1. Malignant transformation of central neurocytoma with dissemination 17 years after initial treatment: illustrative case
- Author
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20378649, 50716602, 10252462, Kojima, Kazuhiro, Arakawa, Yoshiki, Takeuchi, Yasuhide, Terada, Yukinori, Tanji, Masahiro, Mineharu, Yohei, Haga, Hironori, Miyamoto, Susumu, 20378649, 50716602, 10252462, Kojima, Kazuhiro, Arakawa, Yoshiki, Takeuchi, Yasuhide, Terada, Yukinori, Tanji, Masahiro, Mineharu, Yohei, Haga, Hironori, and Miyamoto, Susumu
- Abstract
BACKGROUND: Central neurocytomas usually have a favorable clinical course, and gross total resection (GTR) results in long-term survival. Recurrences of central neurocytomas are usually local, and dissemination is extremely rare. OBSERVATIONS: A 24-year-old man who presented with vomiting was found to have a mass in the right lateral ventricle. After GTR, he received whole-brain irradiation and chemotherapy and had remained disease-free on follow-up for years. The review of the initial tumor revealed central neurocytoma. Seventeen years later, he presented with deterioration of memory, and magnetic resonance imaging showed an enhanced lesion in the left hippocampus. The enhanced lesion was resected, and the histological examination revealed that the tumor was a disseminated atypical central neurocytoma with frequent mitoses. Although he was treated with chemotherapy, the disseminated tumor slowly grew and invaded the brain. Massive brain invasion occurred without enhanced lesions, and he died 27 months after the tumor recurrence. LESSONS: In this patient, a central neurocytoma disseminated after an extremely long period of time. Once neurocytomas disseminate and show aggressive behavior, patients usually follow a poor course. Patients with central neurocytomas should be followed up for a long time.
- Published
- 2022