Search

Your search keyword '"A Morioka"' showing total 29,249 results
Start Over Author "A Morioka"
29,249 results on '"A Morioka"'

1. Emergence of giant spin-orbit torque in a two-dimensional hole gas on the hydrogen-terminated diamond surface

Author

Sako, Fujio, Ohshima, Ryo, Ando, Yuichiro, Morioka, Naoya, Kawashima, Hiroyuki, Kawase, Riku, Mizuochi, Norikazu, Huebl, Hans, and Shiraishi, Masashi

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science
Abstract

Two-dimensional (2D) carrier systems exhibit various significant physical phenomena for electronics and spintronics, where one of the most promising traits is efficient spin-to-charge conversion stemming from their Rashba-type spin-orbit interaction. Meanwhile, a nuisance in quests of promising materials for spintronics application is that vast majority of the investigated platforms consists of rare and/or toxic elements, such as Pt and Te, which hinders progress of spin conversion physics in view of element strategy and green technology. Here, we show the emergence of giant spin-orbit torque driven by 2D hole gas at the surface of hydrogen-terminated diamond, where the constituent substances are ubiquitous elements, carbon and hydrogen. The index of its spin torque efficiency at room temperature is several times greater than that of rare metal, Pt, the benchmark system/element for spin-to-charge conversion. Our finding opens a new pathway for more sustainable spintronics and spin-orbitronics applications, with efficient spin-orbit torque employing ubiquitous non-toxic elements., Comment: 19pages, 4figures

Published
2024

2. Search for the $K_{L} \to \pi^{0} \nu \bar{\nu}$ Decay at the J-PARC KOTO Experiment

Author

KOTO Collaboration, Ahm, J. K., Farriagton, M., Gonzalez, M., Grethen, N., Hanai, K., Hara, N., Haraguchi, H., Hsiung, Y. B., Inagaki, T., Katayama, M., Kato, T., Kawata, Y., Kim, E. J., Kim, H. M., Kitagawa, A., Komatsubara, T. K., Kotera, K., Lee, S. K., Li, X., Lim, G. Y., Lin, C., Luo, Y., Mari, T., Matsumura, T., Morioka, I., Nanjo, H., Nishimiya, H., Noichi, Y., Nomura, T., Ono, K., Osugi, M., Paschos, P., Redeker, J., Sato, T., Sato, Y., Shibata, T., Shimizu, N., Shinkawa, T., Shiomi, K., Shiraishi, R., Suzuki, S., Tajima, Y., Taylor, N., Tung, Y. C., Wah, Y. W., Watanabe, H., Wu, T., Yamanaka, T., and Yoshida, H. Y.

Subjects
High Energy Physics - Experiment
Abstract

We performed a search for the $K_L \to \pi^{0} \nu \bar{\nu}$ decay using the data taken in 2021 at the J-PARC KOTO experiment. With newly installed counters and new analysis method, the expected background was suppressed to $0.252\pm0.055_{\mathrm{stat}}$$^{+0.052}_{-0.067}$$_{\mathrm{syst}}$. With a single event sensitivity of $(9.33 \pm 0.06_{\rm stat} \pm 0.84_{\rm syst})\times 10^{-10}$, no events were observed in the signal region. An upper limit on the branching fraction for the decay was set to be $2.2\times10^{-9}$ at the 90% confidence level (C.L.), which improved the previous upper limit from KOTO by a factor of 1.4. With the same data, a search for $K_L \to \pi^{0} X^{0}$ was also performed, where $X^{0}$ is an invisible boson with a mass ranging from 1 MeV/$c^{2}$ to 260 MeV/$c^{2}$. For $X^{0}$ with a mass of 135 MeV/$c^{2}$, an upper limit on the branching fraction of $K_L \to \pi^{0} X^{0}$ was set to be $1.6\times10^{-9}$ at the 90% C.L., Comment: 6 pages, 4 figures; submitted for publication

Published
2024

3. A remark on the absence of eigenvalues in continuous spectra for discrete Schr\'{o}dinger operators on periodic lattices

Author

Ando, Kazunori, Isozaki, Hiroshi, and Morioka, Hisashi

Subjects
Mathematics - Spectral Theory, Mathematical Physics, Mathematics - Analysis of PDEs, 47A75, 47A40
Abstract

We prove a Rellich-Vekua type theorem for Schr\"{o}dinger operators with exponentially decreasing potentials on a class of lattices containing square, triangular, hexagonal lattices and their ladders. We also discuss the unique continuation theorem and the non-existence of eigenvalues embedded in the continuous spectrum.

Published
2024

4. Diversity and Opacity of the 'Other' in Educational Relationships: A Critique of the 'Metric Fixation' and the 'Tyranny of Meritocracy'

Author

Jiro Morioka

Abstract

This paper focuses first on the issue of measuring education. When we consider "education and equity," we tend to quantify educational outcomes and compare these figures with others. While it is necessary to consider "equity" (or inequity) through comparisons with others, if we quantify the achievement of outcomes and evaluate the management of the organisation, we fall into a "metric fixation." Next, the paper discusses the issue of meritocracy, presenting a perspective on abilities as social and communal rather than individual. Finally, it discusses the concept of "collaborative learning" as presented by the Central Council for Education Report of 2021. This report states the importance of respecting all others as valuable beings. In order to clarify the significance and value of the presence of others in educational relationships, the paper considers a certain high school discussion situation. "Equity" in education cannot be realised by comparing personal figures on a particular scale. If we wish to realise "equity," paradoxically, it is essential that we do not ask whether we are achieving "equity" through comparison with others. Being equally opaque to one another, being diverse, is essential for the realization of pleasurable "collaborative learning."

Published
2024

5. Action-Outcome Regularity Perceptual Sensitivity in Children with Developmental Coordination Disorder

Author

Satoshi Nobusako, Wen Wen, Michihiro Osumi, Akio Nakai, and Shu Morioka

Abstract

Purpose: An internal model deficit is considered to underlie developmental coordination disorder (DCD); thus, children with DCD have an altered sense of agency (SoA), which is associated with depressive symptoms. Furthermore, the perception of action-outcome regularity is present in early development, is involved in the generation of SoA, and has roles in adaptive motor learning and coordinated motor skills. However, perceptual sensitivity to action-outcome regularity has not been examined in children with DCD. Methods: We investigated perceptual sensitivity to action-outcome regularity in 6-15-year-old children with DCD and age- and sex-matched typically developing (TD) children. Both groups were assessed for coordinated motor skills with the Movement Assessment Battery for Children-2nd Edition, while the DCD group was assessed with the DCD Questionnaire, Social Communication Questionnaire, Attention-Deficit/Hyperactivity Disorder-Rating Scale, and Depression Self- Rating Scale for Children. Results: Perceptual sensitivity to action-outcome regularity was significantly reduced in children with DCD. However, there was a significant correlation between perceptual sensitivity to action-outcome regularity and age in DCD and TD children. Perceptual sensitivity to action-outcome regularity was significantly lower in younger children with DCD than in younger and older TD children, but there were no significant differences between older children with DCD and younger and older TD children. Conclusion: The current results suggest that children with DCD have significantly reduced perceptual sensitivity to action-outcome regularity at younger ages, which may alter SoA and inhibit internal model development, thereby reducing motor skill coordination.

