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1. Temporal, age, and geographical variation in vaccine efficacy against infection by the Delta and Omicron variants in the community in France, December 2021 to March 2022

Author

François Blanquart, Clémence Abad, Joevin Ambroise, Mathieu Bernard, Florence Débarre, Jean-Marc Giannoli, Thomas Rey, and Vincent Vieillefond

Subjects
SARS-CoV-2, Variants of concern, Vaccine efficacy, Behavior, Infectious and parasitic diseases, RC109-216
Abstract

Objectives: We aimed to quantify how the vaccine efficacy of BNT162b2, messenger RNA-1273, AD26.COV2-S, and ChAdOx1 nCoV-19 against detected infection by the SARS-CoV-2 Delta and Omicron variants varied by time since the last dose, vaccine scheme, age, and geographic areas. Methods: We analyzed 3,261,749 community polymerase chain reaction tests conducted by private laboratories in France from December 2021 to March 2022 with a test-negative design comparing vaccinated to unvaccinated individuals. Results: Efficacy against detected infection by Delta was 89% (95% confidence interval, 86-91%) at 2 weeks, down to 59% (56-61%) at 26 weeks and more after the second dose. Efficacy against Omicron was 48% (45-51%) at 2 weeks, down to 4% (2-5%) at 16 weeks after the second dose. A third dose temporarily restored efficacy. Efficacy against Omicron was lower in children and the elderly. Geographical variability in efficacy may reflect variability in the ratio of the number of contacts of vaccinated vs unvaccinated individuals. This ratio ranged from 0 to +50% across departments and correlated with the number of restaurants and bars per inhabitant (beta = 15.0 [0.75-29], P-value = 0.04), places that only vaccinated individuals could access in the study period. Conclusion: SARS-CoV-2 vaccines conferred low and transient protection against Omicron infection.

Published
2023
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6. Universal Tc depression by irradiation defects in underdoped and overdoped cuprates

Author

Rullier-Albenque, F., Vieillefond, P. A., Alloul, H., Tyler, A. W., Lejay, P., and Marucco, J. F.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Superconductivity
Abstract

We report on a study of the influence of defects introduced in the CuO$_{2}$ planes of cuprates in a wide range of hole dopings n. T$_{c}$ and electrical resistivity $\rho (T)$ measurements have been performed on electron irradiated YBa$_{2}$Cu$_{3}$O$_{7-\delta}$ and Tl$_{2}$Ba$_{2}$CuO$_{6+x}$ single crystals. A universal scaling between the decrease in T$_{c}$ and $\UNICODE[m]{0x394}\rho_{2D}\UNICODE[m]{0xd7}n$, where $\UNICODE[m]{0x394}\rho _{2D}$ is the increase of the 2D-resistance induced by the defects, is found for all the samples investigated here. This demonstrates that n is the relevant parameter to describe the transport properties all over the phase diagram, in contradiction with a recent suggestion of a change in the number of carriers from n to 1-n at the optimal doping. Moreover, the analysis of our data suggests that strong scattering persists on the overdoped side., Comment: 11 pages in Latex/Revtex format, 3 postscript figures

Published
1999
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7. Supplementary Figure Legend from Activation of the PI3K/AKT Pathway Induces Urothelial Carcinoma of the Renal Pelvis: Identification in Human Tumors and Confirmation in Animal Models

Author

Qian, Chao-Nan, primary, Furge, Kyle A., primary, Knol, Jared, primary, Huang, Dan, primary, Chen, Jindong, primary, Dykema, Karl J., primary, Kort, Eric J., primary, Massie, Aaron, primary, Khoo, Sok Kean, primary, Vanden Beldt, Kristin, primary, Resau, James H., primary, Anema, John, primary, Kahnoski, Richard J., primary, Morreau, Hans, primary, Camparo, Philippe, primary, Comperat, Eva, primary, Sibony, Mathilde, primary, Denoux, Yves, primary, Molinie, Vincent, primary, Vieillefond, Annick, primary, Eng, Charis, primary, Williams, Bart O., primary, and Teh, Bin Tean, primary

Published
2023
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8. Supplementary Table 2 from Activation of the PI3K/AKT Pathway Induces Urothelial Carcinoma of the Renal Pelvis: Identification in Human Tumors and Confirmation in Animal Models

