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OBJECTIVES: Following the outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus and the subsequent global spread of the 2019 novel coronavirus disease (COVID-19), health systems and the populations who use them have faced unprecedented challenges. We aimed to measure the impact of COVID-19 on the uptake of hospital-based care at a national level. DESIGN: The study period (weeks ending 5 January to 28 June 2020) encompassed the pandemic announcement by the World Health Organization and the initiation of the UK lockdown. We undertook an interrupted time-series analysis to evaluate the impact of these events on hospital services at a national level and across demographics, clinical specialties and National Health Service Health Boards. SETTING: Scotland, UK. PARTICIPANTS: Patients receiving hospital care from National Health Service Scotland. MAIN OUTCOME MEASURES: Accident and emergency (A&E) attendances, and emergency and planned hospital admissions measured using the relative change of weekly counts in 2020 to the averaged counts for equivalent weeks in 2018 and 2019. RESULTS: Before the pandemic announcement, the uptake of hospital care was largely consistent with historical levels. This was followed by sharp drops in all outcomes until UK lockdown, where activity began to steadily increase. This time-period saw an average reduction of −40.7% (95% confidence interval [CI]: −47.7 to −33.7) in A&E attendances, −25.8% (95% CI: −31.1 to −20.4) in emergency hospital admissions and −60.9% (95% CI: −66.1 to −55.7) in planned hospital admissions, in comparison to the 2018–2019 averages. All subgroup trends were broadly consistent within outcomes, but with notable variations across age groups, specialties and geography. CONCLUSIONS: COVID-19 has had a profoundly disruptive impact on hospital-based care across National Health Service Scotland. This has likely led to an adverse effect on non-COVID-19-related illnesses, increasing the possibility of potentially avoidable morbidity and mortality. Further research is required to elucidate these impacts.

A koronavirus előtti időszakban stabil gazdasagi novekedes jellemezte a futball iparagat. A klubok egyenkenti es osszesitett arbevetel novekedese egyertelműen osszefuggesbe hozhato a jatekosok jatek joganak adas-vetelevel, azaz a klubok jatekostranszfer tevekenysegevel. A folyamatos gazdasagi fejlődes egyben vissza is hatott a jatekos jogok atruhazasanak ertekere is, hiszen az utobbi evtizedben folyamatosan emelkedő transzfer arak tapaszhatok. Ez a jelenseg bar veszelyt is hordoz magaban a jatekosokkal kapcsolatos kiadasok novekedese reven, osszessegeben megis inkabb az agazat fejlődehez jarul hozza. Ezt igazolja, hogy az europai klubfutball 2018-ban masodszor zarta az uzleti evet nyeresegesen. A folyamatos fejlődest a COVID-19 pandemias helyzet akasztotta meg 2020-ban. A merkőzesek halasztasra kerultek, a szurkolok csak kozvetiteseken keresztul kovethettek kedvenc csapataikat. A korlatozasok nem csak a klubok arbevetelere, hanem ezzel parhuzamosan a jatekosok piaci ertekere is befolyasolt gyakoroltak, amelyek atlagosan 13-18%-os piaci ertekvesztest eredmenyeztek, korabban becsult ertekeikhez kepest a legutobbi atigazolasi időszak legnagyobb ertekű atigazolasait vizsgalva.Alternate Before the recent coronavirus pandemic the football sector could be described with stable economic growth. The individual and cummulated revenue growth of football clubs are obviously in coherence with the nuncupation of player rights’, i.e. the player transfer activity of football clubs. The consecutive economical growth had it’s effect on player transfer values, since in the last decade constantly rising transfer prices could be experienced. In spite of the fact that this phenomenon carries a danger as well through the growth of player transfer values, by and large it contributes to the growth of the sector. European club football in total reported operating profits in 2018 for the second consecutive year. The continous development had been stopped by the COVID-19 pandemic. Matches were postponed and fans could only follow their teams via broadcasting. Restrictions had their effect not only on club revenue, but on players’ valuation as well, resulting 13-18% impairment on their market value by the analysis of the most costly transfers of the last transfer window.