Published
2024
Full Text
View/download PDF

6. Inverse problems for quantum graph associated with square and hexagonal lattices

Author

Ando, K., Blåsten, E., Exner, P., Isozaki, H., Korotyaev, E., Lassas, M., Lu, J., and Morioka, H.

Subjects
Mathematical Physics
Abstract

We solve inverse problems from the D-N map for the quantum graph on a finite domain in a square lattice and that on a hexagonal lattice, as well as inverse scattering problems from the S-matrix for a locally perturbed square lattice and a hexagonal lattice.

Published
2024

7. Improving rigor and reproducibility in western blot experiments with the blotRig analysis.

Author

Omondi, Cleopa, Chou, Austin, Fond, Kenneth, Morioka, Kazuhito, Joseph, Nadine, Sacramento, Jeffrey, Iorio, Emma, Torres-Espin, Abel, Radabaugh, Hannah, Davis, Jacob, Gumbel, Jason, Huie, J, and Ferguson, Adam

Subjects
Analytical chemistry, Antibodies, Biostatistics, Computational biology, Computational chemistry, Western blot, Reproducibility of Results, Blotting, Western, Research Design, Software, Humans
Abstract

Western blot is a popular biomolecular analysis method for measuring the relative quantities of independent proteins in complex biological samples. However, variability in quantitative western blot data analysis poses a challenge in designing reproducible experiments. The lack of rigorous quantitative approaches in current western blot statistical methodology may result in irreproducible inferences. Here we describe best practices for the design and analysis of western blot experiments, with examples and demonstrations of how different analytical approaches can lead to widely varying outcomes. To facilitate best practices, we have developed the blotRig tool for designing and analyzing western blot experiments to improve their rigor and reproducibility. The blotRig application includes functions for counterbalancing experimental design by lane position, batch management across gels, and analytics with covariates and random effects.

Published
2024

10. Evaluating Combinations of Biological and Clinicopathologic Factors Linked to Poor Outcomes in Resected Colorectal Liver Metastasis: An External Validation Study

Author

Sasaki, Kazunari, Wang, Jane, Kamphues, Carsten, Buettner, Stefan, Gagniere, Johan, Ardilles, Victoria, Imai, Katsunori, Wagner, Doris, Pozios, Ioannis, Papakonstantinou, Dimitris, Pikoulis, Emmanouil, Antoniou, Efstathios, Morioka, Daisuke, Løes, Inger Marie, Lønning, Per Eystein, Kornprat, Peter, Aucejo, Federico N., Baba, Hideo, de Santibañes, Eduardo, Kaczirek, Klaus, Burkhart, Richard, Endo, Itaru, Beyer, Katharina, Kreis, Martin E., Pawlik, Timothy M., and Margonis, Georgios Antonios

