hélène, Pastinelli, Jean-Louis, Pepin, Christophe, Perrin, Carole, Philippe, Sandrine, Pontier, Arnaud, Prigent, Pascaline, Priou, Vincent, Puel, Claudio, Rabec, Benjamin, Richard, Claude, Richard, Marijke, Rutten, Manuel, Sastry, Murielle, Salvat, Kamila, Sedkaoui, Bharati, Shivalkar, Renaud, Tamisier, Dries, Testelmans, Johan, Verbraecken, Tamisier, Renaud, Damy, Thibaud, Bailly, Sébastien, Goutorbe, Frédéric, Davy, Jean-Marc, Lavergne, Florent, Palot, Alain, Verbraecken, Johan A., d’Ortho, Marie-Pia, and Pépin, Jean-Louis

Published
2024
Full Text
View/download PDF

30. Tailored immunotherapy approach with nivolumab with or without nivolumab plus ipilimumab as immunotherapeutic boost in patients with metastatic renal cell carcinoma (TITAN-RCC): a multicentre, single-arm, phase 2 trial

Author

Barone, Carlo, Castellano, Daniel, Chevreau, Christine, Gajate Borau, Pablo, Gopalakrishnan, Srinavasan, Grande, Enrique, Hamid, Abdel, Heinzelbecker, Julia, Janssen, Martin, Kopecký, Jindřich, Kubala, Eugen, Loidl, Wolfgang, Lorch, Anja, Melichar, Bohuslav, Lainez Milagro, Nuria, Niegisch, Günter, Ohlmann, Carsten, Sacré, Anne, Sarwar, Naveed, Schinzari, Giovanni, Schrijvers, Dirk, Tartas, Sophie, Wirth, Manfred, Wolter, Pascal, Zemanova, Milanda, Grimm, Marc-Oliver, Esteban, Emilio, Barthélémy, Philippe, Schmidinger, Manuela, Busch, Jonas, Valderrama, Begoña P, Charnley, Natalie, Schmitz, Marc, Schumacher, Ulrike, Leucht, Katharina, Foller, Susan, Baretton, Gustavo, Duran, Ignacio, de Velasco, Guillermo, Priou, Frank, Maroto, Pablo, and Albiges, Laurence

Published
2023
Full Text
View/download PDF

33. Efficacy and safety of nivolumab in bone metastases from renal cell carcinoma: Results of the GETUG-AFU26-NIVOREN multicentre phase II study

Author

Velev, Maud, Dalban, Cécile, Chevreau, Christine, Gravis, Gwenaelle, Negrier, Sylvie, Laguerre, Brigitte, Gross-Goupil, Marine, Ladoire, Sylvain, Borchiellini, Delphine, Geoffrois, Lionnel, Joly, Florence, Priou, Frank, Barthelemy, Philippe, Laramas, Mathieu, Narciso, Berangère, Thiery-Vuillemin, Antoine, Berdah, Jean-François, Ferrari, Victoria, Dominique Thomas, Quentin, Mione, Cécile, Curcio, Hubert, Oudard, Stephane, Tantot, Florence, Escudier, Bernard, Chabaud, Sylvie, Albiges, Laurence, and Thibault, Constance

Published
2023
Full Text
View/download PDF

37. Abiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design

Author

Fizazi, Karim, Foulon, Stéphanie, Carles, Joan, Roubaud, Guilhem, McDermott, Ray, Fléchon, Aude, Tombal, Bertrand, Supiot, Stéphane, Berthold, Dominik, Ronchin, Philippe, Kacso, Gabriel, Gravis, Gwenaëlle, Calabro, Fabio, Berdah, Jean-François, Hasbini, Ali, Silva, Marlon, Thiery-Vuillemin, Antoine, Latorzeff, Igor, Mourey, Loïc, Laguerre, Brigitte, Abadie-Lacourtoisie, Sophie, Martin, Etienne, El Kouri, Claude, Escande, Anne, Rosello, Alvar, Magne, Nicolas, Schlurmann, Friederike, Priou, Frank, Chand-Fouche, Marie-Eve, Freixa, Salvador Villà, Jamaluddin, Muhammad, Rieger, Isabelle, and Bossi, Alberto

Published
2022
Full Text
View/download PDF

38. Uncrewed surface vehicles (USVs) as platforms for fisheries and plankton acoustics.

Author

Handegard, Nils Olav, De Robertis, Alex, Holmin, Arne Johannes, Johnsen, Espen, Lawrence, Joshua, Le Bouffant, Naig, O'Driscoll, Richard, Peddie, David, Pedersen, Geir, Priou, Pierre, Rogge, Rabea, Samuelsen, Mikal, and Demer, David A

