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2. POSTER SESSIONS SCHEDULE

Author

C Hinkin, M Cuevas, A Rauscher, W Kim, T Fogel, G Walls, M Heran, L Drag, S Akeson, K An, Mark T. Barisa, J Cantor, R Pella, C Ward, D Terry, E Parke, I Grant, K Blackstone, David B. Salisbury, P Davidson, G McDonald, C Strongin, Sudhin A. Shah, R Kim, A Miele, K Carlson, N Cadavid, J Donders, S Mahal, T Feaster, K Griffits, J Mayfield, T Brand, A Vernon, Scott R. Miller, C Price, C Vickery, L Carrion, J Beaute, L Weigand, G Crucian, A Tan, M Shuman, Talin Babikian, T Van Vleet, D La, I Thiruselvam, N Nemanim, L Baum, L Loneman, A Schmitt, R Hoadley, J Keller, J Kim, Bonnie M. Scott, M Edwards, M Rohling, B Palmer, G Godoy-Garcete, Ana Rosario, M Taylor, S Letendre, I Sanchez, A Harmell, David L. McArthur, S Greco, M O'Neil, H Yoshida, Jerome H. Carter, Marie N. Dahdah, E Jeffay, L McCutcheon, E Stambrook, A Rach, A Minassian, S Vinogradov, R Akarakian, S Khen, D Schiehser, M Young-Bernier, B Roberg, P Marchetti, L Kenworthy, P Ross, N Didehbani, M Lally, T Brickell, G Vasilev, D Kansagara, Glen A. Palmer, Amanda R. Rabinowitz, A Bedard, Desiree Byrd, K daCruz, A Torstrick, T Nguyen, M Solomon, E Hanson, S Turecka, J Moskowitz, Catherine Stasio, J Kenton, E Call, J McLeod, H Rossetti, Paula I. Martin, J Wasisco, C Depp, Sunni A. Barnes, R Lange, T Lotze, S Erikson, Samantha E. John, K Gulliver, Daniel N. Allen, M Schoenberg, M Joan, S Hass, D Munic-Miller, N Grant, M Weiner, S. DeBoard Marion, C Waksmunski, H Muetze, K Brady, P Roskos, Cynthia Dunklin, N Puente, K Russler, M Salzberg, I Neeland, J McKeever, A Fonteh, J Peer, M Choe, K Russ, C Marini, E Hui, C Kimmel, N Kecala, L. Schwent Shultz, Shelley Peery, R Gonzalez, C Spickler, E Lanni, L Flaro, E Talbot, E Giese, A Davis, Sam Vogel, D Hachey, W Mittenberg, Kenneth L. Jones, S Mahdavi, V. Alipio Jocson, M Marquine, B Ivins, S Paisley, E Weber, G Silk-Eglit, R Singer, K Barnes, A Ghias, J Sordahl, M Spiers, J Anderson, C Mathiowetz, S Fritz, R Fazio, E Miles-Mason, M Glusman, Octavio A. Santos, Jessica A. Kaczorowski, T Dugbartey, K Burns, A Gottuso, Nicholas J. Pastorek, Shahid Shafi, Librada Callender, R Dean, M Thomas, S Schleicher-Dilks, C Bermudez, J Muir, E Van Ness, R Odom, R Dye, F van der Fluit, C Lindbergh, J Grups, Monica U. Ellis, M Coe, M Schmitter-Edgecombe, S Lanting, Rosemary Dubiel, Katherine W Sullivan, A Bonner-Jackson, A Lyon, Daniel J. Schwartz, M Pachalska, S Hibyan, J Long, S Watson, N Nardi, L