235 results on '"A, Soilihi"'
Search Results
2. Correction: Takotsubo syndrome linked to paroxysmal sympathetic hyperactivity as a postoperative complication after brain tumor removal: a case report and literature review
- Author
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Krouma, Manel, Soilihi, A. Aboudou, Pech-Gourg, Gregoire, Arnaud, Sophie, Fadoua, El Louali, Caruselli, Marco, and Scavarda, Didier
- Published
- 2024
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3. Environmental signals perceived by the brain abate pro-metastatic monocytes by dampening glucocorticoids receptor signaling
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Canali, María Magdalena, Guyot, Mélanie, Simon, Thomas, Daoudlarian, Douglas, Chabry, Joelle, Panzolini, Clara, Petit-Paitel, Agnès, Hypolite, Nicolas, Nicolas, Sarah, Bourdely, Pierre, Schmid-Antomarchi, Heidy, Schmid-Alliana, Annie, Soria, Javier, Karimdjee Soilihi, Babou, Hofman, Paul, Prevost-Blondel, Armelle, Kato, Masashi, Mougneau, Evelyne, Glaichenhaus, Nicolas, and Blancou, Philippe
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- 2023
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4. Environmental signals perceived by the brain abate pro-metastatic monocytes by dampening glucocorticoids receptor signaling
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María Magdalena Canali, Mélanie Guyot, Thomas Simon, Douglas Daoudlarian, Joelle Chabry, Clara Panzolini, Agnès Petit-Paitel, Nicolas Hypolite, Sarah Nicolas, Pierre Bourdely, Heidy Schmid-Antomarchi, Annie Schmid-Alliana, Javier Soria, Babou Karimdjee Soilihi, Paul Hofman, Armelle Prevost-Blondel, Masashi Kato, Evelyne Mougneau, Nicolas Glaichenhaus, and Philippe Blancou
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Cytology ,QH573-671 - Abstract
Abstract While positive social-behavioral factors predict longer survival in cancer patients, the underlying mechanisms are unknown. Since tumor metastasis are the major cancer mortality factor, we investigated how an enriched environment (EE) conductive to enhanced sensory, cognitive and motor stimulation impact metastatic progression in lungs following intravasation in the circulation. We find that mice housed in EE exhibited reduced number of lung metastatic foci compared to control mice housed in a standard environment (SE). Compared to SE mice, EE mice increased lung inflammation as early as 4 days after circulating tumor cells extravasation. The impact of environmental signals on lung metastasis is independent of adrenergic receptors signaling. By contrast, we find that serum corticosterone levels are lower in EE mice and that glucocorticoid receptor (GR) antagonist reduces the number of lung metastasis in SE mice. In addition, the difference of the number of lung metastasis between SE and EE mice is abolished when inflammatory monocytes are rendered deficient in GR signaling. This decreased GR signaling in inflammatory monocytes of SE mice results in an exacerbated inflammatory profile in the lung. Our study shows that not only EE reduces late stages of metastatic progression in lungs but disclose a novel anti-tumor mechanism whereby GR-dependent reprogramming of inflammatory monocytes can inhibit metastatic progression in lungs. Moreover, while inflammatory monocytes have been shown to promote cancer progression, they also have an anti-tumor effect, suggesting that their role is more complex than currently thought.
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- 2023
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5. CX3CL1 as potential immunotherapeutic tool for bone metastases in lung cancer: A preclinical study
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Cohen, Charlotte, Goguet, Emilie, Antomarchi, Julie, Al-Sahlanee, Rasha, Cherfils-Vicini, Julien, Glaichenhaus, Nicolas, Balaguer, Thierry, Ambrosetti, Damien, Millet, Marie-Ange, Soilihi, Babou Karimdjee, Amoretti, Nicolas, Schmid-Antomarchi, Heidy, and Schmid-Alliana, Annie
- Published
- 2022
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6. CX3CL1 as potential immunotherapeutic tool for bone metastases in lung cancer: A preclinical study
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Charlotte Cohen, Emilie Goguet, Julie Antomarchi, Rasha Al-Sahlanee, Julien Cherfils-Vicini, Nicolas Glaichenhaus, Thierry Balaguer, Damien Ambrosetti, Marie-Ange Millet, Babou Karimdjee Soilihi, Nicolas Amoretti, Heidy Schmid-Antomarchi, and Annie Schmid-Alliana
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CX3CL1 ,Lung cancer ,Experimental bone metastases ,Tumor microenvironment ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
The chemokine CX3CL1 emerges as a double-edged sword in the pathophysiology of cancer. We investigated whether CX3CL1 would act as an impediment or as a support to the development of non-small cell lung cancer skeletal metastases.We set up an in vivo experimental skeletal metastasis model using the LL2 lung cancer cell line expressing low or high levels of CX3CL1. The resulting bone tumors were analyzed using histological, flow cytometry and transcriptomic techniques.The increased CX3CL1 expression was associated with a strong anti-tumor effect. We observed a significant reduced tumor burden in the high-CX3CL1 group compared to the low-CX3CL1 group with significant differences in the composition of the tumor-infiltrating leukocytes and immunity- and osteogenesis-related gene expression.Our results highlight the CX3CL1 ability to reduce cancer cell tumorigenicity by potentially disrupting both the vicious cycle linking bone resorption and the tumor cell proliferation as well as by generating an immune permissive tumor microenvironment rich in cancer-fighting immune cells, especially M1 monocytes, B cells and NK cells. In that regard, CX3CL1 could be an interesting tool to increase and/or predict the success of immune-based therapies requiring immune cell trafficking.
