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The objective of human motion capture data recovery is to recover the missing positions of motion markers and to remove noises. The existing low-rank matrix completion based methods that usually exploit the low-rank property underlying in human motion data matrix. However, as the frame number increases, the low-rank property may not be satisfied. To characterize the low-rank property of motion data well, a non-convex temporal difference low-rank constrained human motion capture data recovery algorithm is proposed by combining the Schatten-p norm and the q-norm. First, the data matrix is projected into the temporal difference space, and the temporal difference matrix is constructed. Then we introduce the non-convex Schatten-p norm to characterize the low-rank property of the data temporal difference matrix, and the non-convex q-norm to constrain the sparse noise terms. The alternating direction method of multipliers (ADMM) is used to solve the problem, and the Newton-Raphson iterative method is used to solve the sub-problems. Comparison is made between the proposed algorithm NTDLR and three classical algorithms, i.e., TrNN, CaNN and IRNNL Lp, on CMU dataset and HDM05 dataset. Both of the recovery error and visual effect show that our NTDLR has better recovery performance.(人体运动捕获数据恢复问题旨在恢复缺少的运动标记点位置信息，同时消除噪声。现有基于低秩矩阵填充的恢复方法大多利用人体运动捕获数据矩阵的低秩性。然而，随着运动数据帧数的不断增加，低秩性可能不再满足。为更好地刻画运动数据的低秩性，提出一种联合Schatten-p范数和lq范数的非凸时序差分低秩约束（NTDLR）的人体运动捕获数据恢复算法。首先，将数据矩阵投影至时序差分空间，构造时序差分矩阵。其次，引入非凸Schatten-p范数，刻画数据时序差分矩阵的低秩性，同时引入非凸lq范数约束稀疏噪声项。再次，利用交替方向乘子法求解模型，采用Newton-Raphson迭代法求解子问题。最后，在CMU数据集和HDM05数据集上，将NTDLR与经典的TrNN、CaNN和IRNNL Lp算法进行了比较，结果表明，NTDLR算法的视觉效果更优，具有更好的恢复性能。)

观鸟旅游是游客生态认知和行为的重要表现，提高观鸟旅游的游客重游率有利于提高游客对候鸟保护和生态环境保护的认知及意识。本文以鄱阳湖湿地候鸟保护区吴城为例，在对游览区游客问卷调查的基础上，运用二分类逻辑回归模型，分析了该游览区游客重游意愿的影响因素。结果表明：鄱阳湖湿地吴城保护区内游客重游意愿较强；与游客重游意愿呈显著相关关系的10个因素分别为服务满意度>专业讲解需求>性别>候鸟种类认知>白鹤认知水平>解说体系满意度>常住地>对鸟类的认知收获>有无子女>职业；多数游客对候鸟及其保护有一定的认知度，观鸟后有一定的鸟类认知收获，对旅游地各方面相对满意。据此提出相关建议，以期为增强游客的重游意愿提供对策参考。

【目的】筛选高效的foxp3 RNA干扰的靶点用于阻断CD4^＋CD25^＋ Treg细胞的免疫抑制功能。【方法】使用oligoengine软件设计foxp3基因shRNA序列，化学合成法合成4条shRNA序列，构建含foxp3的靶序列的慢病毒载体：构建出表达FLAG融合蛋白和目的基因的工具细胞293T细胞用于筛选RNA干扰的有效靶点。【结果】成功包装了4条foxp3基因靶序列相应的慢病毒颗粒；成功构建了表达融合蛋白和目的基因的293T工具细胞：在工具细胞上筛选出了2条RNAi效率分别为91.3％和95．6％的有效靶点。【结论】使用FLAG融合蛋白和慢病毒载体能够筛选出Foxp3基因的RNAi最佳靶点。

【目的】了解生存蛋白Survivin在T细胞非霍奇金淋巴瘤（T—NHL）中的表达，以及Survivin表达与预后的关系。【方法】用免疫组化S-P法检测83例T细胞NHL组织Survivin表达情况，分析Survivin表达与预后的关系。【结果】Survivin表达阴性10例（12％），表达阳性73例（88％），Survivin表达与病理类型、性别、年龄、B症状、结外病变数、PS、分期、LDH水平、IPI等临床特征均无相关性（P〉0．05）。78例接受了化疗，大多数采用CHOP方案化疗，全组CR率45％，有效率86％，Survivin阴性者CR率60％，阳性者43％（P〉0．05）。中位随访22月（1—76月），全组5年生存率31％，Survivin表达阳性的T—NHL患者5年生存率明显低于Survivin表达阴性患者（21％比70％，P〈0．001）。多因素分析显示Survivin表达是T细胞NHL的独立预后指标。【结论】Survivin在T细胞NHL表达上调，Survivin阳性T—NHL患者5年生存率低于Survivin阴性者，Survivin表达可能为T细胞NHL预后的独立指标。

