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The biomedical applications of hyaluronic acid(HA)/sodium alginate(Alg) based hydrogels have been widely studied, showing the potentials in tissue engineering and wound healing. In this study, the quinine was introduced into the HA/Alg-based hydrogel to prepare anti-inflammatory hydrogel. Micro-structure, physicochemical properties were investigated. The results showed that the hydrogels possessed a uniform structure with pores inside, exhibited similar mechanical performance with or without quinine. Employing the in vitro model of lipopolysaccharides(LPS)-induced inflammation, the effects of the hydrogels on inflammation in cultured RAW 264.7 mouse macrophages was determined. The results showed that all the hydrogels did not affect the cell availability. In addition, the LPS-induced interleukin-1(IL-1), IL-6, tumor necrosis factor-α production was inhibited by the conditional medium of the hydrogels with quinine at 20-80 mg/mL, indicating its significant anti-inflammatory activity. Taken together, the prepared hydrogels with quinine may be an anti-inflammatory biomaterials and have potential application in skin wound healing. [ABSTRACT FROM AUTHOR]

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