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- 2022
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7. EUROFUSION CONTRIBUTIONS TO ITER NUCLEAR OPERATION
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Litaudon, Xavier L, primary, Fantz, Ursel, additional, Villari, Rosaria, additional, Toigo, Vanni, additional, Aumeunier, Marie-Helene, additional, Autran, Jean-Luc, additional, Batistoni, Paola, additional, Belonohy, Eva, additional, Bradnam, Steven, additional, CECCHETTO, Matteo, additional, Colangeli, Andrea, additional, DACQUAIT, Frederic, additional, Dal Bello, Samuele, additional, DENTAN, Martin, additional, De Pietri, Marco, additional, Eriksson, Jacob, additional, Fabbri, Marco, additional, Falchetto, Gloria L, additional, Figini, Lorenzo, additional, Figueiredo, Joao, additional, Flammini, Davide, additional, Fonnesu, Nicola, additional, Frassinetti, Lorenzo, additional, Galdon-Quiroga, Joaquin, additional, Garcia Alia, Ruben, additional, Garcia-Munoz, Manuel, additional, Ghani, Zamir, additional, Gonzalez Martin, Javier, additional, Grelier, Erwan, additional, DIGRAZIA, Luigi Manuel, additional, Grove, Bob, additional, GROVE, Callum, additional, GUSAROV, Andrei, additional, Heinemann, Bernd, additional, Hjalmarsson, Anders, additional, Hyvarinen, otsojuhani, additional, Ioannou-Sougleridis, Vassilios, additional, JONES, Luke, additional, Kim, Hyun-Tae, additional, Klosowski, Marius, additional, Kocan, Martin, additional, Kos, Bor, additional, Kos, Leon, additional, Kotnik, Domen, additional, Laszynska, Ewa, additional, Leichtle, Dieter, additional, Lengar, Igor, additional, Leon-Gutierrez, Edgard, additional, López Revelles, Antonio Jesús, additional, Loreti, Stefano, additional, LOUGHLIN, Mike J, additional, Marcuzzi, Diego, additional, McClements, Kenneth G, additional, Mariano, Giovanni, additional, Mattei, Massimiliano, additional, Mergia, K, additional, Mietelski, Jerzy, additional, Mitteau, Raphael, additional, Moindjie, soilihi, additional, Munteanu, Daniela, additional, Naish, Richard, additional, NOCE, simone, additional, Packer, Lee, additional, Pamela, Stanislas, additional, Pampin, Raul, additional, Pau, Alessandro, additional, Peacock, Alan, additional, Peluso, Emmanuele, additional, Peneliau, Yannick, additional, Peric, julijan, additional, Radulovic, Vladimir, additional, Ricci, Daria, additional, Rimini, Fernanda, additional, Sauvan, Patrick, additional, Savva, Marilia, additional, Serianni, Gianluigi, additional, SHAND, Chantal, additional, Snicker, Antti, additional, Snoj, Luka, additional, Stamatelatos, Ion, additional, Štancar, Žiga, additional, Vasilopoulou, Theodora, additional, Vila, rafael, additional, Waterhouse, John, additional, Wimmer, Christian, additional, Wünderlich, Dirk, additional, Zohar, andrej, additional, Terranova, Nicholas, additional, and Sanchis, Lucia, additional
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- 2024
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8. Tumeur intrapapillaire et mucineuse du pancréas comme diagnostic différentiel de pseudokystes du pancréas : à propos d’un cas au Madagascar
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Mahavivola, Ernestho-ghoud Indretsy, primary, Hasina, Rajaonarison Ny Ony Narindra Lova, additional, Abdou, Soilihi Moustafa, additional, Enintsoa, Raveloson Nasolotsiry, additional, Ahmad, Ahmad, additional, and Danielle, Vololontiana Hanta Marie, additional
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- 2024
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9. Spiel, Spaß, … Vision!
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Lotz, Katinka, primary and Soilihi Mzé, Hassan, additional
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- 2024
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10. Fast cycling culture of the annelid model Platynereis dumerilii
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Legras, M, Ghisleni, G, Regnard, L, Dias, M, Soilihi, R, Celmar, E, Balavoine, G, Mathieu Legras, Giulia Ghisleni, Léna Regnard, Manon Dias, Rabouant Soilihi, Enzo Celmar, Guillaume Balavoine, Legras, M, Ghisleni, G, Regnard, L, Dias, M, Soilihi, R, Celmar, E, Balavoine, G, Mathieu Legras, Giulia Ghisleni, Léna Regnard, Manon Dias, Rabouant Soilihi, Enzo Celmar, and Guillaume Balavoine
- Abstract
Platynereis dumerilii, a marine annelid, is a model animal that has gained popularity in various fields such as developmental biology, biological rhythms, nervous system organization and physiology, behaviour, reproductive biology, and epigenetic regulation. The transparency of P. dumerilii tissues at all developmental stages makes it easy to perform live microscopic imaging of all cell types. In addition, the slow-evolving genome of P. dumerilii and its phylogenetic position as a representative of the vast branch of Lophotrochozoans add to its evolutionary significance. Although P. dumerilii is amenable to transgenesis and CRISPRCas9 knockouts, its relatively long and indefinite life cycle, as well as its semelparous reproduction have been hindrances to its adoption as a reverse genetics model. To overcome this limitation, an adapted culturing method has been developed allowing much faster life cycling, with median reproductive age at 13–14 weeks instead of 25–35 weeks using the traditional protocol. A low worm density in boxes and a strictly controlled feeding regime are important factors for the rapid growth and health of the worms. This culture method has several advantages, such as being much more compact, not requiring air bubbling or an artificial moonlight regime for synchronized sexual maturation and necessitating only limited water change. A full protocol for worm care and handling is provided.
- Published
- 2023
11. Radiation Hardness of Modern Photogate Pixels Under Total Ionizing Dose: Impact of Pixel Pitch and Electron or Hole Collection
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Malherbe, Victor, Nier, Olivier, Moindjie, Soilihi, Roche, Philippe, Roy, Francois, and Tournier, Arnaud
- Abstract
Gamma and X-ray irradiation results are reported on several variants of deep-trench photogate research and development pixels from STMicroelectronics. Dark current performances are compared for electron and hole-collecting pixels (n, p-type) of 2 and
$1~{\mu }$ $2~{\mu }$ $1~{\mu }$ $1~{\mu }$ $2~{\mu }$ - Published
- 2024
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12. Fast cycling culture of the annelid model Platynereis dumerilii
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Legras, Mathieu, primary, Ghisleni, Giulia, additional, Regnard, Léna, additional, Dias, Manon, additional, Soilihi, Rabouant, additional, Celmar, Enzo, additional, and Balavoine, Guillaume, additional
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- 2023
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13. Decompressive craniectomy: indications and results of 24 cases at the neurosurgery clinic of Fann university hospital of Dakar
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El Hadji Cheikh Ndiaye Sy, Yakhya Cisse, Alioune Badara Thiam, Louncény Fatoumata Barry, Maguette Mbaye, Abdoulaye Diop, Mbaye Thioub, Mohameth Faye, Attoumane, Mouhamadou Moustapha Ndongo, Ansaou Aboudou Soilihi, Nantenin Doumbia, Momar Codé Ba, and Seydou Boubacar Badiane
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craniectomy ,decompression ,infarction ,trauma ,Medicine - Abstract
Decompressive craniectomy is a surgical technique considered to be the last step in the management of intracranial hypertension. The objective of our study was to evaluate our results in the management of intracranial hypertension by decompressive craniectomy. This was a retrospective study of 24 cases of decompressive craniectomy performed over a 9-year period (from January 2010 to December 2019) at the Fann Neurosurgery Clinic. The mean age of the patients was 33.82 years, there was a male predominance with a sex ratio of 2.42. The most frequent indication was severe cranioencephalic trauma with 50%. The cerebral CT scan was the key examination and was performed in all our patients. Complications were entirely infectious and were the cause of 73.33% of deaths. Thirty-five percent of the patients had received prior treatment before the decompressive craniectomy. The functional prognosis was good in 44.44% of cases, moderate in 33.33% of cases, 1 (11.11%) patient had a severe disability and 1 (11.11%) patient was in a vegetative state. Mortality was 62.5% of patients in our study series. Despite the lack of sophisticated techniques for diagnosis and monitoring of intracranial hypertension, our results remain acceptable with 37.5% survival. The early completion of this surgery allows us to be more efficient with a significant reduction in morbidity and mortality.
