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Background: Insufficient rigidity of the foot owing to its ligaments and muscles can decrease the attenuation of the ground reaction force during landing. Therefore, dysfunction of the ankle invertors may increase the proximal joint load during landing. Research question: What are the effects of the fatigued ankle invertors on workload in the lower extremity joints during single-leg landing? Methods: Twenty-seven young adults (13 men and 14 women) performed landing trials in the forward and medial directions before and after exercise-induced fatigue of the ankle invertors. The exercise consisted of repeated concentric and eccentric ankle inversions until the maximum torque was below 80% of the baseline value. Negative joint workload during the landing tasks was calculated for the hip, knee, and ankle in the sagittal and frontal planes. Additionally, lower extremity work (the sum of the work of the hip, knee, and ankle) was calculated. Results: Invertor fatiguing exercise resulted in a significant increase in negative joint work in the frontal and sagittal plane hip and the frontal plane knee during medial landing, whereas no significant change in negative joint work was observed during forward landing. Significance: These findings suggested that ankle invertor dysfunction may induce a high load on the proximal joints and have direction-specific effects.

Background: Joint moment arm is a major element that determines joint torque. This study aimed to investigate factors associated with knee extensor and valgus moment arms of the patellar tendon in older individuals with and without knee osteoarthritis. Methods: Thirty-six participants with knee osteoarthritis (mean age, 78.1 ± 6.0 years) and 43 healthy controls (mean age, 73.0 ± 6.3 years) were analyzed. Magnetic resonance images (MRI) from the knee joint and thigh were acquired using a 3.0 T MRI scanner. The three-dimensional moment arm was defined as the distance between the contact point of the tibiofemoral joint and the patellar tendon line. The three-dimensional moment arm was decomposed into sagittal and coronal components, which were calculated as knee extensor and valgus moment arms, respectively. Quadriceps muscle volume, epicondylar width, bisect offset, Insall–Salvati ratio, and Kellgren–Lawrence grade were assessed. Multiple regression analyses were performed in the healthy control and knee osteoarthritis groups, with knee extensor and valgus moment arms as dependent variables. Findings: Knee extensor moment arm was significantly associated with epicondylar width and the Insall–Salvati ratio in the healthy control group and with Kellgren–Lawrence grade, epicondylar width, and quadriceps muscle volume in the knee osteoarthritis group. Valgus knee moment arm was significantly associated with bisect offset in both the groups. Interpretation: Knee size, osteoarthritis severity, and quadriceps muscle volume affect the knee extensor moment arm in knee osteoarthritis, whereas lateral patellar displacement affects the valgus knee moment arms in older individuals with and without knee osteoarthritis.

Intrinsic factors related to neuromuscular function are time-of-day dependent, but diurnal rhythms in neural and muscular components of the human neuromuscular system remain unclear. The present study aimed to investigate the time-of-day effects on neural excitability and muscle contractile properties by assessing firing properties of tracked motor units and electrically evoked twitch muscle contraction. In fifteen young adults (22.9±4.7 years), neuromuscular function was measured in the morning (10:00), at noon (13:30), in the evening (17:00), and at night (20:30). Four measurements were completed within 24 hours. The measurements consisted of maximal voluntary contraction (MVC) strength of knee extension, recording of high-density surface electromyography (HDsEMG) from the vastus lateralis during ramp-up contraction to 50% of MVC, and evoked twitch torque of knee extensors by electrical stimulation. Recorded HDsEMG signals were decomposed to individual motor unit firing behaviors and the same motor units were tracked among the times of day, and recruitment thresholds and firing rates were calculated. The number of detected and tracked motor units was 127. Motor unit firing rates significantly increased from morning to noon, evening and night (p<0.01), but there were no significant differences in recruitment thresholds among the times of day (p>0.05). Also, there were no significant effects of time-of-day on evoked twitch torque (p>0.05). Changes in the motor unit firing rate and evoked twitch torque were not significantly correlated (p>0.05). These findings suggest that neural excitability may be affected by the time-of-day, but it did not accompany changes in peripheral contractile properties in a diurnal manner.

