Search

Copyright of Journal of International Reproductive Health/Family Planning is the property of Editorial Board of the Journal of International Reproductive Health/Family Planning and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Insulin resistance (IR) is not only one of the important cause of various metabolic diseases, but also an important factor affecting female reproductive function. In recent years, more and more attention has been paid to the effect of IR on female reproductive function by scholars at home and abroad, and a series of studies on the influence of IR on female reproductive function have been carried out from different angles and levels. By disturbing the function of mitochondria of oocyte, destroying the balance of oxidation and antioxidation, producing inflammatory factors, the oocyte quality decreases, the damage of mitochondrial function aggravates IR, and the oocyte quality further decreases, which is a vicious circle. IR reduces endometrial receptivity and ultimately leads to reduced fertility by affecting endometrial energy metabolism, expression of AMPK pathway and PI3K/Akt pathway molecules, chronic inflammatory state and expression of other micro molecules. In addition, a variety of adverse pregnancy outcomes and pregnancy complications are also related to IR. For example, IR is a risk factor for spontaneous abortion, and pre-pregnancy IR will increase the incidence of gestational diabetes, as well as the risk of glucose intolerance, macrocephaly, obesity and hypertension in offspring. [ABSTRACT FROM AUTHOR]

Reactive oxygen species (ROS) is the product of the reaction between oxygen and electrons. The appropriate level of ROS and the oxidative stress balance play an important role in maintaining physiological function. When ROS was produced too much or the ability to eliminate ROS was weakened, the increased oxidative stress (OS) could lead to a variety of infertility-related diseases. OS is involved in the occurrence and development of polycystic ovary syndrome, endometriosis, recurrent abortion and other diseases, as well as the prognosis of these diseases. In addition to being involved in female reproductive-related diseases, OS can also reduce semen quality and affect male reproductive function. This article reviews the pathogenesis of oxidative stress and its effect on reproduction-related diseases. [ABSTRACT FROM AUTHOR]

Copyright of Journal of International Obstetrics & Gynecology is the property of TianJin Medical Information Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of International Obstetrics & Gynecology is the property of TianJin Medical Information Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of International Reproductive Health/Family Planning is the property of Editorial Board of the Journal of International Reproductive Health/Family Planning and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of International Reproductive Health/Family Planning is the property of Editorial Board of the Journal of International Reproductive Health/Family Planning and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of International Reproductive Health/Family Planning is the property of Editorial Board of the Journal of International Reproductive Health/Family Planning and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)