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- 2021
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14. Immunosuppressive Tumor Microenvironment Status and Histological Grading of Endometrial Carcinoma
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Antomarchi, Julie, Ambrosetti, Damien, Cohen, Charlotte, Delotte, Jérôme, Chevallier, Anne, Karimdjee-Soilihi, Babou, Ngo-Mai, Mélanie, Schmid-Alliana, Annie, and Schmid-Antomarchi, Heidy
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- 2019
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15. Spiel, Spaß, ... Vision!: Über Planspiele als Instrumente partizipativer Bibliotheksentwicklung mit besonderem Blick auf dashochdrei – Visionenspielder Kulturstiftung des Bundes als digitalem Prototyp.
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Lotz, Katinka and Soilihi Mzé, Hassan
- Subjects
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LIBRARIES , *LIBRARY design & construction , *SIMULATION games , *DIGITAL technology , *GAMBLING , *POLITICAL science , *PARTICIPANT observation , *TEAMS - Abstract
The cooperative and participatory development of concepts, processes and spaces is becoming increasingly important for libraries. For library teams as well as for administrations it is vital that participatory processes can be initiated in easy ways regarding time and money. The article addresses this question and shows how the use of simulation games can lead to constructive solutions. Furthermore, it presents the "hochdrei – vision game" provided by the German Federal Cultural Foundation – a digital tool to design a simulation game specifically for libraries. [ABSTRACT FROM AUTHOR]
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- 2024
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16. Multi-Poisson process analysis of real-time soft-error rate measurements in bulk 65 nm and 40 nm SRAMs.
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Soilihi Moindjie, Jean-Luc Autran, Daniela Munteanu, Gilles Gasiot, and Philippe Roche
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- 2017
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17. Single-event-transient effects in Junctionless Double-Gate MOSFETs with Dual-Material Gate investigated by 3D simulation.
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Daniela Munteanu, Jean-Luc Autran, and Soilihi Moindjie
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- 2017
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18. Fusion Neutron-Induced Soft Errors During Long Pulse D-D Plasma Discharges in the WEST Tokamak
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Moindjie, Soilihi, Munteanu, Daniela, Autran, Jean-Luc, Dentan, Martin, Moreau, Philippe, Pellissier, Francis-Pierre, Santraine, Benjamin, Bucalossi, Jérôme, Malherbe, Victor, Thery, Thomas, Gasiot, Gilles, Roche, Philippe, Cecchetto, Matteo, Alía, Rubén García, Institut des Matériaux, de Microélectronique et des Nanosciences de Provence (IM2NP), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), CEA Cadarache, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), STMicroelectronics [Crolles] (ST-CROLLES), and CERN [Genève]
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fusion ,static random access memory (SRAM) ,neutron ,WEST ,real-time experiment ,ITER ,CMOS ,single event effects (SEE) ,[SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics ,tokamak ,deuterium-deuterium (D-D) ,deuterium-tritium (D-T) ,single-event upset - Abstract
International audience; We conducted real-time SER measurements on bulk 65 nm SRAMs in the WEST tokamak during long pulse deuterium-deuterium plasma discharges (~60 s), evidencing bursts of SEUs during the most efficient shots and 12% of MCU events.
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- 2023
19. In Vivo Activation of cAMP Signaling Induces Growth Arrest and Differentiation in Acute Promyelocytic Leukemia
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Guillemin, Marie-Claude, Raffoux, Emmanuel, Vitoux, Dominique, Kogan, Scott, Soilihi, Hassane, Lallemand-Breitenbach, Valérie, Zhu, Jun, Janin, Anne, Daniel, Marie-Thérèse, Gourmel, Bernard, Degos, Laurent, Dombret, Hervé, Lanotte, Michel, and de Thé, Hugues
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Autoimmune Disease ,Hematology ,Cancer ,Rare Diseases ,5.1 Pharmaceuticals ,Development of treatments and therapeutic interventions ,Animals ,Arsenic Trioxide ,Arsenicals ,Cell Differentiation ,Cell Division ,Cyclic AMP ,Leukemia ,Promyelocytic ,Acute ,Mice ,Mice ,Transgenic ,Oxides ,Signal Transduction ,Theophylline ,Tretinoin ,Tumor Cells ,Cultured ,theophylline ,arsenic ,retinoic acid ,transgenic mice ,clinical trial ,Medical and Health Sciences ,Immunology - Abstract
Differentiation therapy for acute myeloid leukemia uses transcriptional modulators to reprogram cancer cells. The most relevant clinical example is acute promyelocytic leukemia (APL), which responds dramatically to either retinoic acid (RA) or arsenic trioxide (As(2)O(3)). In many myeloid leukemia cell lines, cyclic adenosine monophosphate (cAMP) triggers growth arrest, cell death, or differentiation, often in synergy with RA. Nevertheless, the toxicity of cAMP derivatives and lack of suitable models has hampered trials designed to assess the in vivo relevance of theses observations. We show that, in an APL cell line, cAMP analogs blocked cell growth and unraveled As(2)O(3)-triggered differentiation. Similarly, in RA-sensitive or RA-resistant mouse models of APL, continuous infusions of 8-chloro-cyclic adenosine monophosphate (8-Cl-cAMP) triggered major growth arrest, greatly enhanced both spontaneous and RA- or As(2)O(3)-induced differentiation and accelerated the restoration of normal hematopoiesis. Theophylline, a well-tolerated phosphodiesterase inhibitor which stabilizes endogenous cAMP, also impaired APL growth and enhanced spontaneous or As(2)O(3)-triggered cell differentiation in vivo. Accordingly, in an APL patient resistant to combined RA-As(2)O(3) therapy, theophylline induced blast clearance and restored normal hematopoiesis. Taken together, these results demonstrate that in vivo activation of cAMP signaling contributes to APL clearance, independently of its RA-sensitivity, thus raising hopes that other myeloid leukemias may benefit from this therapeutic approach.
- Published
- 2002
20. Fast Cycling Culture of the Marine AnnelidPlatynereis dumerilii
- Author
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Legras, Mathieu, primary, Ghisleni, Giulia, additional, Soilihi, Rabouant, additional, Celmar, Enzo, additional, and Balavoine, Guillaume, additional
- Published
- 2023
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21. Les perceptions des populations locales de la forêt du Karthala aux Comores et du projet de sa mise en protection : une approche par les cartes cognitives et des représentations sociales
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Abdou Soilihi, Harold Levrel, Anne-Caroline Prévot, and William’s Daré
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social representations ,Comoros ,biodiversity conservation ,Karthala forest ,cognitive maps ,human development ,Environmental sciences ,GE1-350 - Abstract
The Karthala Forest (Comoros) is currently the subject of a national protection policy, in conjunction with the international community. This policy may be more or less in line with the perceptions and expectations of the residents of the forest. In order to better understand these issues, we have studied the representations of the forest by local populations, upstream of its protection. The following assumptions are made : (i) the degree of knowledge of the components of the forest is different according to the trades, the gender, the age and the ways of frequenting the forest ; (ii) the successful establishment of the protected area of the Karthala forest is based on taking into account the representations and uses of the forest by local residents. Surveys carried out in 2016 and 2017 in eight localities around the Karthala forest and in the capital Moroni have allowed us to capture the representations of the components of the forest and the protected area creation project. The collected data were collected in the form of cognitive maps and freelisting. From these data, we constructed an index of the cognitive complexity of each respondent in relation to the forest, which we compared between socio-professional categories, age categories, gender and place of residence. We also compared the social representations of the forest between the residents and the inhabitants of the capital. Our results show that the cognitive maps approach improves the discussions around environmental public policy for both pragmatic and ethical reasons and allows us to study reconciliation issues between conservation objectives of biodiversity and biodiversity, human development of territories.
