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38 results on '"A Frélik"'

1. The CR geometry of the three-segment snake

Author

Frelik, Tymon

Subjects
Mathematics - Differential Geometry
Abstract

We study the geometry associated with the kinematics of a planar robot known as the "three-segment snake," whose velocity distribution belongs to a class of (2,3,5) distributions. We discover that, under certain assumptions on its construction parameters, the snake may be endowed with a CR structure of CR dimension 1 and real codimension 3. We solve the associated Cartan equivalence problem and find the invariants of the snake's CR structure., Comment: 6 pages, 1 figure

Published
2024

23. International Forum on typing and matching strategies in patients on anti-CD38 monoclonal therapy

Author

K. M. K. de Vooght, E. Zhiburt, A Alarcón, Laura Infanti, H. Hustinx, D Brilhante, Christine Cserti-Gazdewich, Ashish Jain, R.R. Sharma, Miquel Lozano, K Suzuki, Jacob Pendergrast, Paolo Perseghin, Jill R. Storry, Janice Hawes, Neelam Marwaha, Véronique Deneys, Julie Staves, M Dassi, Jose Mauro Kutner, Andreas Buser, J Bueno, C Bonet Bub, Andreas Greinacher, Kathleen Selleng, M E Colling, Michael F. Murphy, Claire Thiry, Arianna Incontri, A Frélik, M N Lundgren, L Castilho, Richard M. Kaufman, A Macédo, I Romera, and Andreas Holbro

Subjects
medicine.medical_specialty, Matching (statistics), business.industry, General Medicine, Hematology, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Monoclonal, Journal Article, Medicine, Medical physics, In patient, 030212 general & internal medicine, Typing, business
Published
2018

24. Vox Sanguinis International Forum on typing and matching strategies in patients on anti-CD38 monoclonal therapy: summary

Author

Miquel Lozano, Andreas Greinacher, Andreas Buser, Arianna Incontri, Jill R. Storry, D Brilhante, Paolo Perseghin, Richard M. Kaufman, Christine Cserti-Gazdewich, C Thiry, Janice Hawes, Michael F. Murphy, K Suzuki, M Dassi, Laura Infanti, Jose Mauro Kutner, Jacob Pendergrast, Véronique Deneys, H. Hustinx, Neelam Marwaha, A Alarcón, R.R. Sharma, L Castilho, A Macédo, I Romera, Andreas Holbro, J Bueno, Kathleen Selleng, M E Colling, K. M. K. de Vooght, A Frélik, C Bonet Bub, Ashish Jain, M N Lundgren, Julie Staves, and E. Zhiburt

Subjects
Matching (statistics), business.industry, Hematology, General Medicine, Computational biology, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Monoclonal, Medicine, In patient, Typing, business, 030215 immunology
Published
2018

25. International Forum on typing and matching strategies in patients on anti-CD38 monoclonal therapy

Author

De Vooght, K. M. K., primary, Lozano, M., additional, Bueno, J-L., additional, Alarcón, A., additional, Romera, I., additional, Suzuki, K., additional, Zhiburt, E., additional, Holbro, A., additional, Infanti, L., additional, Buser, A., additional, Hustinx, H., additional, Deneys, V., additional, Frélik, A., additional, Thiry, C., additional, Murphy, M., additional, Staves, J., additional, Selleng, K., additional, Greinacher, A., additional, Kutner, J. M., additional, Bonet Bub, C., additional, Castilho, L., additional, Kaufman, R. M., additional, Colling, M. E., additional, Perseghin, P., additional, Incontri, A., additional, Dassi, M., additional, Brilhante, D., additional, Macédo, A., additional, Cserti-Gazdewich, C., additional, Pendergrast, J. M., additional, Hawes, J., additional, Lundgren, M. N., additional, Storry, J. R., additional, Jain, A., additional, Marwaha, N., additional, and Sharma, R. R., additional

Published
2018
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26. Vox Sanguinis International Forum on typing and matching strategies in patients on anti-CD38 monoclonal therapy: summary

Author

de Vooght, K. M. K., primary, Lozano, M., additional, Bueno, J-L., additional, Alarcón, A., additional, Romera, I., additional, Suzuki, K., additional, Zhiburt, E., additional, Holbro, A., additional, Infanti, L., additional, Buser, A., additional, Hustinx, H., additional, Deneys, V., additional, Frélik, A., additional, Thiry, C., additional, Murphy, M., additional, Staves, J., additional, Selleng, K., additional, Greinacher, A., additional, Kutner, J.M., additional, Bonet Bub, C., additional, Castilho, L., additional, Kaufman, R., additional, Colling, M.E., additional, Perseghin, P., additional, Incontri, A., additional, Dassi, M., additional, Brilhante, D., additional, Macêdo, A., additional, Cserti-Gazdewich, C., additional, Pendergrast, J.M., additional, Hawes, J., additional, Lundgren, M.N., additional, Storry, J.R., additional, Jain, A., additional, Marwaha, N., additional, and Sharma, R.R., additional

