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Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the effect of dexmedetomidine combined with butorphanol on cognitive dysfunction after gastrointestinal tumors laparoscopic radicalin elderly patients. Methods: 80 elderly patients who underwent laparoscopic radical for gastrointestinal tumors in our hospital from August 2015 to September 2018 were selected for retrospective analysis. According to the different preoperative drug use, they were divided into two groups. The observation group was given dexmedetomidine combined with butofenol preoperatively, and the control group was given the same amount of normal saline preoperatively. Ramsay sedative score, Ramsay sedative score, preoperative and postoperative cognitive function score, S-100β, NSE and IL-6 levels and adverse reactions were compared between the two groups. Results:The Ramsay sedative score of patients in the observation group was significantly better than that in the control group (P<0.05) at the time of extubation, at 4h, 8h and 12h after extubation. There was no statistically significant difference in the MMSE score and total score between the two groups at T0 before surgery(P>0.05). The MMSE scores and total scores in the observation group at T1 and T2 were significantly higher than those in the control group (P<0.05). At T1, the serum levels of S-100β and IL-6 in the observation group were significantly lower than those in the control group, and serum NSE levels at T1 and T2 were significantly lower than those in the control group (P<0.05). There was no statistically significant difference in the incidence of nausea, vomiting, drowsiness and dizziness between the two groups (P>0.05). Conclusion: The application of dexmedetomidine combined with butorphanol before laparoscopic radical can significantly improve the postoperative cognitive function, anesthesia effect for the elderly patients with gastrointestinal tumors, and it won't increase the incidence of complications. [ABSTRACT FROM AUTHOR]

Objective: To investigate effects of PEEP ventilation on respiratory function and hemodynamics during general anesthesia in patients with bone tumor surgery. Methods: 60 cases of patients with bone tumors were selected during January 2014 to 2015 December in our hospital, all patients were treated with routine anesthesia induction underwent mechanical ventilation, to observe and record the respiratory function and hemodynamic parameters under different PEEP ventilation (0 cmH2O,5 cmH2O and 10 cmH2O). Results: Peak and Plat of PEEP 10 cm H2O were significantly higher than that of PEEP 5 cm H2O and PEEP 0 cm H2O, Peak and Plat of PEEP 5 cm H2O were significantly higher than PEEP 0 cm H2O, the difference was statistically significant (P<0.05). The difference of HR, MAP and CVP of different PEEP levels were no statistical significance (P> 0.05). The difference of CI, SVI, GEF, CFI, SVV, PVV, ITBI, ELWI and PVPI of different PEEP levels were no statistical significance (P>0.05). Conclusion: Increased PEEP values can significantly improve the absorption function such as Peak and Plat, but no influence on hemodynamic, which is worthy of clinical application. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To evaluate the application value of perioperative interventional strategy guided by enhanced recovery after surgery (ERAS) in elderly recipients undergoing liver transplantation. Methods Clinical data of 405 liver transplant recipients were retrospectively analyzed. According to age, all recipients were divided into the elderly (≥60 years, n=122) and non-elderly groups (<60 years, n=283). All patients received perioperative interventions under the guidance of ERAS. Intraoperative and postoperative indexes, incidence of postoperative complications and discharge were analyzed between two groups. Results There were no significant differences in the duration of anesthesia, operation time, anhepatic phase, hemorrhage volume, blood transfusion volume, lactic acid level before abdominal closure, ventilatorassisted time, the length of intensive care unit (ICU) stay, Caprini score, CHIPPS score, time of gastric tube, urinary tube and drainage tube removal, time to first drinking, time to first physical activity and time to first flatus between two groups (all P>0.05). In the elderly group, the time to first feeding was later than that in the non-elderly group (P<0.05). There were no significant differences in the incidence of fever, ascites, pulmonary infection, delayed gastric emptying, hemorrhage and inactive venous thrombosis between two groups (all P>0.05). No significant differences were observed in the levels of aspartate aminotransferase, total bilirubin, direct bilirubin, serum creatinine before discharge and total length of hospital stay between two groups (all P>0.05). The alanine aminotransferase level in elderly recipients was lower than that in nonelderly counterparts, and the difference was statistically significant (P<0.05). No unplanned reoperation was performed within postoperative 30 d in two groups. There was no significant difference in the re-hospitalization rate within 30 d after discharge (P>0.05). Conclusions ERAS-guided interventional strategy contributes to perioperative recovery of elderly recipients undergoing liver transplantation, and yields equivalent postoperative recovery between elderly and non-elderly recipients. Objective To evaluate the application value of perioperative interventional strategy guided by enhanced recovery after surgery (ERAS) in elderly recipients undergoing liver transplantation. Methods Clinical data of 405 liver transplant recipients were retrospectively analyzed. According to age, all recipients were divided into the elderly (≥60 years, n=122) and non-elderly groups (<60 years, n=283). All patients received perioperative interventions under the guidance of ERAS. Intraoperative and postoperative indexes, incidence of postoperative complications and discharge were analyzed between two groups. Results There were no significant differences in the duration of anesthesia, operation time, anhepatic phase, hemorrhage volume, blood transfusion volume, lactic acid level before abdominal closure, ventilatorassisted time, the length of intensive care unit (ICU) stay, Caprini score, CHIPPS score, time of gastric tube, urinary tube and drainage tube removal, time to first drinking, time to first physical activity and time to first flatus between two groups (all P>0.05). In the elderly group, the time to first feeding was later than that in the non-elderly group (P<0.05). There were no significant differences in the incidence of fever, ascites, pulmonary infection, delayed gastric emptying, hemorrhage and inactive venous thrombosis between two groups (all P>0.05). No significant differences were observed in the levels of aspartate aminotransferase, total bilirubin, direct bilirubin, serum creatinine before discharge and total length of hospital stay between two groups (all P>0.05). The alanine aminotransferase level in elderly recipients was lower than that in nonelderly counterparts, and the difference was statistically significant (P<0.05). No unplanned reoperation was performed within postoperative 30 d in two groups. There was no significant difference in the re-hospitalization rate within 30 d after discharge (P>0.05). Conclusions ERAS-guided interventional strategy contributes to perioperative recovery of elderly recipients undergoing liver transplantation, and yields equivalent postoperative recovery between elderly and non-elderly recipients. [ABSTRACT FROM AUTHOR]