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Abstract In Brazil, the judicialization of public health for access to medications has resulted in significant challenges to the management of public policies, especially at the municipal level. To evaluate the profile of drug litigations against the Campinas municipal health system from 2017 to 2021, this study analyzed the characteristics of litigants, medicine dispensation, and the timing of court decisions. A quantitative, analytical, and comparative cross-sectional study was conducted using data on the dispensation of 506 types of medications and 493 court cases. The analysis included sociodemographic, procedural, medical–sanitary, and pharmaceutical assistance management variables. The time of court decisions was assessed using the Kruskal‒Wallis test complemented by the Dunn test. The plaintiffs were predominantly adults, females, and self-declared students, and some cases involved nonresidents. Most of the lawsuits were represented by private lawyers, gratuitousness of justice and with decisions favorable to the plaintiff. However, only 43% of the patients obtained a preliminary injunction or early tutelage. The median time needed for a court decision from the date of case filing was 12 days until the granting of a preliminary injunction or early tutelage and 6.5 months until a judgment or dismissal without a decision on the merits. Approximately 32.4% of the medications dispensed by the judicial pharmacy already belonged to the list of the Brazil’s Unified Health System in 2020; 46.3% were prescribed by their generic name; 75.5% had therapeutic equivalents, and 94.9% had marketing authorization from the Brazilian National Health Surveillance Agency. Judicialization in Campinas is an alternative way of accessing medications, but it is time-consuming and benefits only a small portion of the population (0.068%). The characteristics of the plaintiffs and judicialized medicines highlight the need to review health policies to promote equitable and efficient access to essential treatments for the population.

Stigma and discrimination against the trans* community have been shown to exacerbate mental health issues among its members. In Catalonia, the Gender Identity Unit at the Clinic's Hospital traditionally adhered to a biomedical model (BMM) of health for trans* individuals. However, a few years ago, the Transit Service introduced a biopsychosocial model (BPSM). This observational cohort study explores the mental health effects in BMM compared to BPSM centers for trans* individuals.A web-based survey was employed to gather essential data, such as socio-demographics information, and mental health outcomes. All data was analyzed from the BPSM group (n = 81) and the BMM group (n = 21).The BPSM group exhibited statistically significant lower odds of experiencing emotional distress (p

Juan Francisco Mir-Bonafé,1 Jaime Piquero-Casals,2 Ludmila Prudkin,3 Jesus Delgado,3 Julia Santamaria Martínez,3 Vicente Garcia-Patos Briones4 1Department of Dermatology, Hospital Son Llàtzer, Palma de Mallorca, Spain; 2Department of Aesthetic Dermatology and Laser, Dermik, Clínica Dermatológica Multidisciplinar, Barcelona, Spain; 3Innovation and Development, ISDIN, Barcelona, Spain; 4Department of Dermatology, Hospital Vall d’Hebron, Barcelona, SpainCorrespondence: Jaime Piquero-Casals, Department of Aesthetic Dermatology and Laser, Dermik, Clínica Dermatológica Multidisciplinar, Barcelona, Spain, Tel +34 935464710, Email j.piquero@dermik.esBackground: Noninfectious inflammatory dermatoses of the scalp are common, and their symptomsin particular, those affecting appearance, can have a psychological effect that may be disproportionate to their clinical severity. Effective, cosmetically acceptable treatments are important to manage these conditions. Topical corticosteroids form the cornerstone of acute treatment for many of these conditions. We surveyed practicing dermatologists and dermatology residents to determine the current clinical practice in prescribing topical corticosteroids for these disorders in their various preparation formats.Methods: A Delphi method was used, consisting of 2 questionnaire rounds. The first round contained 34 questions and was completed by 612 dermatologists and dermatology residents via email. The first round of responses was analyzed, and points that had > 70% agreement were used to form a second questionnaire of 21 statements. This second round was completed by 346 participants, and their responses were used to generate a final report. Participants were practicing in both public and private practices.Results: Clobetasol propionate 0.05% topical solution was considered to be the most appropriate treatment for noninfectious inflammatory scalp dermatoses in general, with 75.1% agreement in the second round of questionnaire. The main advantages of clobetasol propionate over other topical corticosteroids were reported as potency, effectiveness, and broad action spectrum (94.8% agreement). The preferred pharmaceutical format was the solution of clobetasol propionate.Conclusion: Clobetasol propionate was the preferred topical treatment for the management of scalp dermatoses, usually as first-line treatment; solution was the preferred preparation.Keywords: seborrheic dermatitis, psoriasis, shampoo, topical, solution, clobetasol, scalp, therapy