Published
2018
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27. International Forum on typing and matching strategies in patients on anti-CD38 monoclonal therapy

Author

De Vooght, K. M.K., Lozano, M., Bueno, J. L., Alarcón, A., Romera, I., Suzuki, K., Zhiburt, E., Holbro, A., Infanti, L., Buser, A., Hustinx, H., Deneys, V., Frélik, A., Thiry, C., Murphy, M., Staves, J., Selleng, K., Greinacher, A., Kutner, J. M., Bonet Bub, C., Castilho, L., Kaufman, R. M., Colling, M. E., Perseghin, P., Incontri, A., Dassi, M., Brilhante, D., Macédo, A., Cserti-Gazdewich, C., Pendergrast, J. M., Hawes, J., Lundgren, M. N., Storry, J. R., Jain, A., Marwaha, N., Sharma, R. R., De Vooght, K. M.K., Lozano, M., Bueno, J. L., Alarcón, A., Romera, I., Suzuki, K., Zhiburt, E., Holbro, A., Infanti, L., Buser, A., Hustinx, H., Deneys, V., Frélik, A., Thiry, C., Murphy, M., Staves, J., Selleng, K., Greinacher, A., Kutner, J. M., Bonet Bub, C., Castilho, L., Kaufman, R. M., Colling, M. E., Perseghin, P., Incontri, A., Dassi, M., Brilhante, D., Macédo, A., Cserti-Gazdewich, C., Pendergrast, J. M., Hawes, J., Lundgren, M. N., Storry, J. R., Jain, A., Marwaha, N., and Sharma, R. R.

Published
2018

28. Daratumumab: Therapeutic asset, biological trap!

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Centre de transfusion sanguine, UCL - (MGD) Service d'hématologie, Deneys, Véronique, Thiry, Claire, Frélik, Alex, Debry, Cécile, Martin, Benoît, Doyen, Chantal, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Centre de transfusion sanguine, UCL - (MGD) Service d'hématologie, Deneys, Véronique, Thiry, Claire, Frélik, Alex, Debry, Cécile, Martin, Benoît, and Doyen, Chantal

Abstract

OBJECTIVES : Recently, daratumumab has been included in the therapeutic strategies for myeloma patients. This molecule is an antibody directed against CD38, strongly expressed on plasma cells. Nevertheless, as CD38 is also present on erythrocyte membrane, daratumumab interferes with immunohaematological tests, complicating the selection of compatible blood. METHODS : A total of 14 patients treated by daratumumab have been followed in our transfusion laboratory. Among them, 11 have been transfused. Dithiotreitol (DTT) has been used to inhibit the daratumumab's interference, in the pre-transfusion tests (irregular antibody screening and cross-match). RESULTS : The red blood cell treatment with DTT has been very efficacious to inhibit the daratumumab's interference in 13 patients out of 14. Some precautionary measures had to be taken into account, especially the pH and the storage conditions. An extended pheno/genotype was an additional security element in the selection of compatible blood. To simplify and to optimize the laboratory practices, a decisional flow chart has been written. CONCLUSION : DTT red blood cell treatment is very useful and efficacious in the pre-transfusion tests of patients treated with daratumumab. It allows to avoid the selection of blood bags only on the basis of an extended pheno/genotype, what is more secure and more ethical with respect to other at higher risk patients. A clear decisional flow chart allows a quality assurance gait. Collaboration with physicians is essential., [Daratumumab : joker thérapeutique, piège biologique !] OBJECTIFS : Récemment, le daratumumab a intégré l’arsenal thérapeutique du myélome. Il est dirigé contre la molécule CD38, fortement exprimée sur les plasmocytes. Comme CD38 est également présent à la surface des globules rouges, le traitement par daratumumab induit des interférences dans les tests immunohématologiques, compliquant le choix des poches de sang à transfuser. METHODES : Au total, 14 patients traités par daratumumab ont été suivis dans notre laboratoire de transfusion. Onze d’entre eux ont bénéficié d’une transfusion. Un traitement des globules rouges par le dithiotréitol (DTT) a été utilisé afin de contrecarrer l’interférence par l’anticorps anti-CD38, pour les tests de recherche d’anticorps irréguliers et pour les tests de compatibilité. RESULTATS : Moyennant le respect de quelques mesures de précaution, en particulier le respect du pH et des conditions de conservation, le traitement des hématies par le DTT a permis d’annihiler efficacement l’interférence du daratumumab chez 13 patients sur 14. Un phénotype ou génotype complet des patients avant traitement par daratumumab a apporté une sécurité supplémentaire pour le choix des poches à transfuser. Afin de simplifier et d’homogénéiser les pratiques au laboratoire, un logigramme décisionnel de prise en charge a été rédigé. CONCLUSION : L’utilisation du DTT dans les tests immunohématologiques des patients traités par daratumumab est très efficace. Ceci permet d’éviter la sélection des poches à transfuser sur la seule base du respect du phéno/génotype étendu, ce qui nous semble une démarche plus sûre sur le plan transfusionnel et plus éthique vis-à-vis des autres patients à plus haut risque transfusionnel. Un logigramme décisionnel clair permet une démarche de qualité. La collaboration avec les cliniciens est indispensable.