Pinto, Claudia Kernan, F Thomas, J Messerly, B Walsh, A Daros, S Margolis, M Cullum, B Rainwater, K Baerresen, M Steenari, M Vertinski, P Klas, A Harrison, J Stewart, R Carrasco, D Storzbach, E VonDran, K Carter, M Baldassarre, R Fares, A Freeman, J Barnett, Maggie C. Happe, M Harrington, D D'Argenio, J Piehl, Jacob Sheynin, C Young, A Anum, W Garmoe, T Barker, O Selnes, C Lobue, J Gray, A Rossi, B Stephens, M Jarrett, G Gilbert, A Graefe, J Gfeller, M Murphy, R Perna, B Gouaux, C Leibson, M Heinly, A Allart, Joshua Harrison, M Dudley, B Henry, S O'Bryan, D Miller, J Kennedy, B Edner, M Curri, F Tremblay, T Becker, J Neff, K Gillis, M Poon, C Ukpabi, J Hall, Victoria C. Merritt, D Nemeth, K Tyson, L Glukhovsky, P Vik, Karen K. Miller, R Schroeder, Christopher C. Giza, Benjamin Jurek, M Dawson, T Susmaras, K Rajendran, T Swirsky-Sacchetti, Joseph DeGutis, K Isham, P Massman, M Collier, L Klimik, D Moore, C Baum, J DiGangi, J Francis, B Baughman, A Patel, D Zink, V Carrión, Claire D. Coles, Sarah N. Mattson, A Reveles, T Novakovic-Agopian, D Drasnin, G Sutton, K Jacquin, J Tsou, John D. Medaglia, C Kane, A Starza-Smith, G Lafleche, M Bidzan, J Stenclik, C Smith, J Spat, G Mucci, M Legarreta, Frank G. Hillary, A Mouanoutoua, I Armstrong, C Isaacs, K Beene, C Songy, A Steed, R McCaffrey, J Loftis, A Levan, J Marcinak, Lisa Delano-Wood, C Draffkorn, A Harley, J Shewchuk, J Lynch, P Lebby, Preeti Sunderaraman, R Verbiest, E Stranks, B Hill, A Zisk, L Bolshin, P Stolberg, J Zamzow, V Culotta, J Gross, J Davis, M Fisher, S Mohammed, D Rosario, L Baade, J Fischer, M Muniz, M Kaminetskaya, W Gomes, J Park, K Netson, M Fanning, G Wallace, Nicholas S. Thaler, C Ayers, R Ellis, J Gonzalez, L Zhao, J Thelen, J Kiefel, J Halperin, J Uderman, R Stephan, L Sweet, K Whithers, F Fonseca, A Fedio, D Cooper, Jessica E. Meyer, J Capps, G Getz, M Palewjala, E Rinehardt, A Fernandez, S Tanner, J Ang, Audrey M. Carson, W Finch, S Evans, Gray Vargas, Ellen B. Braaten, J Murry, B Klein-Tasman, M Adler, E Culnan, G Richardson, A Dominska, T Olivier, A Dedmon, E Lane, C Prince, A Mannarino, B Casto, J Calloway, J Mackillop, C Garrett, John F. Linck, A Parks, S Sorg, W Andrew, G Fong, W Gouvier, L Lacritz, Jennifer Romesser, G Small, L Lashley, James B. Hoelzle, Predict-Hd Investigators, M Sakamoto, A Hart, F Dadis, D Pina, J Paulsen, N Stricker, G Iverson, R Macher, A Stringer, C Saucier, J Gallegos, P Andrews, A Chappell, D Jeste, K Mulligan, Pouneh K. Fazeli, D Harrison, R Romero, D Maricle, Joshua