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Supplemental material, sj-docx-1-tag-10.1177_17562848231177151 for Microscopic colitis is a risk factor for low bone density: a systematic review and meta-analysis by Anett Rancz, Brigitta Teutsch, Marie Anne Engh, Dániel Sándor Veres, László Földvári-Nagy, Bálint Erőss, Nóra Hosszúfalusi, Márk Félix Juhász, Péter Hegyi and Emese Mihály in Therapeutic Advances in Gastroenterology

Supplemental material, sj-docx-1-taw-10.1177_20420986231181338 for Survival outcomes of beta-blocker usage in HER2-positive advanced breast cancer patients: a retrospective cohort study by Hui-Hsia Hsieh, Tien-Yuan Wu, Chi-Hua Chen, Yu-Hung Kuo and Mann-Jen Hour in Therapeutic Advances in Drug Safety

Supplemental material, sj-docx-1-sco-10.1177_2050313X231154064 for Use of threshold PEP with an adult non-rebreather oxygen mask plus prone positioning in acute hypoxemic respiratory failure due to SARS-CoV-2 infection during the collapse of the health system in a low-income country by Killen H Briones-Claudett, Monica H Briones-Claudett, Eduardo A Martinez Armijos, Jorge J Rios-Marcillo, Lourdes A Orozco Holguin, Killen H Briones-Zamora, Diana C Briones-Marquez, Andrea P Icaza-Freire and Michelle Grunauer in SAGE Open Medical Case Reports

Supplemental material, sj-docx-1-dhj-10.1177_20552076231155681 for The quality of informational social support in online health communities: A content analysis of cancer-related discussions by Gregor Petrič, Marjan Cugmas, Rok Petrič and Sara Atanasova in Digital Health

Supplemental material, sj-docx-1-dhj-10.1177_20552076231174095 for Student perspectives on the integration of artificial intelligence into healthcare services by Muna N Ahmad, Saja A Abdallah, Saddam A Abbasi and Atiyeh M Abdallah in DIGITAL HEALTH

Supplemental Material for Delivering Genetic Testing for Patients with Prostate Cancer: Moving Beyond Provider Knowledge as a Barrier to Care by Christine M. Gunn, Emma X. Li, Gretchen A. Gignac, Magdalena Pankowska, Stephanie Loo, Kimberly Zayhowski, Catharine Wang in Cancer Control

Supplemental material, sj-docx-3-ict-10.1177_15347354231162080 for The Herbal Medicine Suanzaoren (Ziziphi Spinosae Semen) for Sleep Quality Improvements: A Systematic Review and Meta-analysis by Mingxiao Yang, Hui Wang, Yi Lily Zhang, Furong Zhang, Xiaotong Li, Soo-Dam Kim, Yalan Chen, Jiyao Chen, Susan Chimonas, Deborah Korenstein and Jun J. Mao in Integrative Cancer Therapies

Supplemental material, sj-docx-1-tam-10.1177_17588359221148541 for Atezolizumab plus bevacizumab in patients with child–Pugh B advanced hepatocellular carcinoma by Jaekyung Cheon, Hyeyeong Kim, Han Sang Kim, Chang Gon Kim, Ilhwan Kim, Beodeul Kang, Chan Kim, Sanghoon Jung, Yeonjung Ha and Hong Jae Chon in Therapeutic Advances in Medical Oncology

Supplemental material, sj-docx-1-taw-10.1177_20420986231178126 for Risk of lower limb amputation in diabetic patients using SGLT2 inhibitors versus DPP4 inhibitors or GLP-1 agonists: a meta-analysis of 2 million patients by Yang Lu and Caiyun Guo in Therapeutic Advances in Drug Safety