Responding to a healthcare crisis such as COVID-19 requires a practiced, nimble incident command structure. Our medical center is in one of the areas in the US that was hardest hit by the initial wave. Effective leadership of incident command was critical in our response.

The article focuses on the Americans with Disabilities Act which acknowledges subjectivities and human rights involved in disabled identity and mentions that the coronavirus pandemic has brought into war of survival Topics discussed include biopolitics and thanatopolitics that might display to have been in opposition, proliferation of life that blunted emotional response and utilitarian guidelines adopted by several states

BackgroundConspiracy beliefs are associated with detrimental health attitudes during the coronavirus disease 2019 (Covid-19) pandemic. Most prior research on these issues was cross-sectional, however, and restricted to attitudes or behavioral intentions. The current research was designed to examine to what extent conspiracy beliefs predict health behavior and well-being over a longer period of time.MethodsIn this preregistered multi-wave study on a large Dutch research panel (weighted to provide nationally representative population estimates), we examined if conspiracy beliefs early in the pandemic (April 2020) would predict a range of concrete health and well-being outcomes eight months later (December 2020; N = 5745).ResultsThe results revealed that Covid-19 conspiracy beliefs prospectively predicted a decreased likelihood of getting tested for corona; if tested, an increased likelihood of the test coming out positive; and, an increased likelihood of having violated corona regulations, deteriorated economic outcomes (job loss; reduced income), experiences of social rejection, and decreased overall well-being. Most of these effects generalized to a broader susceptibility to conspiracy theories (i.e. conspiracy mentality).ConclusionsThese findings suggest that conspiracy beliefs are associated with a myriad of negative life outcomes in the long run. Conspiracy beliefs predict how well people have coped with the pandemic over a period of eight months, as reflected in their health behavior, and their economic and social well-being.

The quality of parental support is recognized as a crucial factor in the early stages of a student’s development, and particularly in instrumental music education. At the start of 2020, the outbreak of a global pandemic crisis posed new and unprecedented challenges to education, forcing families to stay at home to prevent contagion. This investigation was conducted during the period of a COVID pandemic lockdown in Portugal. We explored whether parental support, provided during the lockdown period, was associated with their child’s achievement as reported by their instrumental music teacher. For this study, 39 parent–teacher dyads of first-grade students of an instrument music course were recruited from two public music conservatories. Parents supplied information on the frequency in which they provided student-support-related attitudes and actions in the home context. Simultaneously, teachers provided information about the student’s achievement during the lockdown compared with the previous in-person performance period. Results indicate a strong relationship between parental support and musical achievement, with students who received higher levels of supportive parental involvement performing better than before the pandemic crisis. The findings are discussed in relation to the importance of parental involvement in a child’s instrumental music education.

OBJECTIVE: To assess participant attendance and engagement for an in-person Canadian Ophthalmological Society (COS) annual meeting (2019) compared with a virtual COS annual meeting (2020). DESIGN: Retrospective case-control study of key event metrics of the 2019 and 2020 COS meetings as well as Twitter activity. METHODS: Key annual meeting metrics were collected retrospectively for 2020 virtual meeting and compared with the most recent in-person annual meeting cohort from 2019. Metrics collected included attendance by ophthalmology specialist, geographic distribution of attendees, postevent survey rate, and social media engagement (Twitter). RESULTS: Overall, there was a 7% (n = 60) increase in the number of registrants between 2019 and 2020. The largest change noted was the increase in registrants from British Columbia (n = 78). More ophthalmologists registered for the 2020 meeting than for 2019 meeting (627 versus 592). Of those who registered for the meeting, meeting participation (defined as checking in for the 2019 and logging in for the 2020 meetings) increased from 70% in 2019 to 79% in 2020. There was a 158% (n = 15 000) increase in tweet impressions in 2020 compared with 2019. CONCLUSION: The first COS virtual meeting attracted more participants and was available to a geographically wider audience. Indeed, more professionals from provinces that are geographically further from the traditional COS meeting locations were able to participate in the event. Meeting engagement on a social media platform increased in the virtual meeting in 2020 relative to the in-person meeting in 2019, and possible enablers for increased engagement should be sought and incorporated into future meetings.