Muscular dysfunctions involving a decline in muscle strength are often induced by loss of muscle mass in older adults. Understanding neural activation in older adults in addition to muscular characteristics may be important to prevent such age-related dysfunctions. This study aimed to investigate the difference in motor unit firing patterns between community-dwelling older individuals with normal and low skeletal muscle mass. Sixty-six older adults (62–90 years) performed muscle strength and function tests. On conducting high-density surface electromyography of the vastus lateralis, individual motor unit firing properties were assessed. Individual motor units were divided into three different recruitment threshold groups and their firing rates were compared. The skeletal muscle quantity and quality were assessed using bioimpedance methods and ultrasound images. They were divided into two groups according to sarcopenia criteria: a normal group (n = 39) and presarcopenia group with low skeletal muscle mass but normal physical functions (n = 21). Skeletal muscle mass and muscle thickness were greater and echo intensity was lower in the normal group than presarcopenia group. Motor units in normal older adults fired at different rates with a hierarchy depending on their recruitment threshold, observed as a normal phenomenon. However, motor units in the presarcopenia group fired without showing the hierarchical pattern. The results suggest that older adults with low skeletal muscle mass exhibited an abnormal neural input pattern, in addition to declines in muscle quantity and quality.

Iguchi, J, Hojo, T, Fujisawa, Y, Kuzuhara, K, Yanase, K, Hirono, T, Koyama, Y, Tateuchi, H, and Ichihashi, N. Synergistic dominance induced by hip extension exercise alters biomechanics and muscular activity during sprinting and suggests a potential link to hamstring strain. J Strength Cond Res 37(9): 1770–1776, 2023--Hamstring strain is likely to occur during the late swing phase or the first half of the stance phase in sprinting. During the late swing phase, the hamstrings and gluteus maximus (Gmax) contract eccentrically to decelerate the lower limb. We hypothesized that, when the Gmax becomes dysfunctional because of delayed onset muscle soreness (DOMS), the hamstring workload is increased (i.e., there is synergetic dominance), which could lead to an increased risk of strain. A total of healthy 15 male undergraduate or graduate students (age 23.1 ± 1.28 years) were recruited to perform exercises and maximal sprints. On day 1, before subjects performing DOMS-causing exercises, and on day 3, while subjects were experiencing DOMS in the Gmax, lower-limb biomechanical and muscle activity data were recorded using a motion analysis system and electromyography (EMG), respectively. Data were analyzed and compared between day 1 and day 3. Hip flexion angle on day 3 was significantly lower than that on day 1, but the opposite was true for the knee flexion angle (P < 0.05). Vastus medialis (VM), biceps femoris (BF), and Gmax muscle activities on day 3 were significantly higher than those on day 1 (P < 0.05). Peak propulsive forces on day 3 were significantly higher than those on day 1 (P < 0.05). Kinematic changes such as decreased hip flexion angle and EMG changes such as increased BF EMG activity on day 3 to compensate for the loss of function of the Gmax may potentially increase the risk of hamstring strain.

[Background] The characteristics of muscle degeneration in individual quadriceps in early knee osteoarthritis (OA) and the association of muscle quantity and quality on knee dysfunction remain unclear. This study aimed to clarify the characteristics of muscle degeneration in individual quadriceps muscles in early knee OA and elucidate the association of muscle volume and intramuscular adipose tissue (intraMAT) with knee dysfunction, including functional disabilities, symptoms, and joint morphology. [Methods] Fifty participants were categorized into early knee OA and healthy control groups. 3.0 T magnetic resonance imaging (MRI) using T1-weighted and Dixon methods and 3D SPACE in the thigh muscle and knee joint regions was performed. Quadriceps muscle volume, intraMAT, and whole-organ MRI score (WORMS) were assessed. The Knee Society Score (KSS) was used to evaluate functional disabilities and knee symptoms. Univariate analysis of variance was conducted with covariates to clarify the differences in muscle volume and intraMAT between the two groups. Multiple linear regression analyses were performed using the KSS function and symptom subcategories and WORMS as dependent variables and muscle volume, intraMAT, and the presence of early knee OA as independent variables, such as potential confounders. [Results] The quadriceps intraMAT, especially in the vastus medialis (VM), was significantly higher in patients with early knee OA than in healthy controls. The VM intraMAT, not muscle volume, was significantly associated with KSS function [B = − 3.47; 95% confidence interval [CI], − 5.24 to − 1.71; p < 0.001] and symptom scores [B = − 0.63; 95% CI, − 1.09 to − 0.17; p = 0.008], but not with WORMS. [Conclusion] These findings suggest that higher VM intraMAT is characteristic of quadriceps muscle degeneration in early knee OA and its increase is associated with functional disabilities and symptoms.

