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Purpose of the study. Analysis of the molecular and biological features of synovial sarcoma (SS), as well as its tissue microenvironment according to modern research.Materials and methods. The analysis of literature sources was carried out mainly in the databases «Istina» and «PubMed», publication date limitations were set up from 2019 to 2023. The following keywords for the search were used: «synovial sarcoma», «chromosomal aberrations», «carcinogenesis».Results. Understanding the molecular mechanisms and signaling pathways in the development of SS may lead to the development of more effective treatment strategies. The importance of further research in this area cannot be overestimated, as it can provide new data to create innovative approaches aimed at improving the prognosis and quality of patients’ lives. Chromosomal aberrations, such as translocations and deletions, can lead to the activation of oncogenes or inactivation of tumor suppressor genes, which, in turn, contributes to the malignant transformation of cells. Epigenetic changes such as DNA methylation and histone modifications also play an important role in the regulation of genes related to the growth and survival of tumor cells. Disorders in these processes can contribute to tumor progression by altering the expression of key genes involved in the cell cycle, apoptosis, and angiogenesis. Additionally, part of the review is devoted to the interaction of atypical cells against the background of chromosomal aberrations and epigenetic changes with the SS microenvironment. These factors may have a certain effect on the growth and progression of synovial sarcoma. In addition, the review discusses various aspects of the diagnosis of SS using modern molecular genetic methods. Examples of successful use of targeted therapy and immunotherapy are given, which open up new prospects in the treatment of this disease.Conclusion. The importance of molecular biological and molecular genetic analysis of SS for the possibility of an interdisciplinary approach in the study and treatment of this aggressive malignant tumor has been revealed.

The current paper has presented the results of an analysis of promising winter barley lines and varieties developed by the FSBSI “Agricultural Research Center “Donskoy” to select valuable genotypes for breeding programs. The basis for the analysis of the studied samples was the methodology for a comprehensive estimation of breeding results, developed by the researchers from the FSBSI “ARC “Donskoy” and the FSBEI HE DSTU. The study was conducted at the FSBSI “Agricultural Research Center “Donskoy” in 2021–2023. Sowing was carried out in 6-fold repetition, the local variety ‘Timofey’ was taken as a standard. There have been analyzed 14 economically valuable traits, identified as the most significant according to the methodology for a comprehensive estimation of barley breeding identifiers. The purpose of the current study was to conduct a comparative estimation of breeding winter barley lines according to the most significant traits for the selection of promising samples. The studied varieties and lines were ranked according to a set of traits and properties into three groups, such as promising, not very promising, and unpromising. The promising group included the new varieties ‘Step’ and ‘Alabai’, sent to the State study in 2, 5, 6 and 8 regions of the Russian Federation in 2022 and 2023, respectively, as well as the lines ‘Parallelum 2015’, ‘Parallelum 2136’, ‘Pallidum 2100’ and ‘Bezosty 2074’, characterized by high indicators of a complex of basic economically valuable characteristics and properties. These samples are being planned to send to the State Commission of the Russian Federation for Testing and Protection of Breeding Achievements.

