Search

Sugammadex, a selective relaxant binding agent, has transformed the management of neuromuscular blockade, offering rapid and safe recovery during various medical and dental procedures. Its applications extend to managing temporomandibular disorders (TMDs) in elderly patients undergoing complex oral rehabilitation. The integration of sugammadex into multidisciplinary treatment protocols—including prosthetic rehabilitation, balneophysiotherapy, and pharmacological therapies—has the potential to improve outcomes significantly. This review examines the pharmacological impact of sugammadex, its commercial formulations, and its role in the holistic management of TMDs in geriatric populations

In this work, we have developed a method for synthesizing new 8-substituted triazolo[5,1-b]purines using diacetoxyiodobenzene as an oxidizing agent with good yields (59–67%). The advantages of this approach include mild reaction conditions and removing the need to use transition metals. Based on the results obtained, a plausible reaction pathway was proposed. The developed approach opens new possibilities for the preparation of previously inaccessible condensed purine derivatives, which are of interest for the development of biomolecules with a variety of pharmacological applications. The structures of the compounds were confirmed by the data of 1H, 13C NMR spectroscopy, IR spectroscopy, and an elemental analysis.

Objective. The purpose of the study is to develop the design of a thermoelectric device for transpalpebral hypothermia of the anterior segment of the human eyeball.Method. The design of a TEU for thermal impact on the anterior segment of the human eyeball is described. The device includes an impact tip mated with one surface to the human eyelid, and the opposite surface to the cold surface of the thermo-electric module. The hot surface is in contact with a housing filled with a working substance having a stable melting point ranging from 303 to 330 K. The device is equipped with an adjustable power source with a control unit.Result. Ensuring the required mode of thermal exposure, in which the temperature of the anterior segment of the eyeball is at the level of 283-288 K, can be achieved by using in the device a standard TEM type TV-17-1.4-1.15 produced by Kryotherm LLC (St. Petersburg).Conclusion. The operating power range of the TEU will be within 3-4 W with an average temperature difference between the junctions of 45 K. The supply current is 6-7 A with a power consumption of 13-14 W. The refrigeration coefficient varies from 0.1 to 0.5. The device can be used in the treatment of keratitis, keratoconjunctivitis, dystrophic conditions of the cornea, anterior uveitis and non-obscuring corneal opacities.

Temporo-mandibular disorders (TMDs) represent a major cause of non-dental pain in the orofacial region, the effects of which may be presumed to form at the site where the greatest forces are exerted, and host resistance is least. The signs and symptoms of TMDs which are observed in patients with psychiatric easy disease observed and measured by anthropometrical methods and correct with specific treatment. The literature reviewed in the present work revealed that suggests a complex relationship between psychological status and treatment outcome and TMDs signs and symptoms in different groups of individuals persists and the specificity and morphological dates also. Timely identification and the management of this condition may improve the comfort and psychic status of the patients, underlined also in our research.

Dysfunctional syndromes of the stomatognathic system are interconnected with various pathologies, including complex psychiatric conditions. In these intricate cases, an interdisciplinary approach that integrates both dentistry and psychiatry is crucial. Effective oral rehabilitation demands strategic treatment plans designed to enhance quality of life and achieve optimal results for patients with schizophrenia.

Unfavorable biomechanics was found in the prosthetic field for complex rehabilitation in terms of biomechanical stress distribution, restoration of phonetics, comfort, esthetics, and hygiene, as well as postoperative care and maintenance. TMJ dysfunction was also observed, in the obesity group, it can occur even in the absence of dental caries or edentation which indicated the independence of the process and also the connection that can further complicate the clinical situation.

Dysfunctional syndrome of the stomatognathic system interferes with interferes with many pathologies among which in the present situation, with the characteristics of complex psychiatric pathology. There are cases with a high index of complexity that can be treated only by interdisciplinary approach dentistry-psychiatry. Complex oral rehabilitation imposes strategies and treatments to facilitate a good result in increasing the quality of life and the optimum result of patients with schizophrenia-type psychiatric elements.

