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目的探究环形RNA circSLC8A1_005调控心肌成纤维细胞纤维化表型的作用及可能机制。方法利用腺病毒介导在小鼠心肌成纤维细胞（mCFs）中过表达circSLC8A1_005，并检测mCFs中纤维化相关因I型胶原α1链（Col1a1）、Ⅲ型胶原α1链（Col3a1）和平滑肌肌动蛋白α2（Acta2）基因表达，通过EdU和划痕实验检测不同干预对mCFs的增殖和迁移能力的影响。双萤光素酶报告基因实验检测circSLC8A1_005包含的潜在核糖体进入序列（IRES）的活性。通过Western blot实验检测circSLC8A1_005翻译蛋白SLC8A1-605aa及其在细胞内分布情况。双萤光素酶报告基因实验检测SLC8A1-605aa对超氧化物歧化酶2（Sod2）的转录激活作用。通过RNA结合蛋白免疫沉淀（RIP）实验检测SLC8A1-605aa与Sod2 mRNA的结合作用。放线菌素D实验检测SLC8A1-605aa对Sod2 mRNA稳定性的影响。结果利用腺病毒可在mCFs中有效介导过表达circSLC8A1_005，过表达circSLC8A1_005可显著抑制mCFs中纤维化相关基因表达，抑制mCFs的增殖和迁移能力。双萤光素酶报告基因实验结果提示circSLC8A1_005包含的2个IRES具有活性。Western blot检测结果显示circSLC8A1_005可翻译预期大小为70 ku的SLC8A1-605aa蛋白，并主要分布于细胞核内。过表达SLC8A1-605aa和circSLC8A1_005可一致地抑制mCFs的纤维化表型。SLC8A1-605aa可特异上调超氧化物歧化酶2（Sod2）表达，但并不能转录激活Sod2表达；RIP实验结果显示SLC8A1-605aa与Sod2 mRNA有特异结合作用，而放线菌素D实验结果显示SLC8A1-605aa能够增强Sod2 mRNA的稳定性。结论CircSLC8A1_005通过翻译蛋白SLC8A1-605aa发挥抑制心肌成纤维细胞纤维化表型的作用，SLC8A1-605aa可能是潜在的用于心肌纤维化治疗的靶点。

为了研究填充介质对脊波导截止特性的影响,文章采用FDTD（时域有限差分）法计算了填充介质梯形双脊波导在TE（横电波）模式下的截止特性随几何尺寸的变化,并给出了关系曲线。结果表明,脊间距越小,填充介质的相对介电常数越大,截止波长越长,单模带宽越窄。研究结果丰富了现存填充介质波导数据,有助于填充介质波导的设计和工程应用。

在频谱利用率得到保证的前提下 ,为了进一步提高信道对传输差错控制的能力 ,TE-TRA标准采用了较为复杂的信道编码技术 .文章通过介绍 TETRA标准中所采用的信道纠错编码方案对几种纠错编码技术及其性能进行了较为详细的分析 ,在此基础上给出了信道编码器的实现方案 .

为了寻找最佳截止特性的填充介质脊波导结构,提出了填充介质倒梯形对称双脊波导。采用有限元法借助MATLAB软件计算了填充介质倒梯形对称双脊波导在TE模式下的截止特性,即主模截止波长和单模带宽。绘制出主模场结构图,并分析脊波导截止特性与填充介质相对介电常数之间的关系,给出了关系曲线图。这些结果将对填充介质波导的设计和工程应用提供一定的理论依据和数据参考。

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In this study, using data from evaluations of 20 companies by seven raters in a corporate award on the theme of human resource management, I examined the consistency of company evaluations by a small number of experts in different fields and the criterion-related validity of the mean evaluations per company. The evaluation was conducted in the order of documents and interviews, and each was rated on five items. The intraclass correlations showed that the evaluations of "philosophy," "innovation," "leadership," and "motivation" were consistent across raters and that the interview evaluations were more consistent than the document evaluations. Regarding "personnel" evaluations, significant consistency was found only for document evaluations. The correlations between the mean evaluations and indices of application documents showed that companies with more text in their application documents tended to be evaluated more highly. It was confirmed that the few experts' evaluations of the companies had a moderate degree of consistency and validity; however, it was also suggested that some combinations of evaluation items and evaluation materials may not have resulted in appropriate evaluations. [ABSTRACT FROM AUTHOR]

