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Your search keyword '"3,5-dihydroxy-4-isopropylstilbene"' showing total 4 results
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4 results on '"3,5-dihydroxy-4-isopropylstilbene"'

2. A double-blind, randomized, placebo- and positive-controlled phase III trial of 1% benvitimod cream in mild-to-moderate plaque psoriasis

Author

Lin Cai, Gen-Hui Chen, Qian-Jin Lu, Min Zheng, Yu-Zhen Li, Jin Chen, Jie Zheng, Fu-Ren Zhang, Jian-Bin Yu, Sen Yang, Fu-Qiu Li, Sheng-Xiang Xiao, Qiu-Ning Sun, Jin-Hua Xu, Xing-Hua Gao, Hong Fang, Tian-Wen Gao, Fei Hao, Quan-Zhong Liu, Ya-Ting Tu, Ruo-Yu Li, Bao-Xi Wang, Dan-Qi Deng, Qing-Shan Zheng, Hong-Xia Liu, Jian-Zhong Zhang, and Li-Shao Guo.

Subjects
medicine.medical_specialty, lcsh:Medicine, Placebo, Severity of Illness Index, law.invention, Ointments, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Randomized controlled trial, Double-Blind Method, Benvitimod, Psoriasis Area and Severity Index, law, Internal medicine, Severity of illness, Stilbenes, Medicine, Humans, Psoriasis, 3,5-dihydroxy-4-isopropylstilbene, Adverse effect, Calcipotriol, Immune modulator, business.industry, Drug discovery, lcsh:R, General Medicine, Resorcinols, Original Articles, medicine.disease, Clinical trial, Treatment Outcome, chemistry, 030220 oncology & carcinogenesis, business, Contact dermatitis, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract

Background. Benvitimod cream, a novel synthetic small molecule, was effective in treating mild-to-moderate plaque psoriasis. We conducted a phase III clinical trial to assess the efficacy and safety of benvitimod cream in patients with mild-to-moderate plaque psoriasis. Methods. We randomly assigned 686 patients (2:1:1) to receive 1% benvitimod cream, 0.005% calcipotriol ointment or placebo twice a day for 12 weeks. The primary efficacy end points were the percentage of patients with a 75% or greater reduction from baseline in the psoriasis area and severity index (PASI 75) score and with a score of 0 or 1 in static physician's global assessment (sPGA) at week 12. Results. The results showed that 50.4% of patients in the benvitimod group achieved PASI 75, which was significantly higher than that in the calcipotriol (38.5%, P

Published
2020

3. The preparation of 3,5-dihydroxy-4-isopropylstilbene nanoemulsion and in vitro release

Author

Ran Zhang, Yue Zhang, Hetang Zheng, Yucui Han, and Jun-gang Gao

Subjects
Castor Oil, Materials science, pseudo-ternary phase diagram, Biophysics, nanoemulsion, Pharmaceutical Science, Bioengineering, DHPS, Resorcinol, Administration, Cutaneous, Spectrum Analysis, Raman, Dosage form, Biomaterials, chemistry.chemical_compound, Mice, Surface-Active Agents, Pulmonary surfactant, Drug Stability, Microscopy, Electron, Transmission, International Journal of Nanomedicine, Drug Discovery, Stilbenes, medicine, Organic chemistry, Animals, 3,5-dihydroxy-4-isopropylstilbene, Solubility, Isopropyl myristate, Transdermal, Skin, Original Research, Myristates, Viscosity, Organic Chemistry, General Medicine, Resorcinols, Nanostructures, chemistry, Castor oil, Emulsions, Female, medicine.drug, Nuclear chemistry
Abstract

Yue Zhang1,2, Jungang Gao1, Hetang Zheng2, Ran Zhang3, Yucui Han21College of Chemistry and Enviromental Science, Hebei University, Baoding, China; 2School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, China; 3College of Chemical Engineering, East China University of Science and Technology, Shanghai, ChinaAbstract: We have reported a novel procedure to prepare 3,5-dihydroxy-4-isopropylstilbene (DHPS) nanoemulsion, using a low-energy emulsification method. Based on the phase diagram, the optimum prescription of nanoemulsion preparation was screened. With polyoxyethylenated castor oil (EL-40) as the surfactant, ethanol as the co-surfactant, and isopropyl myristate (IPM) as the oil phase, the DHPS nanoemulsion was obtained with a transparent appearance, little viscosity, and spherically uniform distribution verified by transmission electron microscopy and laser scattering analyzer. The nanoemulsion was also determined by FT-Raman spectroscopy. The DHPS nanoemulsion demonstrated good stability and stable physical and chemical properties. The nanoemulsion dramatically improved the transdermal release of DHPS (from 8.02 µg· cm-2 to 273.15 µg· cm-2) and could become a favorable new dosage form for DHPS.Keywords: nanoemulsion, 3,5-dihydroxy-4-isopropylstilbene, DHPS, pseudo-ternary phase diagram

Published
2011

4. The preparation of 3,5-dihydroxy-4-isopropylstilbene nanoemulsion and in vitro release.

Author

Zhang Y, Gao J, Zheng H, Zhang R, and Han Y

Subjects
Administration, Cutaneous, Animals, Castor Oil analogs & derivatives, Castor Oil chemistry, Drug Stability, Female, Mice, Microscopy, Electron, Transmission, Myristates chemistry, Resorcinols chemistry, Resorcinols pharmacokinetics, Skin metabolism, Solubility, Spectrum Analysis, Raman, Stilbenes chemistry, Stilbenes pharmacokinetics, Surface-Active Agents chemistry, Viscosity, Emulsions chemistry, Nanostructures chemistry
Abstract

We have reported a novel procedure to prepare 3,5-dihydroxy-4-isopropylstilbene (DHPS) nanoemulsion, using a low-energy emulsification method. Based on the phase diagram, the optimum prescription of nanoemulsion preparation was screened. With polyoxyethylenated castor oil (EL-40) as the surfactant, ethanol as the co-surfactant, and isopropyl myristate (IPM) as the oil phase, the DHPS nanoemulsion was obtained with a transparent appearance, little viscosity, and spherically uniform distribution verified by transmission electron microscopy and laser scattering analyzer. The nanoemulsion was also determined by FT-Raman spectroscopy. The DHPS nanoemulsion demonstrated good stability and stable physical and chemical properties. The nanoemulsion dramatically improved the transdermal release of DHPS (from 8.02 μg · cm(-2) to 273.15 μg · cm(-2)) and could become a favorable new dosage form for DHPS.

Published
2011
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