Published
2024
Full Text
View/download PDF

15. Gemini 1.5: Unlocking multimodal understanding across millions of tokens of context

Author

Gemini Team, Georgiev, Petko, Lei, Ving Ian, Burnell, Ryan, Bai, Libin, Gulati, Anmol, Tanzer, Garrett, Vincent, Damien, Pan, Zhufeng, Wang, Shibo, Mariooryad, Soroosh, Ding, Yifan, Geng, Xinyang, Alcober, Fred, Frostig, Roy, Omernick, Mark, Walker, Lexi, Paduraru, Cosmin, Sorokin, Christina, Tacchetti, Andrea, Gaffney, Colin, Daruki, Samira, Sercinoglu, Olcan, Gleicher, Zach, Love, Juliette, Voigtlaender, Paul, Jain, Rohan, Surita, Gabriela, Mohamed, Kareem, Blevins, Rory, Ahn, Junwhan, Zhu, Tao, Kawintiranon, Kornraphop, Firat, Orhan, Gu, Yiming, Zhang, Yujing, Rahtz, Matthew, Faruqui, Manaal, Clay, Natalie, Gilmer, Justin, Co-Reyes, JD, Penchev, Ivo, Zhu, Rui, Morioka, Nobuyuki, Hui, Kevin, Haridasan, Krishna, Campos, Victor, Mahdieh, Mahdis, Guo, Mandy, Hassan, Samer, Kilgour, Kevin, Vezer, Arpi, Cheng, Heng-Tze, de Liedekerke, Raoul, Goyal, Siddharth, Barham, Paul, Strouse, DJ, Noury, Seb, Adler, Jonas, Sundararajan, Mukund, Vikram, Sharad, Lepikhin, Dmitry, Paganini, Michela, Garcia, Xavier, Yang, Fan, Valter, Dasha, Trebacz, Maja, Vodrahalli, Kiran, Asawaroengchai, Chulayuth, Ring, Roman, Kalb, Norbert, Soares, Livio Baldini, Brahma, Siddhartha, Steiner, David, Yu, Tianhe, Mentzer, Fabian, He, Antoine, Gonzalez, Lucas, Xu, Bibo, Kaufman, Raphael Lopez, Shafey, Laurent El, Oh, Junhyuk, Hennigan, Tom, Driessche, George van den, Odoom, Seth, Lucic, Mario, Roelofs, Becca, Lall, Sid, Marathe, Amit, Chan, Betty, Ontanon, Santiago, He, Luheng, Teplyashin, Denis, Lai, Jonathan, Crone, Phil, Damoc, Bogdan, Ho, Lewis, Riedel, Sebastian, Lenc, Karel, Yeh, Chih-Kuan, Chowdhery, Aakanksha, Xu, Yang, Kazemi, Mehran, Amid, Ehsan, Petrushkina, Anastasia, Swersky, Kevin, Khodaei, Ali, Chen, Gowoon, Larkin, Chris, Pinto, Mario, Yan, Geng, Badia, Adria Puigdomenech, Patil, Piyush, Hansen, Steven, Orr, Dave, Arnold, Sebastien M. R., Grimstad, Jordan, Dai, Andrew, Douglas, Sholto, Sinha, Rishika, Yadav, Vikas, Chen, Xi, Gribovskaya, Elena, Austin, Jacob, Zhao, Jeffrey, Patel, Kaushal, Komarek, Paul, Austin, Sophia, Borgeaud, Sebastian, Friso, Linda, Goyal, Abhimanyu, Caine, Ben, Cao, Kris, Chung, Da-Woon, Lamm, Matthew, Barth-Maron, Gabe, Kagohara, Thais, Olszewska, Kate, Chen, Mia, Shivakumar, Kaushik, Agarwal, Rishabh, Godhia, Harshal, Rajwar, Ravi, Snaider, Javier, Dotiwalla, Xerxes, Liu, Yuan, Barua, Aditya, Ungureanu, Victor, Zhang, Yuan, Batsaikhan, Bat-Orgil, Wirth, Mateo, Qin, James, Danihelka, Ivo, Doshi, Tulsee, Chadwick, Martin, Chen, Jilin, Jain, Sanil, Le, Quoc, Kar, Arjun, Gurumurthy, Madhu, Li, Cheng, Sang, Ruoxin, Liu, Fangyu, Lamprou, Lampros, Munoz, Rich, Lintz, Nathan, Mehta, Harsh, Howard, Heidi, Reynolds, Malcolm, Aroyo, Lora, Wang, Quan, Blanco, Lorenzo, Cassirer, Albin, Griffith, Jordan, Das, Dipanjan, Lee, Stephan, Sygnowski, Jakub, Fisher, Zach, Besley, James, Powell, Richard, Ahmed, Zafarali, Paulus, Dominik, Reitter, David, Borsos, Zalan, Joshi, Rishabh, Pope, Aedan, Hand, Steven, Selo, Vittorio, Jain, Vihan, Sethi, Nikhil, Goel, Megha, Makino, Takaki, May, Rhys, Yang, Zhen, Schalkwyk, Johan, Butterfield, Christina, Hauth, Anja, Goldin, Alex, Hawkins, Will, Senter, Evan, Brin, Sergey, Woodman, Oliver, Ritter, Marvin, Noland, Eric, Giang, Minh, Bolina, Vijay, Lee, Lisa, Blyth, Tim, Mackinnon, Ian, Reid, Machel, Sarvana, Obaid, Silver, David, Chen, Alexander, Wang, Lily, Maggiore, Loren, Chang, Oscar, Attaluri, Nithya, Thornton, Gregory, Chiu, Chung-Cheng, Bunyan, Oskar, Levine, Nir, Chung, Timothy, Eltyshev, Evgenii, Si, Xiance, Lillicrap, Timothy, Brady, Demetra, Aggarwal, Vaibhav, Wu, Boxi, Xu, Yuanzhong, McIlroy, Ross, Badola, Kartikeya, Sandhu, Paramjit, Moreira, Erica, Stokowiec, Wojciech, Hemsley, Ross, Li, Dong, Tudor, Alex, Shyam, Pranav, Rahimtoroghi, Elahe, Haykal, Salem, Sprechmann, Pablo, Zhou, Xiang, Mincu, Diana, Li, Yujia, Addanki, Ravi, Krishna, Kalpesh, Wu, Xiao, Frechette, Alexandre, Eyal, Matan, Dafoe, Allan, Lacey, Dave, Whang, Jay, Avrahami, Thi, Zhang, Ye, Taropa, Emanuel, Lin, Hanzhao, Toyama, Daniel, Rutherford, Eliza, Sano, Motoki, Choe, HyunJeong, Tomala, Alex, Safranek-Shrader, Chalence, Kassner, Nora, Pajarskas, Mantas, Harvey, Matt, Sechrist, Sean, Fortunato, Meire, Lyu, Christina, Elsayed, Gamaleldin, Kuang, Chenkai, Lottes, James, Chu, Eric, Jia, Chao, Chen, Chih-Wei, Humphreys, Peter, Baumli, Kate, Tao, Connie, Samuel, Rajkumar, Santos, Cicero Nogueira dos, Andreassen, Anders, Rakićević, Nemanja, Grewe, Dominik, Kumar, Aviral, Winkler, Stephanie, Caton, Jonathan, Brock, Andrew, Dalmia, Sid, Sheahan, Hannah, Barr, Iain, Miao, Yingjie, Natsev, Paul, Devlin, Jacob, Behbahani, Feryal, Prost, Flavien, Sun, Yanhua, Myaskovsky, Artiom, Pillai, Thanumalayan Sankaranarayana, Hurt, Dan, Lazaridou, Angeliki, Xiong, Xi, Zheng, Ce, Pardo, Fabio, Li, Xiaowei, Horgan, Dan, Stanton, Joe, Ambar, Moran, Xia, Fei, Lince, Alejandro, Wang, Mingqiu, Mustafa, Basil, Webson, Albert, Lee, Hyo, Anil, Rohan, Wicke, Martin, Dozat, Timothy, Sinha, Abhishek, Piqueras, Enrique, Dabir, Elahe, Upadhyay, Shyam, Boral, Anudhyan, Hendricks, Lisa Anne, Fry, Corey, Djolonga, Josip, Su, Yi, Walker, Jake, Labanowski, Jane, Huang, Ronny, Misra, Vedant, Chen, Jeremy, Skerry-Ryan, RJ, Singh, Avi, Rijhwani, Shruti, Yu, Dian, Castro-Ros, Alex, Changpinyo, Beer, Datta, Romina, Bagri, Sumit, Hrafnkelsson, Arnar Mar, Maggioni, Marcello, Zheng, Daniel, Sulsky, Yury, Hou, Shaobo, Paine, Tom Le, Yang, Antoine, Riesa, Jason, Rogozinska, Dominika, Marcus, Dror, Badawy, Dalia El, Zhang, Qiao, Wang, Luyu, Miller, Helen, Greer, Jeremy, Sjos, Lars Lowe, Nova, Azade, Zen, Heiga, Chaabouni, Rahma, Rosca, Mihaela, Jiang, Jiepu, Chen, Charlie, Liu, Ruibo, Sainath, Tara, Krikun, Maxim, Polozov, Alex, Lespiau, Jean-Baptiste, Newlan, Josh, Cankara, Zeyncep, Kwak, Soo, Xu, Yunhan, Chen, Phil, Coenen, Andy, Meyer, Clemens, Tsihlas, Katerina, Ma, Ada, Gottweis, Juraj, Xing, Jinwei, Gu, Chenjie, Miao, Jin, Frank, Christian, Cankara, Zeynep, Ganapathy, Sanjay, Dasgupta, Ishita, Hughes-Fitt, Steph, Chen, Heng, Reid, David, Rong, Keran, Fan, Hongmin, van