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In order to alleviate the effects of low temperature on tobacco leaf ripening in the upper tobacco-growing area of northeast Yunnan and to improve the yield and quality of the upper leaves, field experiment was used to study the effects of different transplanting time on the agronomic traits, growth period, apparent characteristics, leaf structure, enzyme activity, economic traits, fresh-dry ratio and appearance quality of Yunyan 97 tobacco leaves. Effects on the growth and yield and quality of tobacco plants were researched. Results showed that the transplanting treatment of field growth period from April 21 to April 25 was 113 d, which was the smallest. This treatment increased the SOD, PPO enzyme activities, decreased NR enzyme activities and MDA content, had the smallest fresh-dry ratio and the ratio of palisade tissue to sponge tissue, and the optimal maturity. Increasing the opening degree and stress resistance of the upper tobacco was conducive to the growth and development of tobacco plants and the yield and output value were highest in this transplanting treatment. Compared with the treatment of transplanting from April 26 to April 30, the yield of primary flue-cured tobacco increased by 521. 42 kg / hm², the output value increased by 11 529. 42 yuan / hm², and the proportion of high-grade tobacco reached 50. 71%. Therefore, when the transplanting period was from April 21 to April 25, it was more beneficial to improve the tissue structure of the upper leaves of flue-cured tobacco in Xuanwei tobacco-growing area, and to improve the stress resistance, yield and appearance quality of the upper leaves. [ABSTRACT FROM AUTHOR]

Compared with the static performance of continuous box girder bridge with corrugated steel webs, the research on dynam)ic characteristics of continuous box girder bridge with corrugated steel webs is deficient, especially in the fatigue damage assessment of external tendons under vehicle-bridge coupling vibration. The ANSYS finite element software was used to establish a refined numerical model of corrugated steel web box girder bridges, and to perform external beam fatigue analysis. Using MATLAB, a random traffic flow program was prepared considering factors such as vehicle type, driving position, speed, head distance and axle load. The rain current counting method was used to calculate the equivalent stress amplitude of external beam stress and the number of equivalent stress cycles under the action of random vehicle flow within 24 h. Modified Muller's research results, put forward the S-N ( Stress-Life) formula of steel strands with stress ratio lower than 0. 035 and considering lateral bending wear. Using the Miner cumulative damage criterion and considering the impact of the impact coefficient, the fatigue damage degree and remaining fatigue life of the external prestressed beam of the corrugated steel web box girder bridge are calculated, and the effect of the bridge span on the external beam fatigue damage is also analyzed. The results show that the order of the effect of moving loads on the external beam stress at different positions is: mid-span mid-position > side span mid-position > mid-span 1 / 4 span position, and external beam stress at the mid-span position is greatly affected by vehicle loads. The fatigue damage of the external beam caused by random traffic flow decreases with the increase of the span. [ABSTRACT FROM AUTHOR]

BACKGROUND: After total knee arthroplasty, the quadriceps femoris muscle strength of patients has a certain decline. If the injured quadriceps femoris cannot be effectively rehabilitated for a long time, it may cause a continuous decline in quadriceps femoris muscle strength and even lower limb muscle atrophy. OBJECTIVE: To explore the effect of tendon manipulation with equal emphasis on muscles and bones on the accelerated rehabilitation of quadriceps femoris after total knee arthroplasty METHODS: Totally 80 patients undergoing total knee arthroplasty in the Guanghua Hospital, Shanghai University of Traditional Chinese Medicine were randomly divided into control group and treatment group (n=40 per group). The control group was given routine rehabilitation after total knee arthroplasty, including ankle pump training and quadriceps isometric contraction training. Rehabilitation training was conducted on the 1st to 14th days after operation. The treatment group was given routine rehabilitation combined with tendon manipulation with equal emphasis on muscles and bones to enhance the precise exercise of quadriceps femoris. Rehabilitation training was conducted on the 1st to 14th days after operation. The surface electromyography index, visual analogus scale score, tenderness threshold, hospital for special surgery knee score, the scores of Osteoarthritis Index questionnaire of Western Ontario and McMaster University, and hospital anxiety and depression scale were compared between the two groups. RESULTS AND CONCLUSION: (1) After 7 and 14 days of manipulation intervention, the median frequency of surface electromyography of lateral femoral muscle, hospital for special surgery knee score, and knee tenderness threshold were higher in the treatment group than those in the control group (P < 0.05). Visual analogus scale score, Osteoarthritis Index questionnaire of Western Ontario and McMaster University, and hospital anxiety and depression scale were lower in the treatment group than those in the control group (P < 0.05). (2) There were no adverse events caused by manipulation or no surgical complications during manual rehabilitation. (3) The results show that the tendon manipulation with equal emphasis on muscles and bones can accelerate the functional rehabilitation of quadriceps femoris after total knee arthroplasty, which is safe and effective. [ABSTRACT FROM AUTHOR]