The purpose of the current work was to identify photosynthetic parameters that are predictors of barley drought tolerance, determined at early stages of development, and to verify the results obtained in field conditions. The study was carried out with the barley varieties ‘Leon’, ‘Ratnik’ and ‘Foks 1’, used in mutation breeding to develop drought-resistant genotypes. Drought was modeled by stopping irrigation. Plant resistance was estimated by changes in chlorophyll fluorescence (Fv /Fm, Y(II), NPQ) and morphometric parameters (leaf length, wet and dry weight) compared to the control group with normal water supply. Under stress-free conditions, the variety ‘Leon’ demonstrated a statistically significantly lower efficiency of photosynthesis in terms of Y(II) and Fv /Fm (0.535 ± 0.005 and 0.776 ± 0.004, respectively) in comparison with other varieties (0.577 ± 0.005 and 0.788 ± 0.001 for the variety ‘Foks 1’; 0.574 ± 0.004 and 0.787 ± 0.001 for the variety ‘Ratnik’). When modeling drought, there has been established a decrease in all morphometric indicators for all varieties relative to the control, with the highest degree of inhibition for the variety ‘Ratnik’ (70.16 ± 3.88 %; 8.09 ± 0.73 %; 68.50 ± 4.42 % for leaf length, wet and dry weight, respectively) and with the lowest degree for the variety ‘Leon’ (88.06 ± 7.83 %; 26.51 ± 7.11 %; 79.32 ± 11.17 %, respectively). A decrease in the photosynthesis intensity was manifested in the suppression of Fv /Fm and Y(II) and an increase in NPQ, with the earliest changes in the parameters Y(II) and NPQ in the varieties ‘Foks 1’ and ‘Ratnik’ (on the 4th and 5th day, respectively), compared to the variety ‘Leon’ (on the 7th day). In the field conditions, there has been estimated productivity of the varieties and its dependence on precipitation. A positive correlation between the difference in yield of two varieties ‘Leon’ and ‘Ratnik’, contrasting in their response to drought, and the amount of precipitation during the active vegetation period in 2014–2017 and 2022 (Pearson’s R2 = 0.77, p < 0.05) has been identified. The most sensitive parameters of photosynthesis, which can be used to predict resistance to moisture deficiency, were Y(II) and NPQ.

The subject of the study is the conceptual, theoretical, methodological and applied legal and economic principles of the nature and significance of civil law and labour contracts in public life. Methodology. The research is based on general scientific and special legal methods. The analysis helped to determine the quantitative and qualitative parameters which characterise civil law and employment contract as socio-economic and legal phenomena in modern society. The synthesis provided for the formation of common and distinctive features inherent in civil law and employment contract in modern society. With the help of the comparative legal method it was possible to distinguish the characteristic features of the civil law and labour contract in the economic sphere and the legal consolidation of the above categories in modern international and national legislation on the basis of the quantitative and qualitative indicators of the corresponding origin. The formal-legal method created the conditions for the formulation of conclusions on the effectiveness of the normative consolidation of the principle of freedom of contract within the limits of civil and labour legislation and for the determination of relevant regulatory proposals. The purpose of the article is to define the essence and significance of civil law and employment contracts in the economic and legal sphere. The results of the study show that the state of legal regulation of temporal restrictions on the exercise of private rights in Ukraine on the way to economic integration creates preconditions for its modernisation in terms of both general and special legal provisions. Conclusion. Contractual relations are one of the most important driving forces of civil turnover, as they mediate the movement of a number of non-property and property goods within civil and economic turnover. Based on the study of statistical data, it has been established that the civil law contract, together with the labour contract, creates conditions for the development of economic processes in quantitative and qualitative components due to its involvement as a means of moving material and immaterial goods in civil and economic turnover. At the same time, a civil law contract, due to its wide variability and direct involvement in certain economic processes, creates more important prerequisites for progress in the economic space, which is manifested in new types and forms of contracts of this type. The labour contract in its component aims, first of all, from the position considered, to ensure the social component in the implementation of the content of the right to work by guaranteeing certain social, including economic, standards. This is why, unlike civil law, labour law influences the economy of the country indirectly and with a much smaller specific weight. In the legal sphere, research into the legal nature and scope of contractual constructs in the civil and labour spheres testifies to the weight of the principle of freedom of contract, which, on the one hand, is established within the limits of civil legislation and, on the other, creates the conditions for the implementation of another, broader principle of freedom of work, which is based on the right of the individual to freedom of work as a natural and inalienable human right. The article points to the possibility of extending the principle of freedom of contract, along with civil law relations, to other related relations, primarily labour relations. Where the manifestation of the content of such a principle is the right holder's authorisation to behave in one of the following ways: 1) procedural (conclusion, amendment, termination of the contract); 2) selection of a counterparty; 3) determination of terms and conditions; 4) determination of the contract content.