In recent years, there has been an increasing interest in the development of arthroplasty registries, therefore, in our country, the Italian Arthroplasty Registry (RIAP), was issued by the National Law No. 221/2012. In the last decade, however, some European countries -namely Sweden, Denmark, Norway, and Germany (in development)- have introduced another nationwide orthopaedic registry than arthroplasty registers: the fracture registry. The development of this new tool aims to improve quality and safety in fracture management, thus trying to provide a better postoperative quality of life in trauma patients. Based on these findings, the AO-Trauma Italy Council encouraged the development of a national fracture registry in Italy. The present study aims to (1) provide an overview of the fracture registries in Europe and (2) to develop, for the first time, a pilot Italian Fracture Registry (RIFra). Thirteen AO-Trauma Italy members, chairmen of Level-I orthopaedic and trauma centres, diffused throughout Italy, were involved in the RIFra project. The RIFra form, developed between November 2019 and March 2020, consists of 5 main sections, namely: epidemiologic data, previous surgical procedure (if any), patient and fracture features, surgical procedure, surgical implant details. This study constitutes the first step to start, in future years, the bureaucratic procedure leading to the final establishment of a RIAP-like fracture registry in Italy.

The state of alarm was declared in Spain due to the COVID-19 epidemic on March 14, 2020, and established population confinement measures. The objective is to describe the process of lifting these mitigation measures.The Plan for the Transition to a New Normality, approved on April 28, contained four sequential phases with progressive increase in socio-economic activities and population mobility. In parallel, a new strategy for early diagnosis, surveillance and control was implemented. A bilateral decision mechanism was established between the Spanish Government and the autonomous communities (AC), guided by a set of qualitative and quantitative indicators capturing the epidemiological situation and core capacities. The territorial units were established ad-hoc and could be from Basic Health Zones to entire AC.The process run from May 4 to June 21, 2020. AC implemented plans for reinforcement of core capacities. Incidence decreased from a median (50% of territories) of 7.4 per 100,000 in 7 days at the beginning to 2.5 at the end. Median PCR testing increased from 53% to 89% of suspected cases and PCR total capacity from 4.5 to 9.8 per 1000 inhabitants weekly; positivity rate decreased from 3.5% to 1.8%. Median proportion of cases with traced contacts increased from 82% to 100%.Systematic data collection, analysis, and interterritorial dialogue allowed adequate process control. The epidemiological situation improved but, mostly, the process entailed a great reinforcement of core response capacities nation-wide, under common criteria. Maintaining and further reinforcing capacities remained crucial for responding to future waves.El 14 de marzo de 2020 España declaró el estado de alarma por la pandemia por COVID-19 incluyendo medidas de confinamiento. El objetivo es describir el proceso de desescalada de estas medidas.Un plan de transición hacia una nueva normalidad, del 28 de abril, incluía 4 fases secuenciales incrementando progresivamente las actividades socioeconómicas y la movilidad. Concomitantemente, se implementó una nueva estrategia de diagnóstico precoz, vigilancia y control. Se estableció un mecanismo de decisión bilateral entre Gobierno central y comunidades autónomas (CCAA), guiado por un panel de indicadores cualitativos y cuantitativos de la situación epidemiológica y las capacidades básicas. Las unidades territoriales evaluadas comprendían desde zonas básicas de salud hasta CCAA.El proceso se extendió del 4 de mayo al 21 de junio y se asoció a planes de refuerzo de las capacidades en las CCAA. La incidencia disminuyó de una mediana inicial de 7,4 por 100.000 en 7 días a 2,5 al final del proceso. La mediana de pruebas PCR aumentó del 53% al 89% de los casos sospechosos, y la capacidad total de 4,5 a 9,8 pruebas semanales por 1.000 habitantes; la positividad disminuyó del 3,5% al 1,8%. La mediana de casos con contactos trazados aumentó del 82% al 100%.La recogida y análisis sistemático de información y el diálogo interterritorial logaron un adecuado control del proceso. La situación epidemiológica mejoró, pero sobre todo, se aumentaron las capacidades, en todo el país y con criterios comunes, cuyo mantenimiento y refuerzo fue clave en olas sucesivas.

