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Objective: To compare the effect of ethanol tube sealing with conventional heparin tube sealing on the maintenance hemodialysis patients with long-term indwelling catheter., and provide a clinical clue in the tube sealing approach for them. Methods: The ethanol tube sealing approach was used in 14 maintenance hemodialysis patients with long-term indwelling catheter, and the conventional heparin tube sealing approach was used in another 14 patients with the same status. The catheter-related bacteremia (CRB), thrombus and inflammation in the 28 patients were detected. Results: By using the ethanol tube sealing, the catheter-related inflammatory factors decreased markedly, the lowest of which appeared within 25-48 weeks (P<0.05), while the incidence of thrombus showed no significant difference between using the ethanol tube sealing and the conventional tube sealing. Conclusion: Using the ethanol tube sealing could markedly help reduce the catheter-related inflammation rate in patients with maintenance hemodialysis when compared with the conventional tube sealing, and not likely to lead to the thrombus in catheter. [ABSTRACT FROM AUTHOR]