Objective: To investigate the effect of the Chinese medicine master Shen Baofan for more than thirty years in the treatment of fatty liver and liver function in hyperlipidemia rats with the effect of Huatan Mai Tong tablet on the function of fatty liver and liver in hyperlipidemia rats, and to understand the effect of improving the liver function and treating the effect of fatty liver. Methods:75 SD rats were randomly divided into normal group, model group, fluvastatin group, middle dose group and high dose group of huatatsu Mai Tong, 15 rats in each group. The changes of blood lipid level and liver function after treatment were observed and compared, and the effect of fatty liver in each group was compared by pathological section. Results: The levels of TC, TG and LDL-C in high dose group of normal group, fluvastatin group, middle dose and high dose group of Huatan Maitong were lower than those in the model group(P<0.05),but the level of HDL-C was higher than that in the model group(P<0.05); the levels of TC, TG and LDL-C in the normal group and the high dose group were lower than those in the middle dose group and the fluvastatin group(P<0.05), but the level of HDL-C was higher than that in the middle dose group and the fluvastatin group(P<0.05), and there was no significant difference between the middle dose group and the fluvastatin group(P>0.05); TC, TG, LDL-C C[(1.28±0.38) mmol/L,(0.40±0.16) mmol/L,(0.39±0.07) mmol/L] in the normal group were significantly lower than those in the Huatan Maitong high dose group [(5.18±1.42) mmol/L,(0.51±0.24) mmol/L,(2.07±0.46) mmol/L](P<0.05), while HDL-C[(3.78±0.34) mmol/L] was significantly higher than that in the Huatan Maitong high dose group [(2.89±0.78) mmol/L](P<0.05). The level of AST and ALT in normal group, fluvastatin group, middle dose and high dose group of Huatan Mai Tong were lower than those in the model group(P<0.05); The AST and ALT of normal group [(10.38+1.46) mmol/L,(10.85+1.24) mmol/L], Huatan Maitong middle-dose group [(15.97+3.64) mmol/L,(16.52+1.18) mmol/L], and Huatan Maitong high-dose group [(10.54+1.01) mmol/L,(10.62+1.67) mmol/L] were significantly lower than those of fluvastatin group [(25.47+2.38)mmol/L,(21.34+2.39] respectively. Mmol/L](P<0.05). and the level of AST and ALT between the groups was not significant(P>0.05).In contrast with liver pathology, the degree of fatty liver decreased with increasing dose of Huatan Mai Tong tablet. Conclusions: Huatan Mai Tong tablet has good effect on lipid lowering and is related to the dose. It has good protective effect on liver function and has good therapeutic effect on fatty liver. The mechanism of treatment may be related to the effect of lipid regulating. [ABSTRACT FROM AUTHOR]