To study the relationship between the tissue pregradient protein 2 (AGR2) and microfiber associated protein2 (MFAP2) protein 2expression and clinicopathological features and prognosis of colorectal cancer (CRC). Methods: 84 patients with CRC who were admitted to the hospital from January 2015 to February 2016 were included in the study. CRC tissues and adjacent nor-mal tissues (2 ~ 5cm away from the tumor edge) were collected from all patients, and the AGR2 and MFAP2 protein expression in different tissues were detected and compared. The relationship between AGR2, MFAP2 protein expression and clinicopathological features and prognosis of patients with CRC were analyzed. Cox regression model was used to analyze the prognostic factors of patients with CRC. Results: The positive expression rates of AGR2 and MFAP2 protein in CRC tissues were all higher than those in adjacent normal tissues (P<0.05). The positive expression rates of AGR2 and MFAP2 protein in patients with CRC with low differentiation, TNM stage was Ⅲ and vascular invasion were higher than those in patients with CRC with medium and high differentiation, TNM stage was Ⅰ～Ⅱ, and no vascular invasion (P<0.05). 3-year survival rate and 5-year survival rate in AGR2, MFAP2 protein positive patients were significantly lower than those with negative expression patients (P<0.05). Cox regression model analysis showed that the degree of differentiation was low, TNM stage was stage III, vascular infiltration and the positive expression of AGR2 and MFAP2 protein were the risk factors of death in patients with CRC (P<0.05). Conclusion: The positive expression rate of AGR2 and MFAP2 protein in CRC increased, which are related to the degree of differentiation, TNM stage and vascular infiltration of patients. Detecting their expression is helpful to predict the prognosis of patients with CRC. [ABSTRACT FROM AUTHOR]

BACKGROUND: Neuroimmune and inflammatory reaction have been shown to participate in the occurrence of Parkinson’s disease. Lipoic acid possesses anti-inflammatory and neuroprotective roles. OBJECTIVE: To investigate the protective effects of lipoic acid on PC12 cell models of Parkinson’s disease induced by lipopolysaccharide and the underlying mechanism. METHODS: PC12 cells were divided into blank control, model (Parkinson’s disease model induced by lipopolysaccharide) and treatment (Parkinson’s disease model treated by lipoic acid) groups. PC12 cells were pretreated with lipoic acid for 2 hours, and then stimulated with lipopolysaccharide. The optimal concentration of lipopolysaccharide and lipoic acid was determined by cell counting-kit 8 assay. The expression of tyrosine hydroxylase was detected by immunohistochemistry. The levels of tumor necrosis factor α and interleukin 6 were detected by ELISA kit. The protein expression levels of nuclear factor-κBp65 and tyrosine hydroxylase were detected by western blot assay. RESULTS AND CONCLUSION: The optimal concentration of lipopolysaccharide was 600 μg/L for constructing cell model of Parkinson disease, and 25 μmol/L lipoic acid was the optimal intervention concentration. Lipoic acid could increase the number of tyrosine hydroxylase positive cells, reduce the release of inflammatory factors in cell model of Parkinson’s disease, inhibit the production of nuclear factor-κBp65 and increase tyrosine hydroxylase content. Therefore, lipoic acid exhibits its effects on cell model of Parkinson’s disease through inhibiting the nuclear factor-κB signaling pathway and reducing inflammation, thereby exerting neuroprotection. [ABSTRACT FROM AUTHOR]