Amersfoort, Joost, Zhuang, Vincent, Cohen, Aaron, Gu, Shixiang Shane, Mohananey, Anhad, Ilic, Anastasija, Tobin, Taylor, Wieting, John, Bortsova, Anna, Thacker, Phoebe, Wang, Emma, Caveness, Emily, Chiu, Justin, Sezener, Eren, Kaskasoli, Alex, Baker, Steven, Millican, Katie, Elhawaty, Mohamed, Aisopos, Kostas, Lebsack, Carl, Byrd, Nathan, Dai, Hanjun, Jia, Wenhao, Wiethoff, Matthew, Davoodi, Elnaz, Weston, Albert, Yagati, Lakshman, Ahuja, Arun, Gao, Isabel, Pundak, Golan, Zhang, Susan, Azzam, Michael, Sim, Khe Chai, Caelles, Sergi, Keeling, James, Sharma, Abhanshu, Swing, Andy, Li, YaGuang, Liu, Chenxi, Bostock, Carrie Grimes, Bansal, Yamini, Nado, Zachary, Anand, Ankesh, Lipschultz, Josh, Karmarkar, Abhijit, Proleev, Lev, Ittycheriah, Abe, Yeganeh, Soheil Hassas, Polovets, George, Faust, Aleksandra, Sun, Jiao, Rrustemi, Alban, Li, Pen, Shivanna, Rakesh, Liu, Jeremiah, Welty, Chris, Lebron, Federico, Baddepudi, Anirudh, Krause, Sebastian, Parisotto, Emilio, Soricut, Radu, Xu, Zheng, Bloxwich, Dawn, Johnson, Melvin, Neyshabur, Behnam, Mao-Jones, Justin, Wang, Renshen, Ramasesh, Vinay, Abbas, Zaheer, Guez, Arthur, Segal, Constant, Nguyen, Duc Dung, Svensson, James, Hou, Le, York, Sarah, Milan, Kieran, Bridgers, Sophie, Gworek, Wiktor, Tagliasacchi, Marco, Lee-Thorp, James, Chang, Michael, Guseynov, Alexey, Hartman, Ale Jakse, Kwong, Michael, Zhao, Ruizhe, Kashem, Sheleem, Cole, Elizabeth, Miech, Antoine, Tanburn, Richard, Phuong, Mary, Pavetic, Filip, Cevey, Sebastien, Comanescu, Ramona, Ives, Richard, Yang, Sherry, Du, Cosmo, Li, Bo, Zhang, Zizhao, Iinuma, Mariko, Hu, Clara Huiyi, Roy, Aurko, Bijwadia, Shaan, Zhu, Zhenkai, Martins, Danilo, Saputro, Rachel, Gergely, Anita, Zheng, Steven, Jia, Dawei, Antonoglou, Ioannis, Sadovsky, Adam, Gu, Shane, Bi, Yingying, Andreev, Alek, Samangooei, Sina, Khan, Mina, Kocisky, Tomas, Filos, Angelos, Kumar, Chintu, Bishop, Colton, Yu, Adams, Hodkinson, Sarah, Mittal, Sid, Shah, Premal, Moufarek, Alexandre, Cheng, Yong, Bloniarz, Adam, Lee, Jaehoon, Pejman, Pedram, Michel, Paul, Spencer, Stephen, Feinberg, Vladimir, Xiong, Xuehan, Savinov, Nikolay, Smith, Charlotte, Shakeri, Siamak, Tran, Dustin, Chesus, Mary, Bohnet, Bernd, Tucker, George, von Glehn, Tamara, Muir, Carrie, Mao, Yiran, Kazawa, Hideto, Slone, Ambrose, Soparkar, Kedar, Shrivastava, Disha, Cobon-Kerr, James, Sharman, Michael, Pavagadhi, Jay, Araya, Carlos, Misiunas, Karolis, Ghelani, Nimesh, Laskin, Michael, Barker, David, Li, Qiujia, Briukhov, Anton, Houlsby, Neil, Glaese, Mia, Lakshminarayanan, Balaji, Schucher, Nathan, Tang, Yunhao, Collins, Eli, Lim, Hyeontaek, Feng, Fangxiaoyu, Recasens, Adria, Lai, Guangda, Magni, Alberto, De Cao, Nicola, Siddhant, Aditya, Ashwood, Zoe, Orbay, Jordi, Dehghani, Mostafa, Brennan, Jenny, He, Yifan, Xu, Kelvin, Gao, Yang, Saroufim, Carl, Molloy, James, Wu, Xinyi, Arnold, Seb, Chang, Solomon, Schrittwieser, Julian, Buchatskaya, Elena, Radpour, Soroush, Polacek, Martin, Giordano, Skye, Bapna, Ankur, Tokumine, Simon, Hellendoorn, Vincent, Sottiaux, Thibault, Cogan, Sarah, Severyn, Aliaksei, Saleh, Mohammad, Thakoor, Shantanu, Shefey, Laurent, Qiao, Siyuan, Gaba, Meenu, Chang, Shuo-yiin, Swanson, Craig, Zhang, Biao, Lee, Benjamin, Rubenstein, Paul Kishan, Song, Gan, Kwiatkowski, Tom, Koop, Anna, Kannan, Ajay, Kao, David, Schuh, Parker, Stjerngren, Axel, Ghiasi, Golnaz, Gibson, Gena, Vilnis, Luke, Yuan, Ye, Ferreira, Felipe Tiengo, Kamath, Aishwarya, Klimenko, Ted, Franko, Ken, Xiao, Kefan, Bhattacharya, Indro, Patel, Miteyan, Wang, Rui, Morris, Alex, Strudel, Robin, Sharma, Vivek, Choy, Peter, Hashemi, Sayed Hadi, Landon, Jessica, Finkelstein, Mara, Jhakra, Priya, Frye, Justin, Barnes, Megan, Mauger, Matthew, Daun, Dennis, Baatarsukh, Khuslen, Tung, Matthew, Farhan, Wael, Michalewski, Henryk, Viola, Fabio, Quitry, Felix de Chaumont, Lan, Charline Le, Hudson, Tom, Wang, Qingze, Fischer, Felix, Zheng, Ivy, White, Elspeth, Dragan, Anca, Alayrac, Jean-baptiste, Ni, Eric, Pritzel, Alexander, Iwanicki, Adam, Isard, Michael, Bulanova, Anna, Zilka, Lukas, Dyer, Ethan, Sachan, Devendra, Srinivasan, Srivatsan, Muckenhirn, Hannah, Cai, Honglong, Mandhane, Amol, Tariq, Mukarram, Rae, Jack W., Wang, Gary, Ayoub, Kareem, FitzGerald, Nicholas, Zhao, Yao, Han, Woohyun, Alberti, Chris, Garrette, Dan, Krishnakumar, Kashyap, Gimenez, Mai, Levskaya, Anselm, Sohn, Daniel, Matak, Josip, Iturrate, Inaki, Chang, Michael B., Xiang, Jackie, Cao, Yuan, Ranka, Nishant, Brown, Geoff, Hutter, Adrian, Mirrokni, Vahab, Chen, Nanxin, Yao, Kaisheng, Egyed, Zoltan, Galilee, Francois, Liechty, Tyler, Kallakuri, Praveen, Palmer, Evan, Ghemawat, Sanjay, Liu, Jasmine, Tao, David, Thornton, Chloe, Green, Tim, Jasarevic, Mimi, Lin, Sharon, Cotruta, Victor, Tan, Yi-Xuan, Fiedel, Noah, Yu, Hongkun, Chi, Ed, Neitz, Alexander, Heitkaemper, Jens, Sinha, Anu, Zhou, Denny, Sun, Yi, Kaed, Charbel, Hulse, Brice, Mishra, Swaroop, Georgaki, Maria, Kudugunta, Sneha, Farabet, Clement, Shafran, Izhak, Vlasic, Daniel, Tsitsulin, Anton, Ananthanarayanan, Rajagopal, Carin, Alen, Su, Guolong, Sun, Pei, V, Shashank, Carvajal, Gabriel, Broder, Josef, Comsa, Iulia, Repina, Alena, Wong, William, Chen, Warren Weilun, Hawkins, Peter, Filonov, Egor, Loher, Lucia, Hirnschall, Christoph, Wang, Weiyi, Ye, Jingchen, Burns, Andrea, Cate, Hardie, Wright, Diana Gage, Piccinini, Federico, Zhang, Lei, Lin, Chu-Cheng, Gog, Ionel, Kulizhskaya, Yana, Sreevatsa, Ashwin, Song, Shuang, Cobo, Luis C., Iyer, Anand, Tekur, Chetan, Garrido, Guillermo, Xiao, Zhuyun, Kemp, Rupert, Zheng, Huaixiu Steven, Li, Hui, Agarwal, Ananth, Ngani, Christel, Goshvadi, Kati, Santamaria-Fernandez, Rebeca, Fica, Wojciech, Chen, Xinyun, Gorgolewski, Chris, Sun, Sean, Garg, Roopal, Ye, Xinyu, Eslami, S. M. Ali, Hua, Nan, Simon, Jon, Joshi, Pratik, Kim, Yelin, Tenney, Ian, Potluri, Sahitya, Thiet, Lam