- Published
- 2019
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22. Association entre gammapathie monoclonale de signification indéterminée et thrombose veineuse cérébrale : Une observation clinique inhabituelle : Association between monoclonal gammopathy of undetermined significance and cerebral venous thrombosis: An unusual case report
- Author
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Ernestho-ghoud, Indretsy Mahavivola, Soilihi, Moustafa Abdou, Rajaonarison, Ny Ony Narindra Lova Hasina, Raveloson, Nasolotsiry Enintsoa, Ahmad, Ahmad, and Vololontiana, Hanta Marie Danielle
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Cerebral venous thrombosis ,Monoclonal gammopathy of undetermined significance ,Morbidity association ,Madagascar - Abstract
Cerebral venous thrombosis associated to the monoclonal gammopathy of undetermined significance has been rarely reported. In this paper, we discuss the case of 68-year-old man who presented repeated comitial. A cerebral Magnetic Resonance Imaging (MRI) showed cerebral venous thrombosis. The only biological abnormality highlighted was high level of monoclonal gammaglobulin. The coexistence of cerebral venous thrombosis and the monoclonal gammopathy of undetermined significance were fortuitous without causality links. French Abstract La thrombose veineuse cérébrale est rarement associée à une gammapathie monoclonale de signification indéterminée. Dans cet article, nous discutons le cas d’un homme de 68 ans, qui présentait une crise convulsive récidivante. L’IRM cérébrale montrait une thrombose du sinus sagittal supérieur. La seule anomalie biologique mise en évidence était l’augmentation monoclonale des gammaglobulines. La coexistence entre la thrombose veineuse cérébrale et la gammapathie monoclonale de signification indéterminée était fortuite sans lien de causalité. Mots-clés : Thrombose veineuse cérébrale, Gammapathie monoclonale de signification indéterminée, Association Morbide, Madagascar
- Published
- 2023
23. L’importance du lien ville-hôpital dans l’éducation thérapeutique du patient lupique
- Author
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Soilihi, Chaïma, Aix-Marseille Université - Faculté de pharmacie (AMU PHARM), Aix Marseille Université (AMU), and Nathalie Bardin
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Médecine interne ,FAI2R ,Lupus systémique ,[SDV]Life Sciences [q-bio] ,Pharmacie de ville ,[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences ,Éducation thérapeutique - Abstract
Le Lupus systémique est une pathologie auto-immune rare, qui touche près de 30 000 personnes en France.Le diagnostic de cette maladie chronique est difficile à réaliser, car elle se manifeste par des signes cliniques et biologiques qui varient énormément d’un patient à l’autre.C’est la raison pour laquelle les patients lupiques sont pour la plupart d’entre eux, en situation d’errance diagnostique et thérapeutique.Cela constitue à la fois une souffrance pour eux-mêmes, mais également pour leurs proches.Depuis une dizaine d’années, des programmes d’éducation thérapeutique, ayant pour vocation d’accompagner ces patients dans la gestion de leurs pathologies ont vu le jour partout en France.Ces programmes prennent place en milieu hospitalier, généralement au sein du service de médecine interne, qui est la spécialité médicale de référence dans la prise en charge du Lupus. Ils mobilisent des équipes multidisciplinaires.Cette notion de multidisciplinarité est primordiale. En effet, elle permet, grâce à la réunion de diverses compétences, de prendre en charge le patient dans sa globalité, et ainsi, de mieux répondre à ses besoins.Le pharmacien de ville, en tant que professionnel de santé expert du médicament, a également un rôle à jouer dans l’éducation thérapeutique des patients atteints de Lupus. C’est pourquoi un renforcement du lien ville-hôpital s’avère indispensable afin de favoriser la continuité des soins.Or, à l’heure actuelle, il existe un manque de communication entre les professionnels de santé exerçant en ville et à l’hôpital. Cela constitue un frein dans la coordination des soins, dommageable pour les patients.L’optimisation du lien ville-hôpital représente un enjeu majeur en termes de santé publique, puisqu’elle permettrait d’améliorer le parcours de soins de ces patients, atteints d’une pathologie chronique, très invalidante.
- Published
- 2023
24. Fast Cycling Culture of the Marine AnnelidPlatynereis dumerilii
- Author
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Mathieu Legras, Giulia Ghisleni, Rabouant Soilihi, Enzo Celmar, and Guillaume Balavoine
- Abstract
Platynereis dumerilii, a marine annelid, is a model animal that has gained popularity in various fields such as developmental biology, biological rhythms, nervous system organization and physiology, behaviour, reproductive biology, and epigenetic regulation. The transparency ofP. dumeriliitissues at all developmental stages makes it easy to perform live microscopic imaging of all cell types. In addition, the slow-evolving genome ofP. dumeriliiand its phylogenetic position as a representative of the vast branch of Lophotrochozoans add to its evolutionary significance. AlthoughP. dumeriliiis amenable to transgenesis and CRISPR-Cas9 knockouts, its relatively long and indefinite life cycle, as well as its semelparous reproduction have been hindrances to its adoption as a reverse genetics model. To overcome this limitation, an adapted culturing method has been developed allowing much faster life cycling, with median reproductive age at 15 weeks instead of 6-8 months using the traditional protocol. A low worm density in boxes and a strictly controlled feeding regime are important factors for the rapid growth and health of the worms. Moreover, a genetic selection for fast-reproducing individuals has been applied to isolate a “Fast Forward” strain that can be used for egg microinjection. This culture method has several advantages, such as being much more compact, not requiring air bubbling or an artificial moonlight regime for synchronized sexual maturation, and necessitating only limited water change. A full protocol for worm care and handling is provided.
- Published
- 2023
- Full Text
- View/download PDF
25. Développement d’un serveur LSP pour Typer
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Soilihi, Ben Soilihi Boina and Monnier, Stefan
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LSP server ,OCaml ,JSON-RPC ,serveur LSP - Abstract
Programmer en un langage de programmation peut être une tâche ardue. Même les plus chevronnés ne sont pas à l’abri de commettre des erreurs. Il est donc important pour les programmeurs d’avoir des aides pour écrire leur code plus efficacement et plus rapidement. Typer est un jeune langage de programmation en développement. Actuellement, le langage a beaucoup de limitations d’aides pour les programmeurs. En effet, on ne peut coder en Typer que dans un terminal, dans un fichier et compiler le fichier ou dans des environnements primitifs. On apporte une solution à ce problème en offrant, dans ce travail, un serveur LSP au langage qui va offrir des fonctionnalités comme la complétion de code, le surlignement des erreurs, etc, pour permettre aux programmeurs Typer de coder plus facilement et de pouvoir le faire dans leur éditeur/IDE préféré., Programming in a programming language can be a daunting task. Even the most seasoned are not immune to make mistakes. It is therefore important for programmers to have helpers to write their code more efficiently and quickly. Typer is a young programming language in development. Currently, the language has a lot of helper limitations for programmers. Indeed, we can code in Typer only in a terminal, in a file and compile the file or in primitive environments. We solve this problem by offering in this work, an LSP server to the language which will offer features such as code completion, error highlighting...etc, to allow Typer programmers to code more easily and efficiently, and also, to be able to do it in their favorite editor/IDE.