Objective To explore CT rapid calibration in the vehicle-mounted shelter to ensure CT imaging quality in field conditions. Methods The CT modification in the vehicle-mounted shelter and technical requirements for CT quality control were analyzed. CT installation, state transfer, calibration and testing were investigated, and the quality states in different conditions were tested and compared. Results The CT after rapid calibration had the image quality meeting the requirements of national standards. Condusioii The fast calibration method is appropriate for the CT in the vehicle-mounted shelter with damping deviceswhen used in filed conditions [ABSTRACT FROM AUTHOR]

目的 观察补肾健脾化瘀中药提取物对难治/复发再生障碍性贫血(AA)患者骨髓单个核细胞集落形成的影响。方法 选择15例难治/复发AA患者,采集患者骨髓液,提取骨髓单个核细胞,将其分为补肾健脾化瘀中药组、雷帕霉素组、空白对照组。将细胞置于红系祖细胞红系集落形成单位(CFU-E)、爆式红系集落形成单位(BFU-E)、粒细胞巨噬细胞集落生成单位(CFU-GM)常规培养体系中培养,雷帕霉素组加入终浓度25 nmol/L的雷帕霉素;补肾健脾化瘀中药组加入当归多糖、淫羊藿苷、巴戟天多糖、黄芪多糖、三七总皂苷、黄精多糖各100μg/m L,菟丝子黄酮、人参二醇各50μg/m L;空白对照组加入生理盐水。10 d后计数各组CFU-E、BFU-E、CFU-GM数量。结果 与空白对照组比较,雷帕霉素组、补肾健脾化瘀中药组CFU-E、BFU-E、CFU-GM数量均增加(P均<0. 01),雷帕霉素组与补肾健脾化瘀中药组比较差异无统计学意义(P均> 0. 05)。结论 补肾健脾化瘀中药提取物可增加难治/复发再生障碍性贫血患者骨髓单个核细胞的集落形成,促进骨髓单个核细胞的增殖。 [ABSTRACT FROM AUTHOR]

To obtain a better view on the effect of steam reforming of methane (SRM) reaction on performance of internal combustion (IC) engine,by using HSC 5.1 software, SRM was analyzed at different temperature and steam/methane molar ratios. Then, by using Chemkin-pro software, fuel consumption reduced rate of methane was calculated in synthesis gas of SRM and methane at different equivalence ratios. The results show that the increase of temperature and steam/methane molar ratios will increase conversion rate of methane. When the temperature is 700 ℃ and steam/methane molar ratio is 3 under the same heating conditions, heat value will increase 13.58% , fuel consumption will decrease 11.96%, and cycle efficiency of IC engine will increase with the increase of conversion rate of methane. Efficiency of synthesis gas of SRM is higher than pure methane, unfortunately, decreases with the decrease of the equivalent ratio. [ABSTRACT FROM AUTHOR]

Shandong Province is a major province of iron ore resources in China, and the ore-forming geological conditions of iron ore are superior in western Shandong. Types of mineral deposits are diverse, including sedimentary metamorphic iron ore, contact metasomatic iron ore, hydrothermal metasomatic filling-weathering leaching iron ore, sedimentary iron ore, magmatic iron ore and other types. In particular, sedimentary metamorphic iron ore and contact metasomatic iron ore are the most important and the main sources of iron ore deposits in the province. On the basis of combing the space-time distribution characteristics of various iron ore types in western Shandong, focusing on the analysis of the characteristics of typical iron ore deposits, ore-controlling factors and genesis of deposit, the metallogenic genealogy of various types of iron ore deposits in western Shandong along the axis of the history of geological evolution was establishes. This study indicates that in the process of geological evolution, the formation of iron ore in western Shandong is a series of geological products formed under the highly coupling of geological and mineralization processes such as submarine volcanic eruption, sedimentation, magma intrusion, regional metamorphism, tectonic movement, weathering and leaching. Sedimentary metamorphic iron ores ( such as Hanwang type, Cangyi type, Yangzhuang type and Jining type iron ores) and magmatic iron ores ( Xiaojiagou type iron ore) were formed in the Neo-Archean era. Sedimentary iron ore ( Shanxi type iron ore) was formed in the late Carboniferous. Contact metasomatic iron ore ( such as Laiwu type and Lianziwang type iron ores) and hydrothermal metasomatic filling-weathering leaching type iron ore ( Zhuya type iron ore) were formed in the early Cretaceous. Various types of iron ore deposits in western Shandong have the characteristics of strata ore-controlling, intrusive rock ore-controlling, structural ore-controlling, and multiple elements controlling ore together. In the process of iron ore exploration, targeted arrangement should be carried out according to genetic types and ore-controlling factors, so as to promote the overall in-depth progress of iron ore exploration and research in the western Shandong. [ABSTRACT FROM AUTHOR]