Nguyen, Yuan, Quan, Luisier, Florian, Chronopoulou, Alexandra, Scellato, Salvatore, Srinivasan, Praveen, Chen, Minmin, Koverkathu, Vinod, Dalibard, Valentin, Xu, Yaming, Saeta, Brennan, Anderson, Keith, Sellam, Thibault, Fernando, Nick, Huot, Fantine, Jung, Junehyuk, Varadarajan, Mani, Quinn, Michael, Raul, Amit, Le, Maigo, Habalov, Ruslan, Clark, Jon, Jalan, Komal, Bullard, Kalesha, Singhal, Achintya, Luong, Thang, Wang, Boyu, Rajayogam, Sujeevan, Eisenschlos, Julian, Jia, Johnson, Finchelstein, Daniel, Yakubovich, Alex, Balle, Daniel, Fink, Michael, Agarwal, Sameer, Li, Jing, Dvijotham, Dj, Pal, Shalini, Kang, Kai, Konzelmann, Jaclyn, Beattie, Jennifer, Dousse, Olivier, Wu, Diane, Crocker, Remi, Elkind, Chen, Jonnalagadda, Siddhartha Reddy, Lee, Jong, Holtmann-Rice, Dan, Kallarackal, Krystal, Liu, Rosanne, Vnukov, Denis, Vats, Neera, Invernizzi, Luca, Jafari, Mohsen, Zhou, Huanjie, Taylor, Lilly, Prendki, Jennifer, Wu, Marcus, Eccles, Tom, Liu, Tianqi, Kopparapu, Kavya, Beaufays, Francoise, Angermueller, Christof, Marzoca, Andreea, Sarcar, Shourya, Dib, Hilal, Stanway, Jeff, Perbet, Frank, Trdin, Nejc, Sterneck, Rachel, Khorlin, Andrey, Li, Dinghua, Wu, Xihui, Goenka, Sonam, Madras, David, Goldshtein, Sasha, Gierke, Willi, Zhou, Tong, Liu, Yaxin, Liang, Yannie, White, Anais, Li, Yunjie, Singh, Shreya, Bahargam, Sanaz, Epstein, Mark, Basu, Sujoy, Lao, Li, Ozturel, Adnan, Crous, Carl, Zhai, Alex, Lu, Han, Tung, Zora, Gaur, Neeraj, Walton, Alanna, Dixon, Lucas, Zhang, Ming, Globerson, Amir, Uy, Grant, Bolt, Andrew, Wiles, Olivia, Nasr, Milad, Shumailov, Ilia, Selvi, Marco, Piccinno, Francesco, Aguilar, Ricardo, McCarthy, Sara, Khalman, Misha, Shukla, Mrinal, Galic, Vlado, Carpenter, John, Villela, Kevin, Zhang, Haibin, Richardson, Harry, Martens, James, Bosnjak, Matko, Belle, Shreyas Rammohan, Seibert, Jeff, Alnahlawi, Mahmoud, McWilliams, Brian, Singh, Sankalp, Louis, Annie, Ding, Wen, Popovici, Dan, Simicich, Lenin, Knight, Laura, Mehta, Pulkit, Gupta, Nishesh, Shi, Chongyang, Fatehi, Saaber, Mitrovic, Jovana, Grills, Alex, Pagadora, Joseph, Petrova, Dessie, Eisenbud, Danielle, Zhang, Zhishuai, Yates, Damion, Mittal, Bhavishya, Tripuraneni, Nilesh, Assael, Yannis, Brovelli, Thomas, Jain, Prateek, Velimirovic, Mihajlo, Akbulut, Canfer, Mu, Jiaqi, Macherey, Wolfgang, Kumar, Ravin, Xu, Jun, Qureshi, Haroon, Comanici, Gheorghe, Wiesner, Jeremy, Gong, Zhitao, Ruddock, Anton, Bauer, Matthias, Felt, Nick, GP, Anirudh, Arnab, Anurag, Zelle, Dustin, Rothfuss, Jonas, Rosgen, Bill, Shenoy, Ashish, Seybold, Bryan, Li, Xinjian, Mudigonda, Jayaram, Erdogan, Goker, Xia, Jiawei, Simsa, Jiri, Michi, Andrea, Yao, Yi, Yew, Christopher, Kan, Steven, Caswell, Isaac, Radebaugh, Carey, Elisseeff, Andre, Valenzuela, Pedro, McKinney, Kay, Paterson, Kim, Cui, Albert, Latorre-Chimoto, Eri, Kim, Solomon, Zeng, William, Durden, Ken, Ponnapalli, Priya, Sosea, Tiberiu, Choquette-Choo, Christopher A., Manyika, James, Robenek, Brona, Vashisht, Harsha, Pereira, Sebastien, Lam, Hoi, Velic, Marko, Owusu-Afriyie, Denese, Lee, Katherine, Bolukbasi, Tolga, Parrish, Alicia, Lu, Shawn, Park, Jane, Venkatraman, Balaji, Talbert, Alice, Rosique, Lambert, Cheng, Yuchung, Sozanschi, Andrei, Paszke, Adam, Kumar, Praveen, Austin, Jessica, Li, Lu, Salama, Khalid, Kim, Wooyeol, Dukkipati, Nandita, Baryshnikov, Anthony, Kaplanis, Christos, Sheng, XiangHai, Chervonyi, Yuri, Unlu, Caglar, Casas, Diego de Las, Askham, Harry, Tunyasuvunakool, Kathryn, Gimeno, Felix, Poder, Siim, Kwak, Chester, Miecnikowski, Matt, Dimitriev, Alek, Parisi, Aaron, Liu, Dangyi, Tsai, Tomy, Shevlane, Toby, Kouridi, Christina, Garmon, Drew, Goedeckemeyer, Adrian, Brown, Adam R., Vijayakumar, Anitha, Elqursh, Ali, Jazayeri, Sadegh, Huang, Jin, Carthy, Sara Mc, Hoover, Jay, Kim, Lucy, Kumar, Sandeep, Chen, Wei, Biles, Courtney, Bingham, Garrett, Rosen, Evan, Wang, Lisa, Tan, Qijun, Engel, David, Pongetti, Francesco, de Cesare, Dario, Hwang, Dongseong, Yu, Lily, Pullman, Jennifer, Narayanan, Srini, Levin, Kyle, Gopal, Siddharth, Li, Megan, Aharoni, Asaf, Trinh, Trieu, Lo, Jessica, Casagrande, Norman, Vij, Roopali, Matthey, Loic, Ramadhana, Bramandia, Matthews, Austin, Carey, CJ, Johnson, Matthew, Goranova, Kremena, Shah, Rohin, Ashraf, Shereen, Dasgupta, Kingshuk, Larsen, Rasmus, Wang, Yicheng, Vuyyuru, Manish Reddy, Jiang, Chong, Ijazi, Joana, Osawa, Kazuki, Smith, Celine, Boppana, Ramya Sree, Bilal, Taylan, Koizumi, Yuma, Xu, Ying, Altun, Yasemin, Shabat, Nir, Bariach, Ben, Korchemniy, Alex, Choo, Kiam, Ronneberger, Olaf, Iwuanyanwu, Chimezie, Zhao, Shubin, Soergel, David, Hsieh, Cho-Jui, Cai, Irene, Iqbal, Shariq, Sundermeyer, Martin, Chen, Zhe, Bursztein, Elie, Malaviya, Chaitanya, Biadsy, Fadi, Shroff, Prakash, Dhillon, Inderjit, Latkar, Tejasi, Dyer, Chris, Forbes, Hannah, Nicosia, Massimo, Nikolaev, Vitaly, Greene, Somer, Georgiev, Marin, Wang, Pidong, Martin, Nina, Sedghi, Hanie, Zhang, John, Banzal, Praseem, Fritz, Doug, Rao, Vikram, Wang, Xuezhi, Zhang, Jiageng, Patraucean, Viorica, Du, Dayou, Mordatch, Igor, Jurin, Ivan, Liu, Lewis, Dubey, Ayush, Mohan, Abhi, Nowakowski, Janek, Ion, Vlad-Doru, Wei, Nan, Tojo, Reiko, Raad, Maria Abi, Hudson, Drew A., Keshava, Vaishakh, Agrawal, Shubham, Ramirez, Kevin, Wu, Zhichun, Nguyen, Hoang, Liu, Ji, Sewak, Madhavi, Petrini, Bryce, Choi, DongHyun, Philips, Ivan, Wang, Ziyue, Bica, Ioana, Garg, Ankush, Wilkiewicz, Jarek, Agrawal, Priyanka, Guo, Danhao, Xue, Emily, Shaik, Naseer, Leach, Andrew, Khan, Sadh MNM, Wiesinger, Julia, Jerome, Sammy, Chakladar, Abhishek, Wang, Alek Wenjiao, Ornduff, Tina, Abu, Folake, Ghaffarkhah, Alireza, Wainwright, Marcus, Cortes, Mario, Liu, Frederick, Maynez, Joshua, Terzis, Andreas, Samangouei, Pouya, Mansour, Riham, Kępa, Tomasz, Aubet, François-Xavier, Algymr, Anton, Banica, Dan, Weisz, Agoston, Orban, Andras, Senges, Alexandre, Andrejczuk, Ewa, Geller, Mark, Santo, Niccolo Dal, Anklin, Valentin, Merey, Majd Al, Baeuml, Martin, Strohman, Trevor, Bai, Junwen, Petrov, Slav, Wu, Yonghui, Hassabis, Demis, Kavukcuoglu, Koray, Dean, Jeffrey, and Vinyals, Oriol

