1. Reduction in liver fat by dietary MUFA in type 2 diabetes is helped by enhanced hepatic fat oxidation
- Author
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Giuseppina Costabile, Valentina Cicala, Lidia Patti, Daniele Naviglio, Paola Cipriano, Giovanni Annuzzi, Lutgarda Bozzetto, Chiara Piantadosi, Delia Luongo, Angela A. Rivellese, Bozzetto, Lutgarda, Costabile, Giuseppina, Luongo, Delia, Naviglio, Daniele, Cicala, Valentina, Piantadosi, Chiara, Patti, Lidia, Cipriano, Paola, Annuzzi, Giovanni, and Rivellese, ANGELA ALBAROSA
- Subjects
Adult ,Blood Glucose ,Male ,medicine.medical_specialty ,Stearoyl-coenzyme A desaturase ,1 activity ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Type 2 diabetes ,β-Oxidation ,030204 cardiovascular system & hematology ,β-Hydroxybutyrate ,De novo lipogenesi ,Stearoyl-coenzyme A desaturase-1 activity ,Fatty Acids, Monounsaturated ,03 medical and health sciences ,0302 clinical medicine ,Fat oxidation ,Internal medicine ,Liver fat ,Internal Medicine ,medicine ,Humans ,In patient ,De novo lipogenesis ,Monounsaturated fatty acid ,Aged ,Type 2 Diabete ,Monounsaturated fatty acids ,Chemistry ,Lipogenesis ,?-Oxidation ,Human physiology ,Middle Aged ,medicine.disease ,Postprandial Period ,Type 2 Diabetes ,Diet ,Endocrinology ,?-Hydroxybutyrate ,Diabetes Mellitus, Type 2 ,Liver ,Hepatic lipid ,lipids (amino acids, peptides, and proteins) ,Female ,Oxidation-Reduction ,Stearoyl-CoA Desaturase - Abstract
Aims/hypothesis The aim of this work was to investigate hepatic lipid metabolic processes possibly involved in the reduction of liver fat content (LF) observed in patients with type 2 diabetes after an isoenergetic diet enriched in monounsaturated fatty acids (MUFAs). Methods This is an ancillary analysis of a published study. In a parallel-group design, 30 men and eight women, aged 35-70 years, with type 2 diabetes and whose blood glucose was controlled satisfactorily (HbA1c< 7.5% [58 mmol/mol]) by diet or diet plus metformin, were randomised by MINIM software to follow either a high-carbohydrate/high-fibre/low-glycaemic index diet (CHO/fibre diet, n= 20) or a high-MUFA diet (MUFA diet, n= 18) for 8 weeks. The assigned diets were known for the participants and blinded for people doing measurements. Before and after intervention, LF was measured by 1 H-MRS (primary outcome) and indirect indices of de novo lipogenesis (DNL) (serum triacylglycerol palmitic:linoleic acid ratio), stearoyl-CoA desaturase activity (SCD-1) (serum triacylglycerol palmitoleic:palmitic acid ratio) and hepatic ?-oxidation of fatty acids (?-hydroxybutyrate plasma concentrations) were measured. Results LF was reduced by 30% after the MUFA diet, as already reported. Postprandial ?-hydroxybutyrate incremental AUC (iAUC) was significantly less suppressed after the MUFA diet (n = 16) (-2504 ± 4488 ?mol/l × 360 min vs baseline -9021 ± 6489 ?mol/l × 360 min) while it was unchanged after the CHO/fibre diet (n = 17) (-8168 ± 9827 ?mol/l × 360 min vs baseline -7206 ± 10,005 ?mol/l × 360 min, p = 0.962) (mean ± SD, p = 0.043). In the participants assigned to the MUFA diet, the change in postprandial ?-hydroxybutyrate iAUC was inversely associated with the change in LF (r = -0.642, p = 0.010). DNL and SCD-1 indirect indices did not change significantly after either of the dietary interventions. Conclusions/interpretation Postprandial hepatic oxidation of fatty acids is a metabolic process possibly involved in the reduction of LF by a MUFA-rich diet in patients with type 2 diabetes.
- Published
- 2016
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