[Background] This study aimed to determine in how many individuals the iliocapsularis muscle (IC) could be identified on magnetic resonance imaging (MRI) and whether age and sex are associated with the cross-sectional area (CSA) of the IC. [Methods] Thirty-seven healthy younger adults and 40 healthy older adults were assigned to four groups: 1) 20 younger men; 2) 17 younger women; 3) 20 older men; and 4) 20 older women. The CSAs of the IC, IP, the rectus femoris (RF) and the quadriceps (QUAD) were quantified on an axial MRI. [Results] The number of individuals with the identified IC was n = 17 (85.0%) of 20 younger men, n = 15 (88.2%) of 17 younger women, n = 18 (90.0%) of 20 older men, and 19 (95.0%) of 20 older women. Our results showed the main effect of sex, but not age, in the CSA of the IC. The men-groups had larger CSA of the IC than the women-groups; however, no difference in CSA of the IC was found between the younger and older groups. Meanwhile, the main effects of age and sex were found for the IP, RF, and QUAD; thus, younger or men groups have larger CSAs of the three muscles than the older or women groups. The IC muscle can be discriminated in 85% – 95% of healthy individuals. [Conclusion] Although sex and age are associated with the CSA of lower-limb muscles other than the IC, only sex is associated with the CSA of the IC.

BACKGROUND: Ankle plantar flexor force steadiness, assessed by measuring the fluctuation of the force around the submaximal target torque, has been associated with postural stability. RESEARCH QUESTION: To investigate whether a force-matching exercise, where submaximal steady torque is maintained at the target torque, can modulate postural strategy immediately. METHODS: Twenty-eight healthy young adults performed ankle plantar flexor force-matching exercises at target torques of 5%, 20%, and 50% of maximum voluntary contraction (MVC), in a randomized crossover trial. Participants with their ankle in a neutral position were instructed to maintain isometric contraction at each target torque, as measured by a dynamometer, for 20 s with 3 sets of 5 contractions. Before and after the force-matching exercises, the anterior-posterior velocities and standard deviation of the center of pressure (COP) on the stable platform and the tilt angle of the unstable platform during 20-seconds single-leg standing were measured. The velocities and standard deviations of the COP and tilt angle before and after the exercises were compared using paired t-tests. RESULTS: The tilt angle velocity of an unstable platform significantly decreased after the force-matching exercise at a target torque of 5% MVC (p = 0.029), whereas it was unchanged after the exercises at target torques of 20% and 50% MVC. The standard deviations of the tilt angle of unstable platform test did not change significantly after any exercise. Furthermore, no significant differences were observed in the COP velocities or standard deviations on the stable platform test after any exercise. SIGNIFICANCE: Our findings suggest that repeated exertion training at low-intensity contractions can affect postural stability in an unstable condition. Particularly, force-matching exercise at very low-intensity torque, such as 5% of MVC, may be an effective method to improve postural control in the unstable condition, but not in a stab

Numerous muscles around the shoulder joint are required to work in a coordinated manner, even when a basic shoulder movement is executed. Muscle synergy can be utilized as an index to determine muscle coordination. The purpose of the present study was to investigate the muscle coordination among different shoulder muscles underlying basic shoulder movements based on muscle synergy. Thirteen men performed 14 multiplanar shoulder movements; five movements were associated with elevation and lowering, while five were associated with horizontal abduction and adduction. The four additional movements were simple rotations at different positions. Muscle activity was measured from 12 muscle portions using surface electromyography. Using the dimensionality reduction technique, synergies were extracted first for each movement separately ("separate" synergies), and then for the global dataset (containing all movements; "global" synergies). The least number that provided 90% of the variance accounted for was selected as the optimal number of synergies. For each subject, approximately two separate synergies and approximately six global synergies with small residual values were extracted from the separate and global electromyography datasets, respectively. Specific patterns of these muscle synergies in each task were observed during each movement. In the cross-validation method, six global synergies explained 88.0 ± 1.3% of the global dataset. These findings indicate that muscle activities underlying basic shoulder movements are expressed as six units, and these units could be proxies for shoulder muscle coordination.

