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It established Bengbu-Fushan hydrodynamic mathematical model by the application of MIKE and calibrated and validated the parameters of the model by using the observed flood hydrograph of typical year 2007. It coupled the main channel of Huaihe River and the flooding zone through establishing 1D and 2D models for simulating the evolution process of 100-year flood, establishing flow-stage relationship under the different conditions of flooding area operation, rationality analyzing and optimizing the flooding area operation after implementing the revised plan and providing the basis for the operation and regulation of the flood storage zone. The results show that when encountering 100-year flood, Huayuan Lake flood zone is used in accordance with the water level of Linhuaiguan of 20.6 m under the planning conditions, at the same time, the gate dispatching mode is used simultaneously to open Jinhong Lock and Tuihong Lock. The effect of flood discharge is relatively good. [ABSTRACT FROM AUTHOR]