- Published
- 2022
26. Natural radiation events in CCD imagers at ground level.
- Author
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Tarek Saad Saoud, Soilihi Moindjie, Daniela Munteanu, and Jean-Luc Autran
- Published
- 2016
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27. Association between Giant Cell Arteritis and Hyperthyroidism: An Unusual Case Report from Madagascar
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Ernestho-Ghoud Indretsy Mahavivola, Soilihi Moustafa Abdou, Rakotonaivo Andoniaina, Rajaonarison Ny Ony Narindra Lova Hasina, Raveloson Nasolotsiry Enintsoa, Ahma, Ahmad, and Vololontiana Hanta Marie Danielle
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Giant Cell Arteritis, Hyperthyroidism, Morbidity association, Madagascar - Abstract
Giant Cell Arteritis (GCA), formerly known as Horton Disease associated to the hyperthyroidism has been rarely reported. In this paper, we aimed to discuss a case that illustrating such association. The case consisted of 70-year-old woman who complained a sudden diffuse vision loss in the left eye since a week. Laboratory test showed hyperthyroidism. The cerebral CT-scan without contrast media revealed left ischemic stroke complicated by left choroidopathy. GCA and hyperthyroidism are considered independent and their coexistence was attributed to independent processes related to ischemic stroke., {"references":["1) Hunder GG, Bloch DA, Michel BA, Stevens MB, Arend WP , Calabrese LH, et al. The American College of Rheumatology 1990 criteria for the classification of giant cell arteritis. Arthritis Rheum 1990;33:1122-1128. 2) Biousse V, Newman NJ. Ischemic Optic Neuropathies. N Engl J Med 2015 ;372 (24) :1428-1436. 3) Liozon E, Robert PY. Manifestations ophtalmologiques de la malade de Horton. Rev Med Int 2013 ; 34 : 421-430. 4) Ouaggag B, Hajji I, Rajaa B, Baha AT, Moutaouakil A. Décollement rétinien exsudatif révélateur d'une artérite a cellules géantes. A propos d'un cas. Bull Soc Belge ophtalmol 2011 ; 317 : 25-28. 5) Solans-Laqué R, Bosch-Gil JA, Molina-Catenario CA, Ortega-Aznar A, Alvare Sabin J, Vilardell-Tarres. Stroke and multi-infarct dementia as presenting symptoms of giant cell arteritis: report of 7 cases and review of the literature. Medicine 2008 ; 87(6) : 335‑344. 6) Wiszniewska M, Devuyst G, Bogousslavsky J. Giant cell arteritis as a cause of first-ever stroke. Cerebrovasc Dis 2007 ; 24 : 226-230. 7) Liozon E, Loustaud-Ratti V, Soria P, Bezanahary H, Fauchais AL, Nadalon S, et al. Disease associations in 250 patients with temporal (giant cell) arteritis. Presse Med 2004 ; 33 : 1304-1312. 8) Squizzato A, Gerdes VEA, Brandjes DPM, Büller HR, Stam J. Thyroide Disease And Cerebrovascular Disease. Stroke 2005 ; 36 : 2302-2310. 9) Duhaut P, Bornet H, Pinede L, Demolombe-Rague S, Loire R, Seydoux D, et al. Giant cell arteritis and thyroid dysfunction: multicenter case-control study. The Groupe de Recherche sur l'Arteritea Cellules Geantes. BMJ 1999 ; 318 : 434-435. 10) Sheu JJ, Kang JH, Lin HC, Lin HC. HyperthyrodIsm and risk of ischemic stroke in young adults : A 5 year follow-up study. Stroke 2010; 41: 961-966."]}
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- 2023
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28. ASTEP (2005-2015): Ten years of soft error and atmospheric radiation characterization on the Plateau de Bure.
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Jean-Luc Autran, Daniela Munteanu, Soilihi Moindjie, Tarek Saad Saoud, S. Sauze, Gilles Gasiot, and Philippe Roche
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- 2015
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29. Anémie ferriprive compliquée par une thrombose porte au cours de la pancréatite chronique : une observation clinique inhabituelle au Madagascar
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Indretsy Mahavivola Ernestho-ghoud, Moustafa Abdou Soilihi, Ny Ony Narindra, Lova Hasina Rajaonarison, and Ahmad Ahmad
- Subjects
Thrombose porte ,Anémie ferriprive ,pancréatite chronique ,Madagascar - Abstract
La thrombose porte est rarement associée à l’anémie ferriprive au cours de la pancréatite chronique. Dans cet article, nous discutons d’une possible interaction entre la thrombose porte et l’anémie ferriprive survenue chez un homme de 56 ans porteur d’une pancréatite chronique, admis pour une douleur abdominale aiguë. Le scanner abdominal avait visualisé une thrombose porte associée à une pancréatite chronique. La seule anomalie biologique mise en évidence était une l’anémie ferriprive. English title: Iron deficiency anemia complicated by portal thrombosis in chronic pancreatitis: an unusual case report from Madagascar Portal thrombosis associated with iron deficiency anemia in chronic pancreatitis has been rarely reported. In this paper, we discuss possible interactions between portal thrombosis and iron deficiency anemia occurring in a 56 years-old man having chronic pancreatitis, who presented acute abdominal pain at admission. The abdominal CTscan showed portal thrombosis and chronic pancreatitis. The only biological abnormality highlighted was iron deficiency anemia. Keywords: Portal thrombosis, Iron deficiency anemia, Chronic pancreatitis, Madagascar
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- 2022
30. The Impact of Resampling and Denoising Deep Learning Algorithms on Radiomics in Brain Metastases MRI
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Ilyass Moummad, Cyril Jaudet, Alexis Lechervy, Samuel Valable, Charlotte Raboutet, Zamila Soilihi, Juliette Thariat, Nadia Falzone, Joëlle Lacroix, Alain Batalla, Aurélien Corroyer-Dulmont, Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN), Equipe Image - Laboratoire GREYC - UMR6072, Groupe de Recherche en Informatique, Image et Instrumentation de Caen (GREYC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Service de Radiologie [CLCC Baclesse], Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN), and GenesisCare
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Cancer Research ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,deep learning ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Article ,Oncology ,radiomics ,MRI ,resampling ,denoising ,[INFO.INFO-IM]Computer Science [cs]/Medical Imaging ,RC254-282 - Abstract
Simple Summary Due to the central role of magnetic resonance Imaging (MRI) in the management of patients with cancer, waiting lists exceed clinically relevant delays. For this reason, many research groups and MRI manufacturers develop algorithms as resampling and denoising models to allow faster acquisition time without deterioration in image quality. Whereas these algorithms are available in all new MRI, it is not clear how they will impact image features as well as the validity of statistical model of radiomics which use deep images characteristics to predict treatment outcome. The aim of this study was to develop resampling and denoising deep learning (DL) models and evaluate their impact on radiomics from post-Gd-T1w-MRI brain images with brain metastases. We show that resampling and denoising DL models reconstruct low resolution and noised MRI images acquired quickly into high quality images. While fast acquisition loses most of the radiomic-features and invalidates predictive radiomic models, DL models restore these parameters. Abstract Background: Magnetic resonance imaging (MRI) is predominant in the therapeutic management of cancer patients, unfortunately, patients have to wait a long time to get an appointment for examination. Therefore, new MRI devices include deep-learning (DL) solutions to save acquisition time. However, the impact of these algorithms on intensity and texture parameters has been poorly studied. The aim of this study was to evaluate the impact of resampling and denoising DL models on radiomics. Methods: Resampling and denoising DL model was developed on 14,243 T1 brain images from 1.5T-MRI. Radiomics were extracted from 40 brain metastases from 11 patients (2049 images). A total of 104 texture features of DL images were compared to original images with paired t-test, Pearson correlation and concordance-correlation-coefficient (CCC). Results: When two times shorter image acquisition shows strong disparities with the originals concerning the radiomics, with significant differences and loss of correlation of 79.81% and 48.08%, respectively. Interestingly, DL models restore textures with 46.15% of unstable parameters and 25.96% of low CCC and without difference for the first-order intensity parameters. Conclusions: Resampling and denoising DL models reconstruct low resolution and noised MRI images acquired quickly into high quality images. While fast MRI acquisition loses most of the radiomic features, DL models restore these parameters.