In this paper, the B3 LYP method based on density functional theory was used to optimize the molecular structure of chlorprocaine on 6-31 g(d, p) basis set. On this basis, ethanol was used as solvent to calculate the first 20 excited states of the molecule. All the calculations were carried out in Gaussian 09 W-D01. Multiwfn3.7 software was used to draw the infrared spectrum and analyze its molecular vibration. Using the combination of Origin 2018 64 Bit software and Multiwfn3.7 software to draw the UV spectrum, and calculate the hole-electron to analyze the excited state properties of the molecule. The active site of chlorprocaine was predicted by calculating the frontier orbital. The results show that the excitations from the ground state to the 2 nd, 3 rd, 6 th and 10 th excited states are local excitations, and the excitation from the ground state to the 19 th excited state is charge transfer excitation. The N22 on the ethyl group of chloroprocaine is the electrophilic reaction site, and the carbon atom on the benzene ring and the oxygen atom on the lipid group are the nucleophilic reaction sites. This study provides theoretical reference for better understanding of the reaction mechanism of chloroprocaine and its anesthetic activity in medicine. [ABSTRACT FROM AUTHOR]

【Objective】 In order to establish the reasonable planting density under the double-row planting model of large ridges and build a high-yielding peanut group model, the impact of the double-row planting density of large ridges (90 cm) on the characteristics, group structure changes and yield of peanut plants was studied.【Method】 The semi-trailing type peanut variety ‘Silihong’ and the erect type ‘Jihua26’were used as experimental materials. Set 6 planting densities: M1 (31.71×104 plants/hm² ), M2 (27.75×104 plants/hm² ), M3 (24.67×104 plants/hm² ), M4 (22.20×104 plants/hm² ), M5 (18.50×104 plants/hm² ), M6 (15.85×104 plants/hm² ), based on single ridge (60 cm) double-seed sowing (11.93×104 holes/hm² ) as a comparison (CK). Determine the seedling rate, plant growth, SPAD value, dry matter accumulation and yield of each peanut variety under different density, and establish a reasonable group structure of peanuts and the optimal planting density of different varieties.【Result】 The emergence time of different varieties was different under different planting densities, the emergence time of ‘Silihong’ was earlier than ‘Jihua 26’. 25 days after sowing, the seedling rate of ‘Silihong’ was up to 100% at M3 density, 30 days after sowing, the seedling rate of ‘Jihua26’ was up to 100% at M3 density, which were significantly higher than other densities. With the decrease of planting density, the height of the main stem and the length of the side branch gradually increase with the decrease of the number of plants per unit area; the SPAD value tends to increase first and then decrease with the decrease of planting density; ‘Jihua 26’ with the decrease of density, the quality of dry matter showed a tendency to rise first and then decrease, and ‘Silihong’ the accumulated amount showed a trend of gradually increasing. With the reduction of planting density, the number of pods per plant, pod yield per plant and weight of 100-pod increased first and then decreased of the two experimental varieties, the highest value was under M4 density of ‘Jihua26’ and M5 density of ‘Silihong’, which were significantly higher than other densities. The yield of the two experimental varieties continues to increase, Jihua 26 at M4 density had highest yield was 7 956.67 kg/hm² and ‘Silihong’ at M5 density had highest yield was 4 790.73 kg/hm², compare to control increase 96.14% and 65.42% respectively. 【Conclusion】 Compared with the singlerow double-seed planting mode, the large ridge double-row + single-seed planting mode can increase the peanut height, SPAD and dry matter accumulation. At the same time, the yield is improved. Under the condition that the density remains unchanged, peanuts can be changed from double-seed to single-seed precision sowing, which increases the yield. When planting in two rows of large ridges, the appropriate sowing density should be selected according to the type of peanut varieties. The M5 density of the semi-trailing type peanut varieties is the best, and the M4 density of the erect type peanut is the best [ABSTRACT FROM AUTHOR]