【目的】探讨一种改良IME-FICC( 免疫磁珠富集-免疫荧光细胞化学) 法检测乳腺癌外周血微转移 癌细胞及其意义。【方法】通过与磁珠共价结合的表皮细胞黏附分子( EpCAM) 抗体富集外周血中表达EpCAM 的癌细胞, 结合免疫荧光化学法检测细胞角蛋白( CK) 8/18 阳性的癌细胞(呈绿荧光)。放置MCF-7 乳腺癌细胞于 正常人外周血标本中以检验本方法癌细胞回收率及敏感度, 检测20 例正常女性志愿者及12 例Ⅳ期乳腺癌患 者治疗前的外周血标本, 探索其特异性及临床应用可行性。【结果】免疫磁珠富集后癌细胞回收率达86%～ 93%, 可在107 外周血单个核细胞中检测到1 个癌细胞, 特异性为100%。Ⅳ期乳腺癌患者外周血中CK8/18 阳 性细胞检出率75%。【结论】改良IME-FICC 法是一种简便、省时、敏感性及特异性高的检测方法, 有较大的临床 应用前景。

【目的】探讨螺旋CT 检查对急性闭合性腹部外伤的诊断价值,进一步提高急性腹部外伤的诊断水平。【方法】回顾分析160 例急 性闭合性腹部外伤患者的急诊 CT 征象。【结果】急性闭合性腹部外伤主要累及脾、肝、肾、胰等,其急诊CT 扫描征象主要有:①实质内条片状 等/低密度阴影;②或伴实质内片状高密度出血灶;③实质内血肿;④包膜下血肿;⑤腹腔积血。【结论】螺旋CT 检查对急性闭合性腹部外伤具 有敏感、可靠、检出率高、无创伤的特点,能给临床提供及时、准确的信息,为临床确定治疗方案提供依据,为患者争取治疗时机。

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Copyright of Chinese Journal of Oncology is the property of Chinese Journal of Oncology / Zhonghua Zhongliu Zazhi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To systematically summarize and comparatively analyze the development, establishment and usage of oncology drugs speedy review approaches in China and in the United States between 2012 and 2021. Methods Based on National Medical Products Administration (NMPA) and Food and Drug Administration (FDA) websites, the development and current status of the speedy review approaches were consulted and summarized. Approved oncology drugs in China and in the United States (87 in China, 118 in the United States) over the past decade were analyzed using chi-square test for group comparison. Results Five speedy approaches have been established in China and in the United States, three of which are the same, priority review, conditional approval or accelerated approval and breakthrough therapy. The rest two are special review and approval, special examination and approval in China, and fast track and real-time oncology review in the United States. Compared to the United States, speedy review approaches in China set up late (1992 vs. 2005). The overall utilization rates of the oncology drugs speedy review approaches were similar between the China and United States (90.8% vs. 92.4%, P=0.800) in the previous 10 years, and priority review have highest utilization rates in both China and the United States without significant group difference (77.0% vs. 82.2%, P=0.381); relatively low utilization rates of conditional approval (31.0% vs. 44.9%, P=0.041) and breakthrough therapy (2.3% vs. 50.0%, P＜0.001) were seen in China. 52.9% of new drugs applied for special examination and approval in China and 40.7% of new drugs applied for fast track in the United States. Overall, the priority review both in China and the United States are stable, with a similar average annual utilization rate (84.8% vs. 83.7%); accelerated approval and breakthrough therapies in the United States fluctuate wildly, but the situation is tending towards stability in the last 3 years. Conclusions Both China and the United States have established a relatively complete accelerated review system, with an overall utilization rate over 90%; China's accelerated review started late, although the overall utilization rate is close to that of the United States. The utilization rates of conditional approval and breakthrough therapy are still relatively low. Flexible usage of speedy review approaches, gaining regulatory recognition to use alternative endpoints, achieving real-time review and guidance are keys to accelerate new drug development in China. [ABSTRACT FROM AUTHOR]