Published
2018

29. International Forum on typing and matching strategies in patients on anti-CD38 monoclonal therapy.

Author

UCL - (MGD) Centre de transfusion sanguine, UCL - SSS/IREC/MONT - Pôle Mont Godinne, De Vooght, K M K, Lozano, M, Bueno, J-L, Alarcón, A, Romera, I, Suzuki, K, Zhiburt, E, Holbro, A, Infanti, L, Buser, A, Hustinx, H, Deneys, Véronique, Frélik, A, Thiry, C, Murphy, M, Staves, J, Selleng, K, Greinacher, A, Kutner, J M, Bonet Bub, C, Castilho, L, Kaufman, R M, Colling, M E, Perseghin, P, Incontri, A, Dassi, M, Brilhante, D, Macédo, A, Cserti-Gazdewich, C, Pendergrast, J M, Hawes, J, Lundgren, M N, Storry, J R, Jain, A, Marwaha, N, Sharma, R R, UCL - (MGD) Centre de transfusion sanguine, UCL - SSS/IREC/MONT - Pôle Mont Godinne, De Vooght, K M K, Lozano, M, Bueno, J-L, Alarcón, A, Romera, I, Suzuki, K, Zhiburt, E, Holbro, A, Infanti, L, Buser, A, Hustinx, H, Deneys, Véronique, Frélik, A, Thiry, C, Murphy, M, Staves, J, Selleng, K, Greinacher, A, Kutner, J M, Bonet Bub, C, Castilho, L, Kaufman, R M, Colling, M E, Perseghin, P, Incontri, A, Dassi, M, Brilhante, D, Macédo, A, Cserti-Gazdewich, C, Pendergrast, J M, Hawes, J, Lundgren, M N, Storry, J R, Jain, A, Marwaha, N, and Sharma, R R

Published
2018

30. International Forum on typing and matching strategies in patients on anti-CD38 monoclonal therapy

Author

CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), De Vooght, K. M.K., Lozano, M., Bueno, J. L., Alarcón, A., Romera, I., Suzuki, K., Zhiburt, E., Holbro, A., Infanti, L., Buser, A., Hustinx, H., Deneys, V., Frélik, A., Thiry, C., Murphy, M., Staves, J., Selleng, K., Greinacher, A., Kutner, J. M., Bonet Bub, C., Castilho, L., Kaufman, R. M., Colling, M. E., Perseghin, P., Incontri, A., Dassi, M., Brilhante, D., Macédo, A., Cserti-Gazdewich, C., Pendergrast, J. M., Hawes, J., Lundgren, M. N., Storry, J. R., Jain, A., Marwaha, N., Sharma, R. R., CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), De Vooght, K. M.K., Lozano, M., Bueno, J. L., Alarcón, A., Romera, I., Suzuki, K., Zhiburt, E., Holbro, A., Infanti, L., Buser, A., Hustinx, H., Deneys, V., Frélik, A., Thiry, C., Murphy, M., Staves, J., Selleng, K., Greinacher, A., Kutner, J. M., Bonet Bub, C., Castilho, L., Kaufman, R. M., Colling, M. E., Perseghin, P., Incontri, A., Dassi, M., Brilhante, D., Macédo, A., Cserti-Gazdewich, C., Pendergrast, J. M., Hawes, J., Lundgren, M. N., Storry, J. R., Jain, A., Marwaha, N., and Sharma, R. R.

Published
2018

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