Objective: To analyze the clinical diagnostic value of NLR, MPVLR and MPV in acute lower extremity deep vein thrombosis (DVT) formation after total knee arthroplasty. Methods: A total of 80 patients who underwent total knee arthroplasty in our hospital from October 2020 to October 2021 were screened for research, and the included subjects underwent color ultrasound lower extremity DVT examination within 3 to 5 days after the surgery. DVT was used as the grouping standard, 43 patients with DVT of lower extremities confirmed by the results were included in the observation group, and 37 patients who did not occur were included in the control group. The two groups received routine blood tests at the same time, and the mean platelet volume (MPV), lymphocyte count, and neutrophil count were summarized, and the neutrophil/lymphocyte count (NLR) and mean platelet volume/lymphocyte count (MPVLR) were calculated according to the results), retrospectively analyzed the clinical data of the patients, and judged the differences of various indicators between the patients with and without occurrence, and then evaluated the diagnostic value of MPV, NLR, and MPVLR in the diagnosis of postoperative acute lower extremity DVT. Results: There was no significant difference in gender, age, history of chronic diseases (hypertension, diabetes), smoking history, and body mass index between patients with DVT and those without DVT (P>0.05). Compared with patients without lower extremity DVT, patients with lower extremity DVT had relatively lower neutrophils and higher lymphocyte and platelet counts(P<0.05). There was no significant difference in white blood cells between the two groups (P>0.05). MPV, NLR and MPVLR in patients with lower extremity DVT were significantly higher than those in patients without surgery(P<0.05); patients with swelling days of 7 days or more and more than 7 days had little difference in NLR indexes (P>0.05). There was a statistical difference between groups on MPVLR(P<0.05). Conclusion: MPV, NLR and MPVLR indexes have high diagnostic value for judging whether acute lower extremity DVT occurs after total knee arthroplasty. MPVLR can be used as a typical index for early diagnosis of lower extremity DVT, and provides a basis for clinical diagnosis of the disease, which deserves attention. [ABSTRACT FROM AUTHOR]

The shortage of feed grain is continually worsening in China, which leads to the transformation of feed grain security into national food security. Therefore, comprehensively integrating the basic data resources of feed nutrition and improving the nutritional value of all available feed resources will be one of the key technical strategies to ensure national food security in Chi‐ na. In this study, based on the description specification and attribute data standard of 16 categories of Chinese feed raw materi‐ als, more than 500,000 pieces of data on the types, spatial distribution, chemical composition and nutritional value characteris‐ tics of existing feed resources, which were accumulated through previous projects from the sixth Five-Year Plan to the thir‐ teenth Five-Year Plan period, were digitally collected, recorded, categorized and comprehensively analyzed. By using MySQL relational database technology and PHP program, a new generation of feed nutrition big data online platform (http://www.chin‐ afeeddata.org.cn/) was developed and web data sharing service was provided as well. First of all, the online platform provided visual analysis of all warehousing data, which could realize the visual comparison of a single or multiple feed nutrients in vari‐ ous graphic forms such as scatter diagram, histogram, curve line and column chart. By using two-dimensional code technology, all feed nutrition attribute data and feed entity sample traceability data could be shared and downloaded remotely in real-time on mobile phones. Secondly, the online platform also incorporated various regression models for prediction of feed effective nutri‐ ent values using readily available feed chemical composition in the datasets, providing dynamic analysis for feed raw material nutrient variation. Finally, based on Geographic Information System technology, the online platform integrated the data of feed chemical composition and major mineral element concentrations with their geographical location information, which was able to provide the distribution query and comparative analysis of the geographic information map of the feed raw material nutrition data at both provincial and national level. Meanwhile, the online platform can also provide a download service of the various da‐ tasets, which brought convenience to the comprehensive application of existing feed nutrition data. This research also showed that expanding feed resource data and providing prediction and analysis models of feed effective nutrients could maximize the utilization of the existing feed nutrition data. After embedding online calculation modules of various feed formulation software, this platform would be able to provide a one-stop service and optimize the utilization of the feed nutrition data. [ABSTRACT FROM AUTHOR]