[Objective] Over high humidity in the operating environment of metro train auxiliary power supply system will lead to high leakage current of IGBT (insulated gate bipolar transistor), which may further cause the auxiliary converter failure. Therefore, it is necessary to optimize the internal environment of the auxiliary converter box based on the high temperature and high humidity environment to reduce the failure rate of IGBT. [Method] Based on a case study of the train auxiliary converter failure on Ningbo Metro Line 4, causes of IGBT failure are investigated, and four equipment optimization schemes are proposed, including reducing the speed regulation voltage of the auxiliary converter cooling fan, adjusting the direction of internal circulation fan to reduce the humidity around IGBT, improving the sealing between cabinet and the external part, and optimizing the cooling fan control logic. Simulation and on-site tests verify that the four optimization schemes are effective and operable. [Result & Conclusion] IGBT failure causes are as follows; on Ningbo Metro Line 4, the low on-site operation load of the train auxiliary converter, the low operating temperature of the components, the undischarged moisture inside the IGBT, while the fast air exchange rate in the auxiliary converter box results in rapid increase of humidity in the cabinet, further leading to the over high leakage current of IGBT module. The four optimization schemes can reduce the relative humidity in the auxiliary converter cabinet and improve the reliability of the IGBT operation. [ABSTRACT FROM AUTHOR]

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Copyright of Science & Technology of Food Industry is the property of Science & Technology of Food Industry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To evaluate the impact of atypical sensory response patterns on the development of initiating joint attention (IJA) abilities in toddlers, further exploring the early developmental mechanisms of autism spectrum disorder (ASD). Methods Forty infants at 12 months of age were followed up and divided into three groups at 24 months of age: ASD, developmental differences (D/D), and typical development (TD) groups. The Toddler Sensory Profile Second Edition (TSP-2) was used to assess the degree of atypical sensory response patterns. Interactive videos were coded to evaluate IJA abilities. Linear regression analysis was employed to assess the relationship between sensory responsiveness and IJA abilities. Results The sensory seeking and registration scores at 12 months of age and the sensory seeking score at 24 months of age in ASD toddlers were negatively correlated with IJA frequency ( r_{s} = - 0.735, P = 0.015 ; r_{i} = - 0.635 P = 0.048 ; r_{s} = - 0.68 P = 0.03 ) while the sensory sensitivity and avoiding scores at 12 months were positively correlated with the development of IJA frequency ( r_{p} = 0.674 P = 0.047 ; r_{p} = 0.818, P = 0.007 ) . Conclusions Higher levels of sensory seeking and registration in ASD toddlers will affect their current IJA abilities. However, higher levels of sensory sensitivity and avoiding predict a better developmental trend in IJA abilities. [ABSTRACT FROM AUTHOR]

The “Three Musts” is a major thesis made by the Communist Party of China based on the development orientation of the new era and on the basis of full study and judgment of historical laws. It is an innovation of the important assertion of “Two Musts”. It is the political key for the Party to take the initiative to face the complicated international environment and advance towards the Second Centenary Goal. The “Three Musts” has profound theoretical origin and practical basis. The “Three Musts” highlights the mission of the centennial Party. It is the crystallization of the Party’s experience, and shows the “evergreen way” of the Party. As the guide to unify thought, will and action, the “Three Musts” provides unique ideas and effective paths for solving the unique problems of the Party. [ABSTRACT FROM AUTHOR]

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The offshore waters of southern Zhejiang serve as an important fishing ground in China, where Pennahia argentata is a common economic fish species. This study explores the habitat of P. argentata in the offshore waters of southern Zhejiang in order to reveal the environmental changes during its individual development. The experiment is based on the otolith samples of P. argentata in this area, and ICP-MS technology is used to measure the Sr and Ca elements in the otolith microstructure. By analyzing the Sr/Ca ratio, it is found that the range of environmental changes for P. argentata habitat is between 3. 39×10-3 and 8. 12×10-3, indicating the existence of two habitat types: freshwater and brackish water settlement, and brackish-freshwater and seawater mix. In addition, Sr element has been proven to be an effective tracer of the fish habitat history. This discovery not only enriches our understanding of the ecological habits of P. argentata, but also provides a new, feasible, and accurate method and approach for studying the migration routes of P. argentata. [ABSTRACT FROM AUTHOR]

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The prognosis of patients with myelodysplastic neoplasms（MDS）is closely linked to their cytogenetic and molecular genetic characteristics. Among the most prevalent genetic mutations in MDS，the TP53 gene abnormalities stand out as an independent adverse prognostic factor for MDS and a significant risk factor for the progression to acute myeloid leukemia（AML）. The recently updated 5th edition of the WHO classification of haematolymphoid tumours（WHO 2022）and international consensus classification of myeloid neoplasms and acute leukemia（ICC）recognizes MDS with TP53 biallelic inactivation（biTP53）as a distinct and independent subtype. Patients within this subtype face an exceedingly grim prognosis with an extremely short survival period. Currently，available treatments for MDS patients with TP53 gene abnormalities have proven ineffective in improving their prognosis. Consequently，there is a growing focus on exploring new avenues such as targeted therapies and immunotherapy. This article provides an in⁃depth review of the progress in clinical research related to MDS with TP53 gene abnormalities，both within domestic and international contexts. [ABSTRACT FROM AUTHOR]

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