1. HIV-induced immunodeficiency and mortality from AIDS-defining and non-AIDS-defining malignancies
- Author
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Anne Johnson, Andrea Antinori, Ludmila Viksna, Ferran Torres, Adriano LAZZARIN, Roberto CAUDA, Jens Lundgren, LUZ MARTÍN CARBONERO, Frank Van Leth, Antonio Chiesi, Giuseppe Ippolito, CARLO FEDERICO PERNO, Vicente Soriano, Matthew Law, Paolo Bonfanti, Marc Van der Valk, Simon Collins, Patrizio Pezzotti, Kathleen Falster, STEFANO VELLA, Andrea De Luca, Adriana Ammassari, Đorđe Jevtović, Tatiana Katerina Galpérine, Simon Mallal, Raffaele Bruno, Adrian Streinu-Cercel, Thomas Benfield, Viktar M. Mitsura, Caroline Sabin, Terese L Katzenstein, Antonella Castagna, FRANCESCA CECCHERINI SILBERSTEIN, Bart Rijnders, Vassilenko Anna, Alicja Wiercińska-Drapało, Rita Murri, ANDREA COSTANTINI, Amsterdam institute for Infection and Immunity, Amsterdam Public Health, Infectious diseases, Other departments, General Internal Medicine, Global Health, Monforte, Antonella D'arminio, Abrams, Donald, Pradier, Christian, Weber, Rainer, Reiss, Peter, Bonnet, Fabrice, Kirk, Ole, Law, Matthew, De Wit, Stephane, Friis mã¸ller, Nina, Phillips, Andrew N., Sabin, Caroline A., Lundgren, Jens D., Collins, S., Loeliger, E., Tressler, R., Weiler, I., Friis mã¸ller, N., Worm, S. W., Sabin, C. A., Sjã¸l, A., Lundgren, J. D., Sawitz, A., Rickenbach, M., Pezzotti, P., Krum, E., Gras, L., Balestre, E., Sundstrã¶m, A., Poll, B., Fontas, E., Torres, F., Petoumenos, K., Kjã¦r, J. D:a:d Study Group, Castagna, Antonella, University of Zurich, D'Arminio Monforte, A, Internal medicine, and Medical psychology
- Subjects
Male ,d:a:d study ,Lymphoma ,HIV Infections ,Sex Factor ,10234 Clinic for Infectious Diseases ,non-aids-defining malignancies ,Neoplasms ,Immunology and Allergy ,Age Factor ,HIV Infection ,Young adult ,AIDS-Related ,Immunodeficiency ,Lymphoma, AIDS-Related ,hiv infection ,Mortality rate ,Age Factors ,Homosexuality ,Middle Aged ,AIDS-defining malignancie ,Pathogenesis and modulation of inflammation [N4i 1] ,Infectious Diseases ,Epidemiologic Method ,2723 Immunology and Allergy ,symbols ,Female ,Human ,Cohort study ,Adult ,medicine.medical_specialty ,Anti-HIV Agents ,Immunology ,610 Medicine & health ,Article ,Drug Administration Schedule ,symbols.namesake ,Immunocompromised Host ,Young Adult ,A:D study [D] ,Sex Factors ,Acquired immunodeficiency syndrome (AIDS) ,Internal medicine ,medicine ,Humans ,Poisson regression ,Mortality ,aids-defining malignancies ,mortality ,Homosexuality, Male ,Aged ,Hepatitis ,2403 Immunology ,business.industry ,Non-AIDS-defining malignancie ,Anti-HIV Agent ,2725 Infectious Diseases ,medicine.disease ,Confidence interval ,CD4 Lymphocyte Count ,Neoplasm ,Microbial pathogenesis and host defense [UMCN 4.1] ,business ,Epidemiologic Methods - Abstract
Objective: To evaluate deaths from AIDS-defining malignancies (ADM) and non-AIDS-defining malignancies (nADM) in the D:A:D Study and to investigate the relationship between these deaths and immunodeficiency. Design: Observational cohort study. Methods: Patients (23 437) were followed prospectively for 104 921 person-years. We used Poisson regression models to identify factors independently associated with deaths from ADM and nADM. Analyses of factors associated with mortality due to nADM were repeated after excluding nADM known to be associated with a specific risk factor. Results: Three hundred five patients died due to a malignancy, 298 prior to the cutoff for this analysis (ADM: n = 110; nADM: n = 188). The mortality rate due to ADM decreased from 20.1/1000 person-years of follow-up [95% confidence interval (CI) 14.4, 25.9] when the most recent CD4 cell count was
- Published
- 2008
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