Supplemental material, sj-docx-1-tct-10.1177_15330338221146024 for RhoA G17E/Vav1 Signaling Induces Cancer Invasion via Matrix Metalloproteinase-9 in Gastric Cancer by Satoshi Nakamura, MD, Masato Kitazawa, MD, PhD, Yusuke Miyagawa, MD, PhD, Makoto Koyama, MD, PhD, Satoru Miyazaki, MD, Nao Hondo, MD, Futoshi Muranaka, MD, PhD, Shigeo Tokumaru, MD, Yuta Yamamoto, MD, PhD, Takehito Ehara, MD, PhD, Tomio Matsumura, PhD, Michiko Takeoka, PhD, and Yuji Soejima, MD, PhD in Technology in Cancer Research & Treatment

Supplemental material, sj-pdf-1-imr-10.1177_03000605231177187 for Oximetry at admission as a predictor of tomographic and functional impairment after 3–6 months in hospitalized patients with COVID-19 by Pedro Maximink Esteves Villar, Paulo Roberto Araújo Mendes, Tatiana Alves Kiyota, Henrique Alcântara Engleitner, Carolina Salem Tamesawa, Mayara Magalhães Morello, Nayara Nobre Basso, Lucas Fileti Arruda, Bruna Scharlack Vian, Lígia dos Santos Roceto Ratti, Laís Bacchin de Oliveira, Ana Lucia Cavallaro Baraúna Lima, Hugo Dugolin Ceccato, Julian Furtado Silva, Wander de Oliveira Villalba, Lucieni de Oliveira Conterno, Mariângela Ribeiro Resende and Mônica Corso Pereira in Journal of International Medical Research

Supplemental material, sj-pdf-1-imr-10.1177_03000605231179817 for Delayed gadolinium contrast-enhanced 3D-T1 SPACE STIR sequence can better visualize abnormal cranial nerves: a case report by Lu Zhang, Zhilei Kang, Mingyue Hu and Jingzhe Han in Journal of International Medical Research

The EGFR/RAS/MEK/ERK signaling pathway (ERK/MAPK) is hyperactivated in most colorectal cancers. A current limitation of inhibitors of this pathway is that they primarily induce cytostatic effects in colorectal cancer cells. Nevertheless, these drugs do induce expression of proapoptotic factors, suggesting they may prime colorectal cancer cells to undergo apoptosis. As histone deacetylase inhibitors (HDACis) induce expression of multiple proapoptotic proteins, we examined whether they could synergize with ERK/MAPK inhibitors to trigger colorectal cancer cell apoptosis. Combined MEK/ERK and HDAC inhibition synergistically induced apoptosis in colorectal cancer cell lines and patient-derived tumor organoids in vitro, and attenuated Apc-initiated adenoma formation in vivo. Mechanistically, combined MAPK/HDAC inhibition enhanced expression of the BH3-only proapoptotic proteins BIM and BMF, and their knockdown significantly attenuated MAPK/HDAC inhibitor–induced apoptosis. Importantly, we demonstrate that the paradigm of combined MAPK/HDAC inhibitor treatment to induce apoptosis can be tailored to specific MAPK genotypes in colorectal cancers, by combining an HDAC inhibitor with either an EGFR, KRASG12C or BRAFV600 inhibitor in KRAS/BRAFWT; KRASG12C, BRAFV600E colorectal cancer cell lines, respectively. These findings identify a series of ERK/MAPK genotype-tailored treatment strategies that can readily undergo clinical testing for the treatment of colorectal cancer.

Supplemental material, sj-docx-2-ict-10.1177_15347354231162080 for The Herbal Medicine Suanzaoren (Ziziphi Spinosae Semen) for Sleep Quality Improvements: A Systematic Review and Meta-analysis by Mingxiao Yang, Hui Wang, Yi Lily Zhang, Furong Zhang, Xiaotong Li, Soo-Dam Kim, Yalan Chen, Jiyao Chen, Susan Chimonas, Deborah Korenstein and Jun J. Mao in Integrative Cancer Therapies