Abstract

Uncrewed surface vehicles (USVs) equipped with echosounders have the potential to replace or enhance acoustic observations from conventional research vessels (RVs), increase spatial and temporal coverage, and reduce cost and carbon emission. We discuss the objectives, system requirements, infrastructure, and regulations for using USVs with echosounders to conduct ecological experiments, acoustic-trawl surveys, and long-term monitoring. We present four example applications of USVs with lengths <8 m, and highlight some advantages and disadvantages relative to RV-based data acquisitions. Sail-driven USVs operate continuously for months and are more mature than motorized USVs, but they are slower. To maintain the pace of an RV, multiple sail-powered USVs sample in coordination. In comparison, motorized USVs can travel as fast as RVs and therefore may facilitate a combined survey, interleaving USV and RV transects, with RV-based biological sampling. Important considerations for all USVs include platform design, noise and transducer motion mitigation, communications and operations infrastructure, onboard data processing, biological sampling approach, and legal requirements. This technology is evolving and applied in multiple disciplines, but further development and institutional commitment are needed to allow USVs equipped with echosounders to become ubiquitous and useful components of a worldwide network of autonomous ocean observation platforms. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

39. "Goldmine" or "big mess"? An interview study on the challenges of designing, operating, and ensuring the durability of Clinical Data Warehouses in France and Belgium.

Author

Priou, Sonia, Kempf, Emmanuelle, Jankovic, Marija, and Lamé, Guillaume

Abstract

Objectives Clinical Data Warehouses (CDW) are the designated infrastructures to enable access and analysis of large quantities of electronic health record data. Building and managing such systems implies extensive "data work" and coordination between multiple stakeholders. Our study focuses on the challenges these stakeholders face when designing, operating, and ensuring the durability of CDWs for research. Materials and Methods We conducted semistructured interviews with 21 professionals working with CDWs from France and Belgium. All interviews were recorded, transcribed verbatim, and coded inductively. Results Prompted by the AI boom, healthcare institutions launched initiatives to repurpose data they were generating for care without a clear vision of how to generate value. Difficulties in operating CDWs arose quickly, strengthened by the multiplicity and diversity of stakeholders involved and grand discourses on the possibilities of CDWs, disjointed from their actual capabilities. Without proper management of the information flows, stakeholders struggled to build a shared vision. This was evident in our interviewees' contrasting appreciations of what mattered most to ensure data quality. Participants explained they struggled to manage knowledge inside and across institutions, generating knowledge loss, repeated mistakes, and impeding progress locally and nationally. Discussion and conclusion Management issues strongly affect the deployment and operation of CDWs. This may stem from a simplistic linear vision of how this type of infrastructure operates. CDWs remain promising for research, and their design, implementation, and operation require careful management if they are to be successful. Building on innovation management, complex systems, and organizational learning knowledge will help. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

40. M. Xenopi Pulmonary Infection: A Randomized Clinical Trial Comparing Rifampin + Ethambutol + Either Clarithromycin or Moxifloxacin: The Camomy Study

Author

Andrejak, C., primary, Veziris, N., additional, Lescure, F.-X., additional, Ampere, A., additional, Appere De Vecchi, C., additional, Audoly, C., additional, Blanc, F.-X., additional, Bergeron Lafaurie, A., additional, Bergot, E., additional, Bervar, J.-F., additional, Bildstein, F., additional, Bourdin, A., additional, Boutoille, D., additional, Bouvry, D., additional, Catherinot, E., additional, Claude, F., additional, Couturaud, F., additional, Degano, B., additional, Deslee, G., additional, Dupuy-grasset, M., additional, Gagnadoux, F., additional, Georges, M., additional, Godet, C., additional, Greib, C., additional, Jais, X., additional, Kerjouan, M., additional, Le Meunier, F., additional, Mal, H., additional, Maitre, B., additional, Marchand-Adam, S., additional, Marquette, C.-H., additional, Morel, H., additional, Morisse, H., additional, Nieves, A., additional, Philippe, B., additional, Priou, P., additional, Schlemmer, F., additional, Salaun, M., additional, Tattevin, P., additional, Tazi, A., additional, Cadranel, J., additional, and Jounieaux, V., additional

Published
2024
Full Text
View/download PDF

44. TAXOMET: A French Prospective Multicentric Randomized Phase II Study of Docetaxel Plus Metformin Versus Docetaxel Plus Placebo in Metastatic Castration-Resistant Prostate Cancer

