Search

旨在为提高油橄榄冠层生产力及其树体的整形修剪、病虫害防治提供理论依据，以四川省凉山州主栽油橄榄品种克罗莱卡、科拉蒂、阿布桑娜、鄂植8号为研究对象，研究了4个品种油橄榄上、中、下冠层的果实表型性状、含油率、含水率，橄榄油酸度（以游离油酸含量计）、脂肪酸组成及相对含量变化情况，并采用主成分分析和熵权优劣解距离法（EW-TOPSIS）进行综合评价。结果表明：随着冠层部位由下至上，不同品种油橄榄单果质量、横径、鲜果含油率和不饱和脂肪酸相对含量呈上升趋势，而果形指数、硬度、酸度和饱和脂肪酸相对含量呈下降趋势，不同品种油橄榄鲜果含水率均为树体上部最低；主成分分析和EW-TOPSIS评价结果表明，同一品种冠层上部的综合评价值最大，中部次之，下部最小，其中鄂植8号上部在主成分分析中综合得分最高，科拉蒂上部在EW-TOPSIS中综合得分指数最高。综上，油橄榄树冠层上部的果实性状和品质优于中、下部，在整形修剪过程中，应对不同的冠层进行不同程度的整形修剪，通过改善通风透光性提高冠层生产力，防治病虫害。In order to provide theoretical basis for improving canopy position productivity and its tree shaping and pruning, disease and pest control, the main olive varieties Koroneiki, Coratina, Arbosana and Ezhi No. 8 in Liangshan Prefecture, Sichuan Province were used as the research objects, the changes of phenotypic traits, oil content, moisture content of fruit, and acidity (based on free oleic acid content), fatty acid composition and relative content of olive oil of four varieties of olives in the upper, middle and lower canopy were investigated, and a comprehensive evaluation was made using the principal component analysis method and Entropy Weight Technique for Order Preference by Similarity to Ideal Solution (EW-TOPSIS). The results showed that with the canopy position from the bottom to the top, different varieties of olive single mass, fruit transverse diameter, fresh fruit oil content and the relative content of unsaturated fatty acids showed an increasing trend, while the fruit shape index, fruit hardness, acidity and the relative content of saturated fatty acids showed a decreasing trend; the moisture content of fresh olive fruits of different varieties was the lowest in the upper position of the tree. The results of the principal component analysis and the evaluation of the EW-TOPSIS indicated that the upper canopy of the same variety had the highest composite score, followed by the middle one and the smallest one in the lower position, in which the upper position of Ezhi No. 8 had the highest composite score in the principal component analysis, and the upper position of Coratina had the highest composite score in the EW-TOPSIS. In conclusion, the fruit traits and quality of the upper position of olive tree are better than that of the middle and lower parts, and in the process of shaping and pruning, different degrees of shaping and pruning should be carried out on different canopy layers to improve the canopy productivity by improving ventilation and light transmission, and preventing pests and diseases.

目的评价经远桡动脉入路对肝肿瘤患者行肝动脉持续灌注化疗（HAIC）的安全性和舒适性。方法纳入中山大学附属第一医院放射介入科行经远桡动脉入路进行HAIC的肝肿瘤患者，患者进行1次股动脉入路和1次远桡动脉入路穿刺置管进行自身交叉对照。患者留置导管于肝动脉内行FOLFOX4方案持续动脉灌注化疗。使用生活质量评分量表比较患者远桡动脉入路和股动脉入路的生活质量评分以及记录手术相关并发症。结果共纳入患者18例肝肿瘤患者，其中9例先进行股动脉入路后进行远桡动脉入路HAIC，其余9例则先远桡入路再进行股动脉入路HAIC。dTRA期间，穿刺点血肿2例，穿刺点持续疼痛3例，左手掌麻木1例，均为1~2级手术相关的不良事件。没有发生3~4级手术相关的不良事件。术后超声检查显示近端桡动脉均通畅。dTRA和TFA之间的穿刺时间差异有统计学意义（4分 vs. 3分，Pvs. 2.72，Pvs. 7 h，P