O vaginismo é caracterizado como uma contração involuntária que impossibilita a penetração vaginal, podendo causar sofrimento e mudanças nas relações amorosas. Diante disso, neste estudo buscamos discorrer sobre a vinculação amorosa em mulheres com vaginismo, refletindo acerca da influência de elementos da relação amorosa e do contexto sociocultural na vivência desta disfunção. Trata-se de uma pesquisa qualitativa-exploratória, realizada, por meio de entrevistas semiestruturadas, com nove mulheres que apresentaram sintomas de vaginismo. Os resultados foram categorizados a partir da análise de conteúdo e apontam para a importância do suporte colaborativo dos parceiros, sendo que a ausência deste apoio pode prolongar o tratamento. Os papéis sociais em torno do gênero influenciam na percepção da disfunção sexual e na dinâmica conjugal, instaurando sentimento de culpa e insegurança. Logo, destaca-se a importância de expandir as concepções de sexualidade, sendo papel dos profissionais da saúde instruírem suas pacientes com vaginismo neste processo.

La última dictadura cívico militar argentina modificó el aparato estatal y transformó la estructura productiva del país a partir de una configuración legislativa ad hoc con la que legitimó, entre otras cosas, un nuevo modelo de acumulación. El vínculo entre el Estado y los empresarios fue trascendental para el linea­miento de una política económica basada en la financiarización de la economía y el circuito especulativo, el reordenamiento de la cúpula empresaria y la intervención de empresas o su desplazamiento del nuevo escenario económico. En esta línea, este trabajo analiza las distintas intervenciones económicas estatales realizadas por diversos entes gubernamentales y judiciales sobre el Grupo empresarial cordobés Mackentor entre 1976 y 1983. Para ello, se indaga en la articulación entre la normativa respecto a la “subversión económica”, las intervencio­nes económicas estatales sobre las empresas, que llevaron a su desplazamiento del mercado, y los intereses empresarios en juego.

Abstract The microscopic mechanism of the light-matter interactions that induce orbital angular momentum (OAM) in electromagnetic fields is not thoroughly understood. In this work, we employ Archimedean spiral vortex generators in time-resolved numerical simulations using the Octopus code to observe the behind-the-scenes of OAM generation. We send a perfect circularly-polarized plane-wave light onto plasmonic optical vortex generators and observe the resulting twisted light formation with complete spatio-temporal information. In agreement with previous works, we find that emission from the plasmonic spiral branches shapes the vortex-like structure and governs the OAM generation in the outgoing electromagnetic field. To characterize the generated beam further, we emulate the emission from vortex generators with current emitters preserving the spiral geometry. We subject a point-particle system to the generated field and record the orbital angular momentum transfer between the electromagnetic field and the point particle. Finally, we probe the OAM density locally by studying the induced classical trajectory of point particles, which provides further insight into the spatio-temporal features of the induced OAM.