The current paper is devoted to the study of promising barley lines with an alternative type of development (facultative). Famous breeders P. F. Garkavy and V. M. Shevtsov believed that the future belonged to the facultative barley varieties, since they had high adaptive properties. Facultative varieties have several advantages, such as they can be used for early spring reseeding of sparse autumn crops of winter barley with seeds of the same variety and dead crops of winter cereals, as well as for obtaining high-quality seeds from spring sowing for autumn sowing. In connection with the above, the cultivation of facultative varieties for production is of great relevance and necessity. The purpose of the current study was to estimate new breeding material for facultative barley varieties in the conditions of the south of the Rostov region. The study was carried out in 2021–2023 in the fields of scientific crop rotation of the department of barley breeding and seed production of the ARC «Donskoy». In the first competitive variety testing there have been studied 12 promising facultative barley lines and the two currently best facultative barley varieties ‘Step’ and ‘Marusya’. There has been carried out comprehensive estimation of the studied samples based on such traits as the length of a vegetation period, resistance to lodging and damage by leaf diseases, 1000-grain weight, number of grains per an ear, number of productive stems per square meter, productivity. According to lodging resistance on average over three years, there were identified the varieties ‘Marusya’ and ‘Step’, as well as the lines Parallelum 2019, 2139, 2110, 2128, 2152, 2153 and Pallidum 2100; according to grain size the best varieties and lines were ‘Step’, ‘Marusya’, Parallelum 2141, 2110, 2128, 2149, 2152 and Pallidum 2100. The variety ‘Marusya’ and the lines Parallelum 2139, 2128, 2136, 2110, 2149, 2152, 2153 have shown the greatest productivity increase of 1 t/ha to the standard. Based on the data obtained, all studied varieties received a score based on a complex of economically valuable traits. The variety ‘Parallelum 2128’, which received the maximum number of points, was selected, and prepared for sending to the State Variety Commission of the Russian Federation for study.

The end-stage stage of chronic diseases of solid organs is rather significant in the structure of morbidity and mortality among patients worldwide. To date, there are more than six million patients in this status worldwide. Heart, liver and kidney transplantation is the gold standard of treatment for these patients. The number of transplants is growing every year.At the end of 2019, the world faced a new type of viral infection – SARS-CoV-2 – a highly contagious systemic respiratory disease transmitted by airborne droplets, which in three months led to a pandemic and killed hundreds of thousands of people. The pandemic has made adjustments to the structure of planned medical care. The number of planned operations has decreased significantly, and the number of the infection-associated complications has increased.Patients with end-stage chronic diseases initially have weakened immunity and represent the category most susceptible to the infection. At the moment, the question of patient management tactics remains open. There is no consensus on the patient management tactics before surgery and in the posttransplantation period for patients at the end-stage chronic disease of different organs. This topic requires further study and the development of treatment algorithms for such patients.

The current paper has presented a historical excursion and an overview of scientific research on breeding and seed production of winter and spring barley in the Federal State Budgetary Scientific Institution Agricultural Research Center “Donskoy”. The Southern Federal District includes 8 subjects of the Russian Federation, namely Sevastopol; republics of Adygea, Kalmykia, Crimea; Krasnodar Territory, Astrakhan, Volgograd and Rostov regions. Barley is the main grain forage crop in terms of sown area. Don farmers have long shown interest in this valuable, diverse crop, very unpretentious to the cultivation conditions. Barley breeding work began in our institution in 1932 and is still ongoing, with short interruptions, to the present. Research was carried out in various areas: breeding of winter, spring and facultative barley, seed production and technology of their cultivation. In the XXI-st century, the researchers of the barley department developed new innovative directions in barley breeding, there were developed two-row brewing varieties with high malting rates (the variety ‘Randevu’) in winter barley breeding and in spring barley breeding there were developed fodder barley (green fodder) varieties (the variety ‘Novik’), which were previously absent in the State List of the Russian Federation. In 2014 there were opened new directions in the department, namely the development of hulles spring barley varieties and awnless winter barley varieties. Since 2016, there has been carried out an active work to identify winter barley lines that are genetically resistant to net blotch. Together with the All-Russian Research Institute of Radiology and Agroecology, there was carried out an estimation of the radiosensitivity of winter and spring barley varieties to identify varieties being resistant to the environmental stress factors. Based on research materials, there were successfully defended 11 candidate and two doctoral dissertations, there were published eight monographs and more than 400 scientific articles.