Supplemental material, sj-docx-5-tct-10.1177_15330338231180776 for A Nomogram Based on the Log Odds of Positive Lymph Nodes Predicts the Prognosis of Patients with Colon Neuroendocrine Tumors After Surgery: A Surveillance, Epidemiology, and End Results Population-Based Study by Xue Zhang, Kui Zhang, Su Li and Aman Xu in Technology in Cancer Research & Treatment

Supplemental material, sj-docx-1-tag-10.1177_17562848231168199 for Changes in fecal metabolic and lipidomic features by anti-TNF treatment and prediction of clinical remission in patients with ulcerative colitis by Seok-Young Kim, Seung Yong Shin, Soo Jung Park, Jong Pil Im, Hyo Jong Kim, Kang-Moon Lee, Ji Won Kim, Sung-Ae Jung, Jun Lee, Sang-Bum Kang, Sung Jae Shin, Eun Sun Kim, You Sun Kim, Tae Oh Kim, Hyun-Soo Kim, Dong Il Park, Hyung Kil Kim, Eun Soo Kim, Young-Ho Kim, Dennis Teng, Jong-Hwa Kim, Wonyong Kim, Maham Saeed, Jung Min Moon, Kisung Kim, Chang Hwan Choi and Hyung-Kyoon Choi in Therapeutic Advances in Gastroenterology

Supplemental material, sj-docx-1-dhj-10.1177_20552076231173304 for An artificial intelligence-based chatbot for prostate cancer education: Design and patient evaluation study by Magdalena Görtz, Kilian Baumgärtner, Tamara Schmid, Marc Muschko, Philipp Woessner, Axel Gerlach, Michael Byczkowski, Holger Sültmann, Stefan Duensing and Markus Hohenfellner in DIGITAL HEALTH

Supplemental material, sj-docx-1-tag-10.1177_17562848231160625 for Three-dimensional reconstruction of computed tomography colonography discloses anatomic features associated with colonoscopy failure by David Hochstein, Shai Tejman-Yarden, Olga Saukhat, Oliana Vazgovski, Yisrael Parmet, Netanel Nagar, Edward Ram and Dan Carter in Therapeutic Advances in Gastroenterology

Supplemental material, sj-pdf-1-imr-10.1177_03000605231172452 for Suicide literacy and attitudes toward psychological help-seeking: a cross-sectional study of students by Emilijus Žilinskas and Sigita Lesinskienė in Journal of International Medical Research

Supplemental material, sj-docx-1-dhj-10.1177_20552076231169824 for Mental health support for and telehealth use by Australians living with borderline personality disorder during the onset of the COVID-19 pandemic: A national study by Parvaneh Heidari, Jillian H Broadbear, Rita Brown, Nitin P Dharwadkar and Sathya Rao in DIGITAL HEALTH

Supplemental material, sj-docx-1-smo-10.1177_20503121231152090 for A qualitative assessment of provider satisfaction and experiences with a COVID-19 community mobile health clinic outreach model in underserved Baltimore neighborhoods by Kechna Cadet, David R Baker and Annice Brown in SAGE Open Medicine

Supplemental material, sj-docx-2-jbm-10.1177_03936155231165068 for MMR markers correlate with clinical outcome in patients with esophageal squamous cell carcinoma by Takuro Yamauchi, Fumiyoshi Fujishima, Junichi Tsunokake, Atsushi Kunimitsu, Ryujiro Akaishi, Yohei Ozawa, Toshiaki Fukutomi, Hiroshi Okamoto, Chiaki Sato, Yusuke Taniyama, Takashi Kamei, Ryo Ichinohasama and Hironobu Sasano in The International Journal of Biological Markers

Supplemental material, sj-docx-2-tam-10.1177_17588359221148918 for Comparison of efficacy and tolerability of adjuvant therapy for resected high-risk stage III-IV cutaneous melanoma: a systemic review and Bayesian network meta-analysis by He Ba, Fangyuan Zhu, Xiaoze Zhang, Zubing Mei and Yaodong Zhu in Therapeutic Advances in Medical Oncology