Resumen: Describimos 28 pacientes que desarrollaron una forma de efluvio postrasplante capilar con características no descritas en la literatura: a) morfología lineal; b) aparición inmediata (1-3 días); c) asociación con ‘dense packing’ en entradas (‘signo de Mickey Mouse’); d) progresión del diámetro de la línea (patrón ‘wave-like’); e) posible adición posterior de efluvio lineal concéntrico a vértex (‘signo del Donut’), y f) además de otros efluvios tampoco publicados por su inmediatez de aparición. La morfología lineal podría ser el resultado de la alta densidad colocada en nuestros pacientes, provocando hipoxia perilesional y efluvio de las unidades foliculares miniaturizadas que rodean la zona receptora. Debido a que la línea alopécica provoca inseguridad a los pacientes sobre una posible no colocación de injertos, recomendamos iconografía postoperatoria inmediata demostrando unión de áreas trasplantada y no trasplantada, así como la explicación previa al paciente de este fenómeno transitorio y completamente reversible en 3 meses. Abstract: We describe 28 patients who experienced effluvium with previously unreported features shortly after hair transplant surgery. Notable features were as follows: a) a linear morphology; b) immediate onset (1-3 days); c) association with dense-pack grafting in areas of receding hairline at the temples (Mickey Mouse pattern); d) a progressive increase in the diameter of the hair loss line (wave-like pattern); e) in some cases, subsequent concentric linear effluvium on the crown (donut pattern); and f) other forms of previously unreported immediate-onset effluvium. The linear morphology could be the result of dense packing, which can cause perilesional hypoxia and loss of miniaturized hairs around the recipient area. Since linear hair loss can cause patient concern about graft failure, we recommend taking images of transplanted and nontransplanted areas immediately after surgery and warning patients in advance about these transient effects, which are fully reversed in 3 months.

This study presents fibers based on methacrylic acid–methyl methacrylate (Eudragit L100) as Cu(II) adsorbents, resulting in antimicrobial complexes. Eudragit L100, an anionic copolymer synthesized by radical polymerization, was electrospun in dimethylformamide (DMF) and ethanol (EtOH). The electrospinning process was optimized through a 22-factorial design, with independent variables (copolymer concentration and EtOH/DMF volume ratio) and three repetitions at the central point. The smallest average fiber diameter (259 ± 53 nm) was obtained at 14% w/v Eudragit L100 and 80/20 EtOH/DMF volume ratio. The fibers were characterized using scanning electron microscopy (SEM), infrared spectroscopy in attenuated total reflectance mode (FTIR-ATR), and differential scanning calorimetry (DSC). The pseudo-second-order mechanism explained the kinetic adsorption toward Cu(II). The fibers exhibited a maximum adsorption capacity (qe) of 43.70 mg/g. The DSC analysis confirmed the Cu(II) absorption, indicating complexation between metallic ions and copolymer networks. The complexed fibers showed a lower degree of swelling than the non-complexed fibers. The complexed fibers exhibited bacteriostatic activity against Gram-negative (Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacteria. This study successfully optimized the electrospinning process to produce thin fibers based on Eudragit L100 for potential applications as adsorbents for Cu(II) ions in aqueous media and for controlling bacterial growth.

A pandemia de Covid-19 trouxe complicações e alterações inéditas à sociedade e às famílias, sendo necessária toda uma nova reorganização familiar. No presente estudo foi realizada uma revisão sistemática de artigos de pesquisas empíricas nas bases de dados “LILACS”, “PePSIC”, “SciELO”, “PsycINFO” e “SCOPUS” para verificar os impactos ocasionados nas famílias pela pandemia de Covid-19. As palavras-chaves utilizadas para encontrar os artigos foram “impacts, consequences, grievances AND problems”, “pandemic, Covid pandemic AND Covid-19” e “family, family dynamics AND family relationships”. Os artigos incluídos após a seleção abarcavam pesquisas empíricas; nas em línguas português, inglês ou espanhol; entre os anos 2021 e 2022 e temáticas vinculadas aos impactos da pandemia na dinâmica familiar. Descobriu-se por meio da revisão que a pandemia trouxe bastante impacto negativo às famílias, principalmente aos pais com sobrecarga de função e cuidados. A pandemia serviu também como agregador de um sofrimento já existente dentro da família, potencializando o problema pertencente na relação familiar. Além disto, pode-se perceber que fatores como renda, raça e gênero acarretam uma maior probabilidade de impactos negativos nas famílias. Tais resultados apontam para uma breve noção das consequências da pandemia e do isolamento e mostram a existência de impactos psicológicos e financeiros. Entretanto, faz-se necessário mais estudos, principalmente no Brasil, para mensurar outros tipos de impactos.