This article describes two studies which aimed to explore the impacts of pedestrianisation or road closures on traffic displacement, travel behaviour and the phenomenon of 'disappearing traffic'. The first study surveyed residents whose travel routes were affected by a small-scale localised pedestrianisation scheme in the centre of a town. The second measured the traffic impacts of a temporary closure of a strategic bridge in a city centre. In the first case the pedestrianisation produced no change in the modal shares of residents' travel. Drivers continued to drive to the same locations by longer routes. In the second case, the closure caused some traffic displacement and increased journey times but also reduced traffic volumes in both the immediate area and across the city. It concludes by discussing the remaining knowledge gaps on disappearing traffic, made more pressing by the decisions of authorities to reallocate road space during the COVID-19 crisis. © 2021 ICE Publishing. All rights reserved.

COVID-19 is one of the biggest pandemics that the world is facing today, and every day, we are coming up with new challenges in this area. Still, much research is already going on to overcome this pandemic, and we also get succeeded to some extent. Diverse sources such as MRI, CT scanning, blood samples, X-ray image, and many more are available to detect COVID-19. Thus, it can be easily said that through image processing, the classification of COVID-19 can be done. In this study, the COVID-19 detection is done by classifying with the use of a type of convolutional neural network termed a detail-oriented capsule network. Chest CT scan imaging for the prediction of COVID-19 and non-COVID-19 are classified in the present paper using a Detailed Oriented capsule network (DOCN). Accuracy, specificity, and sensitivity are parameters used for model evaluation. The proposed model has achieved 98% accuracy, 81% sensitivity, and 98.4% specificity.

Coronavirus disease 2019 has affected more than 4 million people throughout the world since December 2019. It seems this infection has been the most insidious virus of the coronavirus family. This virus causes severe respiratory failure and symptoms in patients and can result in death. Designing a restrict protocol to deal with infections from severe acute respiratory syndrome coronavirus type 2 is critical in cell therapy institutes. In this review, we present the important aspects related to this virus in cell therapy protocols.

The grim milestone of three million deaths due to the global pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reached a few weeks ago. COVID-19 is a multi-system all-pervasive disease with protean manifestations, and its major signs and symptoms, such as the incessant dry cough, fever, and pneumonia, are well known. Yet, its mucocutaneous manifestations, particularly those of the oral cavity, appear to be little recognized. This may be due either to the rarity of oral manifestations of COVID-19, or poor detection of such symptoms by attending physicians who may do only a cursory examination of the oral mucosa because of the overwhelming gravity of the other major systemic presentations. Nevertheless, there are now a considerable number of reports, including systematic reviews, on oral manifestations of COVID-19 in the literature. These, apart from the now well-known dysgeusia of COVID-19, range from ulcers, erosions, bullae, vesicles, mucosal pustules, macules, papules and pigmentations, as well as haemorrhagic manifestations including petechiae, crusts and spontaneous bleeding. Unfortunately, the majority of these reports are anecdotal in nature and remain to be substantiated. Here, we provide a brief overview of the reported oral manifestations of COVID-19, and their management protocols. CPD/Clinical Relevance: To raise awareness of the currently reported major and minor oral manifestations of COVID-19 and their management protocols.