Supplemental material, sj-docx-5-taw-10.1177_20420986221143830 for Therapy of women with multiple sclerosis: an analysis of the use of drugs that may have adverse effects on the unborn child in the event of (unplanned) pregnancy by Marie-Celine Haker, Niklas Frahm, Michael Hecker, Silvan Elias Langhorst, Pegah Mashhadiakbar, Jane Louisa Debus, Barbara Streckenbach, Julia Baldt, Felicita Heidler and Uwe Klaus Zettl in Therapeutic Advances in Drug Safety

Supplemental material, sj-docx-2-tag-10.1177_17562848231170948 for Free antibodies-to-infliximab are biomarker for predicting the effect of dose intensification in pediatric Crohn’s disease patients with secondary loss of response by Eun Sil Kim, Yiyoung Kwon, Yon Ho Choe and Mi Jin Kim in Therapeutic Advances in Gastroenterology

Supplemental material, sj-docx-1-tag-10.1177_17562848231168714 for Real-world outcomes associated with vonoprazan-based versus proton pump inhibitor-based therapy for Helicobacter pylori infection in Japan by Colin W. Howden, Erin E. Cook, Elyse Swallow, Karen Yang, Helen Guo, Corey Pelletier, Rinu Jacob and Kentaro Sugano in Therapeutic Advances in Gastroenterology

Supplemental material, sj-docx-1-tam-10.1177_17588359231173181 for Oxaliplatin prior to PARP inhibitor in BRCA-mutated ovarian cancer by Maria Ornella Nicoletto, Alessandra Baldoni, Francesco Cavallin, Andrea Grego, Cristina Falci, Margherita Nardin, Enzo Mammano, Eleonora Lai and Valter Torri in Therapeutic Advances in Medical Oncology

Supplemental material, sj-docx-2-dhj-10.1177_20552076231177146 for Subjective well-being, happiness, and environmental health factors related to women planning a pregnancy or pregnant, using mobile health intervention by Juan Antonio Ortega-García, Miguel Felipe Sánchez-Sauco, José Alberto Zafra-Rodríguez, Laura Teresa Cabrera-Rivera, Francisco Díaz-Martínez, Eduardo Manuel Llegus-Santiago, Juan Luis Delgado-Marín, Esteban Orenes-Piñero, Nicole Kloosterman, Albert Bach, Carlos Ojeda-Sánchez and Rebecca Ramis in DIGITAL HEALTH

Supplemental material, sj-docx-2-tag-10.1177_17562848231154103 for Real-life effectiveness and safety of tofacitinib treatment in patients with ulcerative colitis: a KASID multicenter cohort study by Seung Hwan Shin, Kyunghwan Oh, Sung Noh Hong, Jungbok Lee, Shin Ju Oh, Eun Soo Kim, Soo-Young Na, Sang-Bum Kang, Seong-Joon Koh, Ki Bae Bang, Sung-Ae Jung, Sung Hoon Jung, Kyeong Ok Kim, Sang Hyoung Park, Suk-Kyun Yang, Chang Hwan Choi and Byong Duk Ye in Therapeutic Advances in Gastroenterology

Supplemental material, sj-docx-1-dhj-10.1177_20552076231163786 for Smartphone app-based intervention for reducing stress, depression, and anxiety in caregivers of people with dementia in Vietnam: Study protocol for a pilot randomized controlled trial by The NH Than, Tran TT Nguyen, Tuan C Nguyen, Lan TD Vu, Phong T Vo, Khoa TTruong, Penelope Schofield and Tuan A Nguyen in Digital Health

Supplemental material, sj-docx-1-dhj-10.1177_20552076231163783 for Validation of the influence of biosignals on performance of machine learning algorithms for sleep stage classification by Junggu Choi, Seohyun Kwon, Sohyun Park and Sanghoon Han in Digital Health