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- 2022
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31. Preliminary Study of Electronics Reliability in ITER Neutron Environment
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Dentan, Martin, Borgese, Gianluca, Autran, Jean-Luc, Munteanu, Daniela, Moindjie, Soilihi, Moreau, Philippe, Pellissier, Francis-Pierre, Santraine, Benjamin, Bucalossi, Jérôme, Roche, Philippe, Malherbe, Victor, Cecchetto, Matteo, Rubén, García Alía, ITER organization (ITER), Institut des Matériaux, de Microélectronique et des Nanosciences de Provence (IM2NP), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), CEA Cadarache, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), STMicroelectronics [Crolles] (ST-CROLLES), and CERN [Genève]
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fusion ,static random access memory (SRAM) ,neutron ,WEST ,real-time experiment ,ITER ,CMOS ,single event effects (SEE) ,[SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics ,tokamak ,deuterium-deuterium (D-D) ,deuterium-tritium (D-T) ,single-event upset - Abstract
International audience; We validated a method for predicting the Soft Error Rate (SER) in the WEST tokamak operated with deuterium plasmas, and we applied it to predict the SER in the ITER tokamak operated with deuterium-tritium plasmas.
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- 2022
32. Anémie ferriprive compliquée par une thrombose porte au cours de la pancréatite chronique : une observation clinique inhabituelle au Madagascar
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Ernestho-ghoud, Indretsy Mahavivola, primary, Soilihi, Moustafa Abdou, additional, Narindra, Ny Ony, additional, Rajaonarison, Lova Hasina, additional, and Ahmad, Ahmad, additional
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- 2022
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33. Preliminary study of electronics reliability in ITER neutron environment
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Dentan, Martin, primary, Borgese, Gianluca, additional, Autran, Jean-Luc, additional, Munteanu, Daniela, additional, Moindjie, Soilihi, additional, Bucalossi, Jérôme, additional, Moreau, Philippe, additional, Pellissier, Francis-Pierre, additional, Santraine, Benjamin, additional, Roche, Philippe, additional, Malherbe, Victor, additional, Alía, Rubén García, additional, and Cecchetto, Matteo, additional
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- 2022
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34. Effect of flower development stages on the dynamics of volatile compounds in Ylang-Ylang (Cananga odorata) essential oil
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Chakira, Abacar Soilihi, Garcia, Cyrielle, Soria, Christian, Minier, Jérôme, Chillet, Marc, Chakira, Abacar Soilihi, Garcia, Cyrielle, Soria, Christian, Minier, Jérôme, and Chillet, Marc
- Abstract
Several abiotic factors influence the chemical composition of essential oils. Understanding these factors is an important step in developing quality products that meet market demands. This research work aims to study the chemical composition of the essential oils of ylang-ylang (Cananga odorata, forma genuina) according to the maturity of flowers. The volatile compounds of ylang-ylang flowers from Reunion Island were extracted by hydrodistillation and the samples were analyzed by high resolution gas chromatography coupled with mass spectrometry (GC-MS) allowing for the identification of 70 volatile compounds. The chemical composition of the essential oils extracted from the flowers at 5 different stages of development varies both qualitatively and quantitatively. The volatile compounds observed belong to 4 chemical groups which are esters, alcohols, terpenes, and ether-oxides. The synthesis of light oxygenated compounds is largely the predominant chemical subgroup in all stages of development. Their relative content is considerably increased during flower ripening with a peak concentration in stage 4 (SD4). The highest concentrations of non-terpene esters and heavy oxygenated compounds are found in stages 1 (SD1) and (SD5), respectively, while no chemical subgroup is dominant in the intermediate stages 2 (SD2) and (SD3). The dynamics of volatile compounds have also been studied. This study established that the stage of development of ylang-ylang flowers significantly influences the dynamics of volatile compounds in the extracted essential oils. Total oxygenated compounds that are highly odoriferous in essential oils increase progressively and significantly with flower maturity, unlike hydrocarbon terpenes, which are less valuable in terms of their contribution to the fragrance and following opposite kinetics; suggesting that odoriferous properties increase with the development of the flower, with a higher intensity at SD4.
