1. Relationship between growth velocity and change of levels of insulin-like growth factor-1, insulin-like growth factor binding protein-3 and, IGFBP-3 promoter polymorphism during GnRH agonist treatment
- Author
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Il Tae Hwang, Jun Hong Park, and Seung Yang
- Subjects
Agonist ,medicine.medical_specialty ,medicine.drug_class ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Promoter polymorphism ,030209 endocrinology & metabolism ,Insulin-like growth factor-binding protein ,precocious puberty ,Growth velocity ,03 medical and health sciences ,Insulin-like growth factor ,0302 clinical medicine ,202 a/c igfbp-3 ,030225 pediatrics ,Internal medicine ,medicine ,promoter regions ,Precocious puberty ,biology ,business.industry ,insulin-like growth factor binding protein-3 ,lcsh:RJ1-570 ,Bone age ,lcsh:Pediatrics ,medicine.disease ,insulin-like growth factor-1 ,Endocrinology ,Pediatrics, Perinatology and Child Health ,biology.protein ,growth velocity ,Original Article ,business ,Hormone - Abstract
Purpose This study aims to investigate the effect of gonadotropin-releasing hormone agonist (GnRHa) on growth hormone (GH)-insulin-like growth factor-1 (IGF-1) axis and to evaluate whether -202 A/C IGF binding protein-3 (IGFBP-3) promoter polymorphism affects the growth velocity in girls with central precocious puberty (CPP) during treatment. Methods Data was collected from 97 girls, aged below 9 years, diagnosed with precocious puberty and treated with GnRHa for at least 1 year in Kangdong Sacred Heart Hospital from 2014 to 2015. Their body height, weight, change in height standard deviation scores (∆SDSs), serum IGF-1, serum IGFBP-3, bone age (BA), and -202 A/C IGFBP-3 promoter polymorphism were measured before and after GnRHa treatment. Interrelationship between the variables was further calculated. Results During treatment, height SDS, IGF-1 SDS, IGFBP-3 SDS, and IGF-1/IGFBP-3 ratio significantly decreased. Significant correlations were observed between the ∆IGF-1 SDS and ∆height SDS (r = 0.405, p < 0.001). The presence of C allele was significantly correlated with IGF-1 SDS after the treatment (p = 0.049) and IGFBP-3 SDS before and after the treatment respectively, (p = 0.012 and p = 0.001) but not with ∆IGF-1 SDS, ∆IGFBP-3 SDS, ∆IGF-1/IGFBP-3 ratio, or ∆height SDS. Conclusion Growth velocity during GnRHa treatment is related to ∆IGF-1 SDS, concluding the apparent impact of GnRHa on the GH-IGF-1 axis. -202 A/C IGFBP-3 promoter polymorphism does not affect the growth velocity of GnRHa in CPP girls.
- Published
- 2020