Improvement of feed grain production is an important link in Russia’s food security. Considerable opportunities for solving this problem lie in the cultivation of new domestic varieties of barley. Breeding work in this direction has been carried out for a long time in the Don area by the FSBSI “ARC “Donskoy” (Department of winter and spring barley breeding and seed production). The purpose of the study was to breed a new spring barley variety for regions with high signs of aridy, which has fairly large productivity and its stability in different years. The result of the breeding program 0706-2019-0002 was the development of the spring barley variety ‘Azimut’ of universal use, i.e. for feed, groats and for brewing purposes. The paper has described the morphology of plants and the main biological and valuable economic traits of the new spring barley variety ‘Azimut’, which has been included in the State List of Breeding Achievements of Russia since 2022. There has been found that a remarkable feature of this variety is early maturity (through three contrast years (2017–2019) it ripened on average earlier than the standard variety ‘Ratnik’ on 4 days and the best variety ‘Format’ on 2 days), which is an extremely important indicator in modern climatic conditions. There was found that, on average, over the years, the new variety produced 5.7 t/ha and 52.0 g of 1000-grain weight, exceeding the standard on 0.8 t/ha and 6.5 g, as well as the best variety ‘Format’ on 0 .2 t/ha and 3.8 g, respectively. It has been established that the variety ‘Azimut’ has a certain important set of biologically useful and economically valuable properties and traits.

The aim of the present research is to identify whether teachers' attitudes towards the use of Content and Language Integrated Learning (CLIL) in the Republic of Kazakhstan can undergo significant changes if they study a course introducing them to the fundamentals of CLIL. Despite the country's plans to adopt English as one of the languages of education, stakeholders' attitudes towards teaching through the medium of this language remain rather skeptical. A survey was held among Master's degree students majoring in Education (n = 59) at Pavlodar State University before the course and after its completion. Since it is the affective component that largely determines the quality of attitudes, the levels of participants' anxiety, self-esteem and motivation were used as the indicators. The tools for measuring these variables were the State-Trait Anxiety Inventory, Dembo-Rubinstein's Method of Self-esteem Measurement and Dubovitskaya's Diagnostics of Learning Motivation Orientation. The end-of-course results show a marked reduction in the level of participants' state anxiety, a growth in self-esteem in terms of the readiness to use CLIL,and a shift towards intrinsic motivation. It is argued that for attitudes shift to take place, it is necessary to adopt a constructivist approach to teaching and learning.

The process of atomic hydrogen penetration into the metal phase is complicated by the phase-boundary transition from the liquid and/or gas phase. That is why the cleanliness of metal and alloy surfaces is of particular importance. The purpose of this work was to determine the effect of surface pretreatment using photon pulses, ultrasound, and potential cycling on the parameters of hydrogen permeability for 48Cu52Pd metal cold-rolled membranes. The study was focused on a foil of copper-palladium homogeneous alloy with 48 at. % Cu and 52 at. % Pd composition. The studied samples were obtained by cold rolling and their thickness were 10 and 16 μm. Surface pretreatment included rinsing in acetone, using ultrasound, pulsed photon treatment, and quadruple potential cycling over a wide range of potentials. Electrochemical studies included cyclic voltammetry and cathode-anodic chronoamperometry in a deaerated 0.1 M H2SO4 solution. Hydrogen permeability was calculated using mathematical models for samples of finite and semi-infinite thickness. It was found that the surface treatment of a 48Cu52Pd foil with photon pulses leads to both an increase in the ionisation rate of atomic hydrogen and an increase in the roughness of the foil surface. The diffusion coefficient of atomic hydrogen does not depend on the method of surface pretreatment with ultrasound and photon pulses. The extraction rate constant for the extraction of the atomic hydrogen after photon treatment increases, which facilitates the processes of both H introduction and ionisation due to the release of active centres of the surface. Electrochemical cleaning of the surface during the quadruple potential cycling contributes to the growth of the extraction rate constant for the extraction of atomic hydrogen