Resumo Considerando que experienciar uma disfunção sexual afeta profundamente a autopercepção e a qualidade de vida, este estudo almejou compreender a experiência de viver com vaginismo. Trata-se de uma pesquisa empírica, qualitativa, de caráter exploratório, em que participaram nove mulheres diagnosticadas em algum período da vida com vaginismo. Os dados foram coletados por meio de entrevistas semidirigidas e do procedimento de desenhos-estórias com o tema “Vaginismo”, sendo que, neste trabalho, destaca-se a análise dos desenhos e histórias devido à riqueza deste instrumento. O material foi interpretado em conjunto possibilitando a construção de três categorias temáticas: “Representações: o vaginismo como protagonista”, “O percurso e a história de vida: os diferentes momentos do vaginismo” e “A solidão e os relacionamentos”. Os resultados apontaram para diferentes percepções do vaginismo de acordo com o momento do tratamento, destacando-se a longa duração dos sintomas e o árduo processo de viver com esta disfunção.

Rhipicephalus microplus causes huge losses in cattle. Host genetic background greatly affects the immune efficiency in resistance or susceptibility to tick infestation, which is one of the many factors that play a role on that trait. We performed a systematic review of genome-wide association studies (GWAS) for tick resistance in cattle resulting in 1353 candidate genes for post-GWAS analyses. From those, genes showing possible structural variants from the bovine genome were classified by the Variant Effect Predictor from Ensembl. Ninety-two candidate genes showed potential structural variants in 5′ UTR and coding region and were used for functional annotation. Enriched biological processes (e.g. regulation of eosinophil chemotaxis, RIG-I signalling pathway and monocyte differentiation) and candidate genes (e.g. DAPK2, PUM1, ACIN1, INPP5D) linked with immune system function were identified and thus associated with tick resistance. Besides, gene-transcription factors (TFs) networks were obtained from TFs associated with immune system (FOXO3, PPARG, STAT3, NFKB1, GATA3 and ARNT) and the candidate genes associated with tick resistance in cattle highlighted (e.g. OR4L1, PNP, LRRIQ1, GIMAP8, MYO6, MEP1A and LRFN2). Thus, promising candidate genes with a possible functional role for tick resistance in cattle are presented for further in vitro and/or in vivo analyses.

We describe 28 patients who experienced effluvium with previously unreported features shortly after hair transplant surgery. Notable features were as follows: (a) a linear morphology; (b) immediate onset (1–3 days); (c) association with dense-pack grafting in areas of receding hairline at the temples (Mickey Mouse pattern); (d) a progressive increase in the diameter of the hair loss line (wave-like pattern); (e) in some cases, subsequent concentric linear effluvium on the crown (donut pattern); and (f) other forms of previously unreported immediate-onset effluvium. The linear morphology could be the result of dense packing, which can cause perilesional hypoxia and loss of miniaturized hairs around the recipient area. Since linear hair loss can cause patient concern about graft failure, we recommend taking images of transplanted and nontransplanted areas immediately after surgery and warning patients in advance about these transient effects, which are fully reversed in 3 months. Resumen: Describimos 28 pacientes que desarrollaron una forma de efluvio postrasplante capilar con características no descritas en la literatura: a) morfología lineal; b) aparición inmediata (uno a tres días); c) asociación con «dense packing» en entradas («signo de Mickey Mouse»); d) progresión del diámetro de la línea (patrón «wave-like»); e) posible adición posterior de efluvio lineal concéntrico a vértex («signo del donut»), y f) además de otros efluvios tampoco publicados por su inmediatez de aparición. La morfología lineal podría ser el resultado de la alta densidad colocada en nuestros pacientes, provocando hipoxia perilesional y efluvio de las unidades foliculares miniaturizadas que rodean la zona receptora. Debido a que la línea alopécica provoca inseguridad a los pacientes sobre una posible no colocación de injertos, recomendamos iconografía postoperatoria inmediata demostrando unión de áreas trasplantada y no trasplantada, así como la explicación previa al paciente de este fenómeno transitorio y completamente reversible en tres meses.