D. Miller, S Patel, Jeffrey M. Robbins, S Mansinghani, W Hoffman, K Espinoza, R Roberts, N Londono, M Douangratdy, K Kelley, O Alhassoon, A Quinones, J Taylor, E Ringdahl, A Ness, N DeFilippis, K Marshall, S Jaehnert, R Vergara, P Harvey, J Iudicello, C Ellis, S Tun, Thomas D. Parsons, Amanda E. Hahn-Ketter, C McAlister, T Patterson, R Gomez, K Kloezeman, J Wingo, C Barrio, Michael B. Reid, M Vasserman, Jacob Cohen, C Golden, C Ciobanu, F Carla, D Dinishak, Louis M. French, E Scharaga, Kirsten A. Schohl, A Newman, A Gold, J Bunting, A Puente, R Heaton, A Boettcher, D Wolff, R Baek, T Giovannetti, B Hummer, A Loughan, Ryan J. McKindles, M Bunner, M Kral, W Cole, C Love, E Corley, A Zomet, F Loya, K Young, P May, K Constantine, A Duhig, V Pankratz, J Tam, Maria T. Schultheis, A Junod, K Wyman-Chick, A Houshyarnejad, A Kent, J Wall, D Gansler, M Bens, M Jerram, C Dombrowski, J Segovia, J Hoblyn, M Geyer, N Pliskin, J Strang, B Fuller, J Kloss, J Paxton, J Chow, L Guatney, K Smith, F Foley, Elizabeth R. Sowell, L Brenner, M Rivera Mindt, A Levine, C Irwin, S Rome, J Neiman-Kimel, L Segalà, G Saini, Scott A. Loe, P Vekaria, H Woolery, M Francis, S Newton, Daniel J. Heyanka, J Link, Stephen G. West, T Ala, W Burns, H Pedersen, M Norman, L Delgaty, C Mihailescu, S Cowad, T Melville, Leila Glass, Nathan D. Doty, E Simco, A Holland, R Robbs, Warren T. Jones, S Banks, X Bonilla, R McCue, C Ramirez, M Phoong, N Upshaw, H England, S Woods, K Whigham, L Miller, J Etherton, S Rolin, Sawsan Dabit, S Kohlrus, S Thomlinson, Ryan Olmstead, A Chen, S Mahmoud, S Mauro, B Greenberg, B Lukaszewska, C Brown, R Moore, B Freer, W MacAllister, S Schaffer, R Fontanetta, J Vassileva, J Fine, Amy Wilson, C O'Shea, L Barker, Joseph J. Graca, Anthony C. Ruocco, E Schulze, Brian I. Miller, A Kaup, K Julie, A Nolty, P Siddarth, Jeffrey S. Karst, B Rabinovitz, S Yudovin, C Faraco, M Raymond, Anita H. Sim, I Kunkes, J Kamm, K Zakzanis, R Petersen, A Rudd-Barnard, N Fritz, A Bozorg, R Wellington, R Naslednikova, R Nogin, J Moses, L Tiersky, T Lee, L Cooper, M Smith, A Papadakis, L Hoskins, L Ashendorf, Caitlin Miranda, J Sexton, S Barney, M Le, M Putnam, Lillie Weiss, D Baldock, D Grimm, H Westervelt, M Mattingly, Yelena Bogdanova, C Hopewell, J Kahne, C Moore, B Mausbach, Robert F. Asarnow, Peter A. Arnett, Michael M. Merzenich, R Remel, S Coad, J Hertza, C Romers, L Harrison, M Daniel, J Clark, A Rowden, B Bristow-Murray, A Reyes, C Noggle, D Yeh, Bridget K. Dolan, Keith D. Cicerone, G Goodman, D