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目的 探究自发性脑出血（spontaneous intracerebral hemorrhage，sICH）患者视神经鞘直径（optic nerve sheath diameter，ONSD）与颅内压（intracranial pressure，ICP）的相关性，评估ONSD对ICP升高的诊断效能。 方法 连续纳入2021年12月—2022年5月在首都医科大学附属北京天坛医院急诊科住院治疗并接受有创ICP监测的sICH患者。在入抢救室0 h、4 h、8 h、12 h、24 h、48 h分别通过床旁超声测量ONSD并记录同时刻ICP数值。采用Spearman相关分析评估ONSD与ICP关系。采用ROC曲线评估ONSD对ICP＞20 mmHg（1 mmHg=0.133 kPa）的诊断效能。 结果 共纳入12例患者，年龄59（42～76）岁，共计采集72对ONSD和ICP数据。ONSD与ICP间相关系数为0.768（95%CI 0.578～0.886，P＜0.001）。应用ONSD诊断ICP＞20 mmHg的ROC曲线下面积为0.841（95%CI 0.727～0.921，P=0.007）。以ONSD≥5.35 mm为阈值诊断ICP＞20 mmHg的灵敏度为0.947，特异度为0.796，阳性预测值为0.667，阴性预测值为0.972。 结论 在sICH患者中，超声测量的ONSD与ICP呈正相关，ONSD≥5.35 mm可以诊断ICP增高。 Abstract: Objective To investigate the association between optic nerve sheath diameter (ONSD) and intracranial pressure (ICP) in patients with spontaneous intracerebral hemorrhage (sICH), and to evaluate the performance of ONSD in diagnosis ICP elevation. Methods Patients with sICH admitted to the emergency department of Beijing Tiantan Hospital, Capital Medical University from December 2021 to May 2022 and receiving invasive ICP monitoring were consecutively included. ONSD was measured by bedside ultrasound and ICP was recorded at 0 h, 4 h, 8 h, 12 h, 24 h, 48 h after admission. Spearman correlation analysis was used to evaluate the relationship between ONSD and ICP. ROC was used to evaluate the diagnostic efficacy of ONSD in the diagnosis of ICP >20 mmHg. Results A total of 12 patients, aged 59(42-76) years were enrolled, of which a total of 72 pairs of ONSD and ICP data were collected. Spearman rank correlation coefficient of ONSD and ICP was 0.768 (95%CI 0.578-0.886, P20 mmHg was 0.841 (95%CI 0.727-0.921, P=0.007). Using ONSD 5.35 mm as the threshold for diagnosing ICP>20 mmHg, its sensitivity was 0.947, specificity was 0.796, positive predictive value was 0.667, and negative predictive value was 0.972. Conclusions In patients with sICH, Ultrasound measurement of ONSD is positively correlated with ICP, and increased ICP can be diagnosed when ONSD≥5.35 mm.

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Copyright of Journal of Petrochemical Universities / Shiyou Huagong Gaodeng Xuexiao Xuebao is the property of Journal Editorial Department Of Liaoning Shihua University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To study the regulation effect of preoperative application of chitin derivatives on Tumor necrosis factor-alpha stimulated gene-6 (TSG-6)-p38/c-Jun N-terminal kinase(c-Jun N-terminal kinase, JNK) pathway in keloid. Methods Keloid patients treated in our hospital from October 2019 to August 2021 were selected as the research object. They underwent surgical resection and were divided into the chitin group (n=42) and control group (n=37) according to whether treated with chitin derivatives. The chitin group was given chitin gel twice a day for 14 consecutive days before the operation, while the control group did not receive any treatment before the operation. During surgery, the keloid tissues were collected. The pathological changes were detected by HE staining, the expression levels of PCNA, Ki-67, and the apoptosis rate were detected by the TUNEL method. Results Compared with the control group, the infiltration of inflammatory cells decreased, the expression level of PCNA, Ki-67, Bcl-2 decreased, and the apoptosis rate and the expression levels of TSG-6, Bax and cleaved caspase-3 increased in keloid of chitin group (P<0.05). Conclusion Chitin derivatives regulate cell proliferation and apoptosis in keloid, which is related to the regulation of the TSG6-p38/JNK pathway. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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The sedimentary sequences and geochemistry characteristics of mudstone contain much geological information and are widely used in sedimentology and provenance analysis. The Upper Carboniferous Benxi Formation in Gongyi area, the western Henan is rich in lithium resources. However, the source rocks, deposition conditions, and other controlling factors of lithium resouces and the occurrence minerals are not clear. Based on the field outcrop and the characteristics of major, trace and rare earth elements, the comprehensive analysis of Upper Carboniferous Benxi Formation in the western Henan were carried out. The lithium enrichment characteristics of Benxi Formation was illustrated, the source rocks, weathering degree, sediment sorting and recycling, paleoenvironment of Benxi Formation were discussed, and then the controlling factors of lithium enrichment were analyzed. The results show that lithium is mainly concentrated in mudstone with the average content of 1487×10-6, and the content of lithium in bauxite is low; Benxi Formation is mainly composed of fine-grained sediments, and the sedimentary sequences indicate that the sediments are deposited in lagoon; B/Ga ratio indicates that the sea water is brackish during the sedimentation; Sr/Cu ratio and other parameters show that the sediments are deposited in a warm humid-dry hot climate under anoxic conditions; the different diagrams of trace and rare earth elements in Benxi Formation indicate that the source rocks are mainly felsic igneous rock, and secondary limestones and mudstones; the chemical index of alteration and weathering index of parker parameters and related diagrams show that the source rocks have undergone strong weathering and sedimentary recycling. Lithium enrichment in Benxi Formation is closely related to the content of clay minerals (such as kaolinite and chlorite). Source rocks provide materials for lithium enrichment, and sedimentary characteristics such as sedimentary recycling processes and sedimentary environment, affect the enrichment of lithium resources. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Shanghai Ocean University is the property of Editorial Department of Journal of Shanghai Ocean University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Objective: To investigate the correlation of human cartilage glycoprotein-39 (YKL)-40, chemokine CCL27 (CCL27), chemokine CXCL10 (CXCL10), helper T cell (Th) 17 and its related cytokines interleukin (IL)-17 with disease activity and clinical indexes in patients with dermatomyositis. Methods: 80 patients with dermatomyositis who were treated in the dermatology department of the First Affiliated Hospital of Hebei North University from February 2020 to February 2022 were selected as the dermatomyositis group, and 40 healthy physical examination personnel in the same period were selected as the control group. The levels of serum YKL-40, CCL27, CXCL10, IL-17 and peripheral blood Th17 cells ratio were detected and compared between the two groups. Patients with dermatomyositis were divided into active phase group and remission phase group according to their condition. The levels of YKL-40, CCL27, CXCL10, IL-17, Th17 cell ratio, dermatomyositis related clinical indexes and myositis disease activity assessment visual analogue scale (MYOACT) score were compared between the two groups. Pearson correlation coefficient was used to analyze the correlation between YKL-40, CCL27, CXCL10, IL-17, Th17 cell ratio and MYOACT score and dermatomyositis related clinical indexes. Results: The levels of YKL-40, CCL27, CXCL10, IL-17 and Th17 cell ratio in dermatomyositis group were higher than those in control group (P<0. 05). The levels of YKL-40, CCL27, CXCL10, IL-17 and Th17 cell ratio in the active phase group were higher than those in the remission phase group (P<0. 05). The MYOACT score, erythrocyte sedimentation rate (ESR), ferritin (Fer), lactate dehydrogenase (LDH) and creatine kinase (CK) levels in the active phase group were higher than those in the remission phase group (P<0. 05). Pearson correlation analysis showed that the levels of YKL-40, CCL27, CXCL10, IL-17 and Th17 cells ratio in patients with dermatomyositis were positively correlated with MYOACT score, ESR, fer, LDH and CK (P<0. 05). Conclusion: The levels of serum YKL-40, CCL27, CXCL10, IL-17 and peripheral blood Th17 cells ratio have a certain correlation with the severity of dermatomyositis condition, which can be used as an auxiliary evaluation index of dermatomyositis. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Materials Engineering / Cailiao Gongcheng is the property of Journal of Materials Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Journal of Shenyang Agricultural University is the property of Journal of Shenyang Agricultural University Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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BACKGROUND: Joint arthroplasty of hip and knee significantly improves the quality of life of patients, but periprosthetic joint infection has always been the most serious complication of the operation, and it is also one of the most challenging problems in the field of joint surgery. OBJECTIVE: To summarize the etiology, epidemiology, risk factors, diagnosis and treatment of periprosthetic joint infection on hip and knee, focusing on the diagnosis and treatment, in order to provide reference for clinical treatment of periprosthetic joint infection on hip and knee. METHODS: The articles from the establishment of the database to 2021 were searched in PubMed, Web of Science, CNKI and Wanfang databases. According to the selecting criteria related to the diagnosis and treatment of periprosthetic joint infection of hip and knee joint, screening and analysis were carried out to exclude the articles with poor correlation with the topic and repetitive and obsolete articles. The articles included in the study contained original research, reviews, clinical trials, meta-analysis, and case reports. A total of 890 articles were retrieved. Totally 97 articles were finally included after excluding the poorly related, repetitive and obsolete articles. RESULTS AND CONCLUSION: After summarizing and analyzing these articles, it is found that: (1) At present, there are no clear criteria for diagnosis and treatment of periprosthetic joint infection of hip and knee joint. (2) The sensitivity and specificity of current diagnostic criteria for hip and knee joint periprosthetic joint infection are still low, so it is necessary to develop more accurate, simpler and faster diagnostic methods. (3) Two-stage revision is still the gold standard for the treatment of periprosthetic infection of hip and knee joint, which has the advantages of wide indication and high eradication rate of infection. (4) In recent years, biotherapy for inhibition and destruction of bacterial biofilm is gradually becoming a new treatment, but most of them are in basic research and clinical applications are not universal. Its long-term efficacy and safety remain to be determined. [ABSTRACT FROM AUTHOR]

Copyright of Engineering Management & Technology Discussion is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)