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丙氧苯并咪唑（Oxibendagole）又名丙氧咪唑。是一种新合成的苯并咪唑类药物,据国外介绍。此药对猪、羊、犬、牛、马、小鼠、鸡的多种线虫具有良好的驱虫作用;国内在家畜上也有类似的报道;但在野生珍稀动物中未见使用。1984年4月,我们选择了狮、虎、熊、豹、猞猁等20只蛔虫阳性动物。进行了丙氧苯并咪唑驱除野生肉食动物蛔虫的疗效试验。现将试验结果报告如下,

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Objective To observe the effect and mechanism of Jiaji acupoint on gastrointestinal motility disorder in rats. Methods Forty-five SD rats were randomly divided into the control, model, acupuncture (ACU), ACU + NMDAR anatagonist, ACU + γ-aminobutyric acid (GABAR) antagonist groups, with 9 rats in each group. The rats were subcutaneously injected with atropine to make the models of gastrointestinal dyskinesia except the control group. The rats in the ACU, ACU + NMDAR antagonist, ACU + GABAR antagonist groups were given Jiaji acupuncture. The rats in the ACU + NMDAR antagonist group were mieroinjected with the INIV11)A receptor (NMDAR) antagonist kynurenic acid, and the rats in the ACU + GABAR antagonist group were mieroinjected with the GABA receptor(GABAR)antagonist dieentrine and phaelofen in the dorsal motor nucleus of vagus (DMV), respectively after acupuncture. The rats in the normal control group were given distillated water. After 10 minutes of microinjection, rats in the ACU, ACU + NMDAR anatagonist, ACU + GABAR anatagonist groups were given Jiaji acupoint electro-acupuncture for 30 minutes. The rates of gastric emptying and small bowel peristalsis were calculated. Results Compared with the control group, the gastric emptying rate and small bowel peristalsis rate in the model group were lower (both P <0.01), while the gastric emptying rate and small intestinal peristalsis rate in the ACU group were higher than those of the model group (both P <0.05). There was no significant difference in the gastric emptying rate and small intestinal peristalsis rate between the ACU + GABAR antagonist group and the ACU group (both P >0.05). The gastric emptying rate and small intestinal peristalsis rate in the ACU + NMDAR antagonist group were lower than those in the ACU group (P< 0.05). Conclusion Jiaji acupoint could improve the gastrointestinal motility disorder of rats, which may be related to the NMDA receptors of DMV. [ABSTRACT FROM AUTHOR]

目的　观察脑卒中后抑郁患者血清标志物变化，进一步探讨卒中后抑郁发病的影响因素。方法　选择 65例脑卒中后抑郁患者(HAMD评分8～23分)为PSD组，其中中重度抑郁患者21例(中重度组)，合并糖尿病患 者26例(合并组)。选择同期住院脑卒中后无抑郁患者65例为对照组。住院期间及发病1个月后分别采用 HAMD-17项进行评分；入选患者均进行一般资料及危险因素对比；住院2周内检测血清C反应蛋白(CRP)、胰岛素 样生长因子1(IGＦ-1)及谷氨酸脱羧酶抗体(GAD-Ab)阳性率；分析两组患者病初NIHSS评分及病变部位。结果　 中重度组及合并组患者血清CRP和IGＦ-1水平升高明显，与对照组比较，P<0．05；而PSD组血清CRP、IGＦ-1水平 及GAD-Ab阳性率与对照组比较差异无统计学意义。PSD组额叶、丘脑病变、发病初高NIHSS评分及糖尿病所占 比例高于对照组(P均<0．05)。结论　炎性反应、免疫机制异常及谷氨酸代谢障碍可能参与卒中后抑郁发病的 病理过程，脑卒中后抑郁发病的影响因素有糖尿病、额叶、丘脑病变及病初高NIHSS评分。 [ABSTRACT FROM AUTHOR]