Haberman, Mary K. Colvin, M Noback, Hasan Ayaz, B Natalie, M Cohen, Mary F. Musso, G Abrams, Seth A. Gale, J McGinley, E Bene, Ramon Diaz-Arrastia, S Benbadis, S Northington, S O'Neill, R Ruchinskas, M Hall, B Saffer, L Miarmi, F Webbe, Dobrivoje S. Stokic, C Bowie, B Duda, J Bravo, S Taylor, L Wilson, Henry W. Mahncke, R Scott, Ashita S. Gurnani, K Eichstaedt, H Soper, A Andrews, B Evans, J Bailie, R Poulin, K Evankovich, R Relova, A Gremillion, S Hunter, B Lee, M Beier, Edward P. Riley, S Edmed, M Wills, Sarah M. Kark, E Quasney, K Barrera, Yelena Goldin, Kimberley R. Monden, A Barker, V Sterk, J Fink, J Ikanga, Will Lindstrom, B Hunter, D Denney, S Huberman, C Williams, T Otero, K Spengler, A Pulver, Kathryn L Schmidt, J Meyers, E Gutierrez, V Wheaton, K Downing, A Bhagwat, Stephen A. Olson, E Lande, R Lee, F Vale, F Barwick, Mirella Díaz-Santos, C Mosti, Daniel S. Brown, M Benners, L Horne-Moyer, K Johnson, V Vargas, P Sylvester, E Shapiro, Sarah DeBoard Marion, J Poole, E Strongin, K Fields, M Basso, R Lawson, D Brinckman, E Morgan, A Simone, I Raynov, A Matevosyan, J Emerson, M Motu'apuaka, S Heverly-Fitt, Alexandra L. Clark, E March, B Roper, N Dezhkam, N Dasher, V Patt, Sheryl Stevens, A Choi, S Sautter, A Van Hecke, J. Travis Seidl, T Raines, W Perry, L Moss, M Macaluso, G Carlin, S Sisk, B Bowman, John Hart, Elisabeth M. Vogt, Michael D. Ensley, B Schilling, L Ercoli, M Zupanc, V D'Orio, A Bure-Reyes, L Rabin, J Nunan-Saah, N Rodgers-Neame, Jared M. Bruce, E Crouse, C Boys, H Kletter, T Lo, Brandon E. Gavett, A Sherzai, N Bott, K Walker, J Brubacher, Tanya M. Brown, F Ahmed, Dede M. Ukueberuwa, L Etcoff, K Chu, B Schweinsburg, Y Demsky, K Vitelli, M Huckans, L Nakhutina, A Ghelani, C Higginson, R Zec, A Curiel, David C. Osmon, S Crowe, K Phelps, O Prokhorenko, M Koehle, C Morse, Alice Cronin-Golomb, E Batchelor, J Lum, G Brown, L Silva, M Freeman, C Babika, Janine M. Paxson, P Pimental, W Buddin, J Baker, J Kline, F Hays, M Pollock, M Oganes, Armando Fuentes, M Ring, B Thieme, A Psihogios, A Zimmer, J Thompson, Hannah M. Lindsey, O Graham, Christina L. Casnar, M Arce Rentería, A Rooney, K Bozgunov, M Welch, M Lipowska, M Earleywine, S Lewis, T Floyd, A Tanguay, Yongming Li, C Tai, N Fromm, N Luc, K Barchard, K Musielak, Amir Poreh, R Heinrichs, C Boyd, K Schwab, A Lynch, R Wanlass, K Janke, S Bullard, S Hughes, K Hanson, C Holder, A Legenkaya, J Siegel, S Gold, C Evans, F Hill, Caryn R. Harper, D Binder, S Gill, M Bruhns, E Singer, Sidney O'Bryant, and J Atkinson

