Search

目的 评估成人烟雾病患者的认知水平及其在长期随访中的变化，并探讨成人烟雾病患者认知功能下降的影响因素。 方法 采用前瞻性队列研究设计，连续纳入2015年1月—2016年6月海军军医大学第一附属医院脑血管病中心收治的成人烟雾病患者64例，其中42例接受血流重建术（联合血流重建术16例、间接血流重建术26例）治疗，22例未接受手术治疗。收集所有患者的基线资料，并使用MoCA评估患者基线、短期[（6±1）个月]随访、长期[（10±1）年]随访时的认知功能，采用9条目患者健康问卷（patient health questionnaire-9，PHQ-9）和7条目广泛性焦虑障碍（generalized anxiety disorder-7-item，GAD-7）量表评估患者的情绪状态。分析所有患者以及接受不同治疗患者在短期随访和长期随访中的认知功能和情绪状态变化。采用可靠变化指数（reliable change index，RCI）判断是否存在功能下降，计算公式为RCIMoCA=（X2-X1）/标准差（standard deviation，SD），将RCIMoCA＜-1定义为认知功能下降。采用二元logistic回归模型探讨成人烟雾病患者长期认知功能下降的独立影响因素。 结果 共53例患者完成长期随访，其中接受联合血流重建术治疗患者13例，接受间接血流重建术治疗患者22例，未接受手术者18例。整体人群3个随访时期MoCA评分趋于稳定（P=0.694）：接受联合血流重建术[21（18～25）分 vs. 19（17～24）分，P=0.035]和间接血流重建术[20（17～22）分 vs. 19（16～22）分，P=0.047]治疗的患者短期随访MoCA评分有改善，但长期随访相对基线趋于稳定；未手术患者短期随访MoCA评分无明显下降，长期随访较基线有下降[（15（11～24）分 vs. 18（14～26）分，P=0.039]。随着时间的延长，成人烟雾病患者的认知功能恶化有加重趋势，而焦虑、抑郁状态有好转趋势。长期随访认知功能下降组与未下降组之间的手术治疗比例差异有统计学意义（P=0.037），但logistic回归分析未发现手术治疗是其独立影响因素（P＞0.05）。 结论 在长期随访中，成人烟雾病患者认知功能大致保持稳定，焦虑、抑郁状态趋于好转。血流重建术可能对维持长期认知稳定有积极作用，但仍需扩大样本量进一步明确。 Abstract: Objective To assess the cognitive function of adult patients with Moyamoya disease (MMD) and the changes during long-term follow-up, and to explore the influencing factors of cognitive decline in adult patients with MMD. Methods A prospective cohort study was used to continuously include 64 adult patients with MMD admitted to the First Affiliated Hospital of Naval Medical University from January 2015 to June 2016, of whom 42 patients underwent revascularization (16 patients underwent combined revascularization and 26 patients underwent indirect revascularization), and 22 patients did not receive surgical treatment. Baseline characteristics of all patients were collected, and cognitive function was assessed by the MoCA at baseline, short-term [(6±1) months] follow-up, and long-term [(10±1) years] follow-up. Emotional status was assessed by patient health questionnaire-9 (PHQ-9) and generalized anxiety disorder-7-item (GAD-7). The changes in cognitive function and emotional status were analyzed in all patients, as well as in patients receiving different treatment approaches, during short- and long-term follow-ups. The reliable change index (RCI) was used to determine whether there was a decline in function with the following formula: RCIMoCA= (X2-X1) /standard deviation (SD). It was defined as cognitive decline when RCIMoCA＜-1. The binary logistic regression model was used to explore the independent influencing factors of long-term cognitive decline in adult patients with MMD. Results A total of 53 patients completed the long-term follow-up, including 13 patients who underwent combined revascularization, 22 patients who underwent indirect revascularization, and 18 patients who did not undergo surgery. The MoCA scores of the overall population tended to stabilize during the long-term follow-up period (P=0.694). Patients who underwent combined revascularization [21 (18-25) points vs. 19 (17-24) points, P=0.035] and indirect revascularization [20 (17-22) points vs. 19 (16-22) points, P=0.047] showed improvement in MoCA scores at short-term follow-up, but tended to stabilize relative to baseline at long-term follow-up. There was no significant decrease in MoCA scores in patients who did not undergo surgery at short-term follow-up, but there was a decrease in MoCA scores compared with baseline at long-term follow-up [15 (11-24) points vs. 18 (14-26) points, P=0.039]. Over time, the cognitive function of adult patients with MMD tended to worsen, while the anxiety and depression status tended to improve. There was a significant difference in the proportion of surgical treatment between the two groups with and without cognitive decline during the long-term follow-up (P=0.037), but logistic regression did not find it as an independent influencing factor (P>0.05). Conclusions During long-term follow-up, the cognitive function of adult patients with MMD generally remain stable, and the anxiety and depression status tends to improve. Revascularization may have a positive effect on maintaining long-term cognitive stability, and future studies with larger sample sizes are needed.

Objective To evaluate the clinical effect of using a new cross buccal tube (XBT) to close the extraction gap of the maxillary second premolar and control the anchorage. Methods Fifteen adolescent patients with moderate to severe crowding, skeletal Class Ⅰ, missing maxillary second premolars or difficult to retain during clinical examination were selected. PASS orthodontic technique was used to reduce the number of maxillary second premolars to relieve crowding and retract the anterior teeth. Before and after treatment, head lateral images were taken and cephalometric measurements were taken. Changes of bone and dental indexes related to molar anchorage and anterior adduction were observed. Results After treatment, teeth of all patients were arranged neatly, the occlusion relationship was good and the profile was improved. Before and after treatment, there were no significant changes in bone indicators such as ∠SNA, ∠SNB and ∠ANB (P＞0.05). There was no significant change in vertical height ∠MP-SN (P＞0.05). The angle of the upper and lower central incisors, ∠U1-SN, ∠U1-NA, ∠ L1-MP and ∠L1-NB decreased significantly, while ∠U1-L1 increased significantly (P＜0.05). The upper incisor margin point moving towards the distal (P＜0.05), and there was no significant change in the position of the upper incisor root apex and first molar (P＞0.05). Conclusion The application of the new cross buccal tube is beneficial for adolescent patients to control the occlusion of the extraction gap of the maxillary second premolar. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Stroke is the property of Chinese Journal of Stroke Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Clinical Healthcare is the property of Chinese Journal of Clinical Healthcare and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Henan University of Science & Technology, Natural Science is the property of Editorial Office of Journal of Henan University of Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Engineering Management / Gongcheng Guanli Xuebao is the property of Journal of Engineering Management Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Signal Processing is the property of Journal of Signal Processing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)