Author

Pujalte Martin, Marc, Borchiellini, Delphine, Thamphya, Brice, Guillot, Aline, Paoli, Jean-Baptiste, Besson, Dominique, Hilgers, Werner, Priou, Frank, El Kouri, Claude, Hoch, Benjamin, Deville, Jean-Laurent, Schiappa, Renaud, Cheli, Sandrine, Milano, Gérard, Tanti, Jean-François, Bost, Frédéric, and Ferrero, Jean-Marc

Published
2021
Full Text
View/download PDF

46. Primary results from IMpassion131, a double-blind, placebo-controlled, randomised phase III trial of first-line paclitaxel with or without atezolizumab for unresectable locally advanced/metastatic triple-negative breast cancer

Author

Zhang, Q., Xu, B., Shao, Z., Wang, X., Geng, C., Yan, X., Tong, Z., Shen, K., Yin, Y., Sun, T., Yang, J., Feng, J., Yan, M., Wang, Y., Liu, Q., Zhang, S., De Laurentiis, M., Santoro, A., Guarneri, V., Colleoni, M., Natoli, C., Cortesi, L., Placido, S., Gianni, L., Ferrau, F., Livi, L., Zambelli, A., Del Mastro, L., Tonini, G., Montemurro, F., Bianchi, G., Pedersini, R., Prete, S., Allegrini, G., Naso, G., Vici, P., Loirat, D., Mailliez, A., Priou, F., Tredan, O., Dalenc, F., Perrin, C., Gligorov, J., Timar David, M., Dohollou, N., Teixeira, L., Brocard, F., Arnaud, A., Delaloge, S., Spano, J.-P., Mansi, L., Andrade, L., Damian, F., Pedrini, J., Aleixo, S., Hegg, R., Junior, R., Reinisch, M., Schmidt, M., Wenzel, C., Grischke, E.-M., Schneeweiss, A., Just, M., Harbeck, N., Schumacher, C., Peters, U., Fischer, D., Forstbauer, H., Liersch, R., Warner, E., Bouganim, N., Doyle, C., Price Hiller, J., Vandenberg, T., Pavic, M., Robinson, A., Roldan Urgoiti, G., Califaretti, N., Alacacioglu, A., Gumus, M., Yalcin, B., Cicin, I., Kose, F., Uygun, K., Kaplan, M., Cubukcu, E., Wardley, A., Harries, M., Miles, D., Doval, D., Gupta, S., Mohapatra, P., Chatterjee, S., Ghadyalpatil, N., Singhal, M., Nag, S., Agarwal, A., Wolf, I., Gal Yam, E., Yerushalmi, R., Peretz, T., Fried, G., Ben Baruch, N., Katz, D., Hamilton, E., Kayali, F., Brufsky, A., Telli, M., Wright, G., Oyola, R., Rakowski, T., Graff, S., Tjulandin, S., Semiglazov, V., Aparicio, A., Ruiz Borrego, M., Merino, L., Guerra Martinez, J., Lopez, E., Yamashita, T., Ohtani, S., Inoue, K., Ito, Y., Niikura, N., Nakayama, T., Sagara, Y., Yanagita, Y., Kamada, Y., Kaneko, K., Kaen, D., Nervo, A., Eniu, A., Schenker, M., Priester, P., Melichar, B., Zimovjanova, M., Sormova, P., Sufliarsky, J., Kakalejcik, M., Belbaraka, R., Errihani, H., Le Than, D., Pham, D., Aravantinos, G., Papadimitriou, C., Koumakis, G., Papandreou, C., Podolski, P., Tabane, K., André, F., Cameron, D., Barrios, C., Patel, S., Patre, M., Morales, L., Patel, S.L., Kaul, M., Barata, T., and O’Shaughnessy, J.