Objectives: When using variance component estimation to determine the relative weight ratio, the least square solution is generally used as the initial value of the iteration. In geodetic joint inversion, the least squares method will cause ill ⁃ posed problems, so the regularized solution is used instead of the least square solution. Regularization introduces bias to reduce variance, but when using variance component estimation to determine the relative weight ratio, the influence of bias is not considered, and the introduction of bias will cause inaccurate variance component estimation. Methods: This paper adopts the bias - corrected variance component estimation method to eliminate the influence of bias introduced by regularization. The residual - based bias - corrected variance component estimation and the variance component estimation method are used for simulation experiments, the Visso earthquake and Norcia earthquake are used for verification. Results and Conclusions: Simulation experimental result shows that the variance component estimation method after bias correction can better reverse the slip distribution. The bias-corrected variance component estimation method takes into account the bias introduced by the iterative initial value, and the theory is more rigorous. Two real earthquakes results show that the bias correction is reasonable and advantageous. [ABSTRACT FROM AUTHOR]

Objective To explore the efficacy of allogeneic platelet-rich plasma gel (APG) in the treatment of chronic refractory wounds. Methods From January 2019 to May 2020, 78 patients with chronic refractory wounds were divided into 2 groups according to random number table method, with 39 patients in each group. The routine treatment was performed in the control group and APG treatment based on routine treatment was performed in the observation group. The treatment efficacy, wounds condition, inflammation index, serum hyaluronic acid, vascular endothelial growth factor and serum erythropoietin level between both groups were compared. Results The time of infection control, suitable skin graft, hospitalization and wound healing of observation group was shorter than that of control group (P<0.05). After treatment, the pH and PUSH score of wound exudate in both groups decreased significantly, but more significantly in observation group. The temperature of wounds in both groups increased significantly, but more significantly in observation group (P<0.05). The level of interleukin 1β, tumor necrosis factor α and C-reactive protein in both groups decreased significantly, but more significantly in observation group (P<0.05). The level of serum hyaluronic acid, vascular endothelial growth factor and erythropoietin in both groups increased significantly, but more significantly in observation group (P<0.05). Conclusion APG treatment on the basis of routine treatment can effectively alleviate inflammation, increase the level of serum hyaluronic acid, vascular endothelial growth factor and erythropoietin, reduce the pH and PUSH score of wound exudate, increase the temperature of wounds, reduce the time of infection control, suitable skin graft, hospitalization and wound healing. [ABSTRACT FROM AUTHOR]

Objective To evaluate the clinical value and safety of rigid bronchoscopy combined with electronic bronchoscopy in the treatment of benign and malignant severe central airway stenosis. Methods We retrospectively analyzed the clinical data of 46 patients with benign and malignant central airway stenosis treated from February 2015 to January 2019 in the Respiratory Endoscopy Room, The First Affiliated Hospital of Bengbu Medical College. We analyzed the patients􀆳 general data, diagnosis results, clinical manifestations, imaging and interventional treatment. The severity, type and distribution of stenosis were evaluated. The clinical symptoms and improvement of quality of life were evaluated by modified Medical Research Council Dyspnea Index (MRC DI) and Karnofsky Performance Score (KPS). Through regular follow-up, dynamic observation and evaluation of clinical efficacy, according to the occurrence of intraoperative and postoperative complications, safety assessment was carried out to evaluate the postoperative outcome. The clinical efficacy, safety evaluation and prognosis were observed. Results The average age of 46 patients was (62.43±12.34) years old. 36 (78.26%) had tracheal stenosis, 6 (13.04%) had stenosis in the left main bronchus, 10 (21.74%) in the right main bronchus, and 2 (4.35%) in the right middle bronchus. Among them, 33 patients (71.74%) had malignant central airway stenosis and 13 (28.26%) had benign lesions. Forty-six patients underwent 58 interventional therapies, including stent placement, cryotherapy and balloon dilatation. Endoscopic estimation of the degree of tracheal stenosis was (85.42 ±7.81)% before the first intervention and (24.17±5.79)% after operation. The degree of stenosis in the right main bronchus was improved from (81.00±17.13)% to (20.50±6.43)%. The degree of left main bronchus stenosis (24.17±9.14)% was significantly improved compared with preoperative (77.50±16.66)%. The difference was statistically significant (t=42.73, t=22.43, t=19.02, P <0.001). The degree of dyspnea was relieved in all the patients. Postoperative MRC DI was 0.98±0.62, significantly lower than the preoperative one 3.42±0.57(t=19.65, P <0.001). KPS was 34.01±13.14 and 83.91±8.96 before and after interventional therapy, and KPS increased significantly after operation (t=21.28, P<0.001). The main complications were local hemorrhage, hypoxemia in 4 cases (8.70%, 4/46), transient ventricular premature rupture in 1 case (2.17%, 1/46), and tooth loss in 2 cases(4.35%, 2/46). Most patients had sore throat of varying degrees after operation. The 1- year survival rate of patients with malignant central airway stenosis was 13.79% (4/29), and 4 patients with malignant tumor were followed up; 13 patients with benign airway stenosis had good quality of life. Conclusion For central airway stenosis, especially complex central airway stenosis, rigid bronchoscopy combined with electronic bronchoscopy shows immediate improvement of dyspnea and causes rare severe complications; thus it is safe and effective. It can improve the patients' quality of life. [ABSTRACT FROM AUTHOR]