AIM: The present study aimed to investigate the age-related changes in gait speeds and asymmetry during circular and straight-line gaits among older adults aged 60-79 years. METHODS: The study included 391 community-dwelling older adults aged >60 years, who participated in the Nagahama cohort study. They were assigned to four age groups: 60-64 years (early 60s), 65-69 years (late 60s), 70-74 years (early 70s) and 75-79 years (late 70s). For the circular gait test, the time required to walk twice around a 1-m diameter circle for right and left rotations were measured. The average time of the two trials was measured as the circular gait time, and the side-to-side difference in the circular gait times was calculated as an asymmetry index. Walking speed, asymmetry of step length, and asymmetry of stance duration time during straight-line gait at comfortable and maximal walking pace were measured. RESULTS: Circular gait time in older women in the late 70s group was significantly slower than that in other age groups; however, no age-related change was observed in older men. Maximal gait speeds in the early and late 70s groups were significantly slower than those in the early 60s group. CONCLUSIONS: Age-related decline in circular gait speed was observed in older women aged ≥75 years, but not in older men. Maximal straight-line gait speed decreased significantly in both genders after the age of 70 years. Geriatr Gerontol Int 2021; ••: ••-••.

Repetitive peripheral magnetic stimulation (rPMS) is a non-invasive stimulator that can induce strong muscle contraction in selective regions. This study aimed to measure acute changes in skeletal muscle thickness induced by rPMS following a low-intensity exercise. Fifteen healthy young men performed an isometric knee extensor exercise at 30% of maximum strength consisting of three sets of 10 contractions on their dominant leg. rPMS was then applied on the vastus lateralis (VL) at the maximum intensity of the rPMS device. Muscle thicknesses of the rectus femoris (RF) and VL were measured using an ultrasound device and were compared among baseline, post-exercise, and post-rPMS. There were significant increases in muscle thickness of both the RF and VL post-exercise compared with baseline values (RF: baseline; 24.7 ± 2.4, post-exercise; 25.3 ± 2.4 mm, p = .034, VL: baseline; 27.0 ± 2.8, post-exercise; 27.4 ± 2.8 mm, p = .006). Compared with post-exercise, there was a significant increase post-rPMS in only the VL (VL: post-rPMS; 28.3 ± 2.9 mm, p = .002). These findings suggest that low-intensity isometric exercise can induce acute increases in muscle thickness (muscle swelling) in synergist muscles, and rPMS following exercise can induce further acute muscle swelling via repetitive muscle contraction.

Pectoralis major (PMa) muscle injuries are becoming more prevalent, and their incidence differs among the PMa regions, i.e., the clavicular, sternal, and abdominal regions. Therefore, identifying the position for effectively lengthening each PMa region is critical in preventing PMa injuries. The purpose of this study was to determine the effective stretching position for each PMa region through shear wave elastography, which can indirectly assess individual muscle lengthening. Fifteen men participated in this study. Twelve stretching positions were compounded with shoulder abductions (45°, 90°, and 135°), pelvic rotation (with or without), shoulder external rotation (with or without), and shoulder horizontal abductions. The shear modulus of each PMa region was measured through shear wave elastography in the stretching positions mentioned above. At the clavicular region, the shear modulus was higher for three stretching positions: shoulder horizontal abduction at 45° abduction during pelvic rotation and shoulder external rotation, shoulder horizontal abduction at 90° abduction, and shoulder horizontal abduction at 90° abduction while considering shoulder external rotation. For the sternal region, the shear modulus was higher in two stretching positions: shoulder horizontal abduction at 90° abduction while adding external rotation, and combination of pelvic rotation and external rotation. For the abdominal region, the shear modulus was higher in the shoulder horizontal abduction at 135° abduction with pelvic and external rotation. These results indicated that the effective stretching position was different for each PMa region.

[Purpose]This study was aimed at determining the relationship between ankle plantar flexor force steadiness and postural control during single leg standing on stable and unstable platforms.[Methods]For the thirty-three healthy participants, force steadiness, at target torques of 5%, 20%, and 50% of the maximum voluntary torque (MVT) of the ankle plantar flexors, was measured. Force steadiness was calculated as the coefficient of variation of force. Single leg standing on stable and unstable platforms was performed using the BIODEX Balance System SD. The standard deviation of the anteroposterior center of pressure (COP) displacements was measured as the index for postural control. During both measurements, muscle activities of the soleus were collected using surface electromyography.[Results]On the stable platform, the COP fluctuation significantly correlated with force steadiness at 5% of MVT (r = 0.512, p = 0.002). On the unstable platform, the COP fluctuation significantly correlated with force steadiness at 20% of MVT (r = 0.458, p = 0.007). However, the extent of muscle activity observed for a single leg standing on both stable and unstable platforms was significantly greater than the muscle activity observed while performing force steadiness tasks at 5% and 20% of MVT, respectively.[Conclusion]Postural stability during single leg standing on stable and unstable platforms may be related to one’s ability to maintain constant torque at 5% and 20% of MVT regardless of the muscle activity. These results suggest that the required abilities to control muscle force differ depending on the postural control tasks.