Nanotechnology in association with herbal medicine can lead to enhanced therapeutic and diminished adverse effects of medication. In turn, it can lead to synergistic effects of administered compound overcoming its demerits. Nowadays, the trend of herbal compounds to treat even a small illness is gaining momentum. Gone are the days when the ineffectiveness of a compound was impossible to be dealt with. Nevertheless, in this competitive era of science and innovative technology, it has become possible to maximize the usefulness of ineffective yet potent herbal compounds. The demand for herbal compounds is getting amplified because of their ability to treat a myriad of diseases, including COVID-19, showing fewer side effects. The merger of nanotechnology with traditional medicine augments the potential of herbal drugs for devastating dangerous and chronic diseases like cancer. In this review article, we have tried to assimilate the complete information regarding the use of different nanocarriers to overcome the drawbacks of herbal compounds. In addition, all the recent advancements in the herbal field, as well as the future exploration to be emphasized, have been discussed.

The B.1.1.7 (Alpha) variant has been detected in Mumbai, India during February 2021. Subsequently, we retrieved 43 sequences from specimens of 51 COVID-19 cases from Mumbai. The sequence analysis revealed that the cases were mainly affected with Alpha variant which suggests its role in community transmission of SARS-CoV-2 in Mumbai, India.

There are plenty of parking spaces in big cities, but we often find nowhere to park The reason is the lack of prediction of parking behavior If we could provide parking behavior in advance, we can ease this parking problem that affects human well-being We observe that parking lots have periodic parking patterns, which is an important factor for parking behavior prediction Unfortunately, existing work ignores such periodic parking patterns in parking behavior prediction, and thus incurs low accuracy To solve this problem, we propose PewLSTM, a novel periodic weather-aware LSTM model that successfully predicts the parking behavior based on historical records, weather, environments, weekdays, and events PewLSTM consists of two parts: a periodic weather-aware LSTM prediction module and an event prediction module, for predicting parking behaviors in regular days and events Based on 910,477 real parking records in 904 days from 13 parking lots, PewLSTM yields 93 84% parking prediction accuracy, which is about 30% higher than the state-of-the-art parking behavior prediction method We have also analyzed parking behaviors in events like holidays and COVID-19;PewLSTM can also handle parking behavior prediction in events and reaches 90 68% accuracy IEEE

The COVID-19 pandemic has severely affected urban transport patterns, including the way residents travel. It is of great significance to predict the demand of urban ride-hailing for residents' healthy travel, rational platform operation, and traffic control during the epidemic period. In this paper, we propose a deep learning model, called MOS-BiAtten, based on multi-head spatial attention mechanism and bidirectional attention mechanism for ride-hailing demand prediction. The model follows the encoder-decoder framework with a multi-output strategy for multi-steps prediction. The pre-predicted result and the historical demand data are extracted as two aspects of bidirectional attention flow, so as to further explore the complicated spatiotemporal correlations between the historical, present and future information. The proposed model is evaluated on the real-world dataset during COVID-19 in Beijing, and the experimental results demonstrate that MOS-BiAtten achieves a better performance compared with the state-of-art methods. Meanwhile, another dataset is used to verify the generalization performance of the model. IEEE

The novel coronavirus (COVID-19) is negatively impacting vulnerable and marginalized communities. Growing research among sexual and gender minority communities shows increased COVID-19 risk and burden due to underlying social structure factors, however, not as much is known about the impact on trans women. Our team gathered data on COVID-19 risk, self-reported prevalence, and testing behaviors as part of an ongoing study of trans women's HIV risk and partnerships to fill this gap in data.This is a secondary analysis of data from The Partners Study, a study of HIV risk and transmission among trans women and their sexual partners in the San Francisco Bay Area. We collected COVID-19-related data from 87 trans women from July 2020 to January 2021. Participants were asked whether they were tested for COVID-19, had symptoms, or tested positive for the virus between March 2020 to the time they were screened to participate for a survey interview.The majority of trans women did not report experiencing COVID-19 symptoms (85.05%,The COVID-19 prevalence among trans women in our sample was higher than in other gender groups in San Francisco, suggesting that trans women may be disproportionately impacted by this disease. More research is needed to determine the impact of COVID-19 on trans women, and to develop strategies to increase testing and vaccinations among vulnerable communities preventing onward spread.