Objective: To evaluate long-term outcomes of mitral valve annuloplasty using an autologous pericardial strip (“soft support ring” type) and a rigid support ring in combination with coronary artery bypass graft (CABG) in patients with ischemic mitral regurgitation.Materials and methods: We carried out retrospective and prospective analyses of the treatment outcomes in 90 patients with coronary heart disease (CHD) and ischemic mitral regurgitation. Ischemic mitral regurgitation (grade 2 or above) was an inclusion criterion for patients with CHD. Exclusion criteria were as follows: nonischemic mitral regurgitation, acute myocardial infarction, progressive angina pectoris, and repeated heart interventions. The patients were divided into 2 groups. Patients from group 1 underwent CABG with mitral regurgitation correction using a strip of glutaraldehyde-treated autologous pericardium (“soft support ring” type) according to our own method, whereas patients from group 2 underwent CABG with mitral regurgitation correction using a rigid support ring. The analysis revealed that the groups were comparable in all the studied parameters.Results: There was no statistically significant difference in the number of postoperative complications and hospital mortality between the groups. According to the analyzed data obtained at the time of discharge, all the patients had grade 0-1 mitral regurgitation, which shows a complete restoration of the mitral valve function after annuloplasty. In addition, there was a statistically significant decrease in the end-diastolic volume and an increase in ejection fraction, which is a sign of reverse left ventricular (LV) remodeling. The mean follow-up was 44±7.4 months. No deaths were reported during the follow-up. The results of the examination in the long-term period did not reveal negative dynamics in most patients compared with the findings in the early postoperative period. The LV size also did not change significantly, and the ejection fraction demonstrated an upward trend. One patient in each group had a recurrence of grade 3 mitral regurgitation.Conclusions: The immediate outcomes showed no recurrence of mitral regurgitation, a low number of intraoperative and postoperative complications, and pronounced reverse LV remodeling. We observed stable results in the long-term follow-up: only one patient in each group had a recurrence of mitral regurgitation. Reverse LV remodeling persisted throughout the follow-up. There were no significant differences between the groups in any parameter, which indicates that the developed annuloplasty method is not inferior to the traditional technique with a rigid support ring.

Aim of the study Treatment possibilities for complete edentulous cases by placing implants result in superior functional results, for better aesthetics, as well as stability, strength and support of prostheses and improved masticatory efficiency. Materials and methods The objective of this study is to highlight the importance of fabricating appropriate implant-based fixed prostheses through the appropriate selection and design of all their components in the treatment plan for our patient, with total edentulousness. A 56-year-old patient presented himself at the dental office, with complete edentulous status, in both arches, and the treatment was the “Fast and Fixed” option of “All on 6” in the maxilla jaw and “All on 4” in the mandible, with framework from zirconia and PEEK, respectively. Results The rehabilitation of complete edentulous status with fixed implant supported prostheses is one of the challenging treatments, because of the aesthetic and functional factors that should be considered. Conclusions There is a superior prognosis of oral rehabilitation with implants compared to traditional methods, and statistical data shown a high success rate of around 95% for 10 years. Fixed restorative systems on dental implants are considered the ideal solution for replacing missing teeth in the case of total edentulous arches.

The complex oral rehabilitation team should be aware of the link between an imbalanced TMJ, edentation, occlusion, and an increased caries risk after eating a high-carb diet. Prevention of obesity and metabolic diseases is critical for this population. Co-occurring diseases like as type 2 diabetes may impact periodontal health management, and erosion risk may increase due to reflux.

Hearing loss (HL) is the third most prevalent chronic health problem among older adults and is quite common in our study group research. Our study wants to illustrate the research on the connection between HL and depression as well as the therapeutic ramifications for diagnosing and treating comorbid like intraoral rehabilitation, HL, and mental disorders also.

The therapeutic management of cases with social anxiety in addition to young ages must have a well-developed protocol to achieve the subsequent acquisition of confidence and the possibility of continuity in a short period of time because it takes place over several sessions as well as adaptations during the checks as maintenance and reliability of the treatment plan.

Thanks to the introduction of new screening programs, the emergence rate of novel anticancer drugs and the detection rate of early-stage breast cancer in Russia increase year by year. Organ preservation treatment, after which radiation therapy has to be performed, is the most common type of surgical treatment used in this cohort of patients. Today, various treatment methods are used, the most common is external beam radiation therapy, however, brachytherapy of breast cancer is also used.

In this article, we consider simple-motion pursuit–evasion differential games in the Hilbert space of square summable sequences. We show that when the players have the same dynamic capabilities, evasion is possible under some assumptions about the initial positions of the players.

Chronic apical periodontitis (CAP) is considered to be a dynamic defence response against micro-organisms invasion into periradicular tissues, resulting in a destruction of surrounding periapical bone . Among other important regulatory functions, vitamin D demonstrated to have a role in modulating the inflammatory process of periradicular tissues, in calcium and bone homeostasis and apoptosis. This retrospective study aimed to assess the relationship between vitamin D (VitD) levels and the incidence of large periapical rarefactions in dental patients that further undergo complex prosthetic rehabilitation. In this regard, a number of 28 patients, 54,8% men (n=16) and 45,2% women (n=12) with a complete medical and dental history, in the age range of 18–50 years were taken under observation. They were examined radiographically and clinically to diagnose the presence of CAP, presence and quality of root canal fillings, quality of restoration and periapical status. Another group of 28 patients in the same age range and gender-matched individuals without any history of systemic disease or presence of CAP lesions were included in the study as the control group. Serum VitD levels were analyzed for all patients. The prevalence of teeth with large chronic periapical lesions was 85,7% in the analyzed group The results showed significantly different values of Vitamin D levels in individuals with CAP compared with control patients (P =0,003). The presence or absence of root canal fillings in affected teeth didn’t correlate with the lesion dimension or severity of the evolution.