Author

Qian, Chao-Nan, primary, Furge, Kyle A., primary, Knol, Jared, primary, Huang, Dan, primary, Chen, Jindong, primary, Dykema, Karl J., primary, Kort, Eric J., primary, Massie, Aaron, primary, Khoo, Sok Kean, primary, Vanden Beldt, Kristin, primary, Resau, James H., primary, Anema, John, primary, Kahnoski, Richard J., primary, Morreau, Hans, primary, Camparo, Philippe, primary, Comperat, Eva, primary, Sibony, Mathilde, primary, Denoux, Yves, primary, Molinie, Vincent, primary, Vieillefond, Annick, primary, Eng, Charis, primary, Williams, Bart O., primary, and Teh, Bin Tean, primary

Published
2023
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9. Data from Activation of the PI3K/AKT Pathway Induces Urothelial Carcinoma of the Renal Pelvis: Identification in Human Tumors and Confirmation in Animal Models

Author

Qian, Chao-Nan, primary, Furge, Kyle A., primary, Knol, Jared, primary, Huang, Dan, primary, Chen, Jindong, primary, Dykema, Karl J., primary, Kort, Eric J., primary, Massie, Aaron, primary, Khoo, Sok Kean, primary, Vanden Beldt, Kristin, primary, Resau, James H., primary, Anema, John, primary, Kahnoski, Richard J., primary, Morreau, Hans, primary, Camparo, Philippe, primary, Comperat, Eva, primary, Sibony, Mathilde, primary, Denoux, Yves, primary, Molinie, Vincent, primary, Vieillefond, Annick, primary, Eng, Charis, primary, Williams, Bart O., primary, and Teh, Bin Tean, primary

Published
2023
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10. Supplementary Table 1 from Activation of the PI3K/AKT Pathway Induces Urothelial Carcinoma of the Renal Pelvis: Identification in Human Tumors and Confirmation in Animal Models

Author

Qian, Chao-Nan, primary, Furge, Kyle A., primary, Knol, Jared, primary, Huang, Dan, primary, Chen, Jindong, primary, Dykema, Karl J., primary, Kort, Eric J., primary, Massie, Aaron, primary, Khoo, Sok Kean, primary, Vanden Beldt, Kristin, primary, Resau, James H., primary, Anema, John, primary, Kahnoski, Richard J., primary, Morreau, Hans, primary, Camparo, Philippe, primary, Comperat, Eva, primary, Sibony, Mathilde, primary, Denoux, Yves, primary, Molinie, Vincent, primary, Vieillefond, Annick, primary, Eng, Charis, primary, Williams, Bart O., primary, and Teh, Bin Tean, primary

Published
2023
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11. Supplementary Figure 1 from Activation of the PI3K/AKT Pathway Induces Urothelial Carcinoma of the Renal Pelvis: Identification in Human Tumors and Confirmation in Animal Models

Author

Qian, Chao-Nan, primary, Furge, Kyle A., primary, Knol, Jared, primary, Huang, Dan, primary, Chen, Jindong, primary, Dykema, Karl J., primary, Kort, Eric J., primary, Massie, Aaron, primary, Khoo, Sok Kean, primary, Vanden Beldt, Kristin, primary, Resau, James H., primary, Anema, John, primary, Kahnoski, Richard J., primary, Morreau, Hans, primary, Camparo, Philippe, primary, Comperat, Eva, primary, Sibony, Mathilde, primary, Denoux, Yves, primary, Molinie, Vincent, primary, Vieillefond, Annick, primary, Eng, Charis, primary, Williams, Bart O., primary, and Teh, Bin Tean, primary

Published
2023
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12. Data from Activation of the PI3K/AKT Pathway Induces Urothelial Carcinoma of the Renal Pelvis: Identification in Human Tumors and Confirmation in Animal Models

Author

Bin Tean Teh, Bart O. Williams, Charis Eng, Annick Vieillefond, Vincent Molinie, Yves Denoux, Mathilde Sibony, Eva Comperat, Philippe Camparo, Hans Morreau, Richard J. Kahnoski, John Anema, James H. Resau, Kristin Vanden Beldt, Sok Kean Khoo, Aaron Massie, Eric J. Kort, Karl J. Dykema, Jindong Chen, Dan Huang, Jared Knol, Kyle A. Furge, and Chao-Nan Qian