Subjects
Computer Science - Computation and Language, Computer Science - Artificial Intelligence
Abstract

In this report, we introduce the Gemini 1.5 family of models, representing the next generation of highly compute-efficient multimodal models capable of recalling and reasoning over fine-grained information from millions of tokens of context, including multiple long documents and hours of video and audio. The family includes two new models: (1) an updated Gemini 1.5 Pro, which exceeds the February version on the great majority of capabilities and benchmarks; (2) Gemini 1.5 Flash, a more lightweight variant designed for efficiency with minimal regression in quality. Gemini 1.5 models achieve near-perfect recall on long-context retrieval tasks across modalities, improve the state-of-the-art in long-document QA, long-video QA and long-context ASR, and match or surpass Gemini 1.0 Ultra's state-of-the-art performance across a broad set of benchmarks. Studying the limits of Gemini 1.5's long-context ability, we find continued improvement in next-token prediction and near-perfect retrieval (>99%) up to at least 10M tokens, a generational leap over existing models such as Claude 3.0 (200k) and GPT-4 Turbo (128k). Finally, we highlight real-world use cases, such as Gemini 1.5 collaborating with professionals on completing their tasks achieving 26 to 75% time savings across 10 different job categories, as well as surprising new capabilities of large language models at the frontier; when given a grammar manual for Kalamang, a language with fewer than 200 speakers worldwide, the model learns to translate English to Kalamang at a similar level to a person who learned from the same content.

Published
2024

16. Extending Multilingual Speech Synthesis to 100+ Languages without Transcribed Data

Author

Saeki, Takaaki, Wang, Gary, Morioka, Nobuyuki, Elias, Isaac, Kastner, Kyle, Biadsy, Fadi, Rosenberg, Andrew, Ramabhadran, Bhuvana, Zen, Heiga, Beaufays, Françoise, and Shemtov, Hadar

Subjects
Electrical Engineering and Systems Science - Audio and Speech Processing, Computer Science - Sound
Abstract

Collecting high-quality studio recordings of audio is challenging, which limits the language coverage of text-to-speech (TTS) systems. This paper proposes a framework for scaling a multilingual TTS model to 100+ languages using found data without supervision. The proposed framework combines speech-text encoder pretraining with unsupervised training using untranscribed speech and unspoken text data sources, thereby leveraging massively multilingual joint speech and text representation learning. Without any transcribed speech in a new language, this TTS model can generate intelligible speech in >30 unseen languages (CER difference of <10% to ground truth). With just 15 minutes of transcribed, found data, we can reduce the intelligibility difference to 1% or less from the ground-truth, and achieve naturalness scores that match the ground-truth in several languages., Comment: To appear in ICASSP 2024. Demo page: https://google.github.io/tacotron/publications/extending_tts/

Published
2024

26. E3 TTS: Easy End-to-End Diffusion-based Text to Speech

Author

Gao, Yuan, Morioka, Nobuyuki, Zhang, Yu, and Chen, Nanxin

Subjects
Computer Science - Sound, Computer Science - Computation and Language, Computer Science - Machine Learning, Electrical Engineering and Systems Science - Audio and Speech Processing
Abstract

We propose Easy End-to-End Diffusion-based Text to Speech, a simple and efficient end-to-end text-to-speech model based on diffusion. E3 TTS directly takes plain text as input and generates an audio waveform through an iterative refinement process. Unlike many prior work, E3 TTS does not rely on any intermediate representations like spectrogram features or alignment information. Instead, E3 TTS models the temporal structure of the waveform through the diffusion process. Without relying on additional conditioning information, E3 TTS could support flexible latent structure within the given audio. This enables E3 TTS to be easily adapted for zero-shot tasks such as editing without any additional training. Experiments show that E3 TTS can generate high-fidelity audio, approaching the performance of a state-of-the-art neural TTS system. Audio samples are available at https://e3tts.github.io., Comment: Accepted by ASRU 2023

Published
2023

27. Cut-free sequent calculi for the provability logic D

Author

Kashima, Ryo, Kurahashi, Taishi, Iwata, Sohei, and Morioka, So

Subjects
Mathematics - Logic, 03F45, 03F05, 03B45
Abstract

We say that a Kripke model is a GL-model if the accessibility relation $\prec$ is transitive and converse well-founded. We say that a Kripke model is a D-model if it is obtained by attaching infinitely many worlds $t_1, t_2, \ldots$, and $t_\omega$ to a world $t_0$ of a GL-model so that $t_0 \succ t_1 \succ t_2 \succ \cdots \succ t_\omega$. A non-normal modal logic D, which was studied by Beklemishev (1999), is characterized as follows. A formula $\varphi$ is a theorem of D if and only if $\varphi$ is true at $t_\omega$ in any D-model. D is an intermediate logic between the provability logics GL and S. A Hilbert-style proof system for D is known, but there has been no sequent calculus. In this paper, we establish two sequent calculi for D, and show the cut-elimination theorem. We also introduce new Hilbert-style systems for D by interpreting the sequent calculi. Moreover, we show that D-models can be defined using an arbitrary limit ordinal as well as $\omega$. Finally, we show a general result as follows. Let $X$ and $X^+$ be arbitrary modal logics. If the relationship between semantics of $X$ and semantics of $X^+$ is equal to that of GL and D, then $X^+$ can be axiomatized based on $X$ in the same way as the new axiomatization of D based on GL.

