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Objective: The main purpose of this review is to systematize the data on the effectiveness of Bifidobacterium longum 35624 in the treatment of patients with irritable bowel syndrome (IBS). Materials and Methods: Studies were searched in the electronic databases MEDLINE/PubMed, EMBASE, Cochrane, and the Russian Science Citation Index (RSCI) based on the Scientific Electronic Library. The analysis included papers published between January 2000 and November 2023 (inclusive). Results: The final analysis included 5 studies in 796 patients with IBS carried out in France (n = 2), Ireland (n = 1), Great Britain (n = 1) and Russia (n = 1). Two studies used the Rome II Diagnostic Criteria for IBS, and three studies used the Rome IV. The conducted studies, the findings of which were summarized in this systematic review, have convincingly shown that the use of Bifidobacterium longum 35624 in patients with IBS contributes to the regression of disease symptoms and an improvement in the quality of life. Recent observational studies with different follow-up periods have shown that an extended course of Bifidobacterium longum 35624 results in a more pronounced clinical response compared to the standard duration of the probiotic course (30 days). Conclusions: This systematic review has demonstrated that the use of Bifidobacterium longum 35624 in patients with IBS, particularly an extended course of up to 3 months, contributes to the regression of disease symptoms and improvement in the quality of life.

The article proposes the integrated digital ecosystem concept for Kemerovo region with a mechanism for data collection and transformation. The concept meets the requirements for the creation of a data management center in the Kemerovo region. The requirements are specified in the Digital transformation strategy for economic sectors, social sphere and public administration of the Kemerovo region – Kuzbass. The authors analyze the strategy and list the characteristics of the current digital ecosystem of the region. The article reveals inconsistency in the interaction of state and municipal authorities with business structures and citizens of the region in the digital environment. The authors describe the expediency of applying the proposed concept in the Kemerovo region for a positive impact on the provision of social and economic benefits in the region. The effectiveness of digital ecosystems with data collection and transformation mechanisms is confirmed by examples of different countries. Thanks to the proposed concept, the requirements of legislation are met, the lack of consistency in the interaction of public authorities is resolved.

Introduction The tumors of the diencephalon region (thalamic-hypothalamic-pituitary system) include a large group: pituitary adenomas, craniopharyngiomas, gliomas, and others. Tumors differ in the histological structure, and manifestations of the clinical symptoms; by hormonal data; by approaches and methods in treatment. Psychic symptoms are revealed in disease in addition to cerebral, neuroendocrine symptoms, neurological disorders. Psychoorganic syndrome is represented by emotional, motivational, personal, cognitive impairments, inversion of the sleep-wake cycle, seizures. Disorders of mental activity are detected in all tumors of this localization in varying degrees, according to the different authors from 20 to 100%; affective pathology varies from 2 to 80% by the literature. Objectives To study the emotional disorders in the structure of psychoorganic pathology in tumors of diencephalon region Methods 290 patients (18-78 years old, mean age 38+2): pituitary adenomas (PA), as the most common – 170 (58,6%), craniopharyngiomas (CG), as with the most varied manifestation of mental symptoms – 120 (41,4%). Methods: psychopathological, data from endocrinological, neurological, neuroimaging methods. Results Emotional disorders were detected in patients from 30 to 68% of cases, depending on the histology of the tumours: PA with excessive secretion of growth hormone - emotional disorders are in 60%; PA with excessive secretion of adrenocorticotropic hormone - in 50%; PA with excessive secretion of prolactin - in 30%; with excessive secretion of thyroid-stimulating hormone - in 40%; non-functioning PA - in 16%; CG - in 68%. Emotional disorders were more often represented by changeable mood, depression, apathy, sleep disturbance, and visceral symptoms. Symptoms differed depending on the histology of the tumor (type and level of hormones), the volume of the lesion and direction of growth, and concomitant hypertensive-hydrocephalic symptoms. Emotional disturbances often include memory impairment, personality and behavior changes. Conclusions Emotional disorders are detected in patients in 30-68% of cases in the structure of psychoorganic pathology with damage to the diencephalon region (in particular, with pituitary adenomas and craniopharyngiomas); are determined by the topography of the tumor and histology with the involvement of the corresponding structures and nuclei in the pathological process. Disclosure of Interest None Declared

