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Copyright of Science Technology & Engineering is the property of Chinese Society of Technology Economics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Practical Oncology Journal is the property of Journal of Practical Oncology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In the traditional text classification, KNN algorithm is widely used in text classification because of its simplicity, high classification accuracy and non parameter. However, in the process of text classification, traditional KNN needs to calculate the similarity between the text to be classified and each training sample. When faced with massive text, the classification effect will be significantly reduced. To solve this problem, a KNN progressive text classification method based on three-way decision making is proposed to improve its classification efficiency. Combined with the advantages of three-way decision in classification, and it is combined with KNN algorithm, through the title, abstract, keywords and other progressive classification processing, so as to complete the text classification, improve the efficiency and performance of text classification. Experiments show that the algorithm can ensure the classification accuracy of KNN algorithm and improve the classification efficiency at the same time. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the risk factors of olfactory dysfunction in patients with chronic sinusitis and its effect on mental health and quality of life of patients. Methods: 120 patients with chronic sinusitis who were admitted to Beijing Tongren Hospital Affiliated to Capital Medical University from September 2017 to September 2020 were selected for olfactory function test. The incidence of olfactory dysfunction was analyzed, and patients were divided into olfactory dysfunction group (n=64) and olfactory normal group (n=56) according to the olfactory function test. The basic data, clinical data, mental health status and quality of life of patients in the two groups were compared and analyzed. The influencing factors of olfactory dysfunction in patients with chronic sinusitis were analyzed by univariate analysis, and risk factors of olfactory dysfunction in patients with chronic sinusitis were analyzed by multivariate Logistic regression. Results: According to the olfactory function test results, 64 of the 120 patients showed olfactory dysfunction, and the prevalence rate of olfactory dysfunction was 53.33%, included 36 cases (56.25%) of male patients, and 28 cases (43.75%) of female patients. 46 cases (38.33%) had hypoolfactory, and 18 cases (15.00%) had anosmia. Univariate analysis showed that nasal endoscopic surgery history, concomitant nasal polyp, asthma history, proportion of eosinophils and nasal endoscopic Lund-Kennedy score were the influential factors for the occurrence of anosmia in chronic sinusitis (all P<0.05). Multivariate Logistic regression analysis showed that nasal endoscopic surgery history, concomitant nasal polyp, asthma history, proportion of eosinophil ＞5%, and nasal endoscopic Lund-Kennedy score ≥2 scores were independent risk factors for olfaction of chronic sinusitis. The scores of anxiety self-rating Scale (SAS) and depression self-rating Scale (SDS) in the olfactory normal group were lower than those in the olfactory dysfunction group (P<0.05). The score of quality of life (SF-36) for each dimension in the olfactory normal group was higher than that in the olfactory dysfunction group (P<0.05). Conclusion: The incidence of anosmia is higher in patients with chronic sinusitis, and the risk factors for anosmia are nasal endoscopic surgery history, concomitant nasal polyp, asthma history, proportion of eosinophilia ＞5% and Lund-Kennedy score ≥2 scores. At the same time, olfactory disorder can also cause depression and anxiety and other adverse emotions, reducing the quality of life of patients. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of high thoracic epidural anesthesia (HTEA) on the cerebral blood flow (CBF) and hippocampal apoptosis-related proteins Bcl-2 and Bax during global cerebral ischemia and reperfusion (GCI) in rats. Methods: Fifteen-minute global ischemia was established by 4-vessel occlusion and epidural catheterization was performed through T4-5 intervertebral spaces hi adult male Wistar rats. According to the different drugs infused into the epidural space, the rats were randomly divided into four groups: Sham group (0.9 % NaCl), Sham-HTEA group (0.25 % bupivacaine), GCI group (global cerebral ischemia, 0.9 % NaCl) and E1TEA group (global cerebral ischemia. 0.25 % bupivacaine). And 0.25 %bupivacaine or 0.9 % saline (20 μL h-1) was infused continuously to the thoracic epidural space from 15 minutes before ischemia to 24 hours after reperfusion. Mean arterial pressure (MAP), heart rate (HR) and cerebral blood flow (CBF) were determined until 2 horns after reperfusion, and the hippocampal Bcl-2 and Bax proteins at 24 hours after reperfusion were examined by Western-blot. Results: Compared with the GCI grouμ HTEA group has no significant difference on MAP and HR during ischemia and 2 horns after reperfusion, andcompared with the Sham grouμ MAP in GCI group increased in ischemia 0 min and decreased in reperfusion 0 min. The CBF hi HTEA group was significantly lower than that hi GCI group (123.1%± 35.2% vs 177.5%± 32.4%, P<0.01) hi reperfusion 10 nun, and higher than that hi GCI group during the hypoperfusion of 60 to 120 minutes after reperfusion (P<0.05), and the ratio of Bax/Bcl-2 hi hippocampus was significantly decreased hi HTEA group 24 hours after reperfusion (P<0.01). Conclusions: Continuous HTEA infusion of 0.25 % bupivacaine 20 μL h-1 could maintain the hemodynamic stability, and improve the CBF of hypoperfusion period hi rats, as well as reduce the ratio of Bax Bcl-2 at 24 hours after reperfusion. [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的观察晚期非小细胞肺腺癌患者铂类药物化疗前后血清表皮生长因子受体(EGFR)基因型变化。方法 40例晚期非小细胞肺腺癌患者均采用铂类药物化疗方案化疗4周期,检测患者化疗前后血清EGFR基因型,检测突变型和野生型基因比例。结果 40例患者中失访1例,DNA提取失败1例,最终纳入38例。化疗前EGFR基因型为野生型21例、突变型17例;化疗后分别为19、19例。化疗前后患者血清EGFR基因型比较差异无统计学意义。化疗前后基因状态一致者26例,基因状态不一致者12例,其中EGFR基因由突变型转为野生型5例、由野生型转为突变型7例。结论铂类药物化疗可导致晚期非小细胞肺腺癌患者EGFR基因型改变。 [ABSTRACT FROM AUTHOR]