Published
2023

28. Causal Representation Learning Made Identifiable by Grouping of Observational Variables

Author

Morioka, Hiroshi and Hyvärinen, Aapo

Subjects
Statistics - Machine Learning, Computer Science - Machine Learning
Abstract

A topic of great current interest is Causal Representation Learning (CRL), whose goal is to learn a causal model for hidden features in a data-driven manner. Unfortunately, CRL is severely ill-posed since it is a combination of the two notoriously ill-posed problems of representation learning and causal discovery. Yet, finding practical identifiability conditions that guarantee a unique solution is crucial for its practical applicability. Most approaches so far have been based on assumptions on the latent causal mechanisms, such as temporal causality, or existence of supervision or interventions; these can be too restrictive in actual applications. Here, we show identifiability based on novel, weak constraints, which requires no temporal structure, intervention, nor weak supervision. The approach is based on assuming the observational mixing exhibits a suitable grouping of the observational variables. We also propose a novel self-supervised estimation framework consistent with the model, prove its statistical consistency, and experimentally show its superior CRL performances compared to the state-of-the-art baselines. We further demonstrate its robustness against latent confounders and causal cycles.

Published
2023

29. Understanding the Relationship Between Adverse Medication Use and Falls Among Older Patients Receiving Home Medical Care: OHCARE study.

Author

Murakami, Naoko, Kabayama, Mai, Yano, Tomoko, Nakamura, Chika, Fukata, Yuka, Morioka, Chihiro, Fang, Wen, Nako, Yumiko, Omichi, Yuki, Koujiya, Eriko, Godai, Kayo, Kido, Michiko, Tseng, Winston, Nakamura, Toshinori, Hirotani, Atsushi, Fukuda, Toshio, Tamatani, Michio, Okuda, Yoshinari, Ikushima, Masashi, Baba, Yoshichika, Nagano, Masahiro, Nakamura, Yukio, Rakugi, Hiromi, and Kamide, Kei

Subjects
falls, home medical care, older patients, polypharmacy
Abstract

Objective: Previous studies suggest older patients with multiple health conditions and medications may experience adverse interactions, leading to negative outcomes. However, theres limited research on this in older adults receiving home medical care. This study assesses whether polypharmacy is linked to falls or other clinical outcomes. Methods: The study population included 217 participants, aged ≥65 years, receiving home medical care, who consented to participate in the Osaka Home Care Registry (OHCARE) study in Japan. The survey examined the association between polypharmacy and clinical outcomes. We defined polypharmacy as six or more medications taken regularly. Results: Of the participants, 135 (62.6%) had polypharmacy and were significantly more likely to have hypertension or diabetes. Common medications included those for hypertension, diabetes, and mental disorders. Participants with polypharmacy experienced significantly more falls. Multivariate analysis showed an association between polypharmacy and falls (odds ratio: 2.81, 95% confidence interval [1.34, 5.92]). Conclusion: Even in older patients receiving home health care, the use of six or more medications poses a risk of falls. Careful observations and life support by medical stuffs are necessary to prevent falls in older patients with polypharmacy receiving home medical care.

Published
2024

30. Cellular signaling pathways in the nervous system activated by various mechanical and electromagnetic stimuli

Author

Ryu, Youngjae, Wague, Aboubacar, Liu, Xuhui, Feeley, Brian T, Ferguson, Adam R, and Morioka, Kazuhito

Subjects
Biochemistry and Cell Biology, Biological Sciences, Neurosciences, Neurodegenerative, Bioengineering, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Generic health relevance, mechanotransduction, nervous system, mechanical stress, cellular signaling, mechanosensor, Clinical Sciences, Biochemistry and cell biology, Biological psychology
Abstract

Mechanical stimuli, such as stretch, shear stress, or compression, activate a range of biomolecular responses through cellular mechanotransduction. In the nervous system, studies on mechanical stress have highlighted key pathophysiological mechanisms underlying traumatic injury and neurodegenerative diseases. However, the biomolecular pathways triggered by mechanical stimuli in the nervous system has not been fully explored, especially compared to other body systems. This gap in knowledge may be due to the wide variety of methods and definitions used in research. Additionally, as mechanical stimulation techniques such as ultrasound and electromagnetic stimulation are increasingly utilized in psychological and neurorehabilitation treatments, it is vital to understand the underlying biological mechanisms in order to develop accurate pathophysiological models and enhance therapeutic interventions. This review aims to summarize the cellular signaling pathways activated by various mechanical and electromagnetic stimuli with a particular focus on the mammalian nervous system. Furthermore, we briefly discuss potential cellular mechanosensors involved in these processes.

Published
2024

36. Distinctive duodenal microbiomes and bile acid profiles in duodenal tumor patients revealed by prospective observational study

Author

Kubosawa, Yoko, Sujino, Tomohisa, Miyamoto, Kentaro, Kayashima, Atsuto, Minezaki, Daisuke, Morioka, Kohei, Iwata, Kentaro, Miyazaki, Kurato, Masunaga, Teppei, Mizutani, Mari, Akimoto, Teppei, Takatori, Yusaku, Matsuura, Noriko, Nakayama, Atsushi, Takabayashi, Kaoru, Nakamoto, Nobuhiro, Honda, Akira, Kato, Motohiko, Yahagi, Naohisa, and Kanai, Takanori

Published
2024
Full Text
View/download PDF

46. Endogenous chondroitin extends lifespan by inhibiting VHA-7-mediated tubular lysosome formation

Author

Yukimasa Shibata, Yuri Tanaka, Shunsuke Mori, Kaito Mitsuzumi, Shion Fujii, Hiroyuki Sasakura, Yuki Morioka, Kenji Sugioka, Kosei Takeuchi, and Kiyoji Nishiwaki

Subjects
Aging, Chondroitin, Hemidesmosomes, Tubular lysosomes, Basement membrane, Medicine, Science
Abstract

Abstract Chondroitin extends lifespan and healthspan in C. elegans, but the relationship between extracellular chondroitin and intracellular anti-aging mechanisms is unknown. The basement membrane (BM) that contains chondroitin proteoglycans is anchored to cells via hemidesmosomes (HDs), and it accumulates damage with aging. In this study, we found that chondroitin regulates aging through the formation of HDs and inhibition of tubular lysosomes (TLs). Reduction of chondroitin due to a mutation in sqv-5/Chondroitin synthase (ChSy) causes the earlier and excessive formation of TLs and leakage of the lysosomal nuclease in a manner dependent on VHA-7, the a-subunit of V-type ATPase. VHA-7, whose mutation suppresses the short lifespan of the sqv-5 mutant, is initially localized to the basal side of the hypodermal cells and transported to lysosomes with aging. These results demonstrate that endogenous chondroitin suppresses aging by inhibiting the earlier excessive formation of TLs. This is a novel anti-aging mechanism that is controlled by the BM.