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- 2022
35. Charge Collection Physical Modeling for Soft Error Rate Computational Simulation in Digital Circuits
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Autran, Jean-Luc, primary, Munteanu, Daniela, additional, Moindjie, Soilihi, additional, Saoud, Tarek Saad, additional, Malherbe, Victor, additional, Gasiot, Gilles, additional, Clerc, Sylvain, additional, and Roche, Philippe, additional
- Published
- 2016
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36. Nanoparticles on p-type Silicon as Catalysts for the Photoelectrochemical CO2 Conversion
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Torralba, E., Chaliyawala, Harsh, Soilihi, Labibe, Muller-Bouvet, D., Cachet-Vivier, C., Marty, Frédéric, Rezgui, Abir, Bourouina, Tarik, Le Gall, Sylvain, Bastide, Stéphane, Torralba, Encarnacion, Institut de Chimie et des Matériaux Paris-Est (ICMPE), and Institut de Chimie du CNRS (INC)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)
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[CHIM.MATE] Chemical Sciences/Material chemistry ,[CHIM] Chemical Sciences ,[CHIM]Chemical Sciences ,[CHIM.MATE]Chemical Sciences/Material chemistry - Abstract
International audience
- Published
- 2022
37. Etude de l'influence du stade de développement des fleurs d'ylang-ylang sur les dynamiques des composés volatils dans les huiles essentielles
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Chakira, Abacar Soilihi, Garcia, Cyrielle, Soria, Christian, Minier, Jérôme, and Chillet, Marc
- Abstract
Plusieurs facteurs abiotiques influencent la composition chimique des huiles essentielles (Dumortier, 2006), et la compréhension de ces facteurs est une étape importante pour l'élaboration de produits de qualité répondants aux exigences du marché (Figueiredo et al., 2008). Ce travail de recherche vise à étudier la composition chimique des huiles essentielles d'ylang-ylang (cananga odorata) en fonction de la maturité de fleurs. Les composés volatils des fleurs d'ylang-ylang cueillies en 3 répliquât entre décembre 2019 et février 2020, ont été obtenus en laboratoire par hydrodistillation type Clevenger. Les échantillons ont été analysés par chromatographie en phase gazeuse à haute résolution, couplée à une spectrométrie de masse (MS). Cette méthode nous a permis d'identifier la présence de 70 composés volatils dans les huiles essentielles d'ylang-ylang à La Réunion. La composition chimique des huiles extraites de fleurs à 5 stades de développement différents varie à la fois qualitativement et quantitativement. La dynamique de ces composés est observée dans 4 groupes chimiques que sont les esters, les alcools, les terpènes et les éther-oxydes. La synthèse des composés oxygénés légers, le sous-groupe chimique largement majoritaire dans tous les stades de développement, a considérablement augmenté pendant la maturation des fleurs avec un pic de concentration au stade 4. Les concentrations les plus importantes d'esters non terpéniques et de composés oxygénés lourds sont retrouvées respectivement au stade 5 et au stade 1, alors qu'aucun sous-groupe chimique n'est dominant aux stades intermédiaires 2 et 3. La dynamique de composés chimiques reste identique ; à l'exemple de l'acétate de benzyle dont la concentration augmente progressivement avec la maturité des fleurs, ou l'acétate de E-cinnamyle absent au début de la floraison (stade 1) mais suivant la même cinétique du stade 2 au stade 5. Cette étude établie que le stade de développement des fleurs d'ylang-ylang influence significativement la dynamique des composés volatils des huiles essentielles extraites. Une étude approfondie d'olfactométrie sur les huiles essentielles d'ylang-ylang en relation avec le stade de développement, nous permettra de mettre en évidence les composés prépondérants pour une huile essentielle de bonne qualité.
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- 2022
38. Activation of a promyelocytic leukemia-tumor protein 53 axis underlies acute promyelocytic leukemia cure
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Ablain, Julien, Rice, Kim, Soilihi, Hassane, Reynies, Aurelien de, Minucci, Saverio, and The, Hugues de
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Oncology, Experimental ,Tumor proteins -- Identification and classification ,Cancer -- Research ,Biological sciences ,Health - Abstract
Acute promyelocytic leukemia (APL) is driven by the promyelocytic leukemia (PML)-retinoic acid receptor-a (PML-RARA) fusion protein, which interferes with nuclear receptor signaling and PML nuclear body (NB) assembly. APL is [...]
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- 2014
39. PML/RARA Oxidation and Arsenic Binding Initiate the Antileukemia Response of As 2O 3
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Jeanne, Marion, Lallemand-Breitenbach, Valérie, Ferhi, Omar, Koken, Marcel, Le Bras, Morgane, Duffort, Stéphanie, Peres, Laurent, Berthier, Caroline, Soilihi, Hassane, Raught, Brian, and de Thé, Hugues
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- 2010
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40. The Impact of Resampling and Denoising Deep Learning Algorithms on Radiomics in Brain Metastases MRI
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Moummad, Ilyass, primary, Jaudet, Cyril, additional, Lechervy, Alexis, additional, Valable, Samuel, additional, Raboutet, Charlotte, additional, Soilihi, Zamila, additional, Thariat, Juliette, additional, Falzone, Nadia, additional, Lacroix, Joëlle, additional, Batalla, Alain, additional, and Corroyer-Dulmont, Aurélien, additional
- Published
- 2021
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41. Priorité mixité. Oui, mais comment ?
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Soilihi, Charifa, primary
- Published
- 2021
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42. Projektarbeit ist keine Beschäftigungstherapie!
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Hassan Soilihi Mzé
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General Medicine - Abstract
Zusammenfassung Projektarbeit gewinnt in Öffentlichen Bibliotheken an Bedeutung. Dabei ist sie nicht Selbstzweck, sondern grundlegend für institutionelle Veränderungsprozesse. Projektarbeit schafft Testräume für neue Verfahrensweisen, Konzepte und Formate. In vielen kleineren und mittleren Bibliotheken läuft sie dennoch häufig nur als on-top-Leistung und wird im Zweifelsfall dem Tagesbetrieb untergeordnet. Umso wichtiger ist, dass Projektarbeit durch entsprechende Förderung ermöglicht wird. Der Beitrag stellt anhand eines knappen Überblicks der deutschen Projektförderlandschaft sowie des Bundesprogramms hochdrei - Stadtbibliotheken verändern dar, weshalb es sinnvoll ist, bibliothekarische Projektarbeit zu unterstützen - und inwiefern Förderung als Beitrag zur Bibliotheksentwicklung verstanden werden kann.