The purpose of the study is to identify and determine the directions and accounting factors included in the algorithm for assessing the digital maturity index of Russian regions to improve this methodology, taking into account aspects of the second and third stages of digital transformation of public and municipal administration (PMA). In the course of the work, methods of analysis, generalization and systematization were applied. The authors noted the problem of inconsistency of the target directions of the PMA digital transformation with the actual activities, indicated the expediency of taking into account the indicators in the proposed directions when assessing the digital maturity index in the regions of Russia. The paper defines digital ecosystems, reflects the relationship between their features and the methodology for assessing the digital transformation of public and municipal administration, the stages of which are characterized and specified by the example of foreign experience. The relevance of the research lies in the strategic need to find growth points to increase the efficiency and effectiveness of PMA in the context of digital realities.The practical significance of the results lies in the possibility of using the proposed directions and accounting factors in the methodology for assessing digital maturity in the constituent entities of the Russian Federation by public authorities while they are being modernized.

SARS-CoV-2 is a novel coronavirus that has been identified as the cause of the 2019 coronavirus infection (COVID-19), which originated at Wuhan city of PRC in late 2019 and widespread worldwide. As the number of patients recovering from COVID-19 continue to grow, it’s very important to understand what health issues they may keep experiencing. COVID-19 is now recognized as an infectious disease that can cause multiple organ diseases of various localization. It is against this background that a new term was introduced: post-acute post-COVID-19 syndrome characterized by several persistent symptoms inherent in the acute phase of the disease, as well as the occurrence of delayed and (or) long-term complications beyond 4 weeks from the onset of the disease. The work reflected in this article revealed a portrait of a patient with post-COVID-19 syndrome, the most common complications of this period, as well as the mechanisms of their development and the resulting metabolic, cellular, tissue disorders leading to the tissue and organ dysfunctions. A comprehensive biochemical and immunological screening was carried out using the example of three clinical cases to identify the most significant disorders in these patients and to correlate with their clinical status over time. In point of fact, such patients were diagnosed with vascular dysfunction factors (development of endothelial dysfunction), metabolic dysfunction factors (metabolic acidosis, mitochondrial dysfunction, carbohydrate metabolism disorder, insulin resistance, altered branched-chain and aromatic amino acid metabolism), neurological disorder factors (neurotoxicity of the resulting metabolites), immunological disorder factors (decreased efficiency of detoxification systems, secondary immunodeficiency, risk of secondary bacterial infection).

The new phase Ba5In2Al2Zr0.9Nb0.1O13.05 with hexagonal perovskite structure was obtained. The substitution of Zr4+ by smaller Nb5+ was accompanied by the incorporation of the oxygen interstitials and did not lead to a significant change in the lattice parameters. It was established that the investigated sample was capable for water incorporation from the gas phase, the hydration degree value was 0.24 mol H2O. IR-spectroscopy analysis defined the presence of OH−-groups with different thermal stability, which participate in different hydrogen bonds. The new phase Ba5In2Al2Zr0.9Nb0.1O13.05 demonstrates the predominant protonic conductivity at pH2O = 2·10−2 atm and Т600 °C.

Introduction In the literature, there are conflicting data regarding the recovery of mental disorders, in particular, pathologies of the emotional, personality, behavioral and cognitive spheres, in patients after surgical treatment of tumors of the diencephalic region. Objectives To evaluate the dynamics of psychopathological disorders after removal of a craniopharyngioma. Methods 45 patients (18–68 y.o.), operated through transcranial access. The follow-up period ranged from 3 months to 9 years (on average 2.8 + 0.4). The main method is psychopathological, supplemented by rating scales and questionnaires. Results In the late postoperative period, mental disorders were detected in 75% of patients (Table 1). Table 1. Dynamics of the main psychopathological symptom complexes (n = 45). Disorders (may be a combination) Before surgery (n,%) 2 weeks after (n,%) 18 months after (n,%) Emotional and volitional 27 (60%) 27 (60%) 15 (33%) Cognitive - Korsakov syndrome 18 (40%) 4 (9%) 27 (59%) 8 (18%) 18 (40%) 7 (15%) Personality 21 (46%) 25 (55%) 23 (51%) The table shows that emotional-volitional disorders have a clear positive dynamics by 18 months after surgery compared with the preoperative level. Korsakov’s syndrome and personality disorders are less favorable. 23 patients (52%) returned to their previous profession; 22 (48%) stopped working due to a severe degree of disability, of which 7 (15%) need constant supervision. Conclusions The positive dynamics of psychopathological symptoms is observed only within 1.5 years after the removal of the craniopharyngioma, in the future they remain without a tendency to improve. 22 patients (48%) stopped working. The most severe degree of disability is 15% patients. Disclosure No significant relationships.