Abstract

Urothelial carcinoma of the renal pelvis is a deadly disease with an unclear tumorigenic mechanism. We conducted gene expression profiling on a set of human tumors of this type and identified a phosphatidylinositol 3-kinase (PI3K)/AKT activation expression signature in 76.9% (n = 13) of our samples. Sequence analysis found both activating mutations of PIK3CA (13.6%, n = 22) and loss of heterozygosity at the PTEN locus (25%, n = 8). In contrast, none of the other subtypes of kidney neoplasms (e.g., clear-cell renal cell carcinoma) harbored PIK3CA mutations (n = 87; P < 0.001). Immunohistochemical analysis of urothelial carcinoma samples found loss of PTEN protein expression (36.4%, n = 11) and elevation of phosphorylated mammalian target of rapamycin (mTOR; 63.6%, n = 11). To confirm the role of the PI3K/AKT pathway in urothelial carcinoma, we generated mice containing biallelic inactivation of Pten in the urogenital epithelia. These mice developed typical renal pelvic urothelial carcinomas, with an incidence of 57.1% in mice older than 1 year. Laser capture microdissection followed by PCR confirmed the deletion of Pten exons 4 and 5 in the animal tumor cells. Immunohistochemical analyses showed increased phospho-mTOR and phospho-S6K levels in the animal tumors. Renal lymph node metastases were found in 15.8% of the animals with urothelial carcinoma. In conclusion, we identified and confirmed an important role for the PI3K/AKT pathway in the development of urothelial carcinoma and suggested that inhibitors of this pathway (e.g., mTOR inhibitor) may serve as effective therapeutic agents. [Cancer Res 2009;69(21):8256–64]

Published
2023

13. Supplementary Figure 1 from Activation of the PI3K/AKT Pathway Induces Urothelial Carcinoma of the Renal Pelvis: Identification in Human Tumors and Confirmation in Animal Models

Author

Bin Tean Teh, Bart O. Williams, Charis Eng, Annick Vieillefond, Vincent Molinie, Yves Denoux, Mathilde Sibony, Eva Comperat, Philippe Camparo, Hans Morreau, Richard J. Kahnoski, John Anema, James H. Resau, Kristin Vanden Beldt, Sok Kean Khoo, Aaron Massie, Eric J. Kort, Karl J. Dykema, Jindong Chen, Dan Huang, Jared Knol, Kyle A. Furge, and Chao-Nan Qian

Abstract

Supplementary Figure 1 from Activation of the PI3K/AKT Pathway Induces Urothelial Carcinoma of the Renal Pelvis: Identification in Human Tumors and Confirmation in Animal Models

Published
2023

14. Supplementary Table 1 from Activation of the PI3K/AKT Pathway Induces Urothelial Carcinoma of the Renal Pelvis: Identification in Human Tumors and Confirmation in Animal Models

Author

Bin Tean Teh, Bart O. Williams, Charis Eng, Annick Vieillefond, Vincent Molinie, Yves Denoux, Mathilde Sibony, Eva Comperat, Philippe Camparo, Hans Morreau, Richard J. Kahnoski, John Anema, James H. Resau, Kristin Vanden Beldt, Sok Kean Khoo, Aaron Massie, Eric J. Kort, Karl J. Dykema, Jindong Chen, Dan Huang, Jared Knol, Kyle A. Furge, and Chao-Nan Qian

Abstract

Supplementary Table 1 from Activation of the PI3K/AKT Pathway Induces Urothelial Carcinoma of the Renal Pelvis: Identification in Human Tumors and Confirmation in Animal Models

Published
2023

15. Supplementary Figure Legend from Activation of the PI3K/AKT Pathway Induces Urothelial Carcinoma of the Renal Pelvis: Identification in Human Tumors and Confirmation in Animal Models

Author

Bin Tean Teh, Bart O. Williams, Charis Eng, Annick Vieillefond, Vincent Molinie, Yves Denoux, Mathilde Sibony, Eva Comperat, Philippe Camparo, Hans Morreau, Richard J. Kahnoski, John Anema, James H. Resau, Kristin Vanden Beldt, Sok Kean Khoo, Aaron Massie, Eric J. Kort, Karl J. Dykema, Jindong Chen, Dan Huang, Jared Knol, Kyle A. Furge, and Chao-Nan Qian

Abstract

Supplementary Figure Legend from Activation of the PI3K/AKT Pathway Induces Urothelial Carcinoma of the Renal Pelvis: Identification in Human Tumors and Confirmation in Animal Models

Published
2023

16. Supplementary Table 2 from Activation of the PI3K/AKT Pathway Induces Urothelial Carcinoma of the Renal Pelvis: Identification in Human Tumors and Confirmation in Animal Models

Author

Bin Tean Teh, Bart O. Williams, Charis Eng, Annick Vieillefond, Vincent Molinie, Yves Denoux, Mathilde Sibony, Eva Comperat, Philippe Camparo, Hans Morreau, Richard J. Kahnoski, John Anema, James H. Resau, Kristin Vanden Beldt, Sok Kean Khoo, Aaron Massie, Eric J. Kort, Karl J. Dykema, Jindong Chen, Dan Huang, Jared Knol, Kyle A. Furge, and Chao-Nan Qian