An 80-year-old female presented to the emergency department with a 3-week history of worsening digital discolouration. She explained that her right little finger was affected first, turning blue and then blistering at the tip ([figure 1][1]). Her left index finger tip subsequently turned black, and

A 74-year-old woman presented with fever, jaw claudication and bilateral temporal pain lasting for 1 week. On examination, the bilateral temporal arteries (TAs) were nodularly swollen, tender and hypopulsatile ([figure 1A][1]). A blood test showed elevated white cell count (9.33×109/L), high

Pacing-induced cardiomyopathy (PICM) consists of heart failure (HF) associated with a drop in the left ventricular ejection fraction (LVEF) in the setting of high-burden right ventricular pacing, with presentation that may range from subclinical to severe. Time to manifestation can go from weeks to years after device implantation. Treatment typically consists in an upgrade to a cardiac resynchronisation therapy (CRT) or His bundle pacing (HisP). Several risk factors for PICM have been described and should be considered before pacemaker (PM) implantation, as thorough patient selection for de novo CRT or HisP, may preclude its manifestation. We present the case of an 82-year-old patient presenting with acute congestive HF and new severely reduced LVEF, 30 days following dual chamber PM implantation for high-grade atrioventricular block. Treatment with HF medication and upgrade to a CRT permitted rapid resolution of the symptoms and normalisation of the LVEF at 1-month follow-up.

In 1961, K Merendino ‘in pure curiosity’, while tracking the murmur of mitral regurgitation, placed his stethoscope ‘on the vertex of the head’, and ultimately led to a medical curiosity and exam finding that not only bears his name, but awes medical learners at all stages of their careers. Merendino and colleagues collected seven such cases of the ‘Murmur on Top of the Head’ building on the work of others who provided a detailed description of mitral regurgitation and noted murmur radiation to the neck and cervical/lumbosacral spine. The majority of patients suffered from rheumatic heart disease or subacute bacterial endocarditis in native heart valves. Here, we report on a case of the ‘Murmur on Top of the Head’ and provide the reader/listener with a direct recording of the ‘Merendino murmur’ (as well as its spinal correlate) in an elderly woman with a bioprosthetic mitral valve.

Objectives. To describe excess mortality during the COVID-19 pandemic in Guatemala during 2020 by week, age, sex, and place of death. Methods. We used mortality data from 2015 to 2020, gathered through the vital registration system of Guatemala. We calculated weekly mortality rates, overall and stratified by age, sex, and place of death. We fitted a generalized additive model to calculate excess deaths, adjusting for seasonality and secular trends and compared excess deaths to the official COVID-19 mortality count. Results. We found an initial decline of 26% in mortality rates during the first weeks of the pandemic in 2020, compared with 2015 to 2019. These declines were sustained through October 2020 for the population younger than 20 years and for deaths in public spaces and returned to normal from July onward in the population aged 20 to 39 years. We found a peak of 73% excess mortality in mid-July, especially in the population aged 40 years or older. We estimated a total of 8036 excess deaths (95% confidence interval = 7935, 8137) in 2020, 46% higher than the official COVID-19 mortality count. Conclusions. The extent of this health crisis is underestimated when COVID-19 confirmed death counts are used. (Am J Public Health. 2021;111(10): 1839–1846. https://doi.org/10.2105/AJPH.2021.306452)

In a sample of 28 individuals cohabiting with a partner in NYC, Boston, or Chicago, this study tested whether implementation of stay-home orders to combat the spread of COVID-19 disrupted physical activity and whether high-quality romantic relationships buffered adverse effects. Participants provided FitBit data between February and October, 2020. Stay-home orders were associated with a reduction in daily step counts, B = −1595.72, p = 0.018, increased sedentary minutes, B = 33.75, p = 0.002, and reduced daily minutes of light and moderate physical activity, B = –25.01, p = 0.011; B = –0.72, p = 0.021. No moderation effects emerged.