Objective To systematically evaluate the efficacy of method of invigorating kidney, invigorating spleen and promoting blood circulation on postmenopausal osteoporosis. Methods Used computers to search major databases, such as Cochrane Library, CNKI, Wanfang, Embase, VIP, web of science, PubMed, Medline and other databases, and search the randomized controlled trial of invigorating kidney, invigorating spleen and promoting blood circulation on postmenopausal osteoporosis from February 2021, Revman5.3 software was used to conduct quantitative meta-analysis on the literature that met the inclusion conditions. Results A total of 14 RCT literatures were included for quantitative analysis. The study involved 1218 patients. The analysis result showed that:(1)compared with the western medicine, the method of invigorating kidney, invigorating spleen and promoting blood circulation had advantages in increasing effective rate of postmenopausal Osteoporosis [OR=2.57, 95%CI(1.37,4.83),P=0.003], E2 level [MD=3.15, 95% CI(0.28,6.02),P=0.03] and decreasing B-ALP level [MD=-17.63, 95%CI(-26.01,-9.25), P<0.000 1], Ca/Cr level [MD=-0.14, 95% CI(-0.27,-0.01), P<0.000 1]; there was no significant difference in bone mineral density of lumbar[MD=0.01, 95%CI(-0.02, 0.04), P=0.42], bone mineral density of femoral neck [MD=0.00, 95%CI(-0.06, 0.05), P=0.91], IGF-1 level[MD=31.71, 95%CI(-18.54,81.96), P<0.000 1], IL-6 level[MD=-5.72,95%CI(-14.05, 2.61), P=0.18], TNF-αlevel[MD=-13.51, 95%CI(-39.89, 12.86), P<0.000 1] between the method of invigorating kidney, invigorating spleen and promoting blood circulation and the western medicine.(2)Compared with the western medicine, the method of invigorating kidney, invigorating spleen and promoting blood circulation combine with the western medicine had advantagesin increasing effective rate of postmenopausal osteoporosis[OR=5.44, 95%CI(2.71, 10.89), P<0.000 01], bone mineral density of lumbar[MD=0.07, 95%CI(0.04, 0.11), P<0.000 01], bone mineral density of femoral neck[MD=0.06, 95%CI(0.02, 0.09), P=0.000 8], E2 level[MD =5.20, 95%CI(1.35, 9.06), P=0.008] and decreasing B-ALP level[MD=-4.31, 95%CI(-5.53,-3.09), P<0.000 01], IL-6 level[MD=-18.06, 95%CI(-26.56,-9.57), P<0.000 1].(3)According to the clinical efficiency, lumbar BMD, femoral neck BMD, E2 level, IL-6 level, the result showed that compared with the simple method of invigorating kidney, invigorating spleen and promoting blood circulation, the combination of the method of invigorating kidney, invigorating spleen and promoting blood circulation with western medicine had synergistic effect. Conclusion The method of invigorating kidney, invigorating spleen and promoting blood circulation has a significant effect on postmenopausal osteoporosis, and it can increase efficiency together with western medicine, but more RCTs are needed to confirm. [ABSTRACT FROM AUTHOR]