Supplemental material, sj-pdf-1-imr-10.1177_03000605221121952 for Spinal subdural hematoma in a patient with immune thrombocytopenic purpura following microvascular decompression: a rare case report by Daoqing Su, Zonglei Chong, Ran Ran, Xiaoxiao Peng, Lei Hou, Qiang Zong and Hongxing Li in Journal of International Medical Research

Supplemental material, sj-docx-1-taw-10.1177_20420986231181334 for Assessing adverse drug reaction reports for antidiabetic medications approved by the food and drug administration between 2012 and 2017: a pharmacovigilance study by Britney A. Stottlemyer, Michael C. McDermott, Mackenzie R. Minogue, Matthew P. Gray, Richard D. Boyce and Sandra L. Kane-Gill in Therapeutic Advances in Drug Safety

Supplemental material, sj-docx-2-smo-10.1177_20503121231158017 for Knowledge of Jordanian women of reproductive age who underwent bariatric surgery and its effect on birth outcomes: A cross-sectional study by Zainah Assaf, Hana Taha, Immanuel Azaad Moonesar, Firas Obeidat, Eman F Badran, Mazen Al-Nabelsi and Raeda Al Qutob in SAGE Open Medicine

Supplemental material, sj-docx-1-smo-10.1177_20503121221143578 for Investigating the challenges of clinical education from the viewpoint of nursing educators and students: A cross-sectional study by Ashrafalsadat Hakim in SAGE Open Medicine

Supplemental material, sj-pdf-1-imr-10.1177_03000605221147186 for Impact of oral health management on mental health and psychological disease: a scoping review by Shinpei Matsuda and Hitoshi Yoshimura in Journal of International Medical Research

Supplemental Material for Integrating Bulk-seq and Single-cell-seq Reveals Estrogen and MAPK Pathways Associating with Neuroblastoma Outcome by Xin Li, Yanlong Zheng, Qiao Ge, Zhenbo Dai, Dejun Zhou and Xiangdong Tian in Cancer Control

Supplemental material, sj-docx-3-taw-10.1177_20420986231159221 for Developing and piloting a cross-sectoral hospital pharmacist intervention for patients in transition between hospital and general practice by Charlotte Arp Sørensen, Linda Jeffery, Jannik Falhof, Philipp Harbig, Klaus Roelsgaard, Solveig Gram and Charlotte Olesen in Therapeutic Advances in Drug Safety

Supplemental material, sj-docx-1-smo-10.1177_20503121231153758 for Radiotherapy services in low resource settings: The situation in Nigeria by Abidoye Matthew Akinwande, Daniel Chimuanya Ugwuanyi, Hyacienth Uche Chiegwu, Felicitas Idigo, Michael Promise Ogolodom, Chidinma Pamela Anakwenze, Roland Abi and Oluwaponmile Odukoya in SAGE Open Medicine

Supplemental material, sj-doc-2-dhj-10.1177_20552076231171482 for Neural networks based on attention architecture are robust to data missingness for early predicting hospital mortality in intensive care unit patients by Zhixuan Zeng, Yang Liu, Shuo Yao, Jiqiang Liu, Bing Xiao, Chenxue Liu and Xun Gong in DIGITAL HEALTH

Supplemental material, sj-docx-1-smo-10.1177_20503121221150104 for Prevalence of inappropriate drug dose adjustment and associated factors among inpatients with renal impairment in Africa: A systematic review and meta-analysis by Debalke Dale, Getahun Asmamaw, Teshale Etiso and Zebenay Bussa in SAGE Open Medicine

Research Data for Psychological factors and oral health during initial outbreak of COVID-19 in China: A cross-sectional study by Qiang Sun, Honglin Ren, Yueran Bian, Yesi Xie, Hui Shi: The International Headache Genetics Consortium (IHGC) in Journal of International Medical Research

