1. Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model
- Author
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D. Baz Lopez, D. S. Mansell, E. Sammut, Katharine Fraser, Thomas W Johnson, Sarah J George, Thomas Krieg, Raimondo Ascione, Igor Khaliulin, Amedeo Chiribiri, Andrew Cookson, Michael P. Murphy, Vito Domenico Bruno, Harinderjit Gill, M-Saadeh Suleiman, Murphy, Mike [0000-0003-1115-9618], Krieg, Thomas [0000-0002-5192-580X], and Apollo - University of Cambridge Repository
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Data Analysis ,Proteomics ,Proteome ,Swine ,Myocardial Infarction ,Infarction ,692/700/1421/1628 ,Ventricular Function, Left ,Translational Research, Biomedical ,Pathogenesis ,Prognostic markers ,631/114/2397 ,692/308/575 ,Image Processing, Computer-Assisted ,Computational models ,Medicine ,Myocardial infarction ,692/308/1426 ,Multidisciplinary ,Ventricular Remodeling ,medicine.diagnostic_test ,Strain (chemistry) ,article ,Magnetic Resonance Imaging ,Experimental models of disease ,692/4019/592 ,Data Interpretation, Statistical ,Cardiology ,Female ,Disease Susceptibility ,631/1647/2067 ,medicine.medical_specialty ,Science ,Proteomic analysis ,Cardiac magnetic resonance imaging ,Internal medicine ,692/53/2422 ,Animals ,General ,business.industry ,Myocardium ,Computational Biology ,Reproducibility of Results ,Magnetic resonance imaging ,Translational research ,medicine.disease ,Cardiovascular biology ,Disease Models, Animal ,Myocardial strain ,business ,Biomarkers ,Large animal - Abstract
Funder: EPSRC DTP, Funder: Developmental pathway funding scheme (DPFS), To identify predictors of left ventricular remodelling (LVR) post-myocardial infarction (MI) and related molecular signatures, a porcine model of closed-chest balloon MI was used along with serial cardiac magnetic resonance imaging (CMRI) up to 5–6 weeks post-MI. Changes in myocardial strain and strain rates were derived from CMRI data. Tissue proteomics was compared between infarcted and non-infarcted territories. Peak values of left ventricular (LV) apical circumferential strain (ACS) changed over time together with peak global circumferential strain (GCS) while peak GLS epicardial strains or strain rates did not change over time. Early LVR post-MI enhanced abundance of 39 proteins in infarcted LV territories, 21 of which correlated with LV equatorial circumferential strain rate. The strongest associations were observed for D-3-phosphoglycerate dehydrogenase (D-3PGDH), cysteine and glycine-rich protein-2, and secreted frizzled-related protein 1 (sFRP1). This study shows that early changes in regional peak ACS persist at 5–6 weeks post-MI, when early LVR is observed along with increased tissue levels of D-3PGDH and sFRP1. More studies are needed to ascertain if the observed increase in tissue levels of D-3PGDH and sFRP1 might be casually involved in the pathogenesis of adverse LV remodelling.
- Published
- 2021
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