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Materiae Compositae Sinica is the property of Acta Materiea Compositae Sinica Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的探讨术前经导管动脉栓塞（Pre-TAE）对Ⅱ/Ⅲ型颈动脉体瘤（CBTs）外科切除术的影响。方法回顾性分析2010年1月至2020年1月我院收治的影像及病理确诊的Ⅱ/Ⅲ型CBTs患者为研究对象，根据是否行Pre-TAE将患者分为栓塞组及未栓塞组。分析并比较两组患者临床资料、手术方式、术中出血量、手术时间、并发症等相关指标。结果本研究共纳入100个病灶（栓塞组n=77，未栓塞组n=23）。栓塞组与未栓塞组肿瘤大小分别为（Ⅱ： 40.91 vs. 37.32 mm， P > 0.05； Ⅲ： 63.58 vs. 65.75 mm， P > 0.05）。术中出血量以及手术时间分别为（Ⅱ：100 vs. 100 mL， P > 0.05；Ⅲ：750 vs. 1 000 mL， P > 0.05） 、（Ⅱ： 184.66 vs. 230.74 mins， P > 0.05； Ⅲ： 288.50 vs. 332.75 mins， P > 0.05）。尽管Pre-TAE能减少Ⅱ/Ⅲ型CBTs术中血管重建率（Ⅱ： 28% vs. 32%，P > 0.05；Ⅲ：58% vs. 100%， P > 0.05），但其差异无统计学意义。Ⅱ/Ⅲ型CBTs栓塞组手术并发症明显低于未栓塞组，其差异无统计学意义（Ⅱ： 22% vs. 47%， P = 0.026； Ⅲ： 50% vs. 75%， P > 0.05）。结论术前栓塞CBTs可有效降低术中失血量，改善手术视野可视化，从而有利于ShamblinⅡ/Ⅲ级CBTs的手术切除，减少手术时间，减少术中血管重建可能及手术并发症。

Copyright of Science Technology & Engineering is the property of Chinese Society of Technology Economics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Brewing is the property of China Brewing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Feed Industry is the property of Liaoning Provincial Institute of Agricultural Mechanization and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Medical Equipment Journal is the property of Chinese Medical Equipment Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Medical Equipment Journal is the property of Chinese Medical Equipment Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

头晕是脑小血管病临床最常见的症状和主诉之一，但临床工作中对于明确其病因存在困 难和认识偏差。最新研究发现有相当一部分头晕患者合并有脑小血管病，而且脑小血管病对于此类 头晕的临床特点、发生发展及转归变化有直接或间接的影响。因此，本文就脑小血管病相关头晕症 状进行综述，着重介绍脑小血管病相关头晕的临床表现及其发生机制。最终从神经内科角度出发， 对脑小血管病相关头晕的诊治方法和流程提出一些思考和总结。 Abstract: Dizziness is one of the most common complaints and symptoms in outpatients with cerebral small vessel disease (CSVD). The cause of dizziness is very complex. Recent studies showed that a large number of patients with dizziness also had CSVD, and CSVD played a direct or indirect effect on the clinical features, progression and outcome of dizziness in these patients. This article reviewed the clinical symptoms, pathogenesis and mechanisms of dizziness related with CSVD. The method and procedure of CSVD-related dizziness diagnosis and treatment in department of neurology were also discussed.