Supplemental material, sj-docx-1-dhj-10.1177_20552076231180466 for Needs of patients with multi-morbidity and heart failure for the development of a mHealth to improve their self-management: A qualitative analysis by Pilar Bas-Sarmiento, Martina Fernández-Gutiérrez and Miriam Poza-Méndez, Mª Ángeles Carrasco-Bernal, Magdalena Cuenca-García, Mercedes Díaz-Rodríguez, Mª Paz Gómez-Jiménez, Olga Paloma-Castro, Alezandra Torres-Castaño, Antonio-Jesús Marín-Paz in DIGITAL HEALTH

Supplemental material, sj-doc-1-tag-10.1177_17562848221150306 for Clinical significance of neoadjuvant chemotherapy for locally advanced colorectal cancer patients with deficient mismatch repair: possibly residual value in the era of immunotherapy by Mian Chen, Junguo Chen, Jun Huang, Huashan Liu, Wuteng Cao, Shuangling Luo, Zhanzhen Liu, Huanxin Hu, Sicong Lai, Yujie Hou, Liang Kang and Liang Huang in Therapeutic Advances in Gastroenterology

Research Data for The impact of family social support on postpartum quality of life among Iranian women: structural equation modelling by Khadijeh Khademi, Mohammad Hossein Kaveh, Leila Ghahremani, Mahin Nazari and Masoud Karimi in Journal of International Medical Research

Supplemental material, sj-docx-5-dhj-10.1177_20552076221150581 for Designing a mobile health smokeless tobacco cessation intervention in Odisha, India: User and provider perspectives by Rajmohan Panda, Supriya Lahoti, Arti Mishra, Rajath R Prabhu, Sangeeta Das, Durga Madhab Satapathy and Irwin Nazareth in Digital Health

Supplemental material, sj-docx-4-dhj-10.1177_20552076231170696 for Development of a video-based evidence synthesis knowledge translation resource: Drawing on a user-centred design approach by Cristian Deliv, Declan Devane, El Putnam, Patricia Healy, Amanda Hall, Sarah Rosenbaum and Elaine Toomey in DIGITAL HEALTH

Supplemental material, sj-pdf-1-imr-10.1177_03000605231180053 for Clinical manifestations, diagnosis, treatment, and outcome of pyogenic liver abscess: a retrospective study by Hui Wang and Xiujie Xue in Journal of International Medical Research

Background: Developing therapies for cancer cachexia has not been successful to date, in part due to the challenges of achieving robust quantitative measures as a readout of patient treatment. Hence, identifying biomarkers to assess the outcomes of treatments for cancer cachexia is of great interest and important for accelerating future clinical trials. Methods: We established a novel xenograft model for cancer cachexia with a cachectic human PC3* cell line, which was responsive to anti-Fn14 mAb treatment. Using RNA-seq and secretomic analysis, genes differentially expressed in cachectic and non-cachectic tumors were identified and validated by digital droplet PCR (ddPCR). Correlation analysis was performed to investigate their impact on survival in cancer patients. Results: A total of 46 genes were highly expressed in cachectic PC3* tumors, which were downregulated by anti-Fn14 mAb treatment. High expression of the top 10 candidates was correlated with low survival and high cachexia risk in different cancer types. Elevated levels of LCN2 were observed in serum samples from cachectic patients compared with non-cachectic cancer patients. Conclusion: The top 10 candidates identified in this study are candidates as potential biomarkers for cancer cachexia. The diagnostic value of LCN2 in detecting cancer cachexia is confirmed in patient samples.

Supplemental material, sj-pdf-1-opp-10.1177_10781552221117734 for Intravenous route for folate supplementation in a patient with celiac disease treated by pemetrexed-based chemotherapy for non-small-cell lung cancer by Marie Beaurain, Catherine Rioufol, Nicolas Vantard, Alexandre Teixeira, Amandine Baudouin, Chloe Herledan, Pierre-Jean Souquet, Sebastien Couraud, and Florence Ranchon in Journal of Oncology Pharmacy Practice