In order to study the attitude switching operation characteristics of the flexible chassis of agricultural vehicles, the attitude switching analysis of the flexible chassis and the attitude switching test based on the second-generation prototype running on the hard surface were carried out. The attitude switching state model was established, and the switching parameters were optimized by the analytic hierarchy process and genetic algorithm. The index weights were determined for the lateral running attitude and the situ rotation attitude, respectively. The first level indicator included the preparatory phase, the holding phase and the recovery phase in the attitude switching process. The secondary indicators included all test indicators such as preparatory precision, preparatory time, lateral precision, lateral time, rotation precision, rotation time, recovery precision and recovery time. The population size of genetic algorithm was 300 and the number of iterations was 200, the genetic operation was roulette selection method and single point intersection method, and the variation used the small probability variation. Through the study of the switching precision and switching time under different translation angle, motor speed, switching angle, translation speed and rotating speed were obtained, the influence of various factors and their interactions on the attitude switching of the flexible chassis and the matching relationship between different switching attitude parameters were obtained. The results showed that the primary and secondary factors affecting the preparatory and recovery precision were the translation anglemotor rotation speed. The translation speed of the lateral running attitude had a very significant influence on lateral precision and time. Under any translation angle, the optimal motor speed of the lateral running attitude was 5.4 r/min, and the optimal translation speed was 3.45 m/s. The primary and secondary factors affecting the rotating precision of the situ rotation attitude was switching angle>rotating speed. The primary and secondary factors affecting the rotating time of the situ rotation attitude was switching angle> rotating speed>interaction. Under any translation angle, the optimal motor speed in the situ rotation attitude was 5.4 r/min. When the switching angle β∈(0, 85°), the optimal rotating speed was (0.003 3β+0.506 8) rad/s. When the switching angle β≥85°, the optimal rotating speed was 0.78 rad/s. The optimal switching verification test results showed that the overall trend of the theoretical and experimental value of comprehensive precision and time was consistent. For the comprehensive precision, the maximum deviation was 1.00% and the minimum deviation was 0.75%. For the situ rotation attitude, the maximum deviation was 1.70% and the minimum deviation was 0.97%. For the comprehensive time, for the lateral running attitude, the maximum deviation was 698 ms and the minimum deviation was 454 ms. For the situ rotation attitude, the maximum deviation was 361 ms and the minimum deviation was 191 ms. The optimization parameter comparison results showed that, in the lateral running attitude, the test results of the optimized parameter group was equal to the precision priority group and 4.16% higher than that of the time priority group in terms of comprehensive precision, the test results of the optimized parameter group was equal to that of the time priority group and 17 110 ms less than that of the precision priority group in terms of comprehensive time. In the situ rotation attitude, the test results of the optimized parameter group was equal to that of the precision priority group and 5. 15% higher than that of the time priority group in terms of comprehensive precision, the test results of the optimized parameter group was 646 and 996 ms less than that of the time priority group and the precision priority group, respectively. The research shows that the optimized attitude switching parameter can ensure the flexible chassis complete attitude switching process with faster attitude switching efficiency with slight loss of attitude switching precision. [ABSTRACT FROM AUTHOR]