Published
2021
Full Text
View/download PDF

47. Pelagic organisms avoid white, blue, and red artificial light from scientific instruments

Author

Maxime Geoffroy, Tom Langbehn, Pierre Priou, Øystein Varpe, Geir Johnsen, Arnault Le Bris, Jonathan A. D. Fisher, Malin Daase, David McKee, Jonathan Cohen, and Jørgen Berge

Subjects
Medicine, Science
Abstract

Abstract In situ observations of pelagic fish and zooplankton with optical instruments usually rely on external light sources. However, artificial light may attract or repulse marine organisms, which results in biased measurements. It is often assumed that most pelagic organisms do not perceive the red part of the visible spectrum and that red light can be used for underwater optical measurements of biological processes. Using hull-mounted echosounders above an acoustic probe or a baited video camera, each equipped with light sources of different colours (white, blue and red), we demonstrate that pelagic organisms in Arctic and temperate regions strongly avoid artificial light, including visible red light (575–700 nm), from instruments lowered in the water column. The density of organisms decreased by up to 99% when exposed to artificial light and the distance of avoidance varied from 23 to 94 m from the light source, depending on colours, irradiance levels and, possibly, species communities. We conclude that observations from optical and acoustic instruments, including baited cameras, using light sources with broad spectral composition in the 400–700 nm wavelengths do not capture the real state of the ecosystem and that they cannot be used alone for reliable abundance estimates or behavioural studies.

Published
2021
Full Text
View/download PDF

48. The expanded French compassionate programme for elexacaftor–tezacaftor–ivacaftor use in people with cystic fibrosis without a F508del CFTRvariant: a real-world study

Author

Burgel, Pierre-Régis, Sermet-Gaudelus, Isabelle, Girodon, Emmanuelle, Durieu, Isabelle, Houdouin, Véronique, Audousset, Camille, Macey, Julie, Grenet, Dominique, Porzio, Michele, Murris-Espin, Marlène, Reix, Philippe, Baravalle, Mélisande, Belleguic, Chantal, Mely, Laurent, Verhille, Juliette, Weiss, Laurence, Reynaud-Gaubert, Martine, Mittaine, Marie, Hamidfar, Rebecca, Ramel, Sophie, Cosson, Laure, Douvry, Benoit, Danner-Boucher, Isabelle, Foucaud, Pierre, Roy, Charlotte, Burnet, Espérie, Raynal, Caroline, Audrezet, Marie-Pierre, Da Silva, Jennifer, Martin, Clémence, Kanaan, Reem, Carlier, Nicolas, Honoré, Isabelle, Chedevergne, Frédérique, Dreano, Elise, Hatton, Aurélie, Hinzpeter, Alexandre, Pranke, Iwona, Le Clainche-Viala, Laurence, Mayer, Sophie, Corvol, Harriet, Thouvenin, Guillaume, de Miranda, Sandra, Remus, Natascha, Douvry, Benoit, Duthoit, Louise, Perez, Thierry, Le Rouzic, Olivier, Wizla, Nathalie, Bon, Claire, Bui, Stéphanie, Poey, Nora, Stremler, Nathalie, Coltey, Bérengère, Dufeu, Nadine, Lebihan, Jean, Gabsi, Asma, Pouradier, Delphine, Andrejak, Claire, Rames, Cinthia, Dupuy-Grasset, Magali, Languepin, Jeanne, Marguet, Christophe, Pramil, Stéphanie, Arnouat, Baptiste, Fanton, Annlyse, Abely, Michel, Ravoninjatovo, Bruno, Blondé, Aurore, Guillaumot, Anne, Kieffer, Sebastien, Tatopoulos, Aurélie, Nove-Josserand, Raphaële, Ohlmann, Camille, Perrin, Thomas, Reynaud, Quitterie, Llerena, Catherine, Quétant, Sébastien, Valois, Sophie, Dalphin, Marie-Laure, Richaud-Thiriez, Bénédicte, Deneuville, Eric, Chiron, Raphael, Socchi, Floriane, Bihouée, Tiphaine, Mankikian, Julie, Flament, Thomas, Coolen-Allou, Nathalie, Gachelin, Elsa, Périsson, Caroline, Vuillard, Constance, Dupuis, Marion, Alkoussa, Wael, Marchal, Sarah, Leroy, Sylvie, Scalbert, Manuela, Campbell, Karine, Laurans, Muriel, Labbé, Guillaume, Montcouquiol, Sylvie, Priou, Pascaline, de Carli, Paola, Lemonnier, Lydie, Dehillotte, Clémence, and Nouvel, Thierry

Abstract

Elexacaftor–tezacaftor–ivacaftor has been approved in Europe for people with cystic fibrosis with at least one F508del CFTRvariant. Additionally, it is approved by the US Food and Drug Administration (FDA) for people with cystic fibrosis with at least one of 177 rare variants. The aims of this study were to describe the clinical response to elexacaftor–tezacaftor–ivacaftor for people with cystic fibrosis without a F508del CFTRvariant in France and to determine CFTRvariant responsiveness to elexacaftor–tezacaftor–ivacaftor based on the observed clinical response.

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results