1. Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals
- Author
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James McKay, Jolanta Lissowska, Antonio Agudo, Valerie Gaborieau, Ivana Holcatova, Cristina Canova, George Xinarianos, Maria Paula Curado, Epic Study, John K. Field, Ray Lowry, Peter Rudnai, Pagona Lagiou, Paolo Boffetta, Luigi Barzan, Andres Metspalu, David Zaridze, David I. Conway, José Eluf-Neto, Vladimir Bencko, Dana Mates, Xavier Castellsagué, Elena Matos, Lenka Foretova, Neonilia Szeszenia-Dabrowska, Claire M. Healy, Ariana Znaor, Simone Benhamou, Kristian Hveem, Paul Brennan, Mia Hashibe, Vladimir Janout, Eleonora Fabianova, Maiken Bratt Elvestad, Triantafillos Liloglou, Tatiana V. Macfarlane, Frank Skorpen, Sergio Koifman, Geoffrey Liu, Simon Heath, Leticia Fernandez, John R. McLaughlin, Ana M. B. Menezes, Esther H. Lips, Amelie Chabrier, Mark Lathrop, Rayjean J. Hung, Franco Merletti, Lars J. Vatten, Kristina Kjærheim, Lips, E.H., Gaborieau, V., McKay, J.D., Chabrier, A., Hung, R.J., Boffetta, P., Hashibe, M., Zaridze, D., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Mates, D., Bencko, V., Foretova, L., Janout, V., Field, J.K., Liloglou, T., Xinarianos, G., McLaughlin, J., Liu, G., Skorpen, F., Elvestad, M.B., Hveem, K., Vatten, L., Benhamou, S., Lagiou, P., Holcátová, I., Merletti, F., Kjaerheim, K., Agudo, A., Castellsagué, X., Macfarlane, T.V., Barzan, L., Canova, C., Lowry, R., Conway, D.I., Znaor, A., Healy, C., Curado, M.P., Koifman, S., Eluf-Neto, J., Matos, E., Menezes, A., Fernandez, L., Metspalu, A., Heath, S., Lathrop, M., and Brennan, P.
- Subjects
Male ,medicine.medical_specialty ,Pathology ,Lung Neoplasms ,Genotype ,Epidemiology ,upper aerodigestive tract cancers ,smoking quantity ,15q25 gene variant ,Single-nucleotide polymorphism ,Genome-wide association study ,Receptors, Nicotinic ,Gastroenterology ,Polymorphism, Single Nucleotide ,tobacco ,smoking ,Internal medicine ,medicine ,Odds Ratio ,Humans ,cancer ,Allele ,15q25 gene ,Lung cancer ,Aged ,Chromosomes, Human, Pair 15 ,business.industry ,Cancer ,General Medicine ,Odds ratio ,Tobacco Use Disorder ,Middle Aged ,medicine.disease ,Minor allele frequency ,Genetic Epidemiology ,Female ,business ,Genome-Wide Association Study - Abstract
Background: Genetic variants in 15q25 have been identified as potential risk markers for lung cancer (LC), but controversy exists as to whether this is a direct association, or whether the 15q variant is simply a proxy for increased exposure to tobacco carcinogens. Methods: We performed a detailed analysis of one 15q single nucleotide polymorphism (SNP) (rs16969968) with smoking behaviour and cancer risk in a total of 17 300 subjects from five LC studies and four upper aerodigestive tract (UADT) cancer studies. Results: Subjects with one minor allele smoked on average 0.3 cigarettes per day (CPD) more, whereas subjects with the homozygous minor AA genotype smoked on average 1.2 CPD more than subjects with a GG genotype (P20 CPD) [odds ratio (OR)=1.13, 95% confidence interval (CI) 0.96-1.34, P=0.13 for heterozygotes and 1.81, 95% CI 1.39-2.35 for homozygotes, P
- Published
- 2010