In a product service supply chain (PSSC) consisting of a manufacturer and a service integrator, consumers' strategic waiting behavior is considered when they purchase a product-service system (PSS) from the service integrator. By building a two-period dynamic game model, how the strategic consumer behavior and equilibrium results are affected by the valuation of the PSS, cost and proportion of service valuation (accounts for the valuation of PSS) is analyzed. Moreover, performance under the decentralized decision is compared with that under the centralized decision and a two-period revenue sharing contract is proposed to achieve the supply chain coordination. The following results are obtained:the improvement of the valuation of PSS and the proportion of service valuation can reduce the strategic consumer behavior, and thus improve profits of both PSSC and two parties; high valuation of PSS and high proportion of service valuation can not only increase the supply chain's profit under the decentralized decision, but also broaden the gap between the supply chain's profit under the decentralized decision and that under the centralized decision; the revenue sharing contract can adjust strategic consumer behavior. That is, when the proportion of service valuation is high, the adjustment of price can restrain the strategic consumer behavior, and thus achieve the supply chain coordination. [ABSTRACT FROM AUTHOR]

Matrilin-4 is a member of the non-collagenous extracellular matrix protein family, and it widely distributes in loose and dense connective tissues, skin and digestive tract epithelial tissues, bone, cartilage, blood vessel wall and nervous system. Because of its widely distribution and specific expression, its mutations can contribute to multiple diseases. Many signaling pathways modulate the extracellular matrix indirectly by regulating the expression of matrilin-4. With the further research of matrilin-4 in recent years, some new ideas for the treatment of some diseases may be provided. This paper summarizes the latest research progress of matrilin-4 in related fields, and reviews the structure ofmatrilin-4, the relationship between other family members and the role ofmatrilin-4 in disease. [ABSTRACT FROM AUTHOR]

Beilun Port is a typical harbor alongside the tidal channel on muddy coast. It is great realistic significance to understand the engineering environmental effects via studying the coastal evolution and erosion -deposition analysis of underwater slope. Based on 5 bathymetric maps of 1935, 1962, 1987, 1996 and 2004, GIS technology is taken to establish the digital elevation models of Beilun Port in these years. With local chronicles as well as 3D hydrodynamic, sediment transport model, we calculated and analyzed the changes of coastline, evolution of tidal flat and erosion-deposition of underwater slope. The results indicate that the position of coastline is advancing seaward due to reclamation and embankment during 1935-1976, while keeping relatively stable except in shape because of dock project after 1976. Affected by the changes of coastline, the tidal flat area is sharply reduced from 18.16 km2 in 1935 to 3.83 km2 in 2004. Meanwhile, the underwater slope experiences an adjustment from slowly erosion to slightly erosion then to fast deposition and then to slightly deposition. This change is mainly as a consequence of human impact, such as port construction and reclamation in Hangzhou Bay. [ABSTRACT FROM AUTHOR]

目的：探讨多个小切口灌洗引流结合负压封闭引流术（VSD）治疗下肢坏死性筋膜炎（NF）的疗效。方法　选取该科2008年5月至2015年5月收治的30例较为典型的急性NF合并中毒性休克患者的病案资料，分为观察组和对照组，各15例。观察组采用多个小切口灌洗引流结合VSD技术治疗，对照组采用广泛切开引流联合换药传统治疗方法。观察比较两组临床疗效、创面愈合率、疼痛评分、创口愈合时间、住院时间情况。结果观察组患者肉芽生长速度、创口上皮化率、创面愈合率、疼痛评分、创口愈合时间及住院时间均优于对照组，差异有统计学意义（P＜0.05）。观察组患者总有效率为92.00%，对照组总有效率为70.08%，两组比较，差异有统计学意义（P＜0.05）。结论　应用多个小切口灌洗引流结合VSD治疗下肢NF疗效明显。 [ABSTRACT FROM AUTHOR]