Subjects
Psychiatry and Mental health, Clinical Psychology, Schedule, Neuropsychology and Physiological Psychology, business.industry, Medicine, Operations management, General Medicine, business
Published
2013
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3. Abnormalities of brain response during encoding into verbal working memory among euthymic patients with bipolar disorder

Author

Lisa T. Eyler, Anna P Legenkaya, Ashley N. Sutherland, and Benjamin S. McKenna

Subjects
Adult, Male, Bipolar Disorder, Inferior frontal gyrus, Verbal learning, Article, Supramarginal gyrus, medicine, Image Processing, Computer-Assisted, Middle frontal gyrus, Humans, Prefrontal cortex, Biological Psychiatry, Aged, Analysis of Variance, Memory Disorders, medicine.diagnostic_test, Working memory, Brain, Cognition, Middle Aged, Verbal Learning, Magnetic Resonance Imaging, Oxygen, Psychiatry and Mental health, Memory, Short-Term, Case-Control Studies, Female, Psychology, Functional magnetic resonance imaging, Neuroscience
Abstract

Bipolar disorder (BD) is a complex mental illness characterized by vacillations in mood from the lows of depression to the highs of mania with relatively normal mood in between (1). Disruptions in brain function and cognition play a prominent role in BD and cognitive deficits have been widely reported among patients experiencing manic and depressive episodes (2, 3). However, there is growing evidence that cognitive impairment persists during periods of remission or euthymia suggesting that cognitive dysfunction may be a trait-like feature of the disorder (4, 5). Two prominent domains of impairment are attention and working memory (WM), both of which are critical for adequate functioning in many other cognitive domains. Studies measuring attention and WM deficits in inter-episode patients with BD have yielded medium-to-large effect sizes (6). Further, BD impairs social and occupational functioning, with cognitive processing deficits playing a particularly important role (7-9). WM refers to a form of ongoing memory involving the active maintenance and/or updating of information (10, 11). WM is believed by many theorists to have limited capacity and composed of dissociable subcomponents (12, 13). Thus, a fundamental dissociation for most WM theories involves the separation of early sensory-perceptual encoding of stimuli (driven by attentional processes) from WM maintenance/updating processes (reliant upon WM proper). A multitude of studies with healthy individuals have identified a neural network underlying WM component processes, though the theoretical accounts of the functions of these regions are debated (14). Studies utilizing functional magnetic resonance imaging (fMRI) have demonstrated that sensory regions (e.g., visual or acoustic depending on the modality) along with prefrontal cortex (PFC) regions and subcortical regions in the basal ganglia and thalamus play a critical role in encoding information into WM (15). This is, in part, due to the role these regions play in selectively attending to stimuli in the environment and encoding the relevant information into temporary storage, processes dependent upon adequate attention. Once information is encoded, the dorsolateral PFC and supramarginal gyrus maintain and/or update the store (16, 17). However, variations in these regional activation patterns and additional sensory regional activation are involved depending on the presentation modality, such as visual or acoustic presentation (18-20). Regardless of modality, the PFC is thought to play a critical role in both the top–down attentional processes required for encoding and the maintenance processes required to keep information within WM, possibly due to reciprocal connections with subcortical and posterior cortical structures. Patients with BD are known to have both structural and functional abnormalities within the PFC (21, 22). This has led to neurobiological theories that attribute cognitive deficits and emotional changes to a disconnect between cognitive top-down centers in the ventrolateral and dorsolateral PFC with emotional bottom-up centers in medial and orbitofrontal PFC and limbic regions (23, 24). Supporting these theories, fMRI studies of WM in inter-episode patients with BD have primarily found attenuated activation patterns in dorsolateral and ventrolateral PFC compared to healthy participants (21), though this is not always the case (25, 26). Additionally, studies demonstrate decreased activation in other brain regions underlying WM including the supramarginal gyrus (5). However, these studies have primarily focused on WM as a whole using block designs to compare brain systems involved in overall WM performance. These task designs are not able to examine WM component processes such as attentional processes required for encoding and processes required for maintenance and/or updating information. As such, while emerging findings suggest inter-episode patients with BD have WM deficits and abnormal neuronal activation, the specific WM component process or processes leading to overall deficits are largely unknown. One study of inter-episode patients with BD employed a fast event-related fMRI design to examine encode, updating, and response intervals in a Sternberg-like task (27). The authors found attenuated patterns of activity, primarily in the frontal lobes, across all task intervals supporting fronto-cortico-limbic dysfunction in BD. However, there were no dissociations between verbal encoding, updating of information, and response component processes reflected in the task intervals. The task complexity, WM updating requirements, fast timing of events, and/or sample size may have limited their ability to discover a clear distinction between perceptual encoding processes and maintenance or updating/manipulation processes. The present study employed a slow event-related fMRI design during a simple delayed match-to-sample WM task to examine if inter-episode patients with BD exhibit WM perceptual verbal encoding and/or maintenance component processing deficits in brain function as measured with the blood oxygen level dependent (BOLD) signal. This task has been used previously in healthy participants to link brain activation patterns in WM brain regions during task encode and maintenance intervals with the respective parameter estimates from a computational model of WM reflecting encoding and maintenance processes (28). Neurobiological models of cognitive dysfunction in BD would predict attenuated response in specific PFC regions underlying deficits in WM behavioral performance. Further, given the broad attentional deficits (i.e., in attentional systems not confined to WM operations) observed in inter-episode patients with BD, we predict that PFC and subcortical regions underlying the selective attention processing responsible for encoding into WM will show the greatest neuronal abnormalities compared to healthy participants. Specifically, these include bilateral dorsolateral PFC, middle frontal gyrus, and inferior frontal gyrus (IFG); and subcortical regions including the thalamus and basal ganglia. To 0fully explore the pattern of activation within these regions, we also hypothesize that functional connectivity among PFC and basal ganglia/thalamus will vary between patients with BD and healthy participants and differentially relate to behavioral performance. Given that recent research suggests that deficits in attention, but not working WM, meet criteria for an endophenotype of BD (6) we do not predict WM maintenance processes will show the same magnitude of deficit compared to encoding processes.

Published
2013

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