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The simulation for sintering of co-firing double layer compacts and substrate-constrained compacts were obtained by coupled Monte Carlo method and finite element method. In the coupled simulation of a co-firing compacts with different sintering shrinkage curves, the amount of warpage during and after sintering changed significantly. As a result of detailed confirmation of the results, it was found that there was a difference between the porosity obtained by the Monte Carlo method and by finite element method, so the coupled simulation was modified to minimize the porosity difference. As a result of the coupled simulation of constraint sintering, it was not contracted in the surface direction, but only in the thickness direction, and the results were represented in the previous experimental results. We found that coupled simulation can be applied as a tool to design and analyze the sintering behavior of products obtained by co-firing and constrained sintering. [ABSTRACT FROM AUTHOR]

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南美洲的金狮绒,也弥金毛绒,是一种世界上最漂亮、最为稀有的小型猴类,属灵长目,绒猴科。世界上绒猴科动物种类比较多,而且生活习性也很相似,但它们的分布区都很狭小,集中栖息在南美森林里。金狮绒的分布区很小,仅产于巴西东南沿海一带的森林中。它用爪爬树,动作敏捷,跳跃的姿态

步入亚寒带或热带的高山丛林之中,会发现一种体形象松鼠,长有毛茸茸长尾巴的动物,从高高树稍上飞向远方。有人误把它认为鸟类,实际上这是鼯鼠,因为会“飞”,也称飞鼠。鼯鼠实际上并不会飞。在它的前后肢之间有皮膜相连,借助皮膜,能从高处向低处滑翔。

随着岁月的流逝,针鼹似乎已被世人所遗忘。这种古老的单孔目动物,是现存哺乳类动物中最原始的类群之一。针鼹小尾巴短腿,爪特别锋利,躯干园胖,布满坚硬的刺,外形很象刺猬,但它们却是迥然不同的两种动物。针鼹具有高超的挖洞绝技,能在地下掘出长长的坑道。掘地时,它先将已掘出的土块,拨到身下,再用后脚将士块踢向身

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Copyright of Multipurpose Utilization of Mineral Resources / Kuangchan Zonghe Liyong is the property of Multipurpose Utilization of Mineral Resources Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Earthquake (1000-3274) is the property of Editorial Office of Earthquake Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Objective To observe the therapeutic effect of lanthanum hydroxide (LH) on hyperphosphatemia in rats with chronic renal failure and explore its mechanism. Methods Thirty Wistar rats were randomly divided into five groups, with 6 rats in each group. No hyperphosphatemia model of chronic renal failure was prepared in the control group, and the hyperphosphatemia models were prepared in the model group, low-dose group, medium-dose group and high-dose group. After modeling, the rats in the low-dose group, medium-dose group, and high-dose group were given 0. 1, 0. 2, and 0. 4 g/kg LH by gavage, respectively, for a total of 8 weeks. The rats in the model group and control group were not treated. Calcium (Ca), phosphorus (PI), creatinine (Scr) and urea nitrogen (BUN) kits were used to detect serum Ca, PI, Scr and BUN, and hematoxylin-eosin (HE) and Masson's staining were used to detect the pathological changes of kidney tissues. In addition, liquid chromatography-mass spectrometry (LC-MS) was used to detect renal differential metabolites in the control group, model group, low-dose, medium-does and high-dose groups, and we analyzed the GO function and KEGG enrichment of renal differential metabolites. Results After 8 weeks of administration, compared with the model group, the serum PI, Scr and BUN levels of rats with chronic renal failure and hyperphosphatemia decreased in the LH groups after treatment, and renal injury, cystic dilatation of renal tubules and inflammatory cell infiltration were improved, and cystic dilatation of renal tubules, inflammatory cell infiltration and fibrosis degree, and renal injury were alle‑ viated. They were in a dose-dependent manner (all P<0. 05) . The differential metabolites of renal function with compensatory up-regulation were D-alanyl-D-alanine, 6-tert-butylsulfonic acid, aminodicyclodicarboxylic acid and 1D inositol. The differential metabolites of renal function with compensatory down-regulation were DL-citrulline, 2, 3-prostaglandin, ornithine, 2-sulfoxymethyl, and p-carboxybenzene sulfonamide, etc. The metabolic pathways enriched by these metabolites in renal function differences included urea cycle, arginine and proline metabolism, pentose phosphate pathway, lysine degradation, malate-aspartic acid cycle, aspartic acid metabolism, and alanine metabolism, etc. Conclusions LH has a therapeutic effect on hyperphosphatemia of chronic renal failure rats, and high-dose LH is the most significant. LH may play a therapeutic role through urea cycle and arginine metabolism. [ABSTRACT FROM AUTHOR]