The aim of the study was to investigate the effect of static stretching (SS) with different rest intervals on muscle stiffness. Fifteen healthy males participated in the study. Four bouts of thirty-second SS for the gastrocnemii were performed at the maximal dorsiflexion using dynamometer with two different rest intervals between stretches, namely 0 s (R0) and 30 s (R30). Each participant underwent both stretching protocols at least 48 h apart in a random order. Between each bout of SS, the ankle was moved to 20°-plantar-flexion in 3 s, held for each rest interval time, and then returned to the stretching position in 3 s. The shear elastic modulus of the medial gastrocnemius was measured before (PRE) and immediately after (POST) four bouts of SS to assess muscle stiffness of the medial gastrocnemius. Two-way repeated measures analysis of variance (protocol × time) indicated a significant interaction effect on the shear elastic modulus. The shear elastic modulus significantly decreased after SS in both protocols [R0, PRE: 11.5 ± 3.3 kPa, POST: 10.0 ± 2.6 kPa, amount of change: 1.6 ± 0.9 kPa (13.0 ± 5.2%); R30, PRE: 11.0 ± 2.8 kPa, POST: 10.2 ± 2.1 kPa, amount of change: 0.8 ± 1.3 kPa (6.0 ± 10.4%)]. Furthermore, the SS with 0-s rest interval induced greater decrease in shear elastic modulus when compared to SS with 30-s rest interval (p = 0.023). Thus, when performing SS to decrease muscle stiffness, rest intervals between stretches should be minimized.

The effects of high-load resistance training on muscle strength and muscle mass depend on rest periods between sets. However, whether differences in rest period length during low-load resistance exercise (RE) has an influence on improving muscle characteristics remains unclear. Better understanding such effects would enable us to prescribe low-load resistance exercise more safely and effectivity. The purpose of this study was to investigate the acute effects of low-load RE on muscle swelling with different length rest periods between sets. A total of 42 young men (age, 22.9 ± 2.4 years; height, 172.1 ± 5.4 cm; body mass, 65.6 ± 6.5 kg) were recruited to participate in this study. They were assigned to one of three groups with different rest periods between sets (20 s [seconds], 60 s, or 180 s). A total of 12 sets of 10 repetitions of RE with 30% of one repetition maximum on knee extensor muscles were performed. Muscle thickness of the vastus lateralis was measured using ultrasonography as an indicator of muscle swelling every 3 sets. Muscle thickness significantly increased after 3 sets of RE in the 20-s (3.9 ± 3.3%) and 60-s groups (5.9 ± 3.8%), but only after 12 sets in the 180-s group (4.3 ± 3.1%). RE with rest periods shorter than 60 s could result in exercise-induced muscle swelling after fewer sets of RE.

Objective: This study aimed to examine the association of independence in activities of daily living with the loads during step ascent motion and other motor functions in 32 nursing home–residing elderly individuals. Design: Independence in activities of daily living was assessed by using the Functional Independence Measure. The loads at the upper (i.e., pulling up) and lower (i.e., pushing up) levels during the step ascent task was measured on a step ascent platform. Hip extensor, knee extensor, plantar flexor muscle, and quadriceps setting strengths; lower extremity agility using the stepping test; and hip and knee joint pain severities were measured. One-legged stance and functional reach distance for balance and maximal walking speed, timed up-and-go time, five-chair-stand time, and step ascent time were also measured to assess mobility. Results: Stepwise regression analysis revealed that the load at pushing up during step ascent motion and timed up-and-go time were significant and independent determinants of Functional Independence Measure score. Functional Independence Measure score decreased with decreased load at pushing up and increased timed up-and-go time. Conclusions: The study results suggest that depending on task specificity, both one step up task's push-up peak load during step ascent motion and timed up-and-go can partially explain activities of daily living's Functional Independence Measure score in nursing home–residing elderly individuals. Lower extremity muscle strength, agility, pain, or balance measures did not add to the prediction.