- Published
- 2019
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43. KOMOR ADALARINDA DIŞ TİCARET VE EKONOMİK BÜYÜME İLİŞKİSİ
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Youssouf Soilihi Ali
- Published
- 2019
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44. Intégration hétérogène pour la mise en œuvre de capteurs imprimés sur support souple connectés
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Vauche, Rémy, Benevent, Evangéline, Moindje, Soilihi, Walder, Jean-Pierre, Blalta, Yacine, Bouchnak, Katrinada, Khelladi, Hajar, Nuon, Sochanshakhéna, Institut des Matériaux, de Microélectronique et des Nanosciences de Provence (IM2NP), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Polytech Marseille (AMU POLYTECH), Aix Marseille Université (AMU), and IUT d'Aix-Marseille
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intégration hétérogène ,Bluetooth Low Energy ,[INFO]Computer Science [cs] ,[INFO.EIAH]Computer Science [cs]/Technology for Human Learning ,capteur connecté ,capteur imprimé ,capteur sur support souple - Abstract
International audience; Cet article présente les résultats obtenus lors de la première édition d’un projet étudiant réalisé par des étu-diants en 3ième année du cycle ingénieur du département Micro-électronique et Télécommunications de Polytech’ Mar-seille au cours du premier semestre de l’année scolaire 2020-2021. Ce projet a été proposé dans le cadre l’action transverseIntégration Hétérogène du laboratoire IM2NP qui vise à développer à terme avec le support de la plate-forme IO LAB del’IM2NP, une plate-forme de démonstration connectée et alimentée sur batterie de capteurs imprimés sur support souple,l’objectif final étant de mettre en avant le savoir-faire qui a été acquis par la plate-forme SPRINT de l’IM2NP en matièrede conception et de fabrication de capteurs sur support souple. Le standard de communications sans-fil retenu pour cedémonstrateur est le Bluetooth Low Energy (BLE) afin de permettre l’affichage des données issues d’un capteur sur undispositif mobile compatible telles qu’une tablette ou un smartphone. Il sera ici mis en œuvre à l’aide du moduleBlueNRG-M2SP de chez STMicroelectronics qui, en plus d’avoir un faible encombrement, dispose d’un Cortex M0,d’une mémoire Flash programmable ainsi qu’un Convertisseur Analogique-Numérique (CAN), lui permettant ainsi d’êtreutilisé seul, sans qu’aucun composant additionnel ne soit nécessaire. Néanmoins, devant les difficultés rencontrées parles étudiants pour développer en autonomie une application personnalisée dédiée à ce module, il a été programmé avecun microcode fourni par STMicroelectronics et contrôlé en SPI par un autre microcontrôleur possédant un CAN pourarriver au résultat attendu
- Published
- 2021
45. Evaluation de l'impact du schéma de vie sur la qualité de la fleur et de l'huile essentielle d'ylang-ylang des Comores
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Chakira, Abacar Soilihi, Soria, Christian, Garcia, Cyrielle, and Chillet, Marc
- Abstract
La majeure partie de la production mondiale d'huile essentielle d'ylang-ylang Cananga odorata est concentrée dans une zone restreinte du sud-ouest de l'Océan Indien dont l'Union des Comores est le premier producteur (Benini, 2013). La filière ylang-ylang occupe une place prépondérante dans l'économie comorienne. Avec la vanille et le girofle, elles sont les trois principales cultures de rente de l'archipel et représentent environ 90% des exportations (BCC, 2016). Cette étude diagnostique vise à identifier les dangers d'altération et les points critiques pour la gestion de la qualité de la fleur et des huiles essentielles d'ylang-ylang relativement à chacune des opérations unitaires composant le schéma de vie pré/post-récolte. L'enquête menée entre février et juillet 2019 auprès des acteurs de la filière, a été réalisée à l'aide de questionnaires à réponses ouvertes inscrits dans un guide d'entretien semi-directif pré-élaboré. La méthode de 5Mou diagramme d'Ishikawa a été adopté pour rechercher et identifier les impacts négatifs de chaque opération sur la qualité. L'analyse de diagrammes des opérations unitaires et du schéma de vie complet a fait apparaître des opérations critiques et optionnelles pour la gestion de la qualité. D'autres facteurs abiotiques impactant fortement de façon négative cette qualité ont été également identifiés. Une étude approfondie déterminant le degré d'impact de ces opérations critiques et optionnelles s'est avéré nécessaire et primordiale. Ainsi, quelques axes de recherche ont été soulevés par cette étude prospective, et ont été initiés ; parmi eux, le dynamisme des métabolites de la fleur d'ylang-ylang à différents stades de développement, aux heures de cueillette, et au temps de stockage avant distillation.
- Published
- 2021
46. Valproic acid induces differentiation and transient tumor regression, but spares leukemia-initiating activity in mouse models of APL
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Leiva, M, Moretti, S, Soilihi, H, Pallavicini, I, Peres, L, Mercurio, C, Dal Zuffo, R, Minucci, S, and de Thé, H
- Published
- 2012
- Full Text
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47. The role of clips in preventing migration of fully covered metallic esophageal stents: a pilot comparative study
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Vanbiervliet, Geoffroy, Filippi, Jérôme, Karimdjee, Babou Soilihi, Venissac, Nicolas, Iannelli, Antonio, Rahili, Amine, Benizri, Emmanuel, Pop, Daniel, Staccini, Pascal, Tran, Albert, Schneider, Stéphane, Mouroux, Jérôme, Gugenheim, Jean, Benchimol, Daniel, and Hébuterne, Xavier
- Published
- 2012
- Full Text
- View/download PDF
48. Origin of high total dose sensitivity on the OP400 bipolar operational amplifier
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Bernard, Muriel F., Dusseau, Laurent, Moindjie, Soilihi, and Bouchet, Thierry
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Integrated circuits -- Analysis ,Semiconductor chips -- Analysis ,Bipolar transistors -- Analysis ,Standard IC ,Business ,Electronics ,Electronics and electrical industries - Abstract
The OP400 bipolar operational amplifier is widely used in space applications due to its performance and its low power consumption. However experimental results exhibit high total dose sensitivity. Circuit analysis is used to understand mechanisms at play and to find appropriate worst case test methods and solutions for design application. Index Terms--Bipolar transistor, integrated circuits (ICs), slew-rate, total dose.
- Published
- 2008
49. Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation
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Nasr, Rihab, Guillemin, Marie-Claude, Ferhi, Omar, Soilihi, Hassan, Peres, Laurent, Berthier, Caroline, Rousselot, Philippe, Robledo-Sarmiento, Macarena, Lallemand-Breitenbach, Valerie, Gourmel, Bernard, Vitoux, Dominique, Rochette-Egly, Cecile, Pandolfi, Pier Paolo, Zhu, Jun, and de The, Hugues
- Subjects
Oncogenes -- Health aspects ,Oncogenes -- Research ,Tretinoin -- Health aspects - Abstract
Retinoic acid and arsenic trioxide target the protein stability and transcriptional repression activity of the fusion oncoprotein PML-RARA, resulting in regression of acute promyelocytic leukemia (APL). Phenotypically, retinoic acid induces differentiation of APL cells. Here we show that retinoic acid also triggers growth arrest of leukemia-initiating cells (LICs) ex vivo and their clearance in PML-RARA mouse APL in vivo. Retinoic acid treatment of mouse APLs expressing the fusion protein PLZF-RARA triggers full differentiation, but not LIC loss or disease remission, establishing that differentiation and LIC loss can be uncoupled. Although retinoic acid and arsenic synergize to clear LICs through cooperative PML-RARA degradation, this combination does not enhance differentiation. A cyclic AMP (CAMP)-dependent phosphorylation site in PML-RARA is crucial for retinoic acid-induced PML-RARA degradation and LIC clearance. Moreover, activation of cAMP signaling enhances LIC loss by retinoic acid, identifying cAMP as another potential APL therapy. Thus, whereas transcriptional activation of PML-RARA is likely to control differentiation, its catabolism triggers LIC eradication and long-term remission of mouse APL. Therapy-triggered degradation of oncoproteins could be a general strategy to eradicate cancer stem cells., APL is characterized by a specific t(15;17) translocation that encodes a fusion of the promyelocytic leukemia (PML) and retinoic acid receptor-[alpha] (RARA) proteins. PML-RARA is a transcriptional repressor with both [...]
- Published
- 2008
50. Existe-t-il un lien entre localisation et réponse thérapeutique des métastases cérébrales ?
- Author
-
Soilihi, Z., Jaudet, C., Batalla, A., Thariat, J., Corroyer-Dulmont, A., Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN), Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), and Brunaud, Carole
- Subjects
[SDV] Life Sciences [q-bio] ,[SDV]Life Sciences [q-bio] - Abstract
CERVOXY; National audience
- Published
- 2020
Catalog
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