Published
2024
Full Text
View/download PDF

47. Wind velocity and dispersion/advection–diffusion of artificial droplets and droplet nuclei in a domed all-weather multi-purpose stadium

Author

Naohide Shinohara, Noboru Kurihara, Wataru Naito, Aya Iwai, Tetsuo Yasutaka, Toshihiro Morioka, Toshiyuki Takatsuji, Masayuki Ogata, and Koichi Tatsu

Subjects
Coronavirus infection 2019 (COVID-19), Mass-gathering events (MGEs), Transmission risk, Infection risk, Cough simulator, Face mask, Medicine, Science
Abstract

Abstract To evaluate the COVID-19 infection risk and the effectiveness of countermeasures at mass-gathering events, we measured the dispersion and advective diffusion of artificial droplets and artificial droplet nuclei at the Tokyo Dome, Japan (capacity 55,000 people). We also measured and evaluated the effectiveness of wearing masks and increasing the space between seating areas. If people were seated facing forward, artificial droplets did not reach the mouths of surrounding people, suggesting low risk of droplet transmission. For an artificially generated cough or sneeze, the volume of droplets deposited on the hair, back of the neck, and back of the human in front, and the backs of the seats in front, decreased by two to three orders of magnitude when a mask was worn, regardless of the type of mask. However, when the mask was worn with the nose out, the amount deposited on the back of the seat in front was reduced by only 17%. Even in seats with the highest particle concentration in the vicinity of the source, only 0.097%–0.24% of the generated droplet nuclei (1.0–3.0 μm) from the source were inhaled. Our results suggest that the infection risk at the Tokyo Dome via droplet and airborne transmission was low.

Published
2024
Full Text
View/download PDF

48. Antarctic sea ice multidecadal variability triggered by Southern Annular Mode and deep convection

Author

Yushi Morioka, Syukuro Manabe, Liping Zhang, Thomas L. Delworth, William Cooke, Masami Nonaka, and Swadhin K. Behera

Subjects
Geology, QE1-996.5, Environmental sciences, GE1-350
Abstract

Abstract Antarctic sea ice exerts great influence on Earth’s climate by controlling the exchange of heat, momentum, freshwater, and gases between the atmosphere and ocean. Antarctic sea ice extent has undergone a multidecadal slight increase followed by a substantial decline since 2016. Here we utilize a 300-yr sea ice data assimilation reconstruction and two NOAA/GFDL and five CMIP6 model simulations to demonstrate a multidecadal variability of Antarctic sea ice extent. Stronger westerlies associated with the Southern Annular Mode (SAM) enhance the upwelling of warm and saline water from the subsurface ocean. The consequent salinity increase weakens the upper-ocean stratification, induces deep convection, and in turn brings more subsurface warm and saline water to the surface. This salinity-convection feedback triggered by the SAM provides favorable conditions for multidecadal sea ice decrease. Processes acting in reverse are found to cause sea ice increase, although it evolves slower than sea ice decrease.

Published
2024
Full Text
View/download PDF

49. Clinical significance of coefficient of variation in continuous glucose monitoring for glycemic management in children and adolescents with type 1 diabetes

Author

Tatsuhiko Urakami, Hiroki Terada, Satomi Tanabe, Yusuke Mine, Masako Aoki, Ryoji Aoki, Junichi Suzuki, and Ichiro Morioka

Subjects
Children and adolescents, Coefficient of variation, Continuous glucose monitoring, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Abstract Aims/Introduction Coefficient of variation (CV) is an indicator for glucose variability in continuous glucose monitoring (CGM), and the target threshold of %CV in type 1 diabetes is proposed to be ≤36%. This study aimed to evaluate the clinical significance of CV in children and adolescents with type 1 diabetes. Materials and Methods Participants included 66 children with type 1 diabetes. A total of 48 participants were treated with multiple daily injections of insulin, and 18 with continues subcutaneous insulin infusion, using intermittently scanned CGM. The frequencies of the CGM metrics and glycosylated hemoglobin values were examined, and the significance of a threshold %CV of 36% was evaluated. Results The mean frequencies in time in range (TIR), time below range, %CV and the mean glycosylated hemoglobin value were 59.3 ± 16.1, 4.0 ± 3.5, 39.3 ± 6.2 and 7.3 ± 0.8%, respectively. The frequencies of participants who achieved a TIR >70% and a %CV of ≤36% were 24.1 and 27.3%, respectively. A total of 18 participants with a %CV of ≤36% had significantly higher TIR, lower time below range and lower glycosylated hemoglobin than the 48 with a %CV of >36% (72.6 ± 12.6 vs 52.4 ± 13.6, 2.4 ± 1.9 vs 4.6 ± 3.6, 6.9 ± 0.8 vs 7.4 ± 0.7%, respectively). Conclusions Children and adolescents with type 1 diabetes using intermittently scanned CGM had difficulties in achieving the recommended targets of TIR and CV. However, the target %CV of ≤36% seems to be an appropriate indicator for assessing glycemic control and risk of hypoglycemia in pediatric patients with type 1 diabetes with any treatment.

Published
2024
Full Text
View/download PDF

50. Association of xanthine oxidoreductase inhibitor use with insulin secretory capacity in patients with type 2 diabetes

Author

Atsushi Kitamura, Masafumi Kurajoh, Yuya Miki, Yoshinori Kakutani, Yuko Yamazaki, Akinobu Ochi, Tomoaki Morioka, Katsuhito Mori, Tetsuo Shoji, and Masanori Emoto

Subjects
insulin secretory capacity, type 2 diabetes, XOR inhibitor, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

ABSTRACT Aim/Introduction Xanthine oxidoreductase (XOR) inhibitor treatment, which reduces reactive oxygen species (ROS) production and increases adenosine triphosphate (ATP) synthesis, has been reported to improve glycemic control. The possible protective effects of XOR inhibitor treatment on insulin secretory capacity were investigated in patients with type 2 diabetes. Materials and Methods This retrospective cross‐sectional study included 428 patients with type 2 diabetes. Insulin secretory capacity was assessed based on fasting serum C‐peptide concentration (CPR) and C‐peptide index (CPI) in all subjects, while insulin resistance in non‐insulin users (n = 312) was determined using the homeostasis model assessment of insulin resistance (HOMA‐IR) index. Results Median values for CPR and CPI in all subjects were 2.4 ng/mL and 1.5, respectively, while that for HOMA‐IR in non‐insulin users was 3.2. The XOR inhibitor users (n = 72) had significantly (P 6.0 mg/dL) uric acid levels (P for interaction

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results