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Objective: To investigate the relationship between serum CC chemokine ligand 5 (CCL5) level and the severity of coronary atherosclerosis. Methods: The expression of CCL5 protein in carotid atherosclerotic plaques obtained from carotid eversion endarterectomy (CEE) of 5 cases of patients with highgrade stenosis (>70 %) (AS group) and 3 cases of normal postmortem arteries (control group) were detected by Immunohistochemistry and Western blotting. The CCL5 expression was compared between the two groups. 110 cases of consecutive patients who underwent coronary angiography were selected and divided into the control group (Gensini's score = 0, n=27), mild lesions group (020, n=51). The blood pressure, blood lipid, blood glucose and serum CCL5 of all groups were investigated. Their serum CCL5 levels were measured by enzyme linked immunosorbent assay (ELISA). The relationship between risk factors, serum CCL5 level and Gensini score were analyzed. Results: The expression of CCL5 protein in the carotid artery atherosclerosis was evidently higher than that in the normal carotid artery, and the serum CCL5 level of CAD patients was significantly higher than that of the control group. Sex, smoking history, systolic pressure, diastolic pressure, glucose and serumCCL5 were significantly different among three groups. Correlation analysis indicated that diastolic pressure, glucose and serum CCL5 were positively correlated with Gensini's score (r=0.276, 0.418, 0.519; P<0.05). In multi-variant linear regression model, serum CCL5 (B=8.775; P=0.000) were established as independent predictors of Gensini's score. Conclusion: Serum CCL5 was positively correlated with the severity of coronary artery atherosclerosis and was proved to be an independent predictor of Gensini's score. [ABSTRACT FROM AUTHOR]

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Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)