Abstract

Supplementary Table 2 from Activation of the PI3K/AKT Pathway Induces Urothelial Carcinoma of the Renal Pelvis: Identification in Human Tumors and Confirmation in Animal Models

Published
2023

17. Cystic Renal Masses

Author

Hélénon, Olivier, Correas, J. M., Merran, S., Vieillefond, A., Reiser, Maximilian F, Series editor, Kauczor, Hans-Ulrich, Series editor, Hricak, Hedvig, Series editor, Knauth, Michael, Series editor, and Quaia, Emilio, editor

Published
2014
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18. Cystic Renal Masses

Author

Hélénon, Olivier, Correas, J. M., Merran, S., Dekeyser, E., Vieillefond, A., and Quaia, Emilio, editor

Published
2011
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21. Epidemiology of symptomatic infective anoproctitis in a population of men having sex with men (MSM)

Author

J. Lourtet-Hascoet, L. Mine, L. Spindler, B. Pilmis, M. Aubert, A. EL Mituialy, V. Vieillefond, V. de Parades, A. Le Monnier, Groupe Hospitalier Paris Saint-Joseph (hpsj), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre hospitalier Saint-Joseph [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and Université Paris-Saclay

Subjects
Microbiology (medical), [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, Infectious Diseases, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, General Medicine, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Abstract

International audience

Published
2022

26. Epidemiology of symptomatic infective anoproctitis in a population of men having sex with men (MSM)

Author

J, Lourtet-Hascoet, L, Mine, L, Spindler, B, Pilmis, M, Aubert, A, El Mituialy, V, Vieillefond, V, de Parades, and A, Le Monnier

Subjects
Male, Gonorrhea, Sexual and Gender Minorities, Coinfection, Prevalence, Humans, Chlamydia trachomatis, Chlamydia Infections, Homosexuality, Male, Neisseria gonorrhoeae, Anti-Bacterial Agents
Abstract

Anoproctitis due to Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are Sexual Transmitted Infections (STIs) reported in MSM population. This study describes clinical and microbiological epidemiology of infective anoproctitis in MSM population.All patients with symptomatic anoproctitis consulting at the proctology Institute of Saint-Joseph's Hospital, Paris, were included. Detection of CT/NG was performed by PCR GeneXpertSymptoms most frequently reported were pain, rectal bleeding and purulent flow in 66%, 52% and 49% of cases, respectively. On the 311 rectal samples collected, 171 (55.2%) were positive to CT/NG. Among the 194 used for mPCR, 148 were positive to STIs pathogens (76.2%) including 106 samples (71.6%) positive in coinfections. Among NG infections, 22.6% of the strains were resistant to azithromycin and 26.8% to tetracyclines.Anorectal infections in this MSM population showed a high prevalence of not only CT/NG but also other pathogens involved in STIs. The high level of coinfections confirms the requirement of accurate PCR tests to improve diagnosis. This study describing increasing antibiotic resistances for NG strains confirms the updating of international guidelines on antibiotic treatments recommendations.

Published
2021

33. Cystic Renal Masses

Author

Hélénon, Olivier, primary, Correas, J. M., additional, Merran, S., additional, and Vieillefond, A., additional

Published
2014
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42. Cistitis crónicas no bacterianas

Author

Sarah J. Drouin, Morgan Rouprêt, A Vieillefond, and Quentin Manach

Subjects
03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, 030232 urology & nephrology
Abstract

El termino de cistopatias cronicas engloba distintas afecciones vesicales de etiologias diversas (infecciosas, traumaticas, irritativas, etc.), cuya presentacion clinica es variada y combina, en la mayoria de los casos, dolor pelvico, hematuria y sintomas irritativos. Las pruebas de imagen suelen ser de escasa utilidad para el diagnostico y se utilizan sobre todo para descartar las complicaciones. El diagnostico suele basarse en la cistoscopia y el estudio histologico de las biopsias vesicales asociadas a la anamnesis y a la busqueda de factores desencadenantes. El tratamiento es medico (tratamiento del agente causal, antibioticoterapia, instilaciones endovesicales) y/o quirurgico (reseccion endoscopica, cistectomia parcial o total). Las recidivas son frecuentes y algunas formas son precancerosas, por lo que se recomienda un seguimiento a largo plazo.

Published
2018

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