Copyright of Acta Agronomica Sinica is the property of Crop Science Society of China and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chemical Engineering (China) / Huaxue Gongcheng is the property of Hualu Engineering Science & Technology Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Data Acquisition & Processing / Shu Ju Cai Ji Yu Chu Li is the property of Editorial Department of Journal of Nanjing University of Aeronautics & Astronautics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Electronic Components & Materials is the property of Electronic Components & Materials and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Geomatics & Information Science of Wuhan University is the property of Geomatics & Information Science of Wuhan University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Mesenchymal stem cells are multipotent stromal cells isolated from bone marrow, fat, umbilical cord and other tissues. It can differentiate into different cell types and secrete a variety of proteins with therapeutic potential, which has a good application prospect in the repair of muscle tissue. OBJECTIVE: To review the research progress of mesenchymal stem cells in promoting muscle tissue repair and provide a theoretical basis for further clinical application. METHODS: Relevant articles published from inception to 2022 were retrieved from CNKI, VIP, WanFang, PubMed, Embase and Web of Science databases. The keywords were “mesenchymal stem cells, muscle tissue, muscle injury, muscle atrophy, exosomes, scaffolds” in Chinese and English. The literature about mesenchymal stem cell migration promoting muscle fiber proliferation and repair was screened. Finally, 98 articles were included for review and analysis. RESULTS AND CONCLUSION: (1) The related mechanisms of mesenchymal stem cell migration promoting muscle fiber proliferation and repair are complex, mostly by anti-inflammatory, inhibiting interstitial fibrosis, inhibiting the fat formation and other ways to promote muscle fiber proliferation and repair. (2) The related biological scaffolds and cell co-culture based on mesenchymal stem cells can significantly compensate for the low survival rate of mesenchymal stem cells after colonization. (3) At present, mesenchymal stem cell therapy still has apparent limitations. In the future, mesenchymal stem cells combined with other therapies should become the primary development trend. [ABSTRACT FROM AUTHOR]

Carbon nanotubes were selected as the reinforcing phase and a carbon nanotube toughened Al-Mg alloy composite material was prepared by stirring casting method. The effects of the amount of carbon nanotubes added on the mechanical properties, microstructure and toughness of the composite materials were studied, and the toughening mechanism of carbon nanotubes on Al-Mg alloy was explored. The results showed that the addition of an appropriate amount of carbon nanotubes refined the grain size of the Al-Mg alloy composite material, with a grain size of approximately 80/im. When the addition amount of carbon nanotubes was 0.8 wt%, the fracture morphology of the composite material was the most uniform. As the amount of carbon nanotubes added increased, the tensile strength, elongation at break, and hardness of the composite material showed a trend of first increasing and then decreasing. When the addition amount of carbon nanotubes was 0.8 wt%, the tensile strength, elongation at break, and hardness all reach their maximum values, which were 208.6 MPa, 15.8% and 53.1 HB, respectively. The addition of appropriate amount of carbon nanotubes significantly improves the toughness of Al-Mg alloy, gradually increasing the fracture elongation, prolonging the yield stage, and improving the toughness. This is because an appropriate amount of carbon nanotubes can bind well with the alloy and penetrate the cracks of the alloy, exerting a bridging effect and hindering the initiation and propagation of cracks, thereby improving the toughness of Al-Mg alloy composites, delaying the failure process of the alloy, and extending the yield stage of the alloy. Based on the above analysis, it can be concluded that the optimal addition amount of carbon nanotubes is 0.8 wt%. [ABSTRACT FROM AUTHOR]

Copyright of Acta Scientiarum Naturalium Universitatis Pekinensis is the property of Editorial Office of Acta Scientiarum Naturalium Universitatis Pekinensis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Geodesy & Geodynamics (1671-5942) is the property of Editorial Board Journal of Geodesy & Geodynamics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

【目的】评价支架治疗肠系膜上动脉夹层的近期临床效果。【方法】回顾中山大学附属第一医院放射介入科2009 年1 月至2018 年12 月收治的14 例肠系膜上动脉夹层并行支架置入治疗的患者作为研究对象，术中采用裸支架或者覆膜支架置入治疗肠系膜上动脉夹层。主要观察支架置入前后腹痛评分、肠系膜上动脉真腔内径的变化，并分析技术成功率和1 年内的支架通畅率。【结果】支架置入技术成功率达100%，术后腹痛症状改善（疼痛评分 5.9 vs. 1.9，P < 0.05），肠系膜上动脉真腔内径较术前有显著改善（6.6 mm vs. 2.6 mm，P < 0.05）。支架置入后12个月的通畅率为100%。【结论】支架置入治疗肠系膜上动脉夹层可改善腹痛症状及血管真腔内径，近期临床疗效好。

肝动脉化疗栓塞术（TACE）作为中晚期肝癌的首选治疗手段，经历了反复论证和不断完善的历程， 目前已经被各大指南所推荐。但在精准医学的时代，TACE 仍然面临很多新的挑战。目前 TACE 最主要的任务是提高其的有效性和安全性。同时顺应医学进步的要求，在包括肝癌的实体肿瘤全程医学管理中，明确其在各期肿瘤中的作用和地位，使其进一步使其成为一种标准化的治疗方案

Copyright of Journal of Anhui Agricultural Sciences is the property of Journal of Anhui Agricultural Sciences Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Fuzhou University is the property of Journal of Fuzhou University, Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Systems Engineering & Electronics is the property of Journal of Systems Engineering & Electronics Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Post-traumatic arthritis is one of the most common forms of osteoarthritis. In vivo and in vitro studies have shown that icariin can treat osteoarthritis through multiple targets and multiple pathways with no obvious side effects. However, the analgesic effect and mechanism of icariin on posttraumatic arthritis has not been reported. OBJECTIVE: To investigate the analgesic effect and mechanism of icariin on post-traumatic arthritis in rats. METHODS: Thirty male Sprague-Dawley rats were randomly divided into sham group (n=10), model group (n=10) and icariin group (n=10). The right knee anterior cruciate ligament was cut off in the model group and icariin group, while the right knee joint capsule was cut only in the sham group. The rats in the icariin group were given intragastric administration of icariin (100 mg/kg/d), and the sham and model groups were given the same amount of normal saline at the same time point for 8 weeks. Mechanical withdrawal threshold and thermal withdrawal latency were measured by mechanical stimulation and thermal radiation to evaluate the pain threshold of rats. Open field test was used to evaluate anxiety and depression. General observation and Pelletier scoring of the knee cartilage were performed. Safranin O-Fast green staining and Osteoarthritis Research Society International score were used to evaluate the degree of cartilage degeneration. ELISA was used to detect the contents of inflammatory factors interleukin-1β and tumor necrosis factor-α in synovial fluid and synovial tissue. The protein expression of monocyte chemotactic protein 1/chemokine C-C-motif receptor 2 ligand receptor axis in cartilage tissue was detected by western blot. RESULTS AND CONCLUSION: The mechanical withdrawal threshold and thermal withdrawal latency of the icariin group were significantly higher than those of the model group (P < 0.05). Compared with the sham group, the total exercise distance, the total number of crossing squares and the residence time in the central area of the model group were significantly decreased (P < 0.05). Compared with the model group, the above three indexes were significantly increased in the icariin group (P < 0.05). Compared with the model group, the levels of interleukin-1β and tumor necrosis factor-α in knee synovial fluid and synovial tissue were significantly decreased in the icariin group (P < 0.05). Compared with the sham operation group, the articular cartilage surface of the model group was more uneven and deformed, the cartilage tissue was hypertrophy, hardened and dull, and a large amount of cartilage tissue was exfoliated, while the cartilage degeneration in the icariin group was significantly less than that in the model group. The results of Safranin O-Fast green staining and Osteoarthritis Research Society International score showed that the degeneration of knee cartilage in the model group was more severe than that in the sham group, while that in the icariin group was significantly less than that in the model group. Compared with the model group, the protein expression level of monocyte chemotactic protein 1/chemokine C-C-motif receptor 2 ligand receptor axis was significantly lower in the icariin group (P < 0.05). The above findings indicate that icariin can significantly reduce hyperalgesia in the rat model of post-traumatic knee arthritis, and its mechanism may be related to reducing the levels of interleukin-1β and tumor necrosis factor-α in the knee joint and inhibiting the protein expression of monocyte chemotactic protein 1/chemokine C-C-motif receptor 2 ligand receptor axis. [ABSTRACT FROM AUTHOR]

Copyright of Automotive Engineer (1674-6546) is the property of Auto Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Cancer Research on Prevention & Treatment is the property of Cancer Research on Prevention & Treatment Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Experimental Technology & Management is the property of Experimental Technology & Management Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Hydrometallurgy of China is the property of Hydrometallurgy of China Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

采用全矢量有限元法,研究了空气孔为正九边形周期性排列的全内反射型光子晶体光纤的温度传感特性,分析了不同空气孔排列形状、占空比以及波长对温度特性的影响,并与正六边形结构的光子晶体光纤进行了对比。研究表明,空气孔为正九边形周期性排列时,光子晶体光纤模场分布随温度变化显著,其有效折射率和限制损耗的大小与温度成反比。保持孔间距不变,占空比越大,输入波长越长,灵敏度越高。在此基础上,提出了一种正九边形熔接点为锥形的单模光纤-光子晶体光纤-单模光纤马赫曾德干涉仪温度传感器,当波长为1 550nm,占空比为0.6,温度范围为-2080℃时,该传感结构的温度灵敏度为0.112 2nm/℃。

【目的】评估载药栓塞微球负载阿霉素联合甲磺酸阿帕替尼治疗中晚期原发性肝癌的安全性和近期疗效。【方法】对本中心采用载药微球经动脉化疗栓塞术（DEB-TACE）联合甲磺酸阿帕替尼治疗的原发性肝癌患者相关资料进行了回顾性分析。所有患者均只进行了1次DEB-TACE治疗，并在DEB-TACE术后推荐开始服用甲磺酸阿帕替尼500mg治疗。对术前及术后4~8周患者第一次随访的影像随访资料以及肿瘤生物学指标甲胎蛋白（AFP）进行分析，同时观察并记录治疗过程包括服用阿帕替尼在内的不良反应事件。【结果】根据实体瘤疗效评价标准（RECIST）、改良实体瘤疗效评价标准（mRECIST）及欧洲肝脏研究协会标准（EASL）结果显示，这11例患者的客观缓解率（ORR）分别为36.4%、63.6%、72.7%，疾病控制率（DCR）分别为90.7%、72.7%、81.8%。患者术后AFP平均水平为44251.7μg/L，较术前平均水平366336μg/L明显下降。有4例患者在服用甲磺酸阿帕替尼后出现Ⅲ级不良反应，其余患者均未出现Ⅳ级不良反应。【结论】使用载药栓塞微球负载阿霉素联合甲磺酸阿帕替尼治疗中晚期原发性肝癌的安全性较高，近期疗效良好。

【目的】研究阿霉素负载的直链烷基修饰的氧化石墨烯（DOX@GO-C18）作为药物载体经导管动脉化疗栓塞（TACE）治疗肝癌的安全性和有效性。【方法】制备并表征DOX@GO-C18。采用雄性新西兰大白兔建立VX2肝癌模型并以动态增强CT扫描明确肿瘤情况。在数字减影血管造影（DSA）引导下，以股动脉入路选择性插管至肝段动脉，通过微导管注射DOX@GO-C18的碘油分散液对肿瘤行TACE治疗。术前及术后第1、3、5、7和14天取外周静脉血液样本行肝功能检查，术后第14天行动态增强CT扫描并对肿瘤行HE染色、油红染色及DAPI荧光染色。【结果】DOX@GO-C18能稳定分散在碘油中。肝癌病灶在治疗前后的最大直径无明显变化，肿瘤血供明显减少。采用RECIST1.1标准进行评价，目标病灶治疗反应均为疾病稳定。病理学检查可见DOX@GO-C18伴随碘油主要沉积于肿瘤内，并释放DOX，肿瘤出现坏死。血清学检查显示术后出现一过性肝酶学异常，在2周内可恢复至正常水平。【结论】本研究初步证明DOX@GO-C18可作为一种应用于肝癌的TACE治疗的有效药物载体，其安全性可控。

Copyright of Experimental Technology & Management is the property of Experimental Technology & Management Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Clean Coal Technology is the property of Clean Coal Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)