1. 電磁波による活性酸素の発生を介したアクチン重合制御.
- Author
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石本 哲也 and 森 寿
- Abstract
Actin, a cytoskeletal protein, has a molecular weight of 42 kDa and both monomeric (G-actin) and polymeric (F-actin) structures exist in cells. Polymerization-depolymerization of actin occurs more frequently than for other cytoskeletal proteins such as microtubules and intermediate filaments, and has a significant impact on cell morphology and motility. Actin and some actin-binding proteins are known to be oxidized by reactive oxygen species (ROS), and the regulation of polymerization-depolymerization is affected by the state of oxidation. Recently, it has been increasingly reported that electromagnetic waves such as UV, visible light, near-infrared light, and X-rays induce the generation of intracellular ROS and actin oxidation, leading to polymerization or depolymerization of actin. Furthermore, attempts are being made to control intracellular actin by combining photosensitizers and electromagnetic waves. Since actin is thought to be involved in many diseases, including cancer, these methods have potential medical applications. This review will provide an overview of advances in this field and discuss the prospects for medical applications of methods to control actin polymerization using optical approaches